Antibody engineering |
Pubbl/distr/stampa | [Place of publication not identified], : Karger, 1997 |
Descrizione fisica | 1 online resource (XII + 212 pages) : : 43 figures, 1 in color, 9 tables |
Soggetto topico |
Biological Science Disciplines
Serum Globulins Technology Immunoproteins Genetic Engineering Blood Proteins Natural Science Disciplines Genetic Techniques Technology, Industry, and Agriculture Globulins Investigative Techniques Proteins Technology, Industry, Agriculture Disciplines and Occupations Amino Acids, Peptides, and Proteins Analytical, Diagnostic and Therapeutic Techniques and Equipment Chemicals and Drugs Immunoglobulins Biotechnology Protein Engineering |
ISBN | 3-318-01990-9 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910155293203321 |
[Place of publication not identified], : Karger, 1997 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Chemistry and Biochemistry of Oxygen Therapeutics [[electronic resource] ] : From Transfusion to Artificial Blood |
Autore | Mozzarelli Andrea |
Pubbl/distr/stampa | Hoboken, : Wiley, 2011 |
Descrizione fisica | 1 online resource (476 p.) |
Disciplina |
615.8/36
615.836 |
Altri autori (Persone) | BettatiStefano |
Soggetto topico |
Hemoglobins - therapeutic use
Hemoglobins -- therapeutic use Nitric oxide - Physiological effect Nitric oxide -- Physiological effect Oxigen - Physiological effect Oxigen -- Physiological effect Oxygen - blood Oxygen -- blood Oxygen Consumption Oxygen Inhalation Therapy - methods Oxygen Inhalation Therapy -- methods Oxygen therapy SCIENCE / Life Sciences / Biochemistry Oxygen therapy - Physiological effect Oxygen - Physiological effect Nitric oxide Metabolic Phenomena Respiratory Therapy Investigative Techniques Body Fluids Globins Chalcogens Blood Proteins Gases Therapeutics Fluids and Secretions Elements Hemeproteins Inorganic Chemicals Proteins Amino Acids, Peptides, and Proteins Anatomy Oxygen Blood Hemoglobins Methods Oxygen Inhalation Therapy Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
ISBN |
1-283-17785-4
9786613177858 1-119-97542-5 1-119-97543-3 |
Classificazione | SCI007000 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Chemistry and Biochemistry of Oxygen Therapeutics; Contents; List of Contributors; Preface; 1. Introduction; References; Part I. Oxygen: Chemistry, Biochemistry, Physiology and Toxicity; 2. Hemoglobin Reactivity and Regulation; 2.1 Introduction; 2.2 Oxygen Loading and Transport; 2.3 NO Reactivity with Hb; 2.4 Hb Oxidation; 2.5 Nitrite Reactivity with Hb; 2.6 Amino-acid Determinants of Hb Reactivity: Natural and Engineered Hbs; 2.6.1 Modulation of Oxygen Affinity and Cooperativity; 2.6.2 NO Reactivity and Oxidation; 2.7 Conclusion; Acknowledgments; References
3. The Major Physiological Control Mechanisms of Blood Flow and Oxygen Delivery3.1 Introduction; 3.2 Autoregulation of Blood Flow to Changes in Perfusion Pressure; 3.3 Metabolic Regulation of Blood Flow; 3.4 O2 Transport; 3.5 O2 Delivery; 3.6 Endothelial Control of Vasomotor Tone; 3.7 Effect of Cell-free Hb on Endothelial Function; 3.8 Hypoxic Hypoxia; 3.9 Carbon Monoxide Hypoxia; 3.10 Anemia; 3.11 Conclusion; References; 4. The Main Players: Hemoglobin and Myoglobin; Nitric Oxide and Oxygen; 4.1 Introduction; 4.2 Role of Mammalian Mb in O2 Homeostasis 4.3 WhatLfs Missing in the Mb Knockout Mouse4.4 Evolutionary Origins of Mb and the Nitrogen Cycle; 4.5 Human Hb: Evolved Sensor of pO2 and Redox; 4.6 Broad Reactivity and Influence of NO: Lessons from the Microcosm Hb; 4.7 Some Fish Demonstrate a Fundamental "Need" for Hb-dependent NO Cycling, as in Humans; 4.8 Reactions of NO with Hb that Preserve NO Bioactivity; 4.9 Mammalian RBC/Hb.NO Interactions; 4.10 A Mutant Mouse Challenges the SNO-Hb Hypothesis, but does not Overthrow it; 4.11 Signaling by Hb-derived SNO: A Metabolically Responsive, Regulated Pathway 4.12 Signaling by Hb-derived SNO: Pathway Complexity Revealed by Multiple Defects in Disease States4.13 Therapeutic Implications of the Hb.NO Signaling System; 4.14 HBOCs, NO, and SNO; 4.15 Other Gaseous Hb Ligands of Potential Therapeutic Significance; 4.16 NO-related Enzymatic Activities of Hb: Reconciling Nitrite Reductase and SNO Synthase Functions; 4.17 Measuring Biologically Relevant Hb.NO Adducts; 4.18 Conclusion; Acknowledgments; References; 5. The Role of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury; 5.1 Introduction 5.2 Redox System and Free Radicals in Biological Systems5.3 Pathophysiology of Ischemia/Reperfusion Injury; 5.3.1 Cell Death; 5.3.2 The Inflammatory Response; 5.4 Protection Against I/R Injury; 5.4.1 Ischemic Pre- and Post-conditioning; 5.4.2 Pharmacological Conditioning; 5.4.2.1 The Protective Role of ROS and Antioxidants; 5.4.2.2 The Protective Role of NO; 5.4.2.3 NO-based Therapies for I/R Injury; 5.5 Conclusion; Acknowledgments; References; Part II. Medical Needs for Oxygen Supply; 6. Acute Traumatic Hemorrhage and Anemia; 6.1 Introduction; 6.2 Blood Transfusion in Trauma 6.2.1 Massive Transfusion |
Record Nr. | UNINA-9910139631203321 |
Mozzarelli Andrea | ||
Hoboken, : Wiley, 2011 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Chemistry and Biochemistry of Oxygen Therapeutics [[electronic resource] ] : From Transfusion to Artificial Blood |
Autore | Mozzarelli Andrea |
Pubbl/distr/stampa | Hoboken, : Wiley, 2011 |
Descrizione fisica | 1 online resource (476 p.) |
Disciplina |
615.8/36
615.836 |
Altri autori (Persone) | BettatiStefano |
Soggetto topico |
Hemoglobins - therapeutic use
Hemoglobins -- therapeutic use Nitric oxide - Physiological effect Nitric oxide -- Physiological effect Oxigen - Physiological effect Oxigen -- Physiological effect Oxygen - blood Oxygen -- blood Oxygen Consumption Oxygen Inhalation Therapy - methods Oxygen Inhalation Therapy -- methods Oxygen therapy SCIENCE / Life Sciences / Biochemistry Oxygen therapy - Physiological effect Oxygen - Physiological effect Nitric oxide Metabolic Phenomena Respiratory Therapy Investigative Techniques Body Fluids Globins Chalcogens Blood Proteins Gases Therapeutics Fluids and Secretions Elements Hemeproteins Inorganic Chemicals Proteins Amino Acids, Peptides, and Proteins Anatomy Oxygen Blood Hemoglobins Methods Oxygen Inhalation Therapy Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
ISBN |
1-283-17785-4
9786613177858 1-119-97542-5 1-119-97543-3 |
Classificazione | SCI007000 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Chemistry and Biochemistry of Oxygen Therapeutics; Contents; List of Contributors; Preface; 1. Introduction; References; Part I. Oxygen: Chemistry, Biochemistry, Physiology and Toxicity; 2. Hemoglobin Reactivity and Regulation; 2.1 Introduction; 2.2 Oxygen Loading and Transport; 2.3 NO Reactivity with Hb; 2.4 Hb Oxidation; 2.5 Nitrite Reactivity with Hb; 2.6 Amino-acid Determinants of Hb Reactivity: Natural and Engineered Hbs; 2.6.1 Modulation of Oxygen Affinity and Cooperativity; 2.6.2 NO Reactivity and Oxidation; 2.7 Conclusion; Acknowledgments; References
3. The Major Physiological Control Mechanisms of Blood Flow and Oxygen Delivery3.1 Introduction; 3.2 Autoregulation of Blood Flow to Changes in Perfusion Pressure; 3.3 Metabolic Regulation of Blood Flow; 3.4 O2 Transport; 3.5 O2 Delivery; 3.6 Endothelial Control of Vasomotor Tone; 3.7 Effect of Cell-free Hb on Endothelial Function; 3.8 Hypoxic Hypoxia; 3.9 Carbon Monoxide Hypoxia; 3.10 Anemia; 3.11 Conclusion; References; 4. The Main Players: Hemoglobin and Myoglobin; Nitric Oxide and Oxygen; 4.1 Introduction; 4.2 Role of Mammalian Mb in O2 Homeostasis 4.3 WhatLfs Missing in the Mb Knockout Mouse4.4 Evolutionary Origins of Mb and the Nitrogen Cycle; 4.5 Human Hb: Evolved Sensor of pO2 and Redox; 4.6 Broad Reactivity and Influence of NO: Lessons from the Microcosm Hb; 4.7 Some Fish Demonstrate a Fundamental "Need" for Hb-dependent NO Cycling, as in Humans; 4.8 Reactions of NO with Hb that Preserve NO Bioactivity; 4.9 Mammalian RBC/Hb.NO Interactions; 4.10 A Mutant Mouse Challenges the SNO-Hb Hypothesis, but does not Overthrow it; 4.11 Signaling by Hb-derived SNO: A Metabolically Responsive, Regulated Pathway 4.12 Signaling by Hb-derived SNO: Pathway Complexity Revealed by Multiple Defects in Disease States4.13 Therapeutic Implications of the Hb.NO Signaling System; 4.14 HBOCs, NO, and SNO; 4.15 Other Gaseous Hb Ligands of Potential Therapeutic Significance; 4.16 NO-related Enzymatic Activities of Hb: Reconciling Nitrite Reductase and SNO Synthase Functions; 4.17 Measuring Biologically Relevant Hb.NO Adducts; 4.18 Conclusion; Acknowledgments; References; 5. The Role of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury; 5.1 Introduction 5.2 Redox System and Free Radicals in Biological Systems5.3 Pathophysiology of Ischemia/Reperfusion Injury; 5.3.1 Cell Death; 5.3.2 The Inflammatory Response; 5.4 Protection Against I/R Injury; 5.4.1 Ischemic Pre- and Post-conditioning; 5.4.2 Pharmacological Conditioning; 5.4.2.1 The Protective Role of ROS and Antioxidants; 5.4.2.2 The Protective Role of NO; 5.4.2.3 NO-based Therapies for I/R Injury; 5.5 Conclusion; Acknowledgments; References; Part II. Medical Needs for Oxygen Supply; 6. Acute Traumatic Hemorrhage and Anemia; 6.1 Introduction; 6.2 Blood Transfusion in Trauma 6.2.1 Massive Transfusion |
Record Nr. | UNINA-9910806996303321 |
Mozzarelli Andrea | ||
Hoboken, : Wiley, 2011 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Current and Future Issues in Hemophilia Care / / edited by Emérito-Carlos Rodríguez-Merchán, Leonard A. Valentino |
Pubbl/distr/stampa | Hoboken, : Wiley, 2011 |
Descrizione fisica | 1 online resource (190 p.) |
Disciplina |
600
616.1572 |
Soggetto topico |
Blood Coagulation Factors
Hemophilia Hemorrhagic Disorders Blood Coagulation Disorders, Inherited Biological Factors Coagulation Protein Disorders Blood Proteins Blood Coagulation Disorders Proteins Genetic Diseases, Inborn Hematologic Diseases Hemic and Lymphatic Diseases Amino Acids, Peptides, and Proteins Congenital, Hereditary, and Neonatal Diseases and Abnormalities Diseases Hemophilia A Medicine Health & Biological Sciences |
ISBN |
1-283-20458-4
9786613204585 1-119-97940-4 1-119-97937-4 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Current and Future Issues in Hemophilia Care; Contents; List of Contributors; Preface; Part 1: Introduction; 1 History of Hemophilia; 2 Hemophilia Care in the Modern World; 3 Comprehensive Care Model in Hemophilia; Part 2: General Topics; 4 When Should We Switch from On-Demand to Prophylaxis Regimen?; 5 Prophylaxis in Children; 6 Prophylaxis in Adults with Hemophilia; 7 The Economics of Prophylaxis: Does Prophylaxis with Clotting Factor Represent Value for Money?; 8 The Transition of Care for the Young Adult Hemophilia Patient; 9 Perinatal Clinical Care and Molecular Diagnosis in Hemophilia
10 Managing the Mature Person with Hemophilia11 Quality of Life in Hemophilia; Part 3: Inhibitors; 12 Immunology of Inhibitor Development; 13 Epidemiology of Inhibitors; 14 Early Tolerization to Minimize Inhibitors in PUPs with Hemophilia A; 15 Prediction of Inhibitors in Severe Hemophilia; 16 Genetic Basis for Inhibitor Development; 17 Non-Genetic Risk Factors for Inhibitor Development; Part 4: Inhibitor Treatment; 18 Immune Tolerance Induction Programs; 19 Prophylaxis in Hemophilia A Patients with Inhibitors; 20 Treatment of Bleeding in FVIII Inhibitor Patients 21 Discordancy of Bypassing Therapy Part 5: Joint Health and Disease; 22 Experimental Studies on Hemarthrosis, Synovitis and Arthropathy; 23 Assessment of Joint Involvement in Hemophilia; 24 Imaging of the Hemophilic Joint; 25 Initial and Advanced Stages of Hemophilic Arthropathy, and Other Musculo-Skeletal Problems: The Role of Orthopedic Surgery; 26 Perioperative Thromboprophylaxis for Persons with Hemophilia Undergoing Orthopedic Surgery; Part 6: New Developments; 27 New Technologies for the Pharmacokinetic Improvement of Coagulation Factor Proteins 28 Current and Future Approaches to Gene Therapy in Patients with Hemophilia29 New Developments in Hemophilic Arthropathy; 30 Physiotherapy Evaluation and Intervention in the Acute Hemarthrosis: Challenging the Paradigm; 31 Laboratory Assays to Predict Response to Bypassing Agents; 32 Combination/Sequential Use of Bypassing Agents; Index |
Record Nr. | UNINA-9910139614103321 |
Hoboken, : Wiley, 2011 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Current and Future Issues in Hemophilia Care / / edited by Emérito-Carlos Rodríguez-Merchán, Leonard A. Valentino |
Pubbl/distr/stampa | Hoboken, : Wiley, 2011 |
Descrizione fisica | 1 online resource (190 p.) |
Disciplina |
600
616.1572 |
Soggetto topico |
Blood Coagulation Factors
Hemophilia Hemorrhagic Disorders Blood Coagulation Disorders, Inherited Biological Factors Coagulation Protein Disorders Blood Proteins Blood Coagulation Disorders Proteins Genetic Diseases, Inborn Hematologic Diseases Hemic and Lymphatic Diseases Amino Acids, Peptides, and Proteins Congenital, Hereditary, and Neonatal Diseases and Abnormalities Diseases Hemophilia A Medicine Health & Biological Sciences |
ISBN |
1-283-20458-4
9786613204585 1-119-97940-4 1-119-97937-4 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Current and Future Issues in Hemophilia Care; Contents; List of Contributors; Preface; Part 1: Introduction; 1 History of Hemophilia; 2 Hemophilia Care in the Modern World; 3 Comprehensive Care Model in Hemophilia; Part 2: General Topics; 4 When Should We Switch from On-Demand to Prophylaxis Regimen?; 5 Prophylaxis in Children; 6 Prophylaxis in Adults with Hemophilia; 7 The Economics of Prophylaxis: Does Prophylaxis with Clotting Factor Represent Value for Money?; 8 The Transition of Care for the Young Adult Hemophilia Patient; 9 Perinatal Clinical Care and Molecular Diagnosis in Hemophilia
10 Managing the Mature Person with Hemophilia11 Quality of Life in Hemophilia; Part 3: Inhibitors; 12 Immunology of Inhibitor Development; 13 Epidemiology of Inhibitors; 14 Early Tolerization to Minimize Inhibitors in PUPs with Hemophilia A; 15 Prediction of Inhibitors in Severe Hemophilia; 16 Genetic Basis for Inhibitor Development; 17 Non-Genetic Risk Factors for Inhibitor Development; Part 4: Inhibitor Treatment; 18 Immune Tolerance Induction Programs; 19 Prophylaxis in Hemophilia A Patients with Inhibitors; 20 Treatment of Bleeding in FVIII Inhibitor Patients 21 Discordancy of Bypassing Therapy Part 5: Joint Health and Disease; 22 Experimental Studies on Hemarthrosis, Synovitis and Arthropathy; 23 Assessment of Joint Involvement in Hemophilia; 24 Imaging of the Hemophilic Joint; 25 Initial and Advanced Stages of Hemophilic Arthropathy, and Other Musculo-Skeletal Problems: The Role of Orthopedic Surgery; 26 Perioperative Thromboprophylaxis for Persons with Hemophilia Undergoing Orthopedic Surgery; Part 6: New Developments; 27 New Technologies for the Pharmacokinetic Improvement of Coagulation Factor Proteins 28 Current and Future Approaches to Gene Therapy in Patients with Hemophilia29 New Developments in Hemophilic Arthropathy; 30 Physiotherapy Evaluation and Intervention in the Acute Hemarthrosis: Challenging the Paradigm; 31 Laboratory Assays to Predict Response to Bypassing Agents; 32 Combination/Sequential Use of Bypassing Agents; Index |
Record Nr. | UNINA-9910810362103321 |
Hoboken, : Wiley, 2011 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Idiotypes in biology and medicine |
Pubbl/distr/stampa | [Place of publication not identified], : Karger, 1990 |
Descrizione fisica | 1 online resource (X + 214 pages) : : 38 figures, 18 tables |
Soggetto topico |
Immunoglobulin Fragments
Epitopes Immunogenetic Phenomena Immunoglobulins Immune System Phenomena Antigens Peptide Fragments Phenomena and Processes Immunoproteins Serum Globulins Biological Factors Peptides Blood Proteins Chemicals and Drugs Globulins Amino Acids, Peptides, and Proteins Proteins Immunoglobulin Idiotypes |
ISBN | 3-318-00040-X |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910155289503321 |
[Place of publication not identified], : Karger, 1990 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Immunochemistry of AIDS |
Pubbl/distr/stampa | [Place of publication not identified], : Karger, 1993 |
Descrizione fisica | 1 online resource (X + 168 pages) : : 18 figures, 6 in color, 12 tables |
Soggetto topico |
env Gene Products, Human Immunodeficiency Virus
Antigens HIV HIV Antigens Deltaretrovirus Antibodies Viral Fusion Proteins Gene Products, env Human Immunodeficiency Virus Proteins Lentiviruses, Primate Antigens, Viral Membrane Fusion Proteins Biological Factors Viral Envelope Proteins Antibodies, Viral Retroviridae Proteins Membrane Proteins Viral Structural Proteins Lentivirus Chemicals and Drugs Antibodies Retroviridae Viral Proteins Immunoglobulins Proteins RNA Viruses Immunoproteins Amino Acids, Peptides, and Proteins Serum Globulins Globulins Vertebrate Viruses Blood Proteins Viruses Organisms Epitopes HIV Envelope Protein gp120 HIV Envelope Protein gp41 HIV Antibodies HIV-1 |
ISBN | 3-318-01752-3 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910155289103321 |
[Place of publication not identified], : Karger, 1993 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Mast cell activation and mediator release |
Pubbl/distr/stampa | [Place of publication not identified], : Karger, 1984 |
Descrizione fisica | 1 online resource (XII + 336 pages) : : 101 figures, 11 tables |
Soggetto topico |
Connective Tissue Cells
Immunoglobulin Isotypes Immune System Hemic and Immune Systems Antibodies Cells Immunoglobulins Anatomy Immunoproteins Serum Globulins Blood Proteins Globulins Proteins Amino Acids, Peptides, and Proteins Chemicals and Drugs Immunoglobulin E Mast Cells |
ISBN | 3-318-00057-4 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910155288103321 |
[Place of publication not identified], : Karger, 1984 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Monoclonal antibody therapy |
Pubbl/distr/stampa | [Place of publication not identified], : Karger, 1988 |
Descrizione fisica | 1 online resource (X + 174 pages) : : 38 figures, 2 tables |
Soggetto topico |
Diseases
Antibodies Immune System Diseases Immunomodulation Immunoglobulins Biological Therapy Serum Globulins Immunoproteins Therapeutics Analytical, Diagnostic and Therapeutic Techniques and Equipment Blood Proteins Globulins Proteins Amino Acids, Peptides, and Proteins Chemicals and Drugs Neoplasms Antibodies, Monoclonal Autoimmune Diseases Immunotherapy |
ISBN | 3-318-01602-0 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910155287403321 |
[Place of publication not identified], : Karger, 1988 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|
Recent trends in allergen and complement research |
Pubbl/distr/stampa | [Place of publication not identified], : Karger, 1982 |
Descrizione fisica | 1 online resource (X + 234 pages) : : 56 figures, 32 tables |
Soggetto topico |
Antigens
Immunoproteins Science Natural Science Disciplines Biological Factors Blood Proteins Chemicals and Drugs Disciplines and Occupations Proteins Amino Acids, Peptides, and Proteins Complement System Proteins Research Allergens |
ISBN | 3-318-01913-5 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910155283003321 |
[Place of publication not identified], : Karger, 1982 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
|