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Biocatalysis [[electronic resource] /] / A. S. Bommarius, B. R. Riebel
| Biocatalysis [[electronic resource] /] / A. S. Bommarius, B. R. Riebel |
| Autore | Bommarius A. S (Andreas Sebastian) |
| Pubbl/distr/stampa | Weinheim ; ; Cambridge, : Wiley-VCH, c2004 |
| Descrizione fisica | 1 online resource (637 p.) |
| Disciplina | 660.634 |
| Altri autori (Persone) | RiebelB. R (Bettina R.) |
| Soggetto topico |
Enzymes - Biotechnology
Biosynthesis Catalysis |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-56086-X
9786610560868 3-527-60605-X 3-527-60236-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Biocatalysis; Preface; Acknowledgments; Contents; 1 Introduction to Biocatalysis; 1.1 Overview: The Status of Biocatalysis at the Turn of the 21st Century; 1.1.1 State of Acceptance of Biocatalysis; 1.1.2 Current Advantages and Drawbacks of Biocatalysis; 1.1.2.1 Advantages of Biocatalysts; 1.1.2.2 Drawbacks of Current Biocatalysts; 1.2 Characteristics of Biocatalysis as a Technology; 1.2.1 Contributing Disciplines and Areas of Application; 1.2.2 Characteristics of Biocatalytic Transformations; 1.2.2.1 Comparison of Biocatalysis with other Kinds of Catalysis
1.2.3 Applications of Biocatalysis in Industry1.2.3.1 Chemical Industry of the Future: Environmentally Benign Manufacturing, Green Chemistry, Sustainable Development in the Future; 1.2.3.2 Enantiomerically Pure Drugs or Advanced Pharmaceutical Intermediates (APIs); 1.3 Current Penetration of Biocatalysis; 1.3.1 The Past: Historical Digest of Enzyme Catalysis; 1.3.2 The Present: Status of Biocatalytic Processes; 1.4 The Breadth of Biocatalysis; 1.4.1 Nomenclature of Enzymes; 1.4.2 Biocatalysis and Organic Chemistry, or "Do we Need to Forget our Organic Chemistry?" 2 Characterization of a (Bio-)catalyst2.1 Characterization of Enzyme Catalysis; 2.1.1 Basis of the Activity of Enzymes: What is Enzyme Catalysis?; 2.1.1.1 Enzyme Reaction in a Reaction Coordinate Diagram; 2.1.2 Development of Enzyme Kinetics from Binding and Catalysis; 2.2 Sources and Reasons for the Activity of Enzymes as Catalysts; 2.2.1 Chronology of the Most Important Theories of Enzyme Activity; 2.2.2 Origin of Enzymatic Activity: Derivation of the Kurz Equation; 2.2.3 Consequences of the Kurz Equation; 2.2.4 Efficiency of Enzyme Catalysis: Beyond Pauling's Postulate 2.3 Performance Criteria for Catalysts, Processes, and Process Routes2.3.1 Basic Performance Criteria for a Catalyst: Activity, Selectivity and Stability of Enzymes; 2.3.1.1 Activity; 2.3.1.2 Selectivity; 2.3.1.3 Stability; 2.3.2 Performance Criteria for the Process; 2.3.2.1 Product Yield; 2.3.2.2 (Bio)catalyst Productivity; 2.3.2.3 (Bio)catalyst Stability; 2.3.2.4 Reactor Productivity; 2.3.3 Links between Enzyme Reaction Performance Parameters; 2.3.3.1 Rate Acceleration; 2.3.3.2 Ratio between Catalytic Constant k(cat) and Deactivation Rate Constant k(d) 2.3.3.3 Relationship between Deactivation Rate Constant k(d) and Total Turnover Number TTN2.3.4 Performance Criteria for Process Schemes, Atom Economy, and Environmental Quotient; 3 Isolation and Preparation of Microorganisms; 3.1 Introduction; 3.2 Screening of New Enzyme Activities; 3.2.1 Growth Rates in Nature; 3.2.2 Methods in Microbial Ecology; 3.3 Strain Development; 3.3.1 Range of Industrial Products from Microorganisms; 3.3.2 Strain Improvement; 3.4 Extremophiles; 3.4.1 Extremophiles in Industry; 3.5 Rapid Screening of Biocatalysts; 4 Molecular Biology Tools for Biocatalysis 4.1 Molecular Biology Basics: DNA versus Protein Level |
| Record Nr. | UNINA-9910146245703321 |
Bommarius A. S (Andreas Sebastian)
|
||
| Weinheim ; ; Cambridge, : Wiley-VCH, c2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biocatalysis [[electronic resource] /] / A. S. Bommarius, B. R. Riebel
| Biocatalysis [[electronic resource] /] / A. S. Bommarius, B. R. Riebel |
| Autore | Bommarius A. S (Andreas Sebastian) |
| Pubbl/distr/stampa | Weinheim ; ; Cambridge, : Wiley-VCH, c2004 |
| Descrizione fisica | 1 online resource (637 p.) |
| Disciplina | 660.634 |
| Altri autori (Persone) | RiebelB. R (Bettina R.) |
| Soggetto topico |
Enzymes - Biotechnology
Biosynthesis Catalysis |
| ISBN |
1-280-56086-X
9786610560868 3-527-60605-X 3-527-60236-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Biocatalysis; Preface; Acknowledgments; Contents; 1 Introduction to Biocatalysis; 1.1 Overview: The Status of Biocatalysis at the Turn of the 21st Century; 1.1.1 State of Acceptance of Biocatalysis; 1.1.2 Current Advantages and Drawbacks of Biocatalysis; 1.1.2.1 Advantages of Biocatalysts; 1.1.2.2 Drawbacks of Current Biocatalysts; 1.2 Characteristics of Biocatalysis as a Technology; 1.2.1 Contributing Disciplines and Areas of Application; 1.2.2 Characteristics of Biocatalytic Transformations; 1.2.2.1 Comparison of Biocatalysis with other Kinds of Catalysis
1.2.3 Applications of Biocatalysis in Industry1.2.3.1 Chemical Industry of the Future: Environmentally Benign Manufacturing, Green Chemistry, Sustainable Development in the Future; 1.2.3.2 Enantiomerically Pure Drugs or Advanced Pharmaceutical Intermediates (APIs); 1.3 Current Penetration of Biocatalysis; 1.3.1 The Past: Historical Digest of Enzyme Catalysis; 1.3.2 The Present: Status of Biocatalytic Processes; 1.4 The Breadth of Biocatalysis; 1.4.1 Nomenclature of Enzymes; 1.4.2 Biocatalysis and Organic Chemistry, or "Do we Need to Forget our Organic Chemistry?" 2 Characterization of a (Bio-)catalyst2.1 Characterization of Enzyme Catalysis; 2.1.1 Basis of the Activity of Enzymes: What is Enzyme Catalysis?; 2.1.1.1 Enzyme Reaction in a Reaction Coordinate Diagram; 2.1.2 Development of Enzyme Kinetics from Binding and Catalysis; 2.2 Sources and Reasons for the Activity of Enzymes as Catalysts; 2.2.1 Chronology of the Most Important Theories of Enzyme Activity; 2.2.2 Origin of Enzymatic Activity: Derivation of the Kurz Equation; 2.2.3 Consequences of the Kurz Equation; 2.2.4 Efficiency of Enzyme Catalysis: Beyond Pauling's Postulate 2.3 Performance Criteria for Catalysts, Processes, and Process Routes2.3.1 Basic Performance Criteria for a Catalyst: Activity, Selectivity and Stability of Enzymes; 2.3.1.1 Activity; 2.3.1.2 Selectivity; 2.3.1.3 Stability; 2.3.2 Performance Criteria for the Process; 2.3.2.1 Product Yield; 2.3.2.2 (Bio)catalyst Productivity; 2.3.2.3 (Bio)catalyst Stability; 2.3.2.4 Reactor Productivity; 2.3.3 Links between Enzyme Reaction Performance Parameters; 2.3.3.1 Rate Acceleration; 2.3.3.2 Ratio between Catalytic Constant k(cat) and Deactivation Rate Constant k(d) 2.3.3.3 Relationship between Deactivation Rate Constant k(d) and Total Turnover Number TTN2.3.4 Performance Criteria for Process Schemes, Atom Economy, and Environmental Quotient; 3 Isolation and Preparation of Microorganisms; 3.1 Introduction; 3.2 Screening of New Enzyme Activities; 3.2.1 Growth Rates in Nature; 3.2.2 Methods in Microbial Ecology; 3.3 Strain Development; 3.3.1 Range of Industrial Products from Microorganisms; 3.3.2 Strain Improvement; 3.4 Extremophiles; 3.4.1 Extremophiles in Industry; 3.5 Rapid Screening of Biocatalysts; 4 Molecular Biology Tools for Biocatalysis 4.1 Molecular Biology Basics: DNA versus Protein Level |
| Record Nr. | UNINA-9910830140403321 |
|
Bommarius A. S (Andreas Sebastian)
|
||
| Weinheim ; ; Cambridge, : Wiley-VCH, c2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biocatalysis / / A. S. Bommarius, B. R. Riebel
| Biocatalysis / / A. S. Bommarius, B. R. Riebel |
| Autore | Bommarius A. S (Andreas Sebastian) |
| Pubbl/distr/stampa | Weinheim ; ; Cambridge, : Wiley-VCH, c2004 |
| Descrizione fisica | 1 online resource (637 p.) |
| Disciplina | 660.634 |
| Altri autori (Persone) | RiebelB. R (Bettina R.) |
| Soggetto topico |
Enzymes - Biotechnology
Biosynthesis Catalysis |
| ISBN |
1-280-56086-X
9786610560868 3-527-60605-X 3-527-60236-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Biocatalysis; Preface; Acknowledgments; Contents; 1 Introduction to Biocatalysis; 1.1 Overview: The Status of Biocatalysis at the Turn of the 21st Century; 1.1.1 State of Acceptance of Biocatalysis; 1.1.2 Current Advantages and Drawbacks of Biocatalysis; 1.1.2.1 Advantages of Biocatalysts; 1.1.2.2 Drawbacks of Current Biocatalysts; 1.2 Characteristics of Biocatalysis as a Technology; 1.2.1 Contributing Disciplines and Areas of Application; 1.2.2 Characteristics of Biocatalytic Transformations; 1.2.2.1 Comparison of Biocatalysis with other Kinds of Catalysis
1.2.3 Applications of Biocatalysis in Industry1.2.3.1 Chemical Industry of the Future: Environmentally Benign Manufacturing, Green Chemistry, Sustainable Development in the Future; 1.2.3.2 Enantiomerically Pure Drugs or Advanced Pharmaceutical Intermediates (APIs); 1.3 Current Penetration of Biocatalysis; 1.3.1 The Past: Historical Digest of Enzyme Catalysis; 1.3.2 The Present: Status of Biocatalytic Processes; 1.4 The Breadth of Biocatalysis; 1.4.1 Nomenclature of Enzymes; 1.4.2 Biocatalysis and Organic Chemistry, or "Do we Need to Forget our Organic Chemistry?" 2 Characterization of a (Bio-)catalyst2.1 Characterization of Enzyme Catalysis; 2.1.1 Basis of the Activity of Enzymes: What is Enzyme Catalysis?; 2.1.1.1 Enzyme Reaction in a Reaction Coordinate Diagram; 2.1.2 Development of Enzyme Kinetics from Binding and Catalysis; 2.2 Sources and Reasons for the Activity of Enzymes as Catalysts; 2.2.1 Chronology of the Most Important Theories of Enzyme Activity; 2.2.2 Origin of Enzymatic Activity: Derivation of the Kurz Equation; 2.2.3 Consequences of the Kurz Equation; 2.2.4 Efficiency of Enzyme Catalysis: Beyond Pauling's Postulate 2.3 Performance Criteria for Catalysts, Processes, and Process Routes2.3.1 Basic Performance Criteria for a Catalyst: Activity, Selectivity and Stability of Enzymes; 2.3.1.1 Activity; 2.3.1.2 Selectivity; 2.3.1.3 Stability; 2.3.2 Performance Criteria for the Process; 2.3.2.1 Product Yield; 2.3.2.2 (Bio)catalyst Productivity; 2.3.2.3 (Bio)catalyst Stability; 2.3.2.4 Reactor Productivity; 2.3.3 Links between Enzyme Reaction Performance Parameters; 2.3.3.1 Rate Acceleration; 2.3.3.2 Ratio between Catalytic Constant k(cat) and Deactivation Rate Constant k(d) 2.3.3.3 Relationship between Deactivation Rate Constant k(d) and Total Turnover Number TTN2.3.4 Performance Criteria for Process Schemes, Atom Economy, and Environmental Quotient; 3 Isolation and Preparation of Microorganisms; 3.1 Introduction; 3.2 Screening of New Enzyme Activities; 3.2.1 Growth Rates in Nature; 3.2.2 Methods in Microbial Ecology; 3.3 Strain Development; 3.3.1 Range of Industrial Products from Microorganisms; 3.3.2 Strain Improvement; 3.4 Extremophiles; 3.4.1 Extremophiles in Industry; 3.5 Rapid Screening of Biocatalysts; 4 Molecular Biology Tools for Biocatalysis 4.1 Molecular Biology Basics: DNA versus Protein Level |
| Altri titoli varianti | Biocatalysis : fundamentals and applications |
| Record Nr. | UNINA-9910876526803321 |
|
Bommarius A. S (Andreas Sebastian)
|
||
| Weinheim ; ; Cambridge, : Wiley-VCH, c2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biorganic synthesis : an introduction / / Gary W. Morrow
| Biorganic synthesis : an introduction / / Gary W. Morrow |
| Autore | Morrow Gary W. <1951-> |
| Pubbl/distr/stampa | New York, New York : , : Oxford University Press, , 2016 |
| Descrizione fisica | 1 online resource (xxi, 429 pages) : illustrations |
| Disciplina | 572/.45 |
| Collana | Oxford scholarship online |
| Soggetto topico |
Organic compounds - Synthesis
Biosynthesis Chemistry, Organic |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-19-756322-8
0-19-986052-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Introduction -- The Unique Role of Carbon -- Distinguishing Primary Versus Secondary Metabolism -- Secondary Metabolites and Natural Products -- Natural Products in Organic Chemistry and Medicine -- The Organic Chemistry of Biosynthesis -- Goals and Structure of This Book -- Review of Functional Groups, Stereochemistry, and Conformational Analysis -- Prochiral Relationships: One Step from Chirality -- Prochiral it-Systems: "Two-Faced" Reaction Centers -- Diastereotopic Atoms and Groups: One Step from a Diasteroeomer -- Monosubstituted Cyclohexanes: Favoring Equatorial Positions -- Disubstituted Cyclohexanes: Equivalent and Nonequivalent Combinations -- Bicyclic Systems: Joining of Rings -- Heterocyclic Ring Systems: One Atom Makes All the Difference -- Bond Making and Breaking: Have Pair, Will Share; Need Two from You -- Bronsted Acid-Base Reactions: Proton Donors Gladly Accepted -- Acidity Trends: Why that Proton Is or Isn't Acidic --
Carbocations: Three Bonds to Carbon Can Be a Plus -- Radicals: Odd and Reactive -- Elimination Reactions: Introducing the Carbon-Carbon n-Bond -- Carbocations: Rearrangements and Fates -- Electrophilic Additions: n-Bonds as Nucleophilic Agents -- Nucleophilic Substitutions and Alkylations: Make or Break for C-X Bonds -- Nucleophilic Carbonyl Addition Reactions: C=O n-Bond under Attack -- Imine Formation: Making the Essential C=N Linkage -- Nucleophilic 1,4-(Conjugate) Addition Reactions: Remote Attack on Conjugated Carbonyls -- Nucleophilic Acyl Substitution Reactions: Turning One Acyl Compound into Another -- Looking Ahead -- Study Problems -- Enzymes: The Catalysts of Biological Organic Chemistry -- Cofactors: Enzyme Assistants in Bioorganic Reactions -- NADH/NADPH: Nature's Version of Sodium Borohydride for Carbonyl Reduction -- NAD+/NADP+: Nature's Version of PCC for Alcohol Oxidation -- FAD: Another Hydride Acceptor for Dehydrogenations -- The Significance of the Anomeric Carbon: Glycoside Formation -- UDP-Sugars and Glycoside Formation: SN2 Chemistry at Work -- Organic Reactions in Carbohydrate Chemistry: Overview of Glucose Metabolism -- Glycolysis: A 10-Step Program -- What Happens to the Pyruvic Acid from Glycolysis -- The Citric Acid Cycle: Another 10-Step Program -- The Pentose Phosphate Pathway: Seven Alternative Steps to Some Familiar Intermediates -- The Big Picture -- Amino Acids: More Important Primary Metabolite Building Blocks for Biosynthesis -- Biosynthesis of Serine: A Good Place to Start -- Peptides and Proteins: A Very Brief Review -- Putting Proteins and Carbohydrates Together: Glycoproteins Versus Protein Glycosylation -- Looking Ahead -- Study Problems -- Classification of Terpenes: How Many Isoprene Units? -- The Mevalonic Acid Route to DMAPP and IPP -- The Deoxyxylulose Phosphate Route to IPP and DMAPP -- Hemiterpenes: Just One Isoprene Unit -- Monoterpenes (C10) and Isoprene Linkage: Heads, IPP Wins; Tails, DMAPP Loses -- Geranyl PP to Neryl PP via Linalyl PP: The Importance of Alkene Stereochemistry -- Some Acyclic Monoterpenes and Their Uses -- Mono- and Bicyclic Monoterpenes via Cationic Cyclizations and Wagner-Meerwein Shifts -- What's that Smell? Limonene Derivatives as Flavor and Fragrance Compounds -- Irregular Monoterpenes: If Not Head-to-Tail, then How? -- Iridoids: From Catnip to Alkaloids -- Sesquiterpenes (C15): Linking of Different Starter Units -- Some FPP Cyclizations in Sesquiterpene Biosynthesis -- Trichodiene and the Trichothecenes: How to Trace a Rearrangement Pathway -- Diterpenes (C20): Taking it to the Next Level of Molecular Complexity and Diversity -- Cyclic Diterpenes: From Baseball and Plant Hormones to Anticancer Drugs -- Sesterterpenes (C25): Less Common, More Complex -- Triterpenes and Steroids: Another Case of Irregular Linkage of Terpene Units -- Oxidosqualene and Steroid Biosynthesis: Cyclization to Lanosterol and Beyond -- Conversion of Lanosterol (C30) to Cholesterol (C27): Where Did the Carbons Go? -- Conversions of Cholesterol: Production of the Sex Hormones -- Dehydrocholesterol, Sunshine, and Vitamin D3 Biosynthesis -- Tetraterpenes and Carotenoids: Tail-to-Tail Linkage of C20 Units -- Looking Ahead -- Study Problems -- Fatty Acids: Multiples of Two Carbons, Saturated or Unsaturated -- Saturated Fatty Acid Biosynthesis: It All Starts with Acetyl-CoA -- Branched Fatty Acids: Different Routes and Different Results -- Mono- and Polyunsaturated Fatty Acids: Putting in the "Essential" Double Bonds -- Aerobic Versus Anaerobic Routes to Desaturation -- Further Desaturation of Fatty Acids: Triple Bonds and Rings -- Prostaglandins, Thromboxanes, and Leukotrienes: The Power of Oxygenated FAs -- Polyketide Biosynthesis: More Starter Units and Extender Units, but with a Twist -- Aromatic Polyketide Natural Products: Phenols and Related Structures -- Isotopic Labeling Studies: Biosynthetic Insights via 13C NMR -- Further Modification of Polyketides: Alkylations, Oxidations, Reductions, and Decarboxylations -- Other Oxidative Modifications of Aromatic Rings: Expansion or Cleavage Processes -- Oxidative Coupling of Phenols: Formation of Aryl-Aryl Bonds -- The Use of Other Starter Groups: From Cancer Drugs and Antibiotics to Poison Ivy -- More on Polyketide Synthase (PKS) Systems: Increasing Product Diversity -- Modular Type I PKS Complexes and Macrolide Antibiotics: Erythromycin Biosynthesis -- Genetic Manipulation of Modular PKS Systems: Rational Drug Modification -- Some Final PKS Products of Medicinal Importance -- Looking Ahead -- Study Problems -- What Is Shikimic Acid? -- Shikimic, Chorismic, and Prephenic Acids at the Heart of the Pathway -- The Claisen Rearrangement: Allyl Vinyl Ethers in a Chair -- Conversion of Chorismic Acid to Prephenic Acid -- Conversion of Prephenic Acid to Phenylalanine or Tyrosine -- More Uses for Chorismic Acid -- Shikimic Acid Pathway Products from Phenylalanine and Tyrosine: An Overview -- Phenylpropanoids: A Large Family of Phenyl C3 Compounds -- Phenylpropanoids: Reduction of Acids to Phenyl C3 Aldehydes and Alcohols -- Reduction of Phenyl C3 Alcohols to Phenylpropenes -- Lignans and Lignin: Oxidative Phenolic Coupling with a Twist -- Coniferyl Alcohol Oxidative Coupling: Allyl C-Radical + Allyl C-Radical -- Coniferyl Alcohol Oxidative Coupling: Ortho C-Radical + Allyl C-Radical -- Coniferyl Alcohol Oxidative Coupling: O-Radical + Allyl C-Radical -- Lignin: A Plant Polymer and Major Source of Carbon -- Podophyllotoxin Biosynthesis: Aryltetralin Lignans from the American Mayapple -- Cleavage of Cinnamic Acids to Phenyl Cl Compounds: Different Routes, Similar Outcomes -- Coumarins: Sweet-Smelling Benzopyrones -- Combining the Shikimate, Polyketide, and Terpenoid Pathways -- Kavalactones: Natural Sedatives from the South Pacific -- Flavonoids: Structurally Diverse Plant Polyphenolics -- The Chalcone-to-Flavanone-to-Flavone Sequence: Formation of Apigenin -- The Flavanone-to-Dihydroflavonol-to-Anthocyanin Sequence: Formation of Pelargonidin -- The Flavanone-to-Isoflavanone-to-Isoflavone Sequence: Formation of Genistein -- Isoflavanoid Structural Modifications: Production of Antimicrobial Phytoalexins -- Rotenoids: Fish Poisons from Isoflavones -- Looking Ahead -- Study Problems -- Alkaloid Structure: The Importance of N-Heterocycles -- Alkaloids Not Derived from Amino Acids: Amination Reactions, Poisons, and Venoms -- Amino Acids and Mannich Reactions: Important Keys to Alkaloid Biosynthesis -- Alkaloids from Ornithine: Tropanes via the Mannich Reaction in Action -- Pyrrolizidine Alkaloids: Poison Plants and Insect Defense -- Piperidine-Type Alkaloids Derived from Lysine -- Quinolizidine Alkaloids: Livestock Poisons from Cadaverine -- Alkaloids from Phenylalanine: From Neurotransmitters to Decongestants and Narcotics -- Alkaloids from Tyrosine: The Pictet-Spengler Reaction in Alkaloid Biosynthesis -- (S)-Reticuline: A Versatile Pictet-Spengler-Derived Benzyltetrahydroisoquinoline -- Oxidative Coupling in Alkaloid Biosynthesis: Biosynthesis of Corytuberine and Morphine -- The Morphine Rule -- Alkaloids from Tryptophan: Adventures in Indole Alkaloid Structural Complexity -- Pictet-Spengler-Type Reactions of Tryptamine: p-Carbolines and Indole Terpene Alkaloids -- Alkaloids from Nicotinic Acid: Toxic Addictive Derivatives of a Common Nutrient -- Alkaloids from Anthranilic Acid: From Tryptophan to Quinolines and Acridines -- Alkaloids from Histidine: From Simple Amides to Glaucoma Drugs -- Purine Alkaloids: Addictive Stimulants in our Coffee, Tea, and Chocolate -- Cyclic and Macrocyclic Peptides: From Sweeteners to Antibiotics and Beyond -- Penicillins, Cephalosporins, and Carbapenums: The Essential p-Lactam Antibiotics -- A Final Look Ahead -- Study Problems -- Why We Synthesize Organic Compounds -- Synthetic Challenges: Total Synthesis -- Synthetic Challenges: Semisynthesis -- Synthetic Challenges: Biomimetic Synthesis -- Synthetic Challenges: Structural Revision or Confirmation -- Synthetic Challenges: Formal Synthesis -- Synthetic Challenges: Stereoselective Synthesis of Optically Pure Compounds -- Resolution of Enantiomers to Obtain Optically Pure Compounds -- Use of Chiral Pool Compounds for Synthesis of Optically Pure Natural Products -- Use of Chiral Reagents for Synthesis of Optically Pure Compounds -- Use of Chiral Substrate Control for Stereoselective Synthesis -- Use of Chiral Auxiliaries for Synthesis of Optically Pure Compounds -- Use of Chiral Catalysis for Synthesis of Optically Pure Compounds -- Use of Enzymes for Synthesis of Optically Pure Compounds: Biocatalysis -- Some Final Thoughts -- Study Problems. |
| Record Nr. | UNINA-9910465672303321 |
|
Morrow Gary W. <1951->
|
||
| New York, New York : , : Oxford University Press, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biorganic synthesis : an introduction / / Gary W. Morrow
| Biorganic synthesis : an introduction / / Gary W. Morrow |
| Autore | Morrow Gary W. <1951-> |
| Pubbl/distr/stampa | New York, New York : , : Oxford University Press, , 2016 |
| Descrizione fisica | 1 online resource (xxi, 429 pages) : illustrations |
| Disciplina | 572/.45 |
| Collana | Oxford scholarship online |
| Soggetto topico |
Organic compounds - Synthesis
Biosynthesis Chemistry, Organic |
| ISBN |
0-19-062734-4
0-19-756322-8 0-19-986052-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Introduction -- The Unique Role of Carbon -- Distinguishing Primary Versus Secondary Metabolism -- Secondary Metabolites and Natural Products -- Natural Products in Organic Chemistry and Medicine -- The Organic Chemistry of Biosynthesis -- Goals and Structure of This Book -- Review of Functional Groups, Stereochemistry, and Conformational Analysis -- Prochiral Relationships: One Step from Chirality -- Prochiral it-Systems: "Two-Faced" Reaction Centers -- Diastereotopic Atoms and Groups: One Step from a Diasteroeomer -- Monosubstituted Cyclohexanes: Favoring Equatorial Positions -- Disubstituted Cyclohexanes: Equivalent and Nonequivalent Combinations -- Bicyclic Systems: Joining of Rings -- Heterocyclic Ring Systems: One Atom Makes All the Difference -- Bond Making and Breaking: Have Pair, Will Share; Need Two from You -- Bronsted Acid-Base Reactions: Proton Donors Gladly Accepted -- Acidity Trends: Why that Proton Is or Isn't Acidic --
Carbocations: Three Bonds to Carbon Can Be a Plus -- Radicals: Odd and Reactive -- Elimination Reactions: Introducing the Carbon-Carbon n-Bond -- Carbocations: Rearrangements and Fates -- Electrophilic Additions: n-Bonds as Nucleophilic Agents -- Nucleophilic Substitutions and Alkylations: Make or Break for C-X Bonds -- Nucleophilic Carbonyl Addition Reactions: C=O n-Bond under Attack -- Imine Formation: Making the Essential C=N Linkage -- Nucleophilic 1,4-(Conjugate) Addition Reactions: Remote Attack on Conjugated Carbonyls -- Nucleophilic Acyl Substitution Reactions: Turning One Acyl Compound into Another -- Looking Ahead -- Study Problems -- Enzymes: The Catalysts of Biological Organic Chemistry -- Cofactors: Enzyme Assistants in Bioorganic Reactions -- NADH/NADPH: Nature's Version of Sodium Borohydride for Carbonyl Reduction -- NAD+/NADP+: Nature's Version of PCC for Alcohol Oxidation -- FAD: Another Hydride Acceptor for Dehydrogenations -- The Significance of the Anomeric Carbon: Glycoside Formation -- UDP-Sugars and Glycoside Formation: SN2 Chemistry at Work -- Organic Reactions in Carbohydrate Chemistry: Overview of Glucose Metabolism -- Glycolysis: A 10-Step Program -- What Happens to the Pyruvic Acid from Glycolysis -- The Citric Acid Cycle: Another 10-Step Program -- The Pentose Phosphate Pathway: Seven Alternative Steps to Some Familiar Intermediates -- The Big Picture -- Amino Acids: More Important Primary Metabolite Building Blocks for Biosynthesis -- Biosynthesis of Serine: A Good Place to Start -- Peptides and Proteins: A Very Brief Review -- Putting Proteins and Carbohydrates Together: Glycoproteins Versus Protein Glycosylation -- Looking Ahead -- Study Problems -- Classification of Terpenes: How Many Isoprene Units? -- The Mevalonic Acid Route to DMAPP and IPP -- The Deoxyxylulose Phosphate Route to IPP and DMAPP -- Hemiterpenes: Just One Isoprene Unit -- Monoterpenes (C10) and Isoprene Linkage: Heads, IPP Wins; Tails, DMAPP Loses -- Geranyl PP to Neryl PP via Linalyl PP: The Importance of Alkene Stereochemistry -- Some Acyclic Monoterpenes and Their Uses -- Mono- and Bicyclic Monoterpenes via Cationic Cyclizations and Wagner-Meerwein Shifts -- What's that Smell? Limonene Derivatives as Flavor and Fragrance Compounds -- Irregular Monoterpenes: If Not Head-to-Tail, then How? -- Iridoids: From Catnip to Alkaloids -- Sesquiterpenes (C15): Linking of Different Starter Units -- Some FPP Cyclizations in Sesquiterpene Biosynthesis -- Trichodiene and the Trichothecenes: How to Trace a Rearrangement Pathway -- Diterpenes (C20): Taking it to the Next Level of Molecular Complexity and Diversity -- Cyclic Diterpenes: From Baseball and Plant Hormones to Anticancer Drugs -- Sesterterpenes (C25): Less Common, More Complex -- Triterpenes and Steroids: Another Case of Irregular Linkage of Terpene Units -- Oxidosqualene and Steroid Biosynthesis: Cyclization to Lanosterol and Beyond -- Conversion of Lanosterol (C30) to Cholesterol (C27): Where Did the Carbons Go? -- Conversions of Cholesterol: Production of the Sex Hormones -- Dehydrocholesterol, Sunshine, and Vitamin D3 Biosynthesis -- Tetraterpenes and Carotenoids: Tail-to-Tail Linkage of C20 Units -- Looking Ahead -- Study Problems -- Fatty Acids: Multiples of Two Carbons, Saturated or Unsaturated -- Saturated Fatty Acid Biosynthesis: It All Starts with Acetyl-CoA -- Branched Fatty Acids: Different Routes and Different Results -- Mono- and Polyunsaturated Fatty Acids: Putting in the "Essential" Double Bonds -- Aerobic Versus Anaerobic Routes to Desaturation -- Further Desaturation of Fatty Acids: Triple Bonds and Rings -- Prostaglandins, Thromboxanes, and Leukotrienes: The Power of Oxygenated FAs -- Polyketide Biosynthesis: More Starter Units and Extender Units, but with a Twist -- Aromatic Polyketide Natural Products: Phenols and Related Structures -- Isotopic Labeling Studies: Biosynthetic Insights via 13C NMR -- Further Modification of Polyketides: Alkylations, Oxidations, Reductions, and Decarboxylations -- Other Oxidative Modifications of Aromatic Rings: Expansion or Cleavage Processes -- Oxidative Coupling of Phenols: Formation of Aryl-Aryl Bonds -- The Use of Other Starter Groups: From Cancer Drugs and Antibiotics to Poison Ivy -- More on Polyketide Synthase (PKS) Systems: Increasing Product Diversity -- Modular Type I PKS Complexes and Macrolide Antibiotics: Erythromycin Biosynthesis -- Genetic Manipulation of Modular PKS Systems: Rational Drug Modification -- Some Final PKS Products of Medicinal Importance -- Looking Ahead -- Study Problems -- What Is Shikimic Acid? -- Shikimic, Chorismic, and Prephenic Acids at the Heart of the Pathway -- The Claisen Rearrangement: Allyl Vinyl Ethers in a Chair -- Conversion of Chorismic Acid to Prephenic Acid -- Conversion of Prephenic Acid to Phenylalanine or Tyrosine -- More Uses for Chorismic Acid -- Shikimic Acid Pathway Products from Phenylalanine and Tyrosine: An Overview -- Phenylpropanoids: A Large Family of Phenyl C3 Compounds -- Phenylpropanoids: Reduction of Acids to Phenyl C3 Aldehydes and Alcohols -- Reduction of Phenyl C3 Alcohols to Phenylpropenes -- Lignans and Lignin: Oxidative Phenolic Coupling with a Twist -- Coniferyl Alcohol Oxidative Coupling: Allyl C-Radical + Allyl C-Radical -- Coniferyl Alcohol Oxidative Coupling: Ortho C-Radical + Allyl C-Radical -- Coniferyl Alcohol Oxidative Coupling: O-Radical + Allyl C-Radical -- Lignin: A Plant Polymer and Major Source of Carbon -- Podophyllotoxin Biosynthesis: Aryltetralin Lignans from the American Mayapple -- Cleavage of Cinnamic Acids to Phenyl Cl Compounds: Different Routes, Similar Outcomes -- Coumarins: Sweet-Smelling Benzopyrones -- Combining the Shikimate, Polyketide, and Terpenoid Pathways -- Kavalactones: Natural Sedatives from the South Pacific -- Flavonoids: Structurally Diverse Plant Polyphenolics -- The Chalcone-to-Flavanone-to-Flavone Sequence: Formation of Apigenin -- The Flavanone-to-Dihydroflavonol-to-Anthocyanin Sequence: Formation of Pelargonidin -- The Flavanone-to-Isoflavanone-to-Isoflavone Sequence: Formation of Genistein -- Isoflavanoid Structural Modifications: Production of Antimicrobial Phytoalexins -- Rotenoids: Fish Poisons from Isoflavones -- Looking Ahead -- Study Problems -- Alkaloid Structure: The Importance of N-Heterocycles -- Alkaloids Not Derived from Amino Acids: Amination Reactions, Poisons, and Venoms -- Amino Acids and Mannich Reactions: Important Keys to Alkaloid Biosynthesis -- Alkaloids from Ornithine: Tropanes via the Mannich Reaction in Action -- Pyrrolizidine Alkaloids: Poison Plants and Insect Defense -- Piperidine-Type Alkaloids Derived from Lysine -- Quinolizidine Alkaloids: Livestock Poisons from Cadaverine -- Alkaloids from Phenylalanine: From Neurotransmitters to Decongestants and Narcotics -- Alkaloids from Tyrosine: The Pictet-Spengler Reaction in Alkaloid Biosynthesis -- (S)-Reticuline: A Versatile Pictet-Spengler-Derived Benzyltetrahydroisoquinoline -- Oxidative Coupling in Alkaloid Biosynthesis: Biosynthesis of Corytuberine and Morphine -- The Morphine Rule -- Alkaloids from Tryptophan: Adventures in Indole Alkaloid Structural Complexity -- Pictet-Spengler-Type Reactions of Tryptamine: p-Carbolines and Indole Terpene Alkaloids -- Alkaloids from Nicotinic Acid: Toxic Addictive Derivatives of a Common Nutrient -- Alkaloids from Anthranilic Acid: From Tryptophan to Quinolines and Acridines -- Alkaloids from Histidine: From Simple Amides to Glaucoma Drugs -- Purine Alkaloids: Addictive Stimulants in our Coffee, Tea, and Chocolate -- Cyclic and Macrocyclic Peptides: From Sweeteners to Antibiotics and Beyond -- Penicillins, Cephalosporins, and Carbapenums: The Essential p-Lactam Antibiotics -- A Final Look Ahead -- Study Problems -- Why We Synthesize Organic Compounds -- Synthetic Challenges: Total Synthesis -- Synthetic Challenges: Semisynthesis -- Synthetic Challenges: Biomimetic Synthesis -- Synthetic Challenges: Structural Revision or Confirmation -- Synthetic Challenges: Formal Synthesis -- Synthetic Challenges: Stereoselective Synthesis of Optically Pure Compounds -- Resolution of Enantiomers to Obtain Optically Pure Compounds -- Use of Chiral Pool Compounds for Synthesis of Optically Pure Natural Products -- Use of Chiral Reagents for Synthesis of Optically Pure Compounds -- Use of Chiral Substrate Control for Stereoselective Synthesis -- Use of Chiral Auxiliaries for Synthesis of Optically Pure Compounds -- Use of Chiral Catalysis for Synthesis of Optically Pure Compounds -- Use of Enzymes for Synthesis of Optically Pure Compounds: Biocatalysis -- Some Final Thoughts -- Study Problems. |
| Record Nr. | UNINA-9910798672103321 |
|
Morrow Gary W. <1951->
|
||
| New York, New York : , : Oxford University Press, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biorganic synthesis : an introduction / / Gary W. Morrow
| Biorganic synthesis : an introduction / / Gary W. Morrow |
| Autore | Morrow Gary W. <1951-> |
| Pubbl/distr/stampa | New York, New York : , : Oxford University Press, , 2016 |
| Descrizione fisica | 1 online resource (xxi, 429 pages) : illustrations |
| Disciplina | 572/.45 |
| Collana | Oxford scholarship online |
| Soggetto topico |
Organic compounds - Synthesis
Biosynthesis Chemistry, Organic |
| ISBN |
0-19-062734-4
0-19-756322-8 0-19-986052-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Introduction -- The Unique Role of Carbon -- Distinguishing Primary Versus Secondary Metabolism -- Secondary Metabolites and Natural Products -- Natural Products in Organic Chemistry and Medicine -- The Organic Chemistry of Biosynthesis -- Goals and Structure of This Book -- Review of Functional Groups, Stereochemistry, and Conformational Analysis -- Prochiral Relationships: One Step from Chirality -- Prochiral it-Systems: "Two-Faced" Reaction Centers -- Diastereotopic Atoms and Groups: One Step from a Diasteroeomer -- Monosubstituted Cyclohexanes: Favoring Equatorial Positions -- Disubstituted Cyclohexanes: Equivalent and Nonequivalent Combinations -- Bicyclic Systems: Joining of Rings -- Heterocyclic Ring Systems: One Atom Makes All the Difference -- Bond Making and Breaking: Have Pair, Will Share; Need Two from You -- Bronsted Acid-Base Reactions: Proton Donors Gladly Accepted -- Acidity Trends: Why that Proton Is or Isn't Acidic --
Carbocations: Three Bonds to Carbon Can Be a Plus -- Radicals: Odd and Reactive -- Elimination Reactions: Introducing the Carbon-Carbon n-Bond -- Carbocations: Rearrangements and Fates -- Electrophilic Additions: n-Bonds as Nucleophilic Agents -- Nucleophilic Substitutions and Alkylations: Make or Break for C-X Bonds -- Nucleophilic Carbonyl Addition Reactions: C=O n-Bond under Attack -- Imine Formation: Making the Essential C=N Linkage -- Nucleophilic 1,4-(Conjugate) Addition Reactions: Remote Attack on Conjugated Carbonyls -- Nucleophilic Acyl Substitution Reactions: Turning One Acyl Compound into Another -- Looking Ahead -- Study Problems -- Enzymes: The Catalysts of Biological Organic Chemistry -- Cofactors: Enzyme Assistants in Bioorganic Reactions -- NADH/NADPH: Nature's Version of Sodium Borohydride for Carbonyl Reduction -- NAD+/NADP+: Nature's Version of PCC for Alcohol Oxidation -- FAD: Another Hydride Acceptor for Dehydrogenations -- The Significance of the Anomeric Carbon: Glycoside Formation -- UDP-Sugars and Glycoside Formation: SN2 Chemistry at Work -- Organic Reactions in Carbohydrate Chemistry: Overview of Glucose Metabolism -- Glycolysis: A 10-Step Program -- What Happens to the Pyruvic Acid from Glycolysis -- The Citric Acid Cycle: Another 10-Step Program -- The Pentose Phosphate Pathway: Seven Alternative Steps to Some Familiar Intermediates -- The Big Picture -- Amino Acids: More Important Primary Metabolite Building Blocks for Biosynthesis -- Biosynthesis of Serine: A Good Place to Start -- Peptides and Proteins: A Very Brief Review -- Putting Proteins and Carbohydrates Together: Glycoproteins Versus Protein Glycosylation -- Looking Ahead -- Study Problems -- Classification of Terpenes: How Many Isoprene Units? -- The Mevalonic Acid Route to DMAPP and IPP -- The Deoxyxylulose Phosphate Route to IPP and DMAPP -- Hemiterpenes: Just One Isoprene Unit -- Monoterpenes (C10) and Isoprene Linkage: Heads, IPP Wins; Tails, DMAPP Loses -- Geranyl PP to Neryl PP via Linalyl PP: The Importance of Alkene Stereochemistry -- Some Acyclic Monoterpenes and Their Uses -- Mono- and Bicyclic Monoterpenes via Cationic Cyclizations and Wagner-Meerwein Shifts -- What's that Smell? Limonene Derivatives as Flavor and Fragrance Compounds -- Irregular Monoterpenes: If Not Head-to-Tail, then How? -- Iridoids: From Catnip to Alkaloids -- Sesquiterpenes (C15): Linking of Different Starter Units -- Some FPP Cyclizations in Sesquiterpene Biosynthesis -- Trichodiene and the Trichothecenes: How to Trace a Rearrangement Pathway -- Diterpenes (C20): Taking it to the Next Level of Molecular Complexity and Diversity -- Cyclic Diterpenes: From Baseball and Plant Hormones to Anticancer Drugs -- Sesterterpenes (C25): Less Common, More Complex -- Triterpenes and Steroids: Another Case of Irregular Linkage of Terpene Units -- Oxidosqualene and Steroid Biosynthesis: Cyclization to Lanosterol and Beyond -- Conversion of Lanosterol (C30) to Cholesterol (C27): Where Did the Carbons Go? -- Conversions of Cholesterol: Production of the Sex Hormones -- Dehydrocholesterol, Sunshine, and Vitamin D3 Biosynthesis -- Tetraterpenes and Carotenoids: Tail-to-Tail Linkage of C20 Units -- Looking Ahead -- Study Problems -- Fatty Acids: Multiples of Two Carbons, Saturated or Unsaturated -- Saturated Fatty Acid Biosynthesis: It All Starts with Acetyl-CoA -- Branched Fatty Acids: Different Routes and Different Results -- Mono- and Polyunsaturated Fatty Acids: Putting in the "Essential" Double Bonds -- Aerobic Versus Anaerobic Routes to Desaturation -- Further Desaturation of Fatty Acids: Triple Bonds and Rings -- Prostaglandins, Thromboxanes, and Leukotrienes: The Power of Oxygenated FAs -- Polyketide Biosynthesis: More Starter Units and Extender Units, but with a Twist -- Aromatic Polyketide Natural Products: Phenols and Related Structures -- Isotopic Labeling Studies: Biosynthetic Insights via 13C NMR -- Further Modification of Polyketides: Alkylations, Oxidations, Reductions, and Decarboxylations -- Other Oxidative Modifications of Aromatic Rings: Expansion or Cleavage Processes -- Oxidative Coupling of Phenols: Formation of Aryl-Aryl Bonds -- The Use of Other Starter Groups: From Cancer Drugs and Antibiotics to Poison Ivy -- More on Polyketide Synthase (PKS) Systems: Increasing Product Diversity -- Modular Type I PKS Complexes and Macrolide Antibiotics: Erythromycin Biosynthesis -- Genetic Manipulation of Modular PKS Systems: Rational Drug Modification -- Some Final PKS Products of Medicinal Importance -- Looking Ahead -- Study Problems -- What Is Shikimic Acid? -- Shikimic, Chorismic, and Prephenic Acids at the Heart of the Pathway -- The Claisen Rearrangement: Allyl Vinyl Ethers in a Chair -- Conversion of Chorismic Acid to Prephenic Acid -- Conversion of Prephenic Acid to Phenylalanine or Tyrosine -- More Uses for Chorismic Acid -- Shikimic Acid Pathway Products from Phenylalanine and Tyrosine: An Overview -- Phenylpropanoids: A Large Family of Phenyl C3 Compounds -- Phenylpropanoids: Reduction of Acids to Phenyl C3 Aldehydes and Alcohols -- Reduction of Phenyl C3 Alcohols to Phenylpropenes -- Lignans and Lignin: Oxidative Phenolic Coupling with a Twist -- Coniferyl Alcohol Oxidative Coupling: Allyl C-Radical + Allyl C-Radical -- Coniferyl Alcohol Oxidative Coupling: Ortho C-Radical + Allyl C-Radical -- Coniferyl Alcohol Oxidative Coupling: O-Radical + Allyl C-Radical -- Lignin: A Plant Polymer and Major Source of Carbon -- Podophyllotoxin Biosynthesis: Aryltetralin Lignans from the American Mayapple -- Cleavage of Cinnamic Acids to Phenyl Cl Compounds: Different Routes, Similar Outcomes -- Coumarins: Sweet-Smelling Benzopyrones -- Combining the Shikimate, Polyketide, and Terpenoid Pathways -- Kavalactones: Natural Sedatives from the South Pacific -- Flavonoids: Structurally Diverse Plant Polyphenolics -- The Chalcone-to-Flavanone-to-Flavone Sequence: Formation of Apigenin -- The Flavanone-to-Dihydroflavonol-to-Anthocyanin Sequence: Formation of Pelargonidin -- The Flavanone-to-Isoflavanone-to-Isoflavone Sequence: Formation of Genistein -- Isoflavanoid Structural Modifications: Production of Antimicrobial Phytoalexins -- Rotenoids: Fish Poisons from Isoflavones -- Looking Ahead -- Study Problems -- Alkaloid Structure: The Importance of N-Heterocycles -- Alkaloids Not Derived from Amino Acids: Amination Reactions, Poisons, and Venoms -- Amino Acids and Mannich Reactions: Important Keys to Alkaloid Biosynthesis -- Alkaloids from Ornithine: Tropanes via the Mannich Reaction in Action -- Pyrrolizidine Alkaloids: Poison Plants and Insect Defense -- Piperidine-Type Alkaloids Derived from Lysine -- Quinolizidine Alkaloids: Livestock Poisons from Cadaverine -- Alkaloids from Phenylalanine: From Neurotransmitters to Decongestants and Narcotics -- Alkaloids from Tyrosine: The Pictet-Spengler Reaction in Alkaloid Biosynthesis -- (S)-Reticuline: A Versatile Pictet-Spengler-Derived Benzyltetrahydroisoquinoline -- Oxidative Coupling in Alkaloid Biosynthesis: Biosynthesis of Corytuberine and Morphine -- The Morphine Rule -- Alkaloids from Tryptophan: Adventures in Indole Alkaloid Structural Complexity -- Pictet-Spengler-Type Reactions of Tryptamine: p-Carbolines and Indole Terpene Alkaloids -- Alkaloids from Nicotinic Acid: Toxic Addictive Derivatives of a Common Nutrient -- Alkaloids from Anthranilic Acid: From Tryptophan to Quinolines and Acridines -- Alkaloids from Histidine: From Simple Amides to Glaucoma Drugs -- Purine Alkaloids: Addictive Stimulants in our Coffee, Tea, and Chocolate -- Cyclic and Macrocyclic Peptides: From Sweeteners to Antibiotics and Beyond -- Penicillins, Cephalosporins, and Carbapenums: The Essential p-Lactam Antibiotics -- A Final Look Ahead -- Study Problems -- Why We Synthesize Organic Compounds -- Synthetic Challenges: Total Synthesis -- Synthetic Challenges: Semisynthesis -- Synthetic Challenges: Biomimetic Synthesis -- Synthetic Challenges: Structural Revision or Confirmation -- Synthetic Challenges: Formal Synthesis -- Synthetic Challenges: Stereoselective Synthesis of Optically Pure Compounds -- Resolution of Enantiomers to Obtain Optically Pure Compounds -- Use of Chiral Pool Compounds for Synthesis of Optically Pure Natural Products -- Use of Chiral Reagents for Synthesis of Optically Pure Compounds -- Use of Chiral Substrate Control for Stereoselective Synthesis -- Use of Chiral Auxiliaries for Synthesis of Optically Pure Compounds -- Use of Chiral Catalysis for Synthesis of Optically Pure Compounds -- Use of Enzymes for Synthesis of Optically Pure Compounds: Biocatalysis -- Some Final Thoughts -- Study Problems. |
| Record Nr. | UNINA-9910815132903321 |
|
Morrow Gary W. <1951->
|
||
| New York, New York : , : Oxford University Press, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biosynthesis in insects [[electronic resource] /] / E. David Morgan
| Biosynthesis in insects [[electronic resource] /] / E. David Morgan |
| Autore | Morgan E. David (Eric David) |
| Pubbl/distr/stampa | Cambridge, : Royal Society of Chemistry, 2004 |
| Descrizione fisica | 1 online resource (225 p.) |
| Disciplina | 571.157 |
| Soggetto topico |
Insects - Physiology
Biosynthesis |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-84755-026-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 01PRELIM; 02PREFAC; 03ACKNOW; 04CONTEN; 05CHAP1; 06CHAP2; 07CHAP3; 08CHAP4; 09CHAP5; 10CHAP6; 11CHAP7; 12CHAP8; 13CHAP9; 14CHAP10; 15A-Z; 16PLATES; 17APPEND; 18SUBIND |
| Record Nr. | UNINA-9910455226303321 |
|
Morgan E. David (Eric David)
|
||
| Cambridge, : Royal Society of Chemistry, 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biosynthesis in insects [[electronic resource] /] / E. David Morgan
| Biosynthesis in insects [[electronic resource] /] / E. David Morgan |
| Autore | Morgan E. David (Eric David) |
| Pubbl/distr/stampa | Cambridge, : Royal Society of Chemistry, 2004 |
| Descrizione fisica | 1 online resource (225 p.) |
| Disciplina | 571.157 |
| Soggetto topico |
Insects - Physiology
Biosynthesis |
| ISBN | 1-84755-026-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 01PRELIM; 02PREFAC; 03ACKNOW; 04CONTEN; 05CHAP1; 06CHAP2; 07CHAP3; 08CHAP4; 09CHAP5; 10CHAP6; 11CHAP7; 12CHAP8; 13CHAP9; 14CHAP10; 15A-Z; 16PLATES; 17APPEND; 18SUBIND |
| Record Nr. | UNINA-9910778310203321 |
|
Morgan E. David (Eric David)
|
||
| Cambridge, : Royal Society of Chemistry, 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biosynthesis in insects / / E. David Morgan
| Biosynthesis in insects / / E. David Morgan |
| Autore | Morgan E. David (Eric David) |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Cambridge, : Royal Society of Chemistry, 2004 |
| Descrizione fisica | 1 online resource (225 p.) |
| Disciplina | 571.157 |
| Soggetto topico |
Insects - Physiology
Biosynthesis |
| ISBN | 1-84755-026-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 01PRELIM; 02PREFAC; 03ACKNOW; 04CONTEN; 05CHAP1; 06CHAP2; 07CHAP3; 08CHAP4; 09CHAP5; 10CHAP6; 11CHAP7; 12CHAP8; 13CHAP9; 14CHAP10; 15A-Z; 16PLATES; 17APPEND; 18SUBIND |
| Record Nr. | UNINA-9910827437603321 |
|
Morgan E. David (Eric David)
|
||
| Cambridge, : Royal Society of Chemistry, 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biosynthesis of heterocycles : from isolation to gene cluster / / Patrizia Diana, Girolamo Cirrincione
| Biosynthesis of heterocycles : from isolation to gene cluster / / Patrizia Diana, Girolamo Cirrincione |
| Autore | Diana Patrizia |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2015 |
| Descrizione fisica | 1 online resource (783 p.) |
| Disciplina | 547/.59 |
| Soggetto topico |
Heterocyclic compounds - Synthesis
Biosynthesis |
| ISBN |
1-118-96062-9
1-118-96055-6 1-118-96042-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Contents; Preface; Acknowledgments; Chapter 1 Introduction; 1.1 Natural Products: Primary and Secondary Metabolites; 1.2 Common Reactions in Secondary Metabolites; 1.2.1 Alkylations; 1.2.2 Wagner-Meerwein Rearrangements; 1.2.3 Aldol and Claisen Reactions; 1.2.4 Schiff Base Formation and Mannich Reactions; 1.2.5 Transaminations; 1.2.6 Decarboxylations; 1.2.7 Oxidation and Reduction Reactions; 1.2.8 Dehalogenation/Halogenation Reactions; 1.2.9 Glycosylation Reactions; References; Chapter 2 Techniques for Biosynthesis; 2.1 Isotopic Labeling; 2.1.1 Stable Isotopes
2.1.2 Radioactive Isotopes2.2 Gene Coding for Enzymes; 2.3 Combinatorial Biosynthesis; References; Chapter 3 Three-Membered Heterocyclic Rings and Their Fused Derivatives; 3.1 Aziridines and Azirines; 3.1.1 Azicemicins; 3.1.2 Miraziridine; 3.1.3 Maduropeptin; 3.1.4 Azinomycins; 3.1.5 Ficellomycin; 3.1.6 Mitomycins; 3.1.7 Azirinomycin and Related Azirines; 3.2 Oxiranes and Oxirenes; 3.2.1 Fosfomycin; 3.2.2 AK, HC, and AF toxins; 3.2.3 Cerulenin; 3.2.4 Polyhydroxyalkanoates; 3.2.5 Epoxyrollins; 3.2.6 Asperlactone, Aspyrone, Asperline; 3.2.7 Tajixanthone; 3.2.8 Cyclomarin; 3.2.9 Cyclopenin 3.2.10 Ovalicin and Fumagillin3.2.11 Methylenomycin A; 3.2.12 Antibiotic LL-C10037; 3.2.13 Manumycins; 3.2.14 Scopolamine; 3.2.15 Iridoid Glucosides; 3.2.16 Cordiaquinone; 3.2.17 Cyclizidine and Indolizomycin; 3.2.18 Enediyne Antibiotics; 3.2.19 Macrolides; 3.2.20 Epothilones; 3.2.21 Pimaricin; 3.2.22 Hypothemycin; 3.2.23 Radicicol and Monocillin I; 3.2.24 Trichothecenes; 3.2.25 Sporolides A and B; References; Chapter 4 Four-Membered Heterocyclic Rings and Their Fused Derivatives; 4.1 Azetidine and Azetines; 4.1.1 Azetidine-2-carboxylic acid; 4.1.2 Polyoxins; 4.1.3 Mugineic Acids 4.1.4 Tabtoxin and Tabtoxinine-β-lactam4.1.5 Nocardicins; 4.1.6 Thienamycin; 4.1.7 Clavulanic Acid and Clavams; 4.1.8 Penicillins and Cephalosporins; 4.2 Oxetanes; 4.2.1 Oxetanocins; 4.2.2 Salinosporamides; 4.2.3 Taxol; 4.3 Dithiethanes; 4.3.1 Tropodithietic acid and Thiotropocin; References; Chapter 5 Five-Membered Heterocyclic Rings and Their Fused Derivatives; 5.1 Pyrroles (Including Tetrapyrroles); 5.1.1 2-Acetyl-1-pyrroline; 5.1.2 Pyrrolnitrin; 5.1.3 Broussonetines; 5.1.4 Prodigiosin and Undecylprodigiosin; 5.1.5 Anatoxin-a and Homoanatoxin-a; 5.1.6 Nostopeptolides A 5.1.7 Pyrrolizidine Alkaloids5.1.8 Toyocamycin and Sangivamycin; 5.1.9 Tetrapyrroles; 5.2 Indoles; 5.2.1 Indole-3-acetic acid and Glucobrassicin; 5.2.2 Camalexin; 5.2.3 Cyclomarazines; 5.2.4 Rebeccamycin and Staurosporine; 5.2.5 Paxilline; 5.3 Furans; 5.3.1 Furanomycin; 5.3.2 Xenofuranones A and B; 5.3.3 Acyl α- L-Rhamnopyranosides and Rhamnosyllactones; 5.3.4 Tuscolid and Tuscoron A and B; 5.3.5 Tetronomycin and Tetronasin; 5.3.6 Nonactin and Macrotetrolides; 5.3.7 Furanonaphthoquinone I; 5.4 Thiophenes; 5.5 Pyrazoles; 5.6 Imidazoles; 5.6.1 Histidine; 5.6.2 Amaranzole A; 5.6.3 Oroidin 5.6.4 Nikkomycins |
| Record Nr. | UNINA-9910140487903321 |
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Diana Patrizia
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||
| Hoboken, New Jersey : , : Wiley, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
