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Engineering Translational Models of Lung Homeostasis and Disease / / edited by Chelsea M. Magin
| Engineering Translational Models of Lung Homeostasis and Disease / / edited by Chelsea M. Magin |
| Edizione | [1st ed. 2023.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023 |
| Descrizione fisica | 1 online resource (328 pages) |
| Disciplina | 262 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Regenerative medicine
Biomedical engineering Cytology Biomaterials Cells Biotechnology Regenerative Medicine and Tissue Engineering Biomedical Engineering and Bioengineering Cell Biology Biomaterials-Cells |
| Soggetto non controllato |
Physiology
Science |
| ISBN | 9783031266256 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Foreword -- Preface -- Contents -- Chapter 1: An Introduction to Engineering and Modeling the Lung -- 1.1 Introduction -- 1.2 Broader Impacts of Understanding Lung Biology in Health and Disease -- 1.3 Lung Physiology in Homeostasis and Disease -- 1.4 Engineering Translational Models of Lung Homeostasis and Disease -- 1.5 Conclusion -- References -- Part I: Engineering and Modeling the Developing Lung -- Chapter 2: Simple Models of Lung Development -- 2.1 Introduction -- 2.1.1 Basics of Lung Development -- 2.2 Models to Study Lung Development -- 2.3 Models of Early Lung Development (Airways) -- 2.3.1 Explant Cultures -- 2.3.2 2D and 3D Imaging of Branching Morphogenesis -- 2.3.3 Time-Lapse Imaging -- 2.3.4 Organoids -- 2.4 Models of Late Lung Development -- 2.4.1 Saccular Phase Models -- 2.4.2 Alveologenesis -- 2.4.3 Other 3D Models of Alveologenesis -- 2.5 Conclusion -- References -- Chapter 3: Lung Development in a Dish: Models to Interrogate the Cellular Niche and the Role of Mechanical Forces in Development -- 3.1 Introduction -- 3.2 Self-Assembled Organoid and Spheroid Models -- 3.2.1 Creating Lung Organoid Models That Represent Regional Composition and Heterogeneity -- 3.2.2 Advancing the Complexity of Organoids to Investigate Tissue Crosstalk -- 3.2.3 Induction of Lung Organoids to Create Multiple Tissue Compartments -- 3.3 Microfluidic and Organ-on-a-Chip Models to Study Lung Development -- 3.3.1 Moving Toward More Complex Physiology with Multiple Channels -- 3.3.2 Integration of Dimensionality and Biomaterials into Organ-on-a-Chip Platforms -- 3.4 Whole Organ Models to Understand the Mechanics of Lung Development -- 3.5 Conclusion -- References -- Chapter 4: Multipotent Embryonic Lung Progenitors: Foundational Units of In Vitro and In Vivo Lung Organogenesis -- 4.1 Introduction -- 4.2 Overview of Embryonic Lung Progenitors.
4.2.1 Stage-Specific Epithelial Progenitors (Primordial, Distal Tip, Basal) -- Lung Primordial Progenitors -- Distal Tip Progenitors -- Airway Basal Cells -- 4.2.2 Stage-Specific Mesenchymal Progenitors -- 4.3 Ex Vivo Culture of Multipotent Embryonic Lung Progenitors -- 4.3.1 Ex Vivo Culture of Mouse Embryonic Progenitors -- 4.3.2 Ex Vivo Culture of Human Embryonic Progenitors -- 4.4 In Vitro Derivation of Multipotent Embryonic Lung Progenitors -- 4.5 Progenitor Cell Similarity Models -- 4.6 Conclusion -- References -- Part II: Engineering and Modeling Large Airways -- Chapter 5: Basic Science Perspective on Engineering and Modeling the Large Airways -- 5.1 Introduction -- 5.2 Proximal Airways: Composition and Function -- 5.3 Regeneration of the Airways -- 5.3.1 Endogenous Stem Cells -- 5.3.2 The Stem Cell Niche -- 5.3.3 Stem Cell Attrition with Disease and Aging -- 5.4 Developing Cellular Therapies for Regeneration of Airway Tissues -- 5.5 In Vitro Models of the Human Airways -- 5.5.1 Transwell Air-Liquid Interface (ALI) Cultures -- 5.5.2 Airway Spheroids: Tracheo/Bronchospheres -- 5.5.3 Organoids -- 5.5.4 Lung-on-a-Chip -- 5.5.5 Xenografts -- 5.6 Cell-Matrix Interactions -- 5.7 Conclusion -- References -- Chapter 6: Computational, Ex Vivo, and Tissue Engineering Techniques for Modeling Large Airways -- 6.1 Large Airways: Structure-Function Relationship -- 6.2 Pathologies and the Need for Modeling the Large Airways -- 6.2.1 Conditions That Cause Large Airway Dysfunction -- 6.2.2 Need for Computational and Physiological Models of the Large Airways -- 6.3 Computational Modeling -- 6.4 Ex Vivo Testing -- 6.5 Tissue Engineering Techniques for Modeling the Large Airways -- 6.5.1 Biomaterial Scaffolds -- Decellularized Scaffolds -- Cellular, Synthetic, or Hybrid Biomaterial Approaches -- 6.5.2 Manufacturing Techniques for Large Airway Models. 6.6 Tools for Functional Assessment of Large Airway Models -- 6.7 Limitations and Future Considerations -- References -- Chapter 7: Engineering Large Airways -- 7.1 Introduction -- 7.2 Forces During Respiration and How They Can Influence Construct Design -- 7.3 The Structure of the Trachea and Its Mechanical Properties -- 7.3.1 Tracheal Cartilage -- 7.3.2 Trachealis Muscle -- 7.3.3 Annular Ligament -- 7.4 Mechanical Properties of the Whole Trachea and the Implications of Mechanical Property Mismatch -- 7.4.1 Compliance -- 7.4.2 Extension and Bending -- 7.5 Key Considerations and Summary of Recommended Mechanical Tests -- 7.6 Conclusion -- References -- Part III: Engineering and Modeling the Mesenchyme and Parenchyma -- Chapter 8: Engineering and Modeling the Lung Mesenchyme -- 8.1 Introduction -- 8.2 Advancing the Discovery of Fibroblast Heterogeneity -- 8.3 The Organization and Heterogeneity of Lung Fibroblasts -- 8.3.1 Platelet-Derived Growth Factor Receptor Alpha (PDGFRα)-Expressing Alveolar Fibroblasts 1 and 2 -- 8.3.2 Platelet-Derived Growth Factor Beta (PDGFRβ)-Expressing Pericytes -- 8.3.3 Airway and Vascular Smooth Muscle (ASM and VSM) -- 8.4 Other Fibroblast Subtypes -- 8.4.1 Developmental Secondary Crest Myofibroblasts (SCMF) -- 8.4.2 Fibrotic Disease-Associated Myofibroblasts (MyoF) -- 8.5 Bioengineering Approaches to Characterize Complex Fibroblast Behaviors -- 8.5.1 Organoids to Model Mesenchymal-Epithelial Interactions -- 8.5.2 Lung-on-a-Chip to Model Human Lung Architecture and Environmental Forces -- 8.5.3 Acellular Tissue Scaffolds to Model Fibroblast and ECM Interactions -- 8.6 Targeting Fibroblasts with Nanoparticles as Strategy for Intervention -- 8.7 Conclusion -- References -- Chapter 9: Engineering Dynamic 3D Models of Lung -- 9.1 Introduction -- 9.2 Building the Extracellular Microenvironment -- 9.2.1 Biomaterials. 9.2.2 Lung Decellularization and Recellularization -- 9.2.3 dECM Hydrogels -- 9.2.4 Synthetic Hydrogels -- 9.2.5 Hybrid-Hydrogels -- 9.3 Constructing Relevant Tissue Geometries -- 9.3.1 Precision-Cut Lung Slices -- 9.3.2 Organoids -- 9.3.3 Engineered 3D Hydrogel Constructs -- 9.3.4 3D Bioprinting -- 9.4 Incorporating Dynamic Mechanical Forces -- 9.4.1 Biomechanical Modeling -- 9.4.2 Lung-on-a-Chip -- 9.5 Conclusion -- References -- Chapter 10: Lung-on-a-Chip Models of the Lung Parenchyma -- 10.1 Introduction -- 10.2 Lung Alveolar Cells and the Alveolar Environment -- 10.2.1 Lung Alveolar Cells and Their Environment -- 10.2.2 Lung Alveolar Epithelial Cells In Vitro -- 10.3 Reproducing the Alveolar Barrier with a Lung-on-a-Chip -- 10.3.1 Reproducing the Lung Alveolar Environment on Chip -- Scaffolds for the Alveolar Barrier: Engineering a Thin, Flexible and Soft Basement Membrane -- Mechanical Stress Induced by the Respiratory Movements -- 10.3.2 Effects of Biochemical and Physical Cues on the Lung Alveolar Barrier -- Effects of Mechanical Forces on Alveolar Epithelial Cells -- Effects of Mechanical Forces on Lung Endothelial Cells -- Lung Alveolar Extracellular Matrix (ECM) -- Effects Induced by the Air-Liquid Interface -- 10.3.3 Read-Outs: Extracting Information from a Lung-on-a-Chip -- 10.4 Lung Disease-on-a-Chip Models -- 10.4.1 Idiopathic Pulmonary Fibrosis (IPF) -- 10.4.2 Emphysema -- 10.4.3 Acute Respiratory Distress Syndrome (ARDS) -- 10.4.4 COVID -- 10.4.5 Lung Adenocarcinoma -- 10.5 Challenges of Lung-on-a-Chip Technologies -- 10.6 Perspectives for Lung-on-a-Chip Technologies -- References -- Chapter 11: Assessment of Collagen in Translational Models of Lung Research -- 11.1 Introduction -- 11.2 Quantification of Collagen -- 11.2.1 The Sircol Assay -- 11.2.2 Hydroxyproline Quantification -- 11.2.3 Immuno-Based Methods. 11.3 Mass Spectrometry Characterization of Collagen -- 11.3.1 Assessment of Collagens in Proteomics Analyses of Pulmonary ECM -- 11.3.2 Analysis of Posttranslational Modifications of Collagen -- 11.3.3 Assessment of Enzymatic Crosslinks in Collagen -- 11.4 Assessment of Collagen Architecture In Situ -- 11.4.1 Masson's Trichrome Staining -- 11.4.2 Picrosirius Red Staining -- 11.4.3 Second Harmonic Generation Microscopy -- 11.4.4 Immunohistochemistry -- 11.4.5 Transmission Electron Microscopy -- 11.4.6 Selected Complementary and Emerging Techniques -- Confocal Reflection Microscopy (CRM) -- Atomic Force Microscopy (AFM) -- Imaging Probes for Magnetic Resonance Imaging (MRI) -- 11.5 Monitoring Fibril Formation in Real Time Using Purified Collagen -- 11.6 Assessment of Collagen Turnover by Peripheral Markers -- 11.7 Conclusion -- References -- Part IV: Engineering and Modeling the Pulmonary Vasculature -- Chapter 12: Understanding and Engineering the Pulmonary Vasculature -- 12.1 Pulmonary Vasculature in Development and Diseases -- 12.2 Pulmonary ECs and Their Angiocrine Functions -- 12.3 Engineering the Pulmonary Vasculature -- 12.3.1 Generation of Vascularized Organoids -- 12.3.2 Bioengineered Lung and Vasculature Using Acellular Native Lung Scaffold -- 12.3.3 Vascularized Lung-on-a-Chip -- 12.3.4 Guided Vascularization Through 3D Bioprinting -- 12.4 Pulmonary Vascular Diseases -- 12.5 Conclusion -- References -- Chapter 13: An Overview of Organ-on-a-Chip Models for Recapitulating Human Pulmonary Vascular Diseases -- 13.1 Introduction -- 13.2 Microfluidics and Organ-on-a-Chip -- 13.2.1 Concepts -- Microfluidics in Vascular Biology -- Patterning Microvascular Networks -- 13.3 OoC for Pulmonary Vascular Diseases -- 13.4 Conclusion -- References -- Chapter 14: Clinical Translation of Engineered Pulmonary Vascular Models -- 14.1 Introduction. 14.2 Brief Overview of Pulmonary Vascular Physiology. |
| Record Nr. | UNINA-9910733729003321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Pluripotent Stem Cell Therapy for Diabetes [[electronic resource] /] / edited by Lorenzo Piemonti, Jon Odorico, Timothy J . Kieffer, Valeria Sordi, Eelco de Koning
| Pluripotent Stem Cell Therapy for Diabetes [[electronic resource] /] / edited by Lorenzo Piemonti, Jon Odorico, Timothy J . Kieffer, Valeria Sordi, Eelco de Koning |
| Autore | Piemonti Lorenzo |
| Edizione | [1st ed. 2023.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023 |
| Descrizione fisica | 1 online resource (597 pages) |
| Disciplina |
571.6
616.02774 |
| Altri autori (Persone) |
OdoricoJon
KiefferTimothy J. SordiValeria de KoningEelco |
| Soggetto topico |
Stem cells
Regenerative medicine Biomaterials Cells Immunotherapy Developmental biology Stem Cell Biology Regenerative Medicine and Tissue Engineering Biomaterials-Cells Developmental Biology and Stem Cells |
| ISBN | 3-031-41943-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Mimicking pancreas development with human pluripotent stem cells -- Pancreatic cell fate specification: insights into developmental mechanisms and their application for lineage reprogramming -- The evolution of methods for in vitro differentiation of stem cell derived islets -- Signaling pathways that govern the formation, expansion and maturation of pancreatic progenitors -- Building islets from the ground up using stem cells -- Pancreatic progenitor proliferation -- Selecting biocompatible biomaterials for stem cell derived islet transplantation -- Scaffolds for encapsulation of stem-cell-derived β cells -- 3d printing of new islets -- Biological scaffolds and hydrogels in islet organoids -- 3-D organoids of mesenchymal stromal and pancreatic islet cells -- Bioengineered insulin producing endocrine tissues -- Bioactive materials for cell encapsulation -- Strategies to boost islet graft oxygenation -- Vascularizing device strategies -- Immunogenicity of stem cell derived islets -- Immune evasive stem cell islets -- Encapsulation of stem cell-derived islets: recent progress -- Islet immunoengineering -- Stem cell genome editing tools -- Selection of SC-derived pancreatic progenitors and β cell -- Considerations pertaining to implant sites for cell-based insulin replacement -- Safety switches in pluripotent stem cells -- Safety: teratoma risk -- Stem cell derived islets transplantation in non-human primates -- Social / Legal / Ethical issues pertaining to use of pluripotent stem cells -- Cost-effectiveness considerations for stem cell derived islet replacement therapy -- Lessons from clinical trials of islet cell replacement -- Scale up and Biomanufacturing of Stem Cell- derived Islets -- Minimal SC-β cell properties for transplantation in diabetic patients -- Autologous stem cell islets for patients with chronic pancreatitis and diabetes -- Clinical Trials -- Modeling monogenic diabetes with stem cells -- Stem and progenitor cells in pancreas development, regeneration and drug screening. . |
| Record Nr. | UNINA-9910838275603321 |
Piemonti Lorenzo
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| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Regenerative Medicine : Emerging Techniques to Translation Approaches / / edited by Nishant Chakravorty, Praphulla Chandra Shukla
| Regenerative Medicine : Emerging Techniques to Translation Approaches / / edited by Nishant Chakravorty, Praphulla Chandra Shukla |
| Autore | Chakravorty Nishant |
| Edizione | [1st ed. 2023.] |
| Pubbl/distr/stampa | Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023 |
| Descrizione fisica | 1 online resource (395 pages) |
| Disciplina | 571.889 |
| Soggetto topico |
Regenerative medicine
Stem cells Nervous system—Regeneration Biomaterials Cells Regenerative Medicine and Tissue Engineering Stem Cell Biology Regeneration and Repair in the Nervous System Biomaterials-Cells |
| ISBN | 981-19-6008-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chapter 1. Regeneration and tissue microenvironment -- Chapter 2. Non stem cell mediated tissue regeneration and repair -- Chapter 3. Immunological Perspectives Involved in Tissue Engineering -- Chapter 4. Advances in Medical Imaging for Wound Repair and Regenerative Medicine -- Chapter 5. Role of Biosensors in Regenerative Therapeutics: Past, Present & Future Prospects -- Chapter 6. Acute and Chronic Wound Management: Assessment, Therapy and Monitoring Strategies -- Chapter 7. Stem cells and therapies in cardiac regeneration -- Chapter 8. Hydrogel-based Tissue-mimics for Vascular Regeneration and Tumor Angiogenesis -- Chapter 9. Advances in 3D Printing Technology for Tissue Engineering -- Chapter 10. Adult Neurogenesis: A Potential Target for Regenerative Medicine -- Chapter 11. Regenerative approaches in the nervous system -- Chapter 12. Prenatal interventions for the treatment of congenital disorders -- Chapter 13. Understanding LncRNAs in biomaterials development for osteointegration -- Chapter 14. Current approaches in vertical bone augmentation and large bone deficiencies in the oro-facial region -- Chapter 15. In-vitro and in-vivo tracking of cell-biomaterial interaction to monitor the process of bone regeneration -- Chapter 16. The Prospects of RNAs and Common Significant Pathways in Cancer Therapy and Regenerative Medicine. |
| Record Nr. | UNINA-9910647382803321 |
|
Chakravorty Nishant
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| Singapore : , : Springer Nature Singapore : , : Imprint : Springer, , 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Scanning Ion Conductance Microscopy / / edited by Tilman E. Schäffer
| Scanning Ion Conductance Microscopy / / edited by Tilman E. Schäffer |
| Edizione | [1st ed. 2022.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022 |
| Descrizione fisica | 1 online resource (238 pages) |
| Disciplina | 502.82 |
| Collana | Bioanalytical Reviews |
| Soggetto topico |
Materials - Microscopy
Analytical chemistry Biophysics Nanoscience Biomaterials Cells Microscopy Analytical Chemistry Nanoscale Biophysics Biomaterials-Cells |
| ISBN |
9783031144431
9783031144424 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | The evolution of scanning ion conductance microscopy -- Scanning ion conductance microscopy and atomic force microscopy: A comparison of strengths and limitations for biological investigations -- Ions and electrons with scanning ion conductance microscopy -- Ion channel recording with a smart patch-clamp system -- Understanding cardiac structure and function at nanoscale resolution with SICM -- Local Electrochemical Characterization using Scanning Electrochemical Cell Microscopy -- Comparison of scanning ion conductance microscopy with scanning electron microscopy for imaging cells and tissues -- Correlating scanning ion conductance and super-resolved fluorescence microscopy. |
| Record Nr. | UNINA-9910616369103321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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