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Asking questions in biology : a guide to hypothesis testing, experimental design and presentation in practical work and research projects / / Chris Barnard, Francis Gilbert, and Peter McGregor
| Asking questions in biology : a guide to hypothesis testing, experimental design and presentation in practical work and research projects / / Chris Barnard, Francis Gilbert, and Peter McGregor |
| Autore | Barnard C. J (Christopher J.) |
| Edizione | [Fourth edition.] |
| Pubbl/distr/stampa | Harlow, England : , : Benjamin Cummings, , [2011] |
| Descrizione fisica | 1 online resource (x, 248 p. ) : ill |
| Disciplina | 570.72 |
| Soggetto topico |
Science - Methodology
Biology - Methodology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-283-17326-3
9786613173263 0-273-73469-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface 1 Doing Science Where do questions come from? 1.1 Science as asking questions 1.2 Basic considerations 1.3 The skill of asking questions 1.4 Where do questions come from? 1.5 What is this book about References 2 Asking questions The art of framing hypotheses and predictions 2.1 Observation 2.2 Exploratory analysis 2.3 Forming hypotheses 2.4 Summary References 3 Answering questions What do the results say? 3.1 Confirmatory analysis 3.2 What is statistical significance 3.3 Significance tests 3.4 Testing hypotheses 3.5 Testing predictions 3.6 Refining hypotheses and predictions 3.7 Summary References 4 Presenting information How to communicate outcomes and conclusions 4.1 Presenting figures and tables 4.2 Presenting results in the text 4.3 Writing reports 4.4 Writing for a more general readership 4.5 Presenting in person: spoken papers and poster presentations 4.6 Plagiarism 4.7 Summary References Test finder and help guide Some self-test questions Appendix I: Table of confidence limits to the median Appendix II: How to calculate some simple significance tests Appendix III: Significance tables Appendix IV: The common codes for the important graphical parameters of R Answers to self-test questions Index Quick test finders |
| Record Nr. | UNINA-9910150243703321 |
Barnard C. J (Christopher J.)
|
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| Harlow, England : , : Benjamin Cummings, , [2011] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biological procedures online
| Biological procedures online |
| Pubbl/distr/stampa | [Waterloo, Ont.], : Biological Procedures Online, 1998- |
| Descrizione fisica | 1 online resource |
| Disciplina | 570 |
| Soggetto topico |
Biology - Methodology
Biology - Research Medical Laboratory Science |
| Soggetto genere / forma |
Online resources.
Periodicals. Periodical |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | BPO |
| Record Nr. | UNISA-996209259903316 |
| [Waterloo, Ont.], : Biological Procedures Online, 1998- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Biological procedures online
| Biological procedures online |
| Pubbl/distr/stampa | [Waterloo, Ont.], : Biological Procedures Online, 1998- |
| Descrizione fisica | 1 online resource |
| Disciplina | 570 |
| Soggetto topico |
Biology - Methodology
Biology - Research Medical Laboratory Science |
| Soggetto genere / forma |
Online resources.
Periodicals. Periodical |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | BPO |
| Record Nr. | UNINA-9910135776003321 |
| [Waterloo, Ont.], : Biological Procedures Online, 1998- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biology methods & protocols
| Biology methods & protocols |
| Pubbl/distr/stampa | [Oxford] : , : Oxford University Press, , [2016]- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Biology - Methodology
Biology - Research Biological Science Disciplines - methods Biological Phenomena |
| Soggetto genere / forma |
Periodicals.
Fulltext Internet Resources. Periodical |
| Soggetto non controllato | Biology - General |
| ISSN | 2396-8923 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
Biology methods and protocols
BIOMAP |
| Record Nr. | UNINA-9910379054603321 |
| [Oxford] : , : Oxford University Press, , [2016]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biology methods & protocols
| Biology methods & protocols |
| Pubbl/distr/stampa | [Oxford] : , : Oxford University Press, , [2016]- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Biology - Methodology
Biology - Research Biological Science Disciplines - methods Biological Phenomena |
| Soggetto genere / forma |
Periodicals.
Fulltext Internet Resources. Periodical |
| Soggetto non controllato | Biology - General |
| ISSN | 2396-8923 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
Biology methods and protocols
BIOMAP |
| Record Nr. | UNISA-996343849403316 |
| [Oxford] : , : Oxford University Press, , [2016]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
How science works [[electronic resource] ] : evaluating evidence in biology and medicine / / Stephen H. Jenkins
| How science works [[electronic resource] ] : evaluating evidence in biology and medicine / / Stephen H. Jenkins |
| Autore | Jenkins Stephen H |
| Pubbl/distr/stampa | Oxford ; ; New York, : Oxford University Press, 2004 |
| Descrizione fisica | 1 online resource (x, 227 p. ) : ill |
| Disciplina | 570/.28 |
| Soggetto topico |
Biology - Methodology
Medicine - Methodology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-50291-6
1-282-36743-9 0-19-803604-3 9786612367434 9786610502912 1-60256-706-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910450321403321 |
|
Jenkins Stephen H
|
||
| Oxford ; ; New York, : Oxford University Press, 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
How science works [[electronic resource] ] : evaluating evidence in biology and medicine / / Stephen H. Jenkins
| How science works [[electronic resource] ] : evaluating evidence in biology and medicine / / Stephen H. Jenkins |
| Autore | Jenkins Stephen H |
| Pubbl/distr/stampa | Oxford ; ; New York, : Oxford University Press, 2004 |
| Descrizione fisica | 1 online resource (x, 227 p. ) : ill |
| Disciplina | 570/.28 |
| Soggetto topico |
Biology - Methodology
Medicine - Methodology |
| ISBN |
0-19-770133-7
1-280-50291-6 1-282-36743-9 0-19-803604-3 9786612367434 9786610502912 1-60256-706-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910783352903321 |
|
Jenkins Stephen H
|
||
| Oxford ; ; New York, : Oxford University Press, 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
How science works [[electronic resource] ] : evaluating evidence in biology and medicine / / Stephen H. Jenkins
| How science works [[electronic resource] ] : evaluating evidence in biology and medicine / / Stephen H. Jenkins |
| Autore | Jenkins Stephen H |
| Pubbl/distr/stampa | Oxford ; ; New York, : Oxford University Press, 2004 |
| Descrizione fisica | 1 online resource (x, 227 p. ) : ill |
| Disciplina | 570/.28 |
| Soggetto topico |
Biology - Methodology
Medicine - Methodology |
| ISBN |
0-19-770133-7
1-280-50291-6 1-282-36743-9 0-19-803604-3 9786612367434 9786610502912 1-60256-706-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910813840803321 |
|
Jenkins Stephen H
|
||
| Oxford ; ; New York, : Oxford University Press, 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Logical modeling of biological systems / / edited by Luis Fariñas del Cerro, Katsumi Inoue
| Logical modeling of biological systems / / edited by Luis Fariñas del Cerro, Katsumi Inoue |
| Pubbl/distr/stampa | London, [England] ; ; Hoboken, New Jersey : , : ISTE : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (429 p.) |
| Disciplina | 570.28 |
| Collana | Bioengineering and Health Science Series |
| Soggetto topico |
Biology - Methodology
Biology - Philosophy Evolution (Biology) |
| ISBN |
1-119-01521-9
1-119-00522-1 1-119-01533-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Contents; Foreword; Chapter 1. Symbolic Representation and Inference of Regulatory Network Structures; 1.1. Introduction: logical modeling and abductive inference in systems biology; 1.2. Logical modeling of regulatory networks; 1.2.1. Background; 1.2.2. Logical model of signed-directed networks; 1.2.2.1. Prior knowledge; 1.2.2.2. Rule-based underlying model; 1.2.2.3. Integrity constraints; 1.2.2.4. Inferring signed-directed networks and explanatory reasoning; 1.3. Evaluation of the ARNI approach; 1.3.1. ARNI predictive power
1.3.1.1. Prediction under biological and experimental noise1.3.1.2. Prediction under incomplete data; 1.3.2. ARNI expressive power; 1.3.2.1. Network motif representations; 1.3.2.2. Representing complex interactions; 1.4. ARNI assisted scientific methodology; 1.4.1. Testing biological hypotheses; 1.4.1.1. Testing cross-talk between signaling pathways; 1.4.2. Informative experiments for networks discrimination; 1.5. Related work and comparison with non-symbolic approaches; 1.5.1. Limitations and future work; 1.6. Conclusions; 1.7. Bibliography Chapter 2. Reasoning on the Response of Logical Signaling Networks with ASP2.1. Introduction; 2.2. Answer set programming at a glance; 2.3. Learn and control logical networks with ASP; 2.3.1. Preliminaries; 2.3.2. Reasoning on the response of logical networks; 2.3.3. Learning models of immediate-early response; 2.3.4. Minimal intervention strategies; 2.3.5. Software toolbox: caspo; 2.4. Conclusion; 2.5. Acknowledgments; 2.6. Bibliography; Chapter 3. A Logical Model for Molecular Interaction Maps; 3.1. Introduction; 3.2. Biological background; 3.3. Logical model 3.3.1. Activation and inhibition3.3.1.1. Activation and inhibition capacities; 3.3.1.2. Relations between the activation and inhibition causes and effects; 3.3.1.3. Relations between causal relations; 3.3.2. Model extension; 3.3.2.1. Phosphorylation; 3.3.2.2. Autophosphorylation; 3.3.2.3. Binding; 3.3.3. Causality relations redefinition; 3.3.3.1. Activation axioms; 3.3.3.2. Phosphorylation axioms; 3.3.3.3. Autophosphorylation axioms; 3.3.3.4. Binding axioms; 3.3.3.5. Inhibition axioms; 3.4. Quantifier elimination for restricted formulas; 3.4.1. Domain formulas; 3.4.2. Restricted formulas 3.4.3. Completion formulas3.4.4. Domain of domain formulas; 3.4.5. Quantifier elimination procedure; 3.5. Reasoning about interactions in metabolic interaction maps; 3.6. Conclusion and future work; 3.7. Acknowledgments; 3.8. Bibliography; Chapter 4. Analyzing Large Network Dynamics with Process Hitting; 4.1. Introduction/state of the art; 4.1.1. The modeling challenge; 4.1.2. Historical context: Boolean and discrete models; 4.1.3. Analysis issues; 4.1.4. The process hitting framework; 4.1.5. Outline; 4.2. Discrete modeling with the process hitting; 4.2.1. Motivation 4.2.2. The process hitting framework |
| Record Nr. | UNINA-9910132156603321 |
| London, [England] ; ; Hoboken, New Jersey : , : ISTE : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Logical modeling of biological systems / / edited by Luis Fariñas del Cerro, Katsumi Inoue
| Logical modeling of biological systems / / edited by Luis Fariñas del Cerro, Katsumi Inoue |
| Pubbl/distr/stampa | London, [England] ; ; Hoboken, New Jersey : , : ISTE : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (429 p.) |
| Disciplina | 570.28 |
| Collana | Bioengineering and Health Science Series |
| Soggetto topico |
Biology - Methodology
Biology - Philosophy Evolution (Biology) |
| ISBN |
1-119-01521-9
1-119-00522-1 1-119-01533-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Contents; Foreword; Chapter 1. Symbolic Representation and Inference of Regulatory Network Structures; 1.1. Introduction: logical modeling and abductive inference in systems biology; 1.2. Logical modeling of regulatory networks; 1.2.1. Background; 1.2.2. Logical model of signed-directed networks; 1.2.2.1. Prior knowledge; 1.2.2.2. Rule-based underlying model; 1.2.2.3. Integrity constraints; 1.2.2.4. Inferring signed-directed networks and explanatory reasoning; 1.3. Evaluation of the ARNI approach; 1.3.1. ARNI predictive power
1.3.1.1. Prediction under biological and experimental noise1.3.1.2. Prediction under incomplete data; 1.3.2. ARNI expressive power; 1.3.2.1. Network motif representations; 1.3.2.2. Representing complex interactions; 1.4. ARNI assisted scientific methodology; 1.4.1. Testing biological hypotheses; 1.4.1.1. Testing cross-talk between signaling pathways; 1.4.2. Informative experiments for networks discrimination; 1.5. Related work and comparison with non-symbolic approaches; 1.5.1. Limitations and future work; 1.6. Conclusions; 1.7. Bibliography Chapter 2. Reasoning on the Response of Logical Signaling Networks with ASP2.1. Introduction; 2.2. Answer set programming at a glance; 2.3. Learn and control logical networks with ASP; 2.3.1. Preliminaries; 2.3.2. Reasoning on the response of logical networks; 2.3.3. Learning models of immediate-early response; 2.3.4. Minimal intervention strategies; 2.3.5. Software toolbox: caspo; 2.4. Conclusion; 2.5. Acknowledgments; 2.6. Bibliography; Chapter 3. A Logical Model for Molecular Interaction Maps; 3.1. Introduction; 3.2. Biological background; 3.3. Logical model 3.3.1. Activation and inhibition3.3.1.1. Activation and inhibition capacities; 3.3.1.2. Relations between the activation and inhibition causes and effects; 3.3.1.3. Relations between causal relations; 3.3.2. Model extension; 3.3.2.1. Phosphorylation; 3.3.2.2. Autophosphorylation; 3.3.2.3. Binding; 3.3.3. Causality relations redefinition; 3.3.3.1. Activation axioms; 3.3.3.2. Phosphorylation axioms; 3.3.3.3. Autophosphorylation axioms; 3.3.3.4. Binding axioms; 3.3.3.5. Inhibition axioms; 3.4. Quantifier elimination for restricted formulas; 3.4.1. Domain formulas; 3.4.2. Restricted formulas 3.4.3. Completion formulas3.4.4. Domain of domain formulas; 3.4.5. Quantifier elimination procedure; 3.5. Reasoning about interactions in metabolic interaction maps; 3.6. Conclusion and future work; 3.7. Acknowledgments; 3.8. Bibliography; Chapter 4. Analyzing Large Network Dynamics with Process Hitting; 4.1. Introduction/state of the art; 4.1.1. The modeling challenge; 4.1.2. Historical context: Boolean and discrete models; 4.1.3. Analysis issues; 4.1.4. The process hitting framework; 4.1.5. Outline; 4.2. Discrete modeling with the process hitting; 4.2.1. Motivation 4.2.2. The process hitting framework |
| Record Nr. | UNINA-9910814187903321 |
| London, [England] ; ; Hoboken, New Jersey : , : ISTE : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
