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Behavioral measures of neurotoxicity : report of a symposium / / Roger W. Russell, namela Ebert Flattau, and Andrew M. Pope, editors
| Behavioral measures of neurotoxicity : report of a symposium / / Roger W. Russell, namela Ebert Flattau, and Andrew M. Pope, editors |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1990 |
| Descrizione fisica | xvi, 432 p. : ill |
| Disciplina | 616.8 |
| Altri autori (Persone) |
RussellRoger W
Flattaunamela Ebert PopeAndrew MacPherson <1950-> |
| Soggetto topico |
Neurotoxicology
Environmental toxicology Nervous system - Diseases - Environmental aspects Neuropsychological tests Behavior - drug effects Nervous System Diseases - chemically induced Neurotoxins - adverse effects |
| Soggetto genere / forma | Conference Proceedings. |
| ISBN |
9786610214501
9781280214509 1280214503 9780309559652 0309559650 9780585148939 0585148937 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Behavioral Measures of Neurotoxicity -- Copyright -- SYMPOSIUM CONTRIBUTORS -- PREFACE -- Contents -- INTRODUCTION -- IDENTIFICATION OF BEHAVIORAL TOXIC AGENTS -- MECHANISMS AND SITES OF ACTION -- THE MEASUREMENT OF BEHAVIOR -- THE LIFE SPAN: WHEN TO MEASURE? -- APPROACHES TO RESEARCH -- REGIONAL REQUIREMENTS -- COMMUNICATION -- CONCLUSION -- REFERENCES -- ARE NEUROTOXINS DRIVING US CRAZY? PLANETARY OBSERVATIONS ON THE CAUSES OF NEURODEGENERATIVE DISEASES OF OLD AGE -- CLINICAL FEATURES OF WESTERN PACIFIC ALS/P-D -- WHAT IS THE CAUSE OF WESTERN PACIFIC ALS/P-D? -- CYCADS: POISONOUS PLANTS USED FOR MEDICINE AND FOOD -- FROM LATHYRISM TO CYCADISM -- LINKING CYCADS TO ALS IN IRIAN JAYA AND JAPAN -- TIMING OF CYCAD EXPOSURE -- RELEVANCE FOR VETERANS OF THE PACIFIC WAR -- TOXIC COMPONENTS OF CYCADS -- SUMMARY -- REFERENCES -- PART I ASSESSMENT OF NEUROBEHAVIORAL TESTS NOW IN USE -- Methods in Behavioral Toxicology: Current Test Batteries and Need for Development -- TEST BATTERIES NOW IN USE -- Epidemiological and Field Studies -- BEHAVIORAL TOXICOLOGY IN CLINICAL PRACTICE -- BASES OF TEST SELECTION -- THE NEUROBEHAVIORAL CORE TEST BATTERY -- FUTURE DIRECTIONS: SOME CRUCIAL ISSUES -- Neuropsychological Description/Definition of Neurotoxic Syndrome(s) -- Natural History of the Neurotoxic Effects -- Dilemma Between Conservative and Progressive Approaches -- Further Questions of Test Selection -- Simple or Complex Tasks? -- Reliability of Tests and Stability of Functions -- Changes in Personality, Mood, and Affect -- Other Areas for Method Development -- SUMMARY -- References -- The Current Status of Test Development in Neurobehavioral Toxicology -- RESEARCH DESIGN AND TEST SELECTION -- REASONS FOR TEST SELECTION -- RECENT APPROACHES TO TEST BATTERY DESIGN -- Neurobehavioral Core Test Battery -- The Computerized Battery Approach.
Model or Theory-Based Tests and Test Batteries -- INFLUENCE ON TESTING SELECTION OF DIFFERENT OBJECTIVES FOR TESTING -- EXPECTED DIRECTIONS IN TEST DEVELOPMENT -- REMAINING BARRIERS TO TEST DEVELOPMENT -- RECOMMENDATIONS FOR FURTHER RESEARCH OR DEVELOPMENT -- References -- Human Neurobehavioral Toxicology Testing -- RATIONALES FOR DEVELOPING TEST BATTERIES -- Finland's Institute of Occupational Health Approach -- Problem-Based Approach -- Approach Recommended by the World Health Organization -- Neurobehavioral Evaluation System Approach -- TARGET ORGAN EFFECTS -- Neurotoxic Chemicals -- Exposure Populations -- Behaviors Affected by Many Chemicals -- NIOSH Recommendations -- Recommendations of the American Conference of Governmental Industrial Hygienists -- POTENTIAL OF TEST BATTERIES TO ASSESS TARGET ORGAN HEALTH EFFECTS -- DEVELOPMENT EFFORTS UNDER WAY -- NOTES -- ACKNOWLEDGMENT AND DISCLAIMER -- References -- Neurobehavioral Tests: Problems, Potential, and Prospects -- TESTS CURRENTLY IN USE -- SOME SPECIFIC POINTS -- Methods in Behavioral Toxicology (Hanninen) -- Current Status of Test Development (Williamson) -- Human Neurobehavioral Tests (Anger) -- THE ADEQUACY OF CURRENT TESTS -- SOME NEW DEVELOPMENTS IN COMPUTER-BASED ASSESSMENT -- Cognitive Componential Models -- Inferential Systems -- IMPLICATIONS FOR NEUROBEHAVIORAL ASSESSMENT -- References -- PART II ASSESSMENT OF ANIMAL MODELS: WHAT HAS WORKED AND WHAT IS NEEDED -- Exposure to Neurotoxins Throughout the Life Span: Animal Models for Linking Neurochemical Effects to Behavioral Consequences -- NEUROCHEMICAL CHANGES DURING DEVELOPMENT AND AGING -- THE CHOLINERGIC SYSTEM IN BEHAVIOR -- EFFECTS OF PRENATAL EXPOSURE TO DFP: FROM BIRTH TO WEANING -- EFFECTS OF EARLY POSTNATAL EXPOSURE TO DFP -- EFFECTS OF EXPOSURE TO DFP: SENESCENT RATS -- Genetic (Strain-Specific) Differences in Effects. Subchronic Intoxication During Senescence -- Time-Course Recovery of mAChRs Following Down-Regulation in Brain of Senescent Rats -- CONCLUSION -- References -- Animal Models of Dementia: Their Relevance to Neurobehavioral Toxicology Testing -- ANIMAL MODELS OF DEMENTIA -- ENVIRONMENTAL CHALLENGES -- PHARMACOLOGICAL CHALLENGES -- MEASURING BEHAVIORAL EFFECTS: SPECIFIC PARADIGMS -- Inhibitory (Passive) Avoidance -- Active Avoidance Tasks -- Operant Conditioning -- Maze Learning -- Other Measures -- CONCLUSION -- ACKNOWLEDGMENTS -- References -- Bridging Experimental Animal and Human Behavioral Toxicology Studies -- THE SCOPE AND AGENDA OF BEHAVIORAL TOXICOLOGY -- STATE OF DEVELOPMENT -- BARRIERS TO ADVANCEMENT -- ACCELERATING THE PACE -- References -- Methods and Issues in Evaluating the Neurotoxic Effects of Organic Solvents -- ACUTE SOLVENT EFFECTS -- APPLICATION OF ANIMAL BEHAVIORAL METHODS -- Acute Effects of Single Exposures -- Acute Effects in the Context of Chronic Exposures -- Reinforcing Properties of Organic Solvents -- CHRONIC SOLVENT EFFECTS ON THE PERIPHERAL NERVOUS SYSTEM -- The Role of Animal Studies -- Neurobehavioral Methods for Screening Sensory and Motor Effects -- Problems in the Interpretation of Human Studies -- Animal Models of Cognitive Effects -- REFERENCES -- Animal Models: What Has Worked and What Is Needed -- References -- PART III CHEMICAL TIME BOMBS: ENVIRONMENTAL CAUSES OF NEURODEGENERATIVE DISEASES -- On the Identification and Measurement of Chemical Time Bombs: A Behavior Development Perspective -- METHODOLOGICAL CONSIDERATIONS -- APPROACHES TO DETECTING BEHAVIORALLY TOXIC SUBSTANCES -- A POTENTIAL TIME BOMB? -- NEW METHODS FOR MEASURING BEHAVIORAL TOXICITY -- ADDITIONAL APPROACHES AND NEW DIRECTIONS -- Multiple Behaviors Can Be Studied -- Comparative Developmental Studies Can Be Undertaken. Knowledge Concerning Neurocircuitry and Neurochemistry of the Response Is Accumulating -- ACKNOWLEDGMENT -- References -- Neurobehavioral Time Bombs: Their Nature and Their Mechanisms -- Relations Between Behavior and Chemical Environment -- CHOLINESTERASE IN PROGRESSIVE DEGENERATIVE DEMENTIAS -- Preclinical Studies of Acetylcholinesterase and Behavior -- Acetylcholinesterase in Behavioral Disorders -- THE TRUTH ABOUT A FALSE TRANSMITTER -- NEUROTROPHIC FACTORS AND BEHAVIOR -- Neurotrophic Factors -- Neurotrophic Factors and Their Environments -- Roles During Neuronal Development and Beyond -- Recovery from Morphological Lesions -- Brain Transplants -- Nerve Growth Factor, Brain Implants, and Behavior -- Behavioral Recovery from Brain Lesions -- CONTRIBUTIONS IN THE FUTURE -- NOTE -- References -- Neurobehavioral Toxicity of Selected Environmental Chemicals: Clinical and Subclinical Aspects -- CLINICAL VERSUS SUBCLINICAL NEUROTOXICITY -- NEUROBEHAVIORAL EFFECTS OF SELECTED INDUSTRIAL CHEMICALS -- Effects in the Developing Nervous System -- Lead -- Mercury -- Polychlorinated Biphenyls -- EFFECTS IN THE ADULT NERVOUS SYSTEM -- Aluminum -- Organic Solvents -- CONCLUSION -- Lack of Consistency -- Lack of Developmental Perspective -- Uncertain Health Significance -- References -- The Health Effects of Environmental Lead Exposure: Closing Pandora's Box -- HISTORY OF THE PRESENT PERSPECTIVE ON THE ENVIRONMENTAL NEUROTOXICITY OF LEAD -- OVERVIEW OF MODERN STUDIES -- Prospective Studies -- Reproductive Effects -- Early Behavioral Effects of Perinatal Lead Exposure -- Retrospective Studies on Correlation of Lead Body Burden and Behavior in Grade School Children -- Later Behavioral Concomitants of Increased Lead Burden -- Effects of Lead on Other Neuropsychological Endpoints -- Other Health Effects of Environmental Lead Exposure -- CRITICAL ISSUES. Markers of Lead Exposure -- Statistical Interpretation -- Adequacy of Behavioral Methodology -- Does Lead Contribute to Aging? -- Overview of Cost to Society -- Have Regulatory Agencies Been Slow to Act? -- CLOSING PANDORA'S BOX -- References -- Chemical Time Bombs: Environmental Causes of Neurodegenerative Diseases -- ESTABLISHING CRITERIA FOR CHEMICAL NEUROTOXICITY -- CLASSIFYING CHEMICALLY INDUCED HUMAN NEUROTOXIC DISORDERS -- THE MATURE NERVOUS SYSTEM AS CHEMICAL TARGET -- DEVELOPING NERVOUS SYSTEM AS CHEMICAL TARGET -- Scientific Basis for Neurobehavioral Toxicity Testing -- CONCLUSION -- Reference -- PART IV BEHAVIORAL ASPECTS OF NEUROTOXICITY: REGIONAL ISSUES -- Neurobehavioral Toxicity Testing in China -- INTRODUCTION -- OVERVIEW OF RESEARCH ACTIVITIES -- Carbon Disulfide -- Lead -- Simulated Video Display Terminal (VDT) Operation -- Static Magnetic Fields (SMF) -- NATIONAL AND INTERNATIONAL COOPERATION -- Mood States -- Performance Tests -- EXPECTED DIRECTIONS: BARRIERS AND RECOMMENDATIONS -- Developments in the Near Future -- Developing and Validating Test Methods -- Generating New Measuring Instruments -- Building a Computerized Evaluation System -- Limitations and Barriers -- Variation of Test Sensitivity from Study to Study -- Bias of Learning Effect -- Controlling Confounding Factors -- Interpreting Results Obtained from Neurobehavioral Tests -- Comments and Recommendations -- Training and Education -- Exploring the Possibility of Combining Quantitative Biochemical Markers and Neurobehavioral Testing -- Development, Validation, and Characterization of Methods -- SUMMARY -- Status of Research and Development of Neurobehavioral Toxicity Tests in China -- Expected Directions in the Development of Behavioral Tests of Neurotoxicity -- Problems and Recommendations -- References. Regional Issues in the Development of the Neurobehavioral Core Test Battery. |
| Record Nr. | UNINA-9910962936303321 |
| Washington, D.C., : National Academy Press, 1990 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Behavioural pharmacology
| Behavioural pharmacology |
| Pubbl/distr/stampa | London, : Clinical Neuroscience Publishers |
| Descrizione fisica | 1 online resource |
| Disciplina | 615.78 |
| Soggetto topico |
Psychopharmacology
Nervous System - drug effects Behavior - drug effects Psychopharmacologie |
| Soggetto genere / forma |
Periodical
periodicals. Periodicals. Périodiques. |
| ISSN | 1473-5849 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910763997803321 |
| London, : Clinical Neuroscience Publishers | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Journal of caffeine and adenosine research
| Journal of caffeine and adenosine research |
| Pubbl/distr/stampa | New Rochelle, N.Y. : , : Mary Ann Liebert, Inc., , [2018]-[2021] |
| Descrizione fisica | 1 online resource |
| Disciplina | 613.8 |
| Soggetto topico |
Caffeine
Adenosine Sleep Deprivation - chemically induced Cognition - drug effects Behavior - drug effects Caffeine - Research Adenosine - Research |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 2573-3400 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910617322003321 |
| New Rochelle, N.Y. : , : Mary Ann Liebert, Inc., , [2018]-[2021] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Neurotoxicology and teratology
| Neurotoxicology and teratology |
| Pubbl/distr/stampa | New York, NY, : Elsevier Science Pub. Co |
| Disciplina | 616 |
| Soggetto topico |
Behavioral toxicology
Neurotoxicology Teratology Drugs - Side effects Human behavior Nervous system - Diseases Toxicology Neurology Drugs Drug-Related Side Effects and Adverse Reactions Nervous System Diseases - chemically induced Abnormalities, Drug-Induced Behavior - drug effects Nervous System - drug effects Behavior Nervous System Diseases Pharmaceutical Preparations Drugs - adverse effects Toxicologie du comportement Neurotoxicologie Tératologie Médicaments - Effets secondaires Comportement humain Système nerveux - Maladies Toxicologie Neurologie Médicaments human behavior toxicology |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 1872-9738 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Neurotoxicology & teratology |
| Record Nr. | UNISA-996203103203316 |
| New York, NY, : Elsevier Science Pub. Co | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Neurotoxicology and teratology
| Neurotoxicology and teratology |
| Pubbl/distr/stampa | New York, NY, : Elsevier Science Pub. Co |
| Disciplina | 616 |
| Soggetto topico |
Behavioral toxicology
Neurotoxicology Teratology Drugs - Side effects Human behavior Nervous system - Diseases Toxicology Neurology Drugs Drug-Related Side Effects and Adverse Reactions Nervous System Diseases - chemically induced Abnormalities, Drug-Induced Behavior - drug effects Nervous System - drug effects Behavior Nervous System Diseases Pharmaceutical Preparations Pharmaceutical Preparations - adverse effects Toxicologie du comportement Neurotoxicologie Tératologie Médicaments - Effets secondaires Comportement humain Système nerveux - Maladies Toxicologie Neurologie Médicaments human behavior toxicology |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 1872-9738 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Neurotoxicology & teratology |
| Record Nr. | UNINA-9910145866103321 |
| New York, NY, : Elsevier Science Pub. Co | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Pharmacology, biochemistry and behavior
| Pharmacology, biochemistry and behavior |
| Pubbl/distr/stampa | [New York], : Pergamon |
| Soggetto topico |
Pharmacology
Biochemistry Toxicology Psychophysiology Pharmacology - Periodicals Biochemistry - Periodicals Toxicology - Periodicals Psychophysiology - Periodicals Behavior - drug effects Pharmacologie - Périodiques Biochimie - Périodiques Toxicologie - Périodiques Psychophysiologie - Périodiques Pharmacologie Biochimie Toxicologie Psychophysiologie biochemistry pharmacology |
| Soggetto genere / forma | Periodicals. |
| ISSN | 1873-5177 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996213238003316 |
| [New York], : Pergamon | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Pharmacology, biochemistry and behavior
| Pharmacology, biochemistry and behavior |
| Pubbl/distr/stampa | [New York], : Pergamon |
| Soggetto topico |
Pharmacology
Biochemistry Toxicology Psychophysiology Behavior - drug effects Pharmacologie - Périodiques Biochimie - Périodiques Toxicologie - Périodiques Psychophysiologie - Périodiques Pharmacologie Biochimie Toxicologie Psychophysiologie biochemistry pharmacology |
| Soggetto genere / forma | Periodicals. |
| ISSN | 1873-5177 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910144226903321 |
| [New York], : Pergamon | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
