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Bacterial Protein Toxins / / Drusilla L. Burns
| Bacterial Protein Toxins / / Drusilla L. Burns |
| Autore | Burns Drusilla L. |
| Pubbl/distr/stampa | Washington, D.C. : , : John Wiley & Sons, Inc., , 2014 |
| Descrizione fisica | 1 online resource (xvi, 348 pages) |
| Disciplina | 615.95299 |
| Collana | Penguin, 10155 |
| Soggetto topico | Bacterial toxins |
| ISBN | 1-68367-227-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910830824503321 |
Burns Drusilla L.
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| Washington, D.C. : , : John Wiley & Sons, Inc., , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Bacterial toxins : genetics, cellular biology and practical applications / / Edited by Thomas Proft
| Bacterial toxins : genetics, cellular biology and practical applications / / Edited by Thomas Proft |
| Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2013] |
| Descrizione fisica | 1 online resource (249 p.) |
| Disciplina | 615.95293 |
| Soggetto topico | Bacterial toxins |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-908230-70-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Table of Contents; Chapter 1. Receptor-related Risk Factors for Verotoxin Pathogenesis; Verotoxins and their receptors; Receptor glycolipid; B subunit receptor-binding sites; VT signalling and internalization; Cholesterol masking of VT receptors; New model for VTB subunit pentamer binding plasma membrane Gb3; Cholesterol is key for VT-Gb3 retrograde transport; Regulation of Gb3 biosynthesis; Soluble GSL mimics; Conclusions; References; Chapter 2. The Helicobacter pylori CagA Protein: A Multifunctional BacterialToxin Delivered by Type IV Secretion; Introduction
The cag pathogenicity island and its effector protein CagAThe Cag type IV secretion system as a toxin delivery system; CagA interaction partners and associated effects in host cells; Conclusions; Chapter 3. Pore-forming Toxins; Introduction; Introduction to Staphylococcus aureus α-haemolysin; Nomenclature and early observations; Primary structure and regulation of toxin production; Three-dimensional structure and function; Role in disease pathogenesis; Summary and future perspectives - α-toxin Introduction to the cholesterol-dependent cytolysins and membrane attack complex/perforin (MACPF) family proteinsGeneral features of the CDC primary structure; The CDC monomer crystal structure; Secretion of the CDCs; Cellular recognition; The CDC membrane anchoring system; The CDC allosteric pathway; Formation of the prepore oligomer; Formation of the pore complex; Ring versus arc oligomers; The CDCs and bacterial pathogenesis; The membrane attack complex/perforin (MACPF) proteins; Summary and futureperspectives - CDCs andMACPF proteins; References Chapter 4. Bacterial Enterotoxins as Immunomodulators and Vaccine AdjuvantsIntroduction; Cholera toxin: the prototype for ADP-ribosylating holotoxin adjuvants; LT: a more complex family of holotoxin adjuvants; Are ADP-ribosylating toxins in general good adjuvants?; Taking toxin adjuvant immunomodulation one step further; Concluding remarks; References; Chapter 5. Mobile Genetic Elements as Carriers for Bacterial Virulence Genes; Core and adaptive genome; The mobile bacterial genome; Mobile genetic elements and their role in virulence; Why MGEs encode exotoxins and other virulence factors? Role of SOS inductionBacteriophage-encoding toxins and other virulence factors; Plasmids encoding toxins; Pathogenicity islands encoding toxins; Open questions; Web resources; References; Chapter 6. The Staphylococcal Superantigen-like Toxins; Introduction; The SSLs - an introduction; Genetics of the ssls; Molecular biology of the SSLs; SSL-related S. aureus immune evasion molecules; Mechanisms of immune evasion mediated by SSLs; Novel SSL-associated applications; Concluding remarks; References; Chapter 7. Botulinum Neurotoxins as Therapeutics; Introduction Mechanistic basis of BoNTs as therapeutics |
| Record Nr. | UNINA-9910462572903321 |
| Norfolk, England : , : Caister Academic Press, , [2013] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Bacterial toxins : genetics, cellular biology and practical applications / / Edited by Thomas Proft
| Bacterial toxins : genetics, cellular biology and practical applications / / Edited by Thomas Proft |
| Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2013] |
| Descrizione fisica | 1 online resource (249 p.) |
| Disciplina | 615.95293 |
| Soggetto topico | Bacterial toxins |
| ISBN | 1-908230-70-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Table of Contents; Chapter 1. Receptor-related Risk Factors for Verotoxin Pathogenesis; Verotoxins and their receptors; Receptor glycolipid; B subunit receptor-binding sites; VT signalling and internalization; Cholesterol masking of VT receptors; New model for VTB subunit pentamer binding plasma membrane Gb3; Cholesterol is key for VT-Gb3 retrograde transport; Regulation of Gb3 biosynthesis; Soluble GSL mimics; Conclusions; References; Chapter 2. The Helicobacter pylori CagA Protein: A Multifunctional BacterialToxin Delivered by Type IV Secretion; Introduction
The cag pathogenicity island and its effector protein CagAThe Cag type IV secretion system as a toxin delivery system; CagA interaction partners and associated effects in host cells; Conclusions; Chapter 3. Pore-forming Toxins; Introduction; Introduction to Staphylococcus aureus α-haemolysin; Nomenclature and early observations; Primary structure and regulation of toxin production; Three-dimensional structure and function; Role in disease pathogenesis; Summary and future perspectives - α-toxin Introduction to the cholesterol-dependent cytolysins and membrane attack complex/perforin (MACPF) family proteinsGeneral features of the CDC primary structure; The CDC monomer crystal structure; Secretion of the CDCs; Cellular recognition; The CDC membrane anchoring system; The CDC allosteric pathway; Formation of the prepore oligomer; Formation of the pore complex; Ring versus arc oligomers; The CDCs and bacterial pathogenesis; The membrane attack complex/perforin (MACPF) proteins; Summary and futureperspectives - CDCs andMACPF proteins; References Chapter 4. Bacterial Enterotoxins as Immunomodulators and Vaccine AdjuvantsIntroduction; Cholera toxin: the prototype for ADP-ribosylating holotoxin adjuvants; LT: a more complex family of holotoxin adjuvants; Are ADP-ribosylating toxins in general good adjuvants?; Taking toxin adjuvant immunomodulation one step further; Concluding remarks; References; Chapter 5. Mobile Genetic Elements as Carriers for Bacterial Virulence Genes; Core and adaptive genome; The mobile bacterial genome; Mobile genetic elements and their role in virulence; Why MGEs encode exotoxins and other virulence factors? Role of SOS inductionBacteriophage-encoding toxins and other virulence factors; Plasmids encoding toxins; Pathogenicity islands encoding toxins; Open questions; Web resources; References; Chapter 6. The Staphylococcal Superantigen-like Toxins; Introduction; The SSLs - an introduction; Genetics of the ssls; Molecular biology of the SSLs; SSL-related S. aureus immune evasion molecules; Mechanisms of immune evasion mediated by SSLs; Novel SSL-associated applications; Concluding remarks; References; Chapter 7. Botulinum Neurotoxins as Therapeutics; Introduction Mechanistic basis of BoNTs as therapeutics |
| Record Nr. | UNINA-9910787665603321 |
| Norfolk, England : , : Caister Academic Press, , [2013] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Bacterial toxins : genetics, cellular biology and practical applications / / Edited by Thomas Proft
| Bacterial toxins : genetics, cellular biology and practical applications / / Edited by Thomas Proft |
| Pubbl/distr/stampa | Norfolk, England : , : Caister Academic Press, , [2013] |
| Descrizione fisica | 1 online resource (249 p.) |
| Disciplina | 615.95293 |
| Soggetto topico | Bacterial toxins |
| ISBN | 1-908230-70-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Table of Contents; Chapter 1. Receptor-related Risk Factors for Verotoxin Pathogenesis; Verotoxins and their receptors; Receptor glycolipid; B subunit receptor-binding sites; VT signalling and internalization; Cholesterol masking of VT receptors; New model for VTB subunit pentamer binding plasma membrane Gb3; Cholesterol is key for VT-Gb3 retrograde transport; Regulation of Gb3 biosynthesis; Soluble GSL mimics; Conclusions; References; Chapter 2. The Helicobacter pylori CagA Protein: A Multifunctional BacterialToxin Delivered by Type IV Secretion; Introduction
The cag pathogenicity island and its effector protein CagAThe Cag type IV secretion system as a toxin delivery system; CagA interaction partners and associated effects in host cells; Conclusions; Chapter 3. Pore-forming Toxins; Introduction; Introduction to Staphylococcus aureus α-haemolysin; Nomenclature and early observations; Primary structure and regulation of toxin production; Three-dimensional structure and function; Role in disease pathogenesis; Summary and future perspectives - α-toxin Introduction to the cholesterol-dependent cytolysins and membrane attack complex/perforin (MACPF) family proteinsGeneral features of the CDC primary structure; The CDC monomer crystal structure; Secretion of the CDCs; Cellular recognition; The CDC membrane anchoring system; The CDC allosteric pathway; Formation of the prepore oligomer; Formation of the pore complex; Ring versus arc oligomers; The CDCs and bacterial pathogenesis; The membrane attack complex/perforin (MACPF) proteins; Summary and futureperspectives - CDCs andMACPF proteins; References Chapter 4. Bacterial Enterotoxins as Immunomodulators and Vaccine AdjuvantsIntroduction; Cholera toxin: the prototype for ADP-ribosylating holotoxin adjuvants; LT: a more complex family of holotoxin adjuvants; Are ADP-ribosylating toxins in general good adjuvants?; Taking toxin adjuvant immunomodulation one step further; Concluding remarks; References; Chapter 5. Mobile Genetic Elements as Carriers for Bacterial Virulence Genes; Core and adaptive genome; The mobile bacterial genome; Mobile genetic elements and their role in virulence; Why MGEs encode exotoxins and other virulence factors? Role of SOS inductionBacteriophage-encoding toxins and other virulence factors; Plasmids encoding toxins; Pathogenicity islands encoding toxins; Open questions; Web resources; References; Chapter 6. The Staphylococcal Superantigen-like Toxins; Introduction; The SSLs - an introduction; Genetics of the ssls; Molecular biology of the SSLs; SSL-related S. aureus immune evasion molecules; Mechanisms of immune evasion mediated by SSLs; Novel SSL-associated applications; Concluding remarks; References; Chapter 7. Botulinum Neurotoxins as Therapeutics; Introduction Mechanistic basis of BoNTs as therapeutics |
| Record Nr. | UNINA-9910813141003321 |
| Norfolk, England : , : Caister Academic Press, , [2013] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Bacterial toxins : tools in cell biology and pharmacology / / Klaus Aktories (Ed.)
| Bacterial toxins : tools in cell biology and pharmacology / / Klaus Aktories (Ed.) |
| Pubbl/distr/stampa | London, [England] : , : Chapman & Hall, , 1997 |
| Descrizione fisica | 1 online resource (336 p.) |
| Disciplina |
579.3165
615.95293 |
| Collana | Laboratory Companion |
| Soggetto topico | Bacterial toxins |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-84256-7
9786611842567 3-527-61461-3 3-527-61460-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Bacterial Toxins; Contents; CHAPTER 1 . Cholera Toxin: Mechanism of Action and Potential Use in Vaccine Development; 1.1 Introduction; 1.2 Molecular Aspects of Cholera Toxin Action; 1.2.1 Structure and Relationship to Other Toxins; 1.2.2 Toxin Entry into Cells and Events Leading to Pathogenesis; 1.2.3 Enzymology of Cholera Toxin; 1.2.4 In Vitro Stimulation of Cholera Toxin Activity by ARF; 1.3 Practical Aspects of Cholera Toxin Use; 1.3.1 Vaccine and Vaccine Development; 1.3.2 Cholera Toxin as a Molecular Tool; 1.4 Summary
CHAPTER 2 . Cholera Toxin and Escherichia coli Heat-labile Enterotoxin: Biochemical Methods for Assessing Enzymatic Activities2.1 Introduction; 2.2 General Information on CT. LT. ARF and Reagents; 2.2.1 Sources, Purification, and Activation of CTA and LTA; 2.2.2 Sources and Purification of ARF; 2.2.3 Reagents and Materials; 2.2.4 Stock Solutions; 2.3 Assay 1 : The Gsa Assay; 2.3.1 Additional Reagents and Materials Required; 2.3.2 Protocol; 2.4 Assay 2: The Agmatine Assay; 2.4.1 Additional Reagents and Materials Required; 2.4.2 Protocol; 2.5 Assay 3: Auto-ADP-ribosylation Assay 2.5.1 Additional Reagents and Materials Required2.5.2 Protocol; 2.6 Assay 4: NAD Glycohydrolase Assay; 2.6.1 Additional Reagents and Materials Required; 2.6.2 Protocol; 2.7 Comments and Considerations; 2.7.1 Appropriate Controls and Analysis of Data; 2.7.1.1 Controls; 2.7.1.2 Data analysis; 2.7.2 Optimization Interfering Substances, Troubleshooting, and Assay; 2.7.2.1 Interfering substances; 2.7.2.2 Troubleshooting; 2.7.2.3 Assay optimization; 2.7.3 Consideration for the Use of ARF; 2.7.3.1 Lipid/Detergent and Nucleotide Requirements; 2.7.3.2 Development of other Assay Conditions CHAPTER 3 . Pertussis Toxin3.1 Introduction; 3.2 Genetic Regulation of Pertussis Toxin Production; 3.3 Biogenesis of Pertussis Toxin; 3.4 Receptor-binding and Translocation; 3.5 ADP-ribosyltransferase Activity and Enzyme Mechanism; 3.6 Biological Activities and Role of Pertussis Toxin in Pathogenesis; CHAPTER 4 . Pertussis Toxin as a Cell Biology Tool; 4.1 Introduction; 4.2 Pertussis Toxin as a Tool to Modify Cellular Functions; 4.2.1 Cell Culture of Bordetella pertussis; 4.2.2 Source of Pertussis Toxin and Preparation of Solution 4.2.3 Treatment of Mammalian Cell Cultures with Pertussis Toxin4.3 Pertussis Toxin as a Tool to Study Cellular Components; 4.3.1 Activation of Pertussis Toxin for in in vitro ADP- ribosylation; 4.3.2 Preparation of Cell Homogenates and Fractions; 4.3.3 ADP-ribosylation of Membrane Proteins by Pertussis Toxin; 4.3.4 ADP-ribosylation of Proteins by Pertussis Toxin; 4.3.5 Preparation of Samples for SDS-PAGE; 4.3.6 Cleavage of ADP-ribose from Ga Subunits; 4.4 SDS-Gel Electrophoresis; 4.5 Reagents and Chemicals; CHAPTER 5 . Clostridium botulinum ADP-ribosyltransferase C3; 5.1 Introduction 5.2 The Family of C3-like Transferases |
| Record Nr. | UNINA-9910144446403321 |
| London, [England] : , : Chapman & Hall, , 1997 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Bacterial toxins : tools in cell biology and pharmacology / / Klaus Aktories (Ed.)
| Bacterial toxins : tools in cell biology and pharmacology / / Klaus Aktories (Ed.) |
| Pubbl/distr/stampa | London, [England] : , : Chapman & Hall, , 1997 |
| Descrizione fisica | 1 online resource (336 p.) |
| Disciplina |
579.3165
615.95293 |
| Collana | Laboratory Companion |
| Soggetto topico | Bacterial toxins |
| ISBN |
1-281-84256-7
9786611842567 3-527-61461-3 3-527-61460-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Bacterial Toxins; Contents; CHAPTER 1 . Cholera Toxin: Mechanism of Action and Potential Use in Vaccine Development; 1.1 Introduction; 1.2 Molecular Aspects of Cholera Toxin Action; 1.2.1 Structure and Relationship to Other Toxins; 1.2.2 Toxin Entry into Cells and Events Leading to Pathogenesis; 1.2.3 Enzymology of Cholera Toxin; 1.2.4 In Vitro Stimulation of Cholera Toxin Activity by ARF; 1.3 Practical Aspects of Cholera Toxin Use; 1.3.1 Vaccine and Vaccine Development; 1.3.2 Cholera Toxin as a Molecular Tool; 1.4 Summary
CHAPTER 2 . Cholera Toxin and Escherichia coli Heat-labile Enterotoxin: Biochemical Methods for Assessing Enzymatic Activities2.1 Introduction; 2.2 General Information on CT. LT. ARF and Reagents; 2.2.1 Sources, Purification, and Activation of CTA and LTA; 2.2.2 Sources and Purification of ARF; 2.2.3 Reagents and Materials; 2.2.4 Stock Solutions; 2.3 Assay 1 : The Gsa Assay; 2.3.1 Additional Reagents and Materials Required; 2.3.2 Protocol; 2.4 Assay 2: The Agmatine Assay; 2.4.1 Additional Reagents and Materials Required; 2.4.2 Protocol; 2.5 Assay 3: Auto-ADP-ribosylation Assay 2.5.1 Additional Reagents and Materials Required2.5.2 Protocol; 2.6 Assay 4: NAD Glycohydrolase Assay; 2.6.1 Additional Reagents and Materials Required; 2.6.2 Protocol; 2.7 Comments and Considerations; 2.7.1 Appropriate Controls and Analysis of Data; 2.7.1.1 Controls; 2.7.1.2 Data analysis; 2.7.2 Optimization Interfering Substances, Troubleshooting, and Assay; 2.7.2.1 Interfering substances; 2.7.2.2 Troubleshooting; 2.7.2.3 Assay optimization; 2.7.3 Consideration for the Use of ARF; 2.7.3.1 Lipid/Detergent and Nucleotide Requirements; 2.7.3.2 Development of other Assay Conditions CHAPTER 3 . Pertussis Toxin3.1 Introduction; 3.2 Genetic Regulation of Pertussis Toxin Production; 3.3 Biogenesis of Pertussis Toxin; 3.4 Receptor-binding and Translocation; 3.5 ADP-ribosyltransferase Activity and Enzyme Mechanism; 3.6 Biological Activities and Role of Pertussis Toxin in Pathogenesis; CHAPTER 4 . Pertussis Toxin as a Cell Biology Tool; 4.1 Introduction; 4.2 Pertussis Toxin as a Tool to Modify Cellular Functions; 4.2.1 Cell Culture of Bordetella pertussis; 4.2.2 Source of Pertussis Toxin and Preparation of Solution 4.2.3 Treatment of Mammalian Cell Cultures with Pertussis Toxin4.3 Pertussis Toxin as a Tool to Study Cellular Components; 4.3.1 Activation of Pertussis Toxin for in in vitro ADP- ribosylation; 4.3.2 Preparation of Cell Homogenates and Fractions; 4.3.3 ADP-ribosylation of Membrane Proteins by Pertussis Toxin; 4.3.4 ADP-ribosylation of Proteins by Pertussis Toxin; 4.3.5 Preparation of Samples for SDS-PAGE; 4.3.6 Cleavage of ADP-ribose from Ga Subunits; 4.4 SDS-Gel Electrophoresis; 4.5 Reagents and Chemicals; CHAPTER 5 . Clostridium botulinum ADP-ribosyltransferase C3; 5.1 Introduction 5.2 The Family of C3-like Transferases |
| Record Nr. | UNISA-996209689703316 |
| London, [England] : , : Chapman & Hall, , 1997 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Bacterial toxins : tools in cell biology and pharmacology / / Klaus Aktories (Ed.)
| Bacterial toxins : tools in cell biology and pharmacology / / Klaus Aktories (Ed.) |
| Pubbl/distr/stampa | London, [England] : , : Chapman & Hall, , 1997 |
| Descrizione fisica | 1 online resource (336 p.) |
| Disciplina |
579.3165
615.95293 |
| Collana | Laboratory Companion |
| Soggetto topico | Bacterial toxins |
| ISBN |
1-281-84256-7
9786611842567 3-527-61461-3 3-527-61460-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Bacterial Toxins; Contents; CHAPTER 1 . Cholera Toxin: Mechanism of Action and Potential Use in Vaccine Development; 1.1 Introduction; 1.2 Molecular Aspects of Cholera Toxin Action; 1.2.1 Structure and Relationship to Other Toxins; 1.2.2 Toxin Entry into Cells and Events Leading to Pathogenesis; 1.2.3 Enzymology of Cholera Toxin; 1.2.4 In Vitro Stimulation of Cholera Toxin Activity by ARF; 1.3 Practical Aspects of Cholera Toxin Use; 1.3.1 Vaccine and Vaccine Development; 1.3.2 Cholera Toxin as a Molecular Tool; 1.4 Summary
CHAPTER 2 . Cholera Toxin and Escherichia coli Heat-labile Enterotoxin: Biochemical Methods for Assessing Enzymatic Activities2.1 Introduction; 2.2 General Information on CT. LT. ARF and Reagents; 2.2.1 Sources, Purification, and Activation of CTA and LTA; 2.2.2 Sources and Purification of ARF; 2.2.3 Reagents and Materials; 2.2.4 Stock Solutions; 2.3 Assay 1 : The Gsa Assay; 2.3.1 Additional Reagents and Materials Required; 2.3.2 Protocol; 2.4 Assay 2: The Agmatine Assay; 2.4.1 Additional Reagents and Materials Required; 2.4.2 Protocol; 2.5 Assay 3: Auto-ADP-ribosylation Assay 2.5.1 Additional Reagents and Materials Required2.5.2 Protocol; 2.6 Assay 4: NAD Glycohydrolase Assay; 2.6.1 Additional Reagents and Materials Required; 2.6.2 Protocol; 2.7 Comments and Considerations; 2.7.1 Appropriate Controls and Analysis of Data; 2.7.1.1 Controls; 2.7.1.2 Data analysis; 2.7.2 Optimization Interfering Substances, Troubleshooting, and Assay; 2.7.2.1 Interfering substances; 2.7.2.2 Troubleshooting; 2.7.2.3 Assay optimization; 2.7.3 Consideration for the Use of ARF; 2.7.3.1 Lipid/Detergent and Nucleotide Requirements; 2.7.3.2 Development of other Assay Conditions CHAPTER 3 . Pertussis Toxin3.1 Introduction; 3.2 Genetic Regulation of Pertussis Toxin Production; 3.3 Biogenesis of Pertussis Toxin; 3.4 Receptor-binding and Translocation; 3.5 ADP-ribosyltransferase Activity and Enzyme Mechanism; 3.6 Biological Activities and Role of Pertussis Toxin in Pathogenesis; CHAPTER 4 . Pertussis Toxin as a Cell Biology Tool; 4.1 Introduction; 4.2 Pertussis Toxin as a Tool to Modify Cellular Functions; 4.2.1 Cell Culture of Bordetella pertussis; 4.2.2 Source of Pertussis Toxin and Preparation of Solution 4.2.3 Treatment of Mammalian Cell Cultures with Pertussis Toxin4.3 Pertussis Toxin as a Tool to Study Cellular Components; 4.3.1 Activation of Pertussis Toxin for in in vitro ADP- ribosylation; 4.3.2 Preparation of Cell Homogenates and Fractions; 4.3.3 ADP-ribosylation of Membrane Proteins by Pertussis Toxin; 4.3.4 ADP-ribosylation of Proteins by Pertussis Toxin; 4.3.5 Preparation of Samples for SDS-PAGE; 4.3.6 Cleavage of ADP-ribose from Ga Subunits; 4.4 SDS-Gel Electrophoresis; 4.5 Reagents and Chemicals; CHAPTER 5 . Clostridium botulinum ADP-ribosyltransferase C3; 5.1 Introduction 5.2 The Family of C3-like Transferases |
| Record Nr. | UNINA-9910677693003321 |
| London, [England] : , : Chapman & Hall, , 1997 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cellular Entry of Binary and Pore-Forming Bacterial Toxins / / Alexey S. Ladokhin
| Cellular Entry of Binary and Pore-Forming Bacterial Toxins / / Alexey S. Ladokhin |
| Autore | Ladokhin Alexey S. |
| Pubbl/distr/stampa | Basel : , : MDPI AG - Multidisciplinary Digital Publishing Institute, , 2018 |
| Descrizione fisica | 1 online resource (128 pages) |
| Disciplina | 615.95299 |
| Soggetto topico | Bacterial toxins |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910674006303321 |
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Ladokhin Alexey S.
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| Basel : , : MDPI AG - Multidisciplinary Digital Publishing Institute, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cellular entry of binary and pore-forming bacterial toxins / / edited by Alexey S. Ladokhin
| Cellular entry of binary and pore-forming bacterial toxins / / edited by Alexey S. Ladokhin |
| Pubbl/distr/stampa | Basel, Switzerland : , : MDPI, , [2018] |
| Descrizione fisica | 1 online resource (128 pages) : illustrations |
| Disciplina | 615.95299 |
| Soggetto topico | Bacterial toxins |
| ISBN | 3-03842-703-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | About the Special Issue Editor v -- Alexey S. Ladokhin Cellular Entry of Binary and Pore-Forming Bacterial Toxins doi: 10.3390/toxins10010011 1 -- Masaya Takehara, Teruhisa Takagishi, Soshi Seike, Masataka Oda, Yoshihiko Sakaguchi, Junzo Hisatsune, Sadayuki Ochi, Keiko Kobayashi and Masahiro Nagahama Cellular Entry of Clostridium perfringens Iota-Toxin and Clostridium botulinum C2 Toxin doi: 10.3390/toxins9080247 3 -- Alfredo J. Guerra and Vern B. Carruthers Structural Features of Apicomplexan Pore-Forming Proteins and Their Roles in Parasite Cell Traversal and Egress doi: 10.3390/toxins9090265 12 -- Sergey N. Savinov and Alejandro P. Heuck Interaction of Cholesterol with Perfringolysin O: What Have We Learned from Functional Analysis? doi: 10.3390/toxins9120381 27 -- Alexandra J. Machen, Narahari Akkaladevi, Caleb Trecazzi, Pierce T. ONeil, Srayanta Mukherjee, Yifei Qi, Rebecca Dillard, Wonpil Im, Edward P. Gogol, Tommi A. White and Mark T. Fisher Asymmetric Cryo-EM Structure of Anthrax Toxin Protective Antigen Pore with Lethal Factor N-Terminal Domain doi: 10.3390/toxins9100298 44 -- Alexey S. Ladokhin, Mauricio Vargas-Uribe, Mykola V. Rodnin, Chiranjib Ghatak and Onkar Sharma Cellular Entry of the Diphtheria Toxin Does Not Require the Formation of the Open-Channel State by Its Translocation Domain doi: 10.3390/toxins9100299 60 -- Primoz Knap, Toma Tebaldi, Francesca Di Leva, Marta Biagioli, Mauro Dalla Serra and Gabriella Viero The Unexpected Tuners: Are LncRNAs Regulating Host Translation during Infections? doi: 10.3390/toxins9110357 72 -- Franziska Tausch, Richard Dietrich, Kristina Schauer, Robert Janowski, Dierk Niessing, Erwin Mrtlbauer and Nadja Jessberger Evidence for Complex Formation of the Bacillus cereus Haemolysin BL Components in Solution doi: 10.3390/toxins9090288 82 -- Leopoldo Palma, David J. Scott, Gemma Harris, Salah-Ud Din, Thomas L. Williams, Oliver J. Roberts, Mark T. Young, Primitivo Caballero and Colin Berry The Vip3Ag4 Insecticidal Protoxin from Bacillus thuringiensis Adopts A Tetrameric Configuration That Is Maintained on Proteolysis doi: 10.3390/toxins9050165 100 -- Madhu Puri, Luigi La Pietra, Mobarak Abu Mraheil, Rudolf Lucas, Trinad Chakraborty and Helena Pillich Listeriolysin O Regulates the Expression of Optineurin, an Autophagy Adaptor That Inhibits the Growth of Listeria monocytogenes doi: 10.3390/toxins9090273 111. |
| Record Nr. | UNINA-9910765854203321 |
| Basel, Switzerland : , : MDPI, , [2018] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The comprehensive sourcebook of bacterial protein toxins / / Joseph Alouf, Institut Pasteur, Paris, France, Daniel Ladant, Institut Pasteur, Unité de Biochimie des Interactions Moléculaires, Paris, France, Michel R. Popoff, Institut Pasteur, Unité des Bactéries anaérobies et Toxines, Paris, France ; contributors, Klaus Aktories [and one hundred ten others]
| The comprehensive sourcebook of bacterial protein toxins / / Joseph Alouf, Institut Pasteur, Paris, France, Daniel Ladant, Institut Pasteur, Unité de Biochimie des Interactions Moléculaires, Paris, France, Michel R. Popoff, Institut Pasteur, Unité des Bactéries anaérobies et Toxines, Paris, France ; contributors, Klaus Aktories [and one hundred ten others] |
| Autore | Alouf J. E (Joseph E.) |
| Edizione | [4th ed.] |
| Pubbl/distr/stampa | Amsterdam, Netherlands : , : Elsevier, , 2015 |
| Descrizione fisica | 1 online resource (1201 p.) |
| Disciplina | 528.2039474 |
| Soggetto topico | Bacterial toxins |
| ISBN |
0-12-800589-0
0-12-800188-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; The Comprehensive Sourcebook of Bacterial Protein Toxins; Copyright Page; Contents; List of Contributors; Introduction to the Fourth Edition; In memory of J. E. Alouf (1929-2014); I. Basic Genomic and Physiological Aspects of Bacterial Protein Toxins; 1 Evolutionary aspects of toxin-producing bacteria; Introduction; Molecular ecology of toxin-producing bacteria; Pathogenicity islands, horizontal gene transfer, and the prevalence of toxins; Toxins encoded by plasmids, bacteriophages, and other pathogenicity islands; PAI-encoded toxins delivered by specialized secretion systems
Molecular evolution of toxins through genetic exchangeGenetic exchange and toxin evolution; Toxin evolution and transmission in the host; Toxin evolution and transmission in the soil environment; Toxin evolution and transmission in aquatic environments; Toxin evolution and transmission in the phyllosphere; Toxin evolution in the guts of insects and other vectors; Toxin evolution in biofilms and regulation by quorum sensing; Vaccines and toxin evolution; Modular recombination of bacterial toxins; Conclusion; References 2 Mobile genetic elements and pathogenicity islands encoding bacterial toxinsIntroduction: The genome structure of prokaryotes; Protein toxins encoded by mobile genetic elements; Protein toxins encoded by plasmids; Gram-negative bacteria; Gram-positive bacteria; Protein toxins encoded by bacteriophages; Gram-negative bacteria; Gram-positive bacteria; Protein toxin genes and other mobile genetic elements; Toxins encoded by PAIs; PAIs; PAI-encoded toxins; Enterobacteria; Other Gram-negative bacteria; The bacterial T6SS; Gram-positive bacteria; Instability of PAIs; Conclusion Evolution of new pathogenic variants caused by PAIs and mobile genetic elementsHGT and the evolution of toxin families; Acknowledgments; References; 3 News and views on protein secretion systems; Introduction; Most historical secretion types; Type I secretion system; Type II secretion system; Type III secretion system; Type IV secretion system: a protein and DNA transport machine; Type V secretion system: free or surface-bound?; Type VI secretion system: weapon for bacterial warfare; How far can we go with secretion types?; Type VII secretion system Extracellular appendages and secretion typesThe type IX secretion system; What about other secretion concepts?; Bacteriocins, colicins, pyocins, contact-dependent inhibition; Cell surface lipoproteins; OM Vesicles; What about Gram-positive bacteria, then?; Closing remarks; References; II. Intracellularly Alive Bacterial Protein Toxins; 4 Diphtheria toxin; Introduction; Diphtheria toxin: from pathology to crystal structure; Symptoms, treatment, prophylaxis, and epidemiology of diphtheria; History of DT research; Regulation of DT production; The structure of DT; The mechanism of action of DT The main steps of cell intoxication |
| Record Nr. | UNINA-9910583473403321 |
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Alouf J. E (Joseph E.)
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| Amsterdam, Netherlands : , : Elsevier, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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