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Autoantibodies / / edited by Yehuda Shoenfeld M.D., FRCP, MACR, Professor of Rheumatology, Head, Zabludowicz Center for Autoimmune Diseases, Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Tel-Aviv University, Sheba Medical Center, Tel-Hashomer, Israel, Pier Luigi Meroni M.D., Professor of Rheumatology Department of Clinical Sciences and Community Health - University of Milan, Chief, Division of Rheumatology, Istituto G. Pini, Milan, Italy, M. Eric Gershwin M.D., MACP, MACR, Distinguished Professor of Medicine, The Jack and Donald Chia Professor of Medicine, Chief, Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA, USA
| Autoantibodies / / edited by Yehuda Shoenfeld M.D., FRCP, MACR, Professor of Rheumatology, Head, Zabludowicz Center for Autoimmune Diseases, Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Tel-Aviv University, Sheba Medical Center, Tel-Hashomer, Israel, Pier Luigi Meroni M.D., Professor of Rheumatology Department of Clinical Sciences and Community Health - University of Milan, Chief, Division of Rheumatology, Istituto G. Pini, Milan, Italy, M. Eric Gershwin M.D., MACP, MACR, Distinguished Professor of Medicine, The Jack and Donald Chia Professor of Medicine, Chief, Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA, USA |
| Edizione | [Third edition.] |
| Pubbl/distr/stampa | Waltham, MA : , : Elsevier, , 2014 |
| Descrizione fisica | 1 online resource (lx, 855 pages) : illustrations (some color) |
| Disciplina | 616.978 |
| Altri autori (Persone) |
ShoenfeldYehuda
MeroniPier-Luigi GershwinM. Eric <1946-> |
| Collana | Elsevier science & technology books |
| Soggetto topico |
Autoantibodies
Autoimmune diseases - Etiology |
| Soggetto genere / forma | Electronic books. |
| ISBN | 0-444-59377-2 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | part 1. Introduction : autoantibodies-unique characteristics -- part 2. Allergic disease autoantibodies -- part 3. Antineutrophil antibodies -- part 4. Introduction : antinuclear antibodies -- part 5. Autoantibodies to biologic factors/structures -- part 6. Cardiac autoantibodies -- part 7. Endocrine autoantibodies -- part 8. GI and liver autoantibodies -- part 9. Hematologic autoantibodies -- part 10. Kidney autoantibodies -- part 11. Neurological system autoantibodies -- part 12. Rheumatic disease autoantibodies -- part 13. Skin disease autoantibodies -- part 14. Unique clinical situations. |
| Record Nr. | UNINA-9910453291703321 |
| Waltham, MA : , : Elsevier, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The epigenetics of autoimmune diseases [[electronic resource] /] / edited by Moncef Zouali
| The epigenetics of autoimmune diseases [[electronic resource] /] / edited by Moncef Zouali |
| Pubbl/distr/stampa | Chichester ; ; Hoboken, NJ, : Wiley-Blackwell, 2009 |
| Descrizione fisica | 1 online resource (473 p.) |
| Disciplina |
571.9/73
571.973 616.978042 |
| Altri autori (Persone) | ZoualiMoncef <1952-> |
| Soggetto topico |
Autoimmunity - Molecular aspects
Autoimmune diseases - Etiology Post-translational modification Epigenesis |
| ISBN |
1-282-13817-0
9786612138171 0-470-74355-7 0-470-74356-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
The Epigenetics of Autoimmune Diseases; Contents; Preface; Contributors; PART I Transcription Factors: Partners of Immune Tolerance to Self; 1 Transcriptional regulation of T cell tolerance; 1.1 Introduction; 1.2 T cell anergy; 1.3 Ca2+/calcineurin/NFAT signalling in T cell anergy; 1.4 Transcriptional programme of T cell anergy; 1.5 Transcriptional repression in T cell anergy: epigenetic modification of the Il2 promoter; 1.6 Regulatory T cells; 1.7 Transcriptional control of Treg development and function; References; 2 Epigenetic regulation of Foxp3 expression in regulatory T cells
2.1 Introduction2.2 Naturally occurring CD25+ CD4+ Tregs; 2.3 The transcription factor FOXP3: determining Treg function and identity; 2.4 Molecular regulation of FOXP3; 2.5 Tregs as a stable lineage: indications of epigenetic imprinting; 2.6 Induced Tregs: stable suppressors or transient immuno-modulators?; 2.7 Conclusions; References; 3 The role of NF-kB in central tolerance; 3.1 Introduction; 3.2 Canonical and alternative NF-kB pathways; 3.3 Thymic stroma and central tolerance; 3.4 NF-kB and regulatory T cell development; 3.5 NF-kB and thymocyte positive and negative selection 3.6 Conclusions and perspectives3.7 Acknowledgement; References; 4 The role of Act1 in the control of autoimmunity; 4.1 Introduction; 4.2 Autoimmunity and autoimmune mouse models; 4.3 Molecular mechanisms of autoimmunity; 4.4 Act1: a modulator of autoimmunity; 4.5 Conclusions; References; 5 Regulation of T cell anergy and escape from regulatory T cell suppression by Cbl-b; 5.1 Introduction; 5.2 Mechanisms of T cell tolerance induction; 5.3 Molecular establishment of T cell anergy; 5.4 Ubiquitin E3 ligases in T cell tolerance; 5.5 Molecular function and regulation of Cbl-b 5.6 Physiological relevance of Cbl-b5.7 The role of Cbl-b in T cell tolerance; 5.8 Deregulation of Cbl-b in disease; 5.9 Therapeutic potential of Cbl-b in tumour immunity; 5.10 Implications for autoimmune disease; References; 6 Indoleamine 2,3-dioxygenase: transcriptional regulation and autoimmunity; 6.1 Introduction; 6.2 L-Trp degradation along the kynurenine pathway and immune functions of IDO; 6.3 IDO immunobiology and therapeutic intervention; 6.4 Transcriptional regulation of the IDO-encoding gene; 6.5 Impaired IDO activity and loss of tolerance in autoimmune diseases 6.6 IDO-based therapies for autoimmune disease6.7 Acknowledgement; References; PART II Stress Responses that Break Immune Silence; 7 Chromatin modifications, oxidative stress and nucleosome autoantibodies; 7.1 Introduction; 7.2 Nucleosome and SLE; 7.3 Epigenetics and SLE; 7.4 Oxidative stress in SLE: definition and mechanisms; 7.5 Oxidative stress, epigenetic alterations and nucleosome immunogenicity; 7.6 Conclusion; 7.7 Acknowledgements; References; 8 Stress, epigenetics and thyroid autoimmunity; 8.1 Introduction; 8.2 The Th1/Th2 balance in immune-response regulation 8.3 Stress hormones and the Th1/Th2 balance |
| Record Nr. | UNINA-9910146133703321 |
| Chichester ; ; Hoboken, NJ, : Wiley-Blackwell, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The epigenetics of autoimmune diseases [[electronic resource] /] / edited by Moncef Zouali
| The epigenetics of autoimmune diseases [[electronic resource] /] / edited by Moncef Zouali |
| Pubbl/distr/stampa | Chichester ; ; Hoboken, NJ, : Wiley-Blackwell, 2009 |
| Descrizione fisica | 1 online resource (473 p.) |
| Disciplina |
571.9/73
571.973 616.978042 |
| Altri autori (Persone) | ZoualiMoncef <1952-> |
| Soggetto topico |
Autoimmunity - Molecular aspects
Autoimmune diseases - Etiology Post-translational modification Epigenesis |
| ISBN |
1-282-13817-0
9786612138171 0-470-74355-7 0-470-74356-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
The Epigenetics of Autoimmune Diseases; Contents; Preface; Contributors; PART I Transcription Factors: Partners of Immune Tolerance to Self; 1 Transcriptional regulation of T cell tolerance; 1.1 Introduction; 1.2 T cell anergy; 1.3 Ca2+/calcineurin/NFAT signalling in T cell anergy; 1.4 Transcriptional programme of T cell anergy; 1.5 Transcriptional repression in T cell anergy: epigenetic modification of the Il2 promoter; 1.6 Regulatory T cells; 1.7 Transcriptional control of Treg development and function; References; 2 Epigenetic regulation of Foxp3 expression in regulatory T cells
2.1 Introduction2.2 Naturally occurring CD25+ CD4+ Tregs; 2.3 The transcription factor FOXP3: determining Treg function and identity; 2.4 Molecular regulation of FOXP3; 2.5 Tregs as a stable lineage: indications of epigenetic imprinting; 2.6 Induced Tregs: stable suppressors or transient immuno-modulators?; 2.7 Conclusions; References; 3 The role of NF-kB in central tolerance; 3.1 Introduction; 3.2 Canonical and alternative NF-kB pathways; 3.3 Thymic stroma and central tolerance; 3.4 NF-kB and regulatory T cell development; 3.5 NF-kB and thymocyte positive and negative selection 3.6 Conclusions and perspectives3.7 Acknowledgement; References; 4 The role of Act1 in the control of autoimmunity; 4.1 Introduction; 4.2 Autoimmunity and autoimmune mouse models; 4.3 Molecular mechanisms of autoimmunity; 4.4 Act1: a modulator of autoimmunity; 4.5 Conclusions; References; 5 Regulation of T cell anergy and escape from regulatory T cell suppression by Cbl-b; 5.1 Introduction; 5.2 Mechanisms of T cell tolerance induction; 5.3 Molecular establishment of T cell anergy; 5.4 Ubiquitin E3 ligases in T cell tolerance; 5.5 Molecular function and regulation of Cbl-b 5.6 Physiological relevance of Cbl-b5.7 The role of Cbl-b in T cell tolerance; 5.8 Deregulation of Cbl-b in disease; 5.9 Therapeutic potential of Cbl-b in tumour immunity; 5.10 Implications for autoimmune disease; References; 6 Indoleamine 2,3-dioxygenase: transcriptional regulation and autoimmunity; 6.1 Introduction; 6.2 L-Trp degradation along the kynurenine pathway and immune functions of IDO; 6.3 IDO immunobiology and therapeutic intervention; 6.4 Transcriptional regulation of the IDO-encoding gene; 6.5 Impaired IDO activity and loss of tolerance in autoimmune diseases 6.6 IDO-based therapies for autoimmune disease6.7 Acknowledgement; References; PART II Stress Responses that Break Immune Silence; 7 Chromatin modifications, oxidative stress and nucleosome autoantibodies; 7.1 Introduction; 7.2 Nucleosome and SLE; 7.3 Epigenetics and SLE; 7.4 Oxidative stress in SLE: definition and mechanisms; 7.5 Oxidative stress, epigenetic alterations and nucleosome immunogenicity; 7.6 Conclusion; 7.7 Acknowledgements; References; 8 Stress, epigenetics and thyroid autoimmunity; 8.1 Introduction; 8.2 The Th1/Th2 balance in immune-response regulation 8.3 Stress hormones and the Th1/Th2 balance |
| Record Nr. | UNINA-9910830763503321 |
| Chichester ; ; Hoboken, NJ, : Wiley-Blackwell, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The epigenetics of autoimmune diseases / / edited by Moncef Zouali
| The epigenetics of autoimmune diseases / / edited by Moncef Zouali |
| Pubbl/distr/stampa | Chichester ; ; Hoboken, NJ, : Wiley-Blackwell, 2009 |
| Descrizione fisica | 1 online resource (473 p.) |
| Disciplina | 571.9/73 |
| Altri autori (Persone) | ZoualiMoncef <1952-> |
| Soggetto topico |
Autoimmunity - Molecular aspects
Autoimmune diseases - Etiology Post-translational modification Epigenesis |
| ISBN |
1-282-13817-0
9786612138171 0-470-74355-7 0-470-74356-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
The Epigenetics of Autoimmune Diseases; Contents; Preface; Contributors; PART I Transcription Factors: Partners of Immune Tolerance to Self; 1 Transcriptional regulation of T cell tolerance; 1.1 Introduction; 1.2 T cell anergy; 1.3 Ca2+/calcineurin/NFAT signalling in T cell anergy; 1.4 Transcriptional programme of T cell anergy; 1.5 Transcriptional repression in T cell anergy: epigenetic modification of the Il2 promoter; 1.6 Regulatory T cells; 1.7 Transcriptional control of Treg development and function; References; 2 Epigenetic regulation of Foxp3 expression in regulatory T cells
2.1 Introduction2.2 Naturally occurring CD25+ CD4+ Tregs; 2.3 The transcription factor FOXP3: determining Treg function and identity; 2.4 Molecular regulation of FOXP3; 2.5 Tregs as a stable lineage: indications of epigenetic imprinting; 2.6 Induced Tregs: stable suppressors or transient immuno-modulators?; 2.7 Conclusions; References; 3 The role of NF-kB in central tolerance; 3.1 Introduction; 3.2 Canonical and alternative NF-kB pathways; 3.3 Thymic stroma and central tolerance; 3.4 NF-kB and regulatory T cell development; 3.5 NF-kB and thymocyte positive and negative selection 3.6 Conclusions and perspectives3.7 Acknowledgement; References; 4 The role of Act1 in the control of autoimmunity; 4.1 Introduction; 4.2 Autoimmunity and autoimmune mouse models; 4.3 Molecular mechanisms of autoimmunity; 4.4 Act1: a modulator of autoimmunity; 4.5 Conclusions; References; 5 Regulation of T cell anergy and escape from regulatory T cell suppression by Cbl-b; 5.1 Introduction; 5.2 Mechanisms of T cell tolerance induction; 5.3 Molecular establishment of T cell anergy; 5.4 Ubiquitin E3 ligases in T cell tolerance; 5.5 Molecular function and regulation of Cbl-b 5.6 Physiological relevance of Cbl-b5.7 The role of Cbl-b in T cell tolerance; 5.8 Deregulation of Cbl-b in disease; 5.9 Therapeutic potential of Cbl-b in tumour immunity; 5.10 Implications for autoimmune disease; References; 6 Indoleamine 2,3-dioxygenase: transcriptional regulation and autoimmunity; 6.1 Introduction; 6.2 L-Trp degradation along the kynurenine pathway and immune functions of IDO; 6.3 IDO immunobiology and therapeutic intervention; 6.4 Transcriptional regulation of the IDO-encoding gene; 6.5 Impaired IDO activity and loss of tolerance in autoimmune diseases 6.6 IDO-based therapies for autoimmune disease6.7 Acknowledgement; References; PART II Stress Responses that Break Immune Silence; 7 Chromatin modifications, oxidative stress and nucleosome autoantibodies; 7.1 Introduction; 7.2 Nucleosome and SLE; 7.3 Epigenetics and SLE; 7.4 Oxidative stress in SLE: definition and mechanisms; 7.5 Oxidative stress, epigenetic alterations and nucleosome immunogenicity; 7.6 Conclusion; 7.7 Acknowledgements; References; 8 Stress, epigenetics and thyroid autoimmunity; 8.1 Introduction; 8.2 The Th1/Th2 balance in immune-response regulation 8.3 Stress hormones and the Th1/Th2 balance |
| Record Nr. | UNINA-9910877403103321 |
| Chichester ; ; Hoboken, NJ, : Wiley-Blackwell, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The epigenetics of autoimmunity / / edited by Rongxin Zhang, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China
| The epigenetics of autoimmunity / / edited by Rongxin Zhang, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China |
| Pubbl/distr/stampa | London : , : Academic Press an imprint of Elsevier, , 2018 |
| Descrizione fisica | 1 online resource (xix, 411 pages) : illustrations |
| Disciplina | 571.973 |
| Collana | Translational epigenetics series |
| Soggetto topico |
Autoimmunity - Molecular aspects
Autoimmune diseases - Etiology Epigenesis Autoimmunity Epigenesis, Genetic - immunology |
| ISBN |
0-12-809928-3
0-12-809912-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. The epigenetics of autoimmunity: an overview -- 2. Immune cell development and epigenetics -- 3. DNA methylation and histone modifications in autoimmunity -- 4. MicroRNA and T helper cell-mediated immune responses -- 5. Long noncoding RNAs in the immune response -- 6. Epigenetics of systemic lupus erythematosus -- 7. Rheumatoid arthritis and epigenetics -- 8. Epigenetic modifications in multiple sclerosis pathophysiology: potential diagnostic and therapeutic applications -- 9. Type 1 diabetes and epigenetics -- 10. Systemic sclerosis and epigenetics -- 11. Primary Sjogren's syndrome and epigenetics -- 12. Autoimmune thyroid diseases and epigenetics -- 13. The epigenetics of primary biliary cholangitis -- 14. Immune-mediated pulmonary disease and epigenetics -- 15. The epigenetics of autoimmunity and epigenetic drug discovery -- 16. Treatment of autoimmune diseases and prevention of transplant rejection and graft-versus-host disease by regulatory T cells: the state of the art and perspectives -- 17. Noncoding RNA-targeted therapeutics in autoimmune diseases: from bench to bedside -- 18. Future challenges and prospects for the epigenetics of autoimmunity. |
| Record Nr. | UNINA-9910583038803321 |
| London : , : Academic Press an imprint of Elsevier, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
