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Apolipoproteins [[electronic resource] ] : regulatory functions, health effects and role in disease / / Adrik D. Sidorov and Misha Y. Nikitin, editors
| Apolipoproteins [[electronic resource] ] : regulatory functions, health effects and role in disease / / Adrik D. Sidorov and Misha Y. Nikitin, editors |
| Pubbl/distr/stampa | New York, : Nova Biomedical, 2012 |
| Descrizione fisica | 1 online resource (166 p.) |
| Disciplina | 572/.6 |
| Altri autori (Persone) |
SidorovAdrik D
NikitinMisha Y |
| Collana |
Protein biochemistry, synthesis, structure and cellular functions
Protein science and engineering |
| Soggetto topico |
Apolipoproteins
Apolipoproteins - Health aspects |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-62257-498-2 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910453216403321 |
| New York, : Nova Biomedical, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Apolipoproteins [[electronic resource] ] : regulatory functions, health effects and role in disease / / Adrik D. Sidorov and Misha Y. Nikitin, editors
| Apolipoproteins [[electronic resource] ] : regulatory functions, health effects and role in disease / / Adrik D. Sidorov and Misha Y. Nikitin, editors |
| Pubbl/distr/stampa | New York, : Nova Biomedical, 2012 |
| Descrizione fisica | 1 online resource (166 p.) |
| Disciplina | 572/.6 |
| Altri autori (Persone) |
SidorovAdrik D
NikitinMisha Y |
| Collana |
Protein biochemistry, synthesis, structure and cellular functions
Protein science and engineering |
| Soggetto topico |
Apolipoproteins
Apolipoproteins - Health aspects |
| ISBN | 1-62257-498-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910779790003321 |
| New York, : Nova Biomedical, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Apolipoproteins : regulatory functions, health effects and role in disease / / Adrik D. Sidorov and Misha Y. Nikitin, editors
| Apolipoproteins : regulatory functions, health effects and role in disease / / Adrik D. Sidorov and Misha Y. Nikitin, editors |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | New York, : Nova Biomedical, 2012 |
| Descrizione fisica | 1 online resource (166 p.) |
| Disciplina | 572/.6 |
| Altri autori (Persone) |
SidorovAdrik D
NikitinMisha Y |
| Collana |
Protein biochemistry, synthesis, structure and cellular functions
Protein science and engineering |
| Soggetto topico |
Apolipoproteins
Apolipoproteins - Health aspects |
| ISBN | 1-62257-498-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- APOLIPOPROTEINS: REGULATORY FUNCTIONS, HEALTH EFFECTS AND ROLE IN DISEASE -- APOLIPOPROTEINS: REGULATORY FUNCTIONS, HEALTH EFFECTS AND ROLE IN DISEASE -- Library of Congress Cataloging-in-Publication Data -- Contents -- Preface -- Chapter I: Macrophages, Lipo (APO) Proteins, Steroid Hormones, and Molecular Mechanisms of Cell Proliferation -- Abstract -- 1. Introduction -- 2. Material and Methods -- 2.1. The Model of Investigation -- 2.2. Biochemical Methods -- 2.3. Analysis of HDL and Cortisol Effects on Chromatin Activity in the Liver Cell Nuclei -- 2.4. Preparation of the Fraction of Acidic Nonhistone Proteins of the Nuclei Isolated from Various Tissues -- 2.5. Isolation of Lipoproteins, Production of Apolipoprotein A-I -- 2.6. Isolation of Liver Cells, Analysis of DNA and Protein Synthesis in Hepatocytes -- 2.7. Determination of Lipoprotein Binding Ability of the Cells -- 2.8. Choice of Interaction Sites between THC-ApoA-I Complex and DNA -- 2.9. Small-Angle X-Ray Scattering (SAXS) -- 3. Results -- 3.1. Mechanisms of Cell Proliferation after PLR and Their Relation with the Activity of Resident Macrophages -- 3.2. The Effect of Resident Macrophages on Protein and Apolipoprotein Biosynthesis in a Regenerating Liver -- 3.3. The Effect of Cortisol (THC)-ApoA-I Complex on In Vitro Biosynthesis of Protein and DNA in the Liver Cells -- 3.4. Molecular Mechanisms of DNA Reduplication during Cell Division -- 3.5. Contribution of Macrophages to the Mechanism of Intracellular Regeneration of Various Organs and Tissues -- Conclusion -- References -- Chapter II: Current Concepts on the Formation of Discoidal Apolipoprotein A-I Lipid Bound Complexes: From Picket Fences to a Double-Belt Model via Inter-Ring Rotation of Apolipoprotein A-I Monomers -- Abstract -- I. Introduction.
I.1. The Structural Arrangement for Apolipoprotein A-I Discoidal Pucks, Competing Models Picket-Fence and Double-Belt -- I.2. Disease Specific Mutants of ApoA-I (Paris and Milan) Point to Double-Belt Model for Remodeling Complexes -- II. Methods Used in Modeling the Dynamic Motion of the Double Belt Models -- II.1. Revisiting the Methods in Detail from the MdMD Method for Biasing -- III. A Discussion of the Current Understanding of the Inter-Ring Rotation of the Double Belt Model via MD Biasing -- III.1. Rotation of the Monomer Rings of ApoA-I is Possible with a Biasing Potential -- I.2. 'Ring Rotation' Has an Independent Feature -- III.3. The Effect of Using MdMD for Biasing the Rotation of the Monomer Rings of ApoA-I -- III.4. Implications for HDL Structure as a Result from the Remodeled Complexes Found in Molecular Dynamics -- III.5. Interactions between the Two Protein Monomers during Rotation Intervals -- III.6. Detailed Analysis of the Conformations -- Concluding Remarks on the Findings from MdMD Biasing Methods for Probing ApoA-I Structural Arrangement during Dynamic Remodeling Events -- References -- Chapter III: Understanding the Role of Apolipoprotein E in Cardiovascular and Renal Diseases -- Abstract -- Introduction -- Apolipoprotein E and Atherosclerosis -- Apolipoprotein E and Diabetes -- Apolipoprotein E and Kidney Diseases -- Conclusion -- References -- Chapter IV: Role of Functional Variants and Mutations of the Apolipoprotein A5 Gene in Human Pathology -- Abstract -- Discovery of Apolipoprotein A5 -- Structure and Molecular Interactions of Apolipoprotein A5 -- Apolipoprotein A5 Mouse Models and Metabolic Experiments -- Apolipoprotein A5 Molecular Mechanism and Mode of Action -- Common Polymorphisms in Apoa5 -- g.-1131T> -- C (rs662799) -- g.IVS3+476G> -- A (rs2072560) -- g.1259T> -- C (rs2266788) -- c.56C>. G (p.Ser19Trp, rs3135506) -- Haplotypes -- Naturally Occurring Rare Functional Variants and Mutations -- Conclusion -- Acknowledgment -- References -- Chapter V: Mechanism of Antiinflammatory Action of the High Density Lipoproteins and Apolipoprotein A-I -- Abstract -- Introduction -- Materials and Methods -- Results -- Analysis of Interaction of Blood Plasma Lipoproteins with Bacterial and Yeast Polysaccharides -- Transfer LPS Complexed with apoA-I into Hepatocytes -- Influence of Lipoproteins and Lipoproteins-bound Polysaccharides on IL-1β Production by Tumor-associated Macrophages -- Conclusion -- References -- Chapter VI: Apolipoprotein A-I Motifs in Discoidal High Density Lipoproteins Influence Lecithin: Cholesterol Acyltransferase Activity -- Abstract -- Abbreviations -- 1. Introduction -- 2. Materials and Methods -- 2.1. Materials -- 2.2. Methods -- 2.2.1. Preparation and Characterization of Apolipoprotein/DPPC/Chol Complexes -- 2.2.2. rHDL-LCAT Binding Assay -- 2.2.3. Kinetic Model -- 2.2.4. The Influence of Altered ApoA-I Structure on LCAT Activity -- 3. Results -- 3.1. Influence of ApoA-I Structure on LCAT Activity -- 3.2. LCAT Binding to rHDL with Plasma and D139-170 apoA-I -- 3.3. LCAT Activity with Native and D139-170 Apolipoproteins -- Discussion -- Conclusion -- References -- Chapter VII: Regulation by FGF-1 of apoE/HDL Generation in Astrocytes -- Abstract -- Introduction -- 1. HDL Generation Mediated by Endogenous apoE and Exogenous apoA-I in Astrocytes -- 2. Regulation by FGF-1 of apoE/HDL Generation -- 3. FGF-1 Release from Astrocytes -- 4. Brain Protection from Injury and Stress by FGF-1 and apoE/HDL -- 5. Production and Function of FGF-1 and apoE/lipoproteins in Alzheimar's Desease -- References -- Index. |
| Record Nr. | UNINA-9910961199403321 |
| New York, : Nova Biomedical, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Apolipoproteins, Triglycerides and Cholesterol / / Viduranga Y. Waisundara, editor
| Apolipoproteins, Triglycerides and Cholesterol / / Viduranga Y. Waisundara, editor |
| Pubbl/distr/stampa | London : , : IntechOpen, , 2020 |
| Descrizione fisica | 1 online resource (238 pages) |
| Disciplina | 572.6 |
| Soggetto topico | Apolipoproteins |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910688587003321 |
| London : , : IntechOpen, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Apoprotein research [[electronic resource] /] / Linda R. Penfield and Rachel T. Nelson, editors
| Apoprotein research [[electronic resource] /] / Linda R. Penfield and Rachel T. Nelson, editors |
| Pubbl/distr/stampa | New York, : Nova Biomedical Books, c2009 |
| Descrizione fisica | 1 online resource (323 p.) |
| Disciplina | 612.015756 |
| Altri autori (Persone) |
PenfieldLinda R
NelsonRachel T |
| Soggetto topico |
Apolipoproteins
Blood proteins Recombinant proteins |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-60876-737-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910452214503321 |
| New York, : Nova Biomedical Books, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Apoprotein research [[electronic resource] /] / Linda R. Penfield and Rachel T. Nelson, editors
| Apoprotein research [[electronic resource] /] / Linda R. Penfield and Rachel T. Nelson, editors |
| Pubbl/distr/stampa | New York, : Nova Biomedical Books, c2009 |
| Descrizione fisica | 1 online resource (323 p.) |
| Disciplina | 612.015756 |
| Altri autori (Persone) |
PenfieldLinda R
NelsonRachel T |
| Soggetto topico |
Apolipoproteins
Blood proteins Recombinant proteins |
| ISBN | 1-60876-737-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910779519103321 |
| New York, : Nova Biomedical Books, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Apoprotein research / / Linda R. Penfield and Rachel T. Nelson, editors
| Apoprotein research / / Linda R. Penfield and Rachel T. Nelson, editors |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | New York, : Nova Biomedical Books, c2009 |
| Descrizione fisica | 1 online resource (323 p.) |
| Disciplina | 612.015756 |
| Altri autori (Persone) |
PenfieldLinda R
NelsonRachel T |
| Soggetto topico |
Apolipoproteins
Blood proteins Recombinant proteins |
| ISBN | 1-60876-737-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Apoprotein Research -- Contents -- Preface -- Research and Review Studies -- Apolipoproteins in Primary Antiphospholipid Syndrome -- Abstract -- Introduction -- Apolipoprotein AI -- Apolipoprotein AII -- Apolipoprotein AIV -- Apolipoprotein B48 -- Apolipoprotein B100 -- Apolipoprotein CI -- Apolipoprotein CII -- Apolipoprotein CIII -- Apolipoprotein D -- Apolipoprotein E -- Lipoprotein (A)/Apolipoprotein (A) -- Relevance for Patients with Primary Antiphospholipid Syndrome -- Conclusions -- Acknowledgments -- References -- A Review of the Association of Apolipoprotein E and Delirium -- Abstract -- Introduction -- Method -- Results -- Discussion -- Conclusion -- References -- Apolipoproteins and Lipids in Overweight Men with Familial Hypertriglyceridemia -- Abstract -- Introduction -- Materials and Methods -- Results and Discussion -- Conclusion -- References -- Apolipoprotein E: Microbial Friend or Foe? -- Abstract -- Introduction -- Viruses -- Bacteria -- Protozoa -- Conclusion -- References -- Apolipoprotein AV: The Riddle of the Sphinx -- Introduction -- Biological Properties -- Nuclear Receptors and Other Factors Influencing Expression of APOAV Gene -- Association between APOAV and Triglyceride as well as DIseases Associated with Hypertriglyceridemia -- Future Perspectives -- Acknowledgment -- References -- Structure of Apoproteins of Hen Egg Yolk Low-density Lipoproteins in Relation to Functionalities: A Review -- Abstract -- Introduction -- Structural Study of DLL Apoproteins -- Insertion of apo B in LDL -- Functional Properties of LDL Apoproteins -- Conclusion -- References -- An Overview of ApoE for Application in Gene Therapy -- Abstract -- Introduction -- ApoE and its Role -- Therapies for Atherosclerosis -- Gene Therapy in Atherosclerosis -- Mouse Models of ApoE Deficiency -- ApoE Gene Transfer.
ApoE and its Neuroprotective Effects -- Conclusions -- References -- The Heritabilities, Genetics and Networks of Apolipoproteins -- Abstract -- Introduction -- Components of the Lipoprotein Metabolism -- Genetics of Apolipoproteins -- Heritabilities of Components in the Metabolic Network of Lipoproteins -- The Significance of Heritability Measures -- The Network of the Lipid Transport System -- References -- Apolipoprotein E Gene Polymorphism and Metabolic Syndrome in a Free-living Elderly Community -- Abstract -- Introduction -- Apolipoprotein E and Metabolic Syndrome: Is there a Link? -- Conclusion -- References -- Short Communications -- Why is apoE Genotype a Risk Factor for Multiple Chronic Neurological Disorders? -- Abstract -- Introduction -- ApoE and Neurological Disorders -- ApoE in the Nervous System -- Isoform Specific Effects of apoE on Neuronal Structure and Function -- Isoform Specific Effects of apoE on Neuronal Plasticity Underlies its Link to Various Neurological DIseases -- References -- The Relationship of Postprandial Lipemia and Apolipoprotein Composition of High Density Lipoproteins -- Abstract -- Introduction -- Material and Methods -- Results -- Conclusion -- References -- The Role of Apoproteins in Modern Cardiovascular and Medical Research -- Apoproteins (Apolipoproteins) A and B -- Apolipoproteins CII, CIII and D -- Apolipoprotein E (APOE) -- Apolipoprotein H (APO H) -- References -- Index. |
| Record Nr. | UNINA-9910955170203321 |
| New York, : Nova Biomedical Books, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
