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Immunodominance [[electronic resource] ] : the choice of the immune system / / edited by Jeffrey A. Frelinger
| Immunodominance [[electronic resource] ] : the choice of the immune system / / edited by Jeffrey A. Frelinger |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH |
| Descrizione fisica | 1 online resource (316 p.) |
| Disciplina | 616.079 |
| Altri autori (Persone) | FrelingerJeffrey A |
| Soggetto topico |
Immune response - Regulation
Antigenic determinants - Research |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-85434-0
9786610854349 3-527-60802-8 3-527-60737-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Immunodominance; Contents; Preface; List of Contributors; Color Plates; I Mechanics of Antigen Processing; 1 Class I MHC Antigen Processing; 1.1 Introduction; 1.2 Properties of MHC; 1.2.1 Structure of MHC; 1.2.2 Polymorphic Residues Generate Specificity Pockets; 1.3 Properties of Peptides; 1.3.1 Peptides That Bind Are Not Random Sequences; 1.3.2 Peptide-binding Motifs; 1.3.3 Peptide Length Is Limited in Class I MHC Peptides; 1.3.4 Binding Affinity; 1.3.5 Molecular Recognition; 1.3.6 Epitope Prediction; 1.4 Cytosolic Processing; 1.4.1 The Proteasome; 1.4.2 The Immunoproteasome
1.4.3 Opening the Immunoproteasome1.4.4 Peptide Trimming; 1.4.5 Association of the Proteasome with the Endoplasmic Reticulum; 1.5 Peptide Transport; 1.5.1 Transport via TAP; 1.5.2 TAP Selectivity; 1.5.3 TAP-independent Peptide Transport; 1.5.3.1 Endogenous Peptides; 1.5.3.2 Exogenous Peptides; 1.6 Class I MHC Maturation and Peptide Loading; 1.6.1 ER Chaperones: Calnexin, Calreticulin, ERp57, and Tapasin; 1.6.1.1 Calnexin; 1.6.1.2 Tapasin; 1.6.1.3 ERp57; 1.6.1.4 Calreticulin; 1.6.2 Peptide Loading; 1.7 Immunodominance and Class I MHC Peptide Processing 2 The Mechanics of Class II Processing: Establishment of a Peptide Class II Hierarchy2.1 General Overview; 2.1.1 Immunodominance and Crypticity; 2.1.2 The Impact of T-Cell Repertoire in the Experimental Analysis of Immunodominance; 2.1.3 Different Antigen-presenting Cells Have Different Functions; 2.1.4 The Phases of Antigen Processing; 2.2 Phase I: MHC Class II Biosynthesis and Delivery to Peptide-loading Compartments; 2.2.1 Invariant Chain Isoforms; 2.2.2 Effects of Cell Signaling on MHC Class II Transport; 2.3 Phase II: Antigen Internalization and Processing 2.3.1 BCR-mediated Antigen Internalization2.3.2 Dendritic Cells and Macrophages; 2.4 Phase III: Formation and Expression of Antigenic Peptide by MHC Class II Molecules; 2.4.1 Proteolytic Antigen Processing; 2.4.2 Class II Peptide Loading; 2.4.2.1 DM; 2.4.2.2 DO; 2.4.2.3 DO-, DM-, and BCR-Mediated Antigen Processing; 2.4.2.4 The Distribution of MHC Class II and Other Proteins Within MIIC; 2.4.3 Cell-surface Delivery of Peptide-Class II Complexes; 2.4.3.1 Exosomes; 2.4.3.2 Signaling Properties of Peptide-Class II Complexes; 2.5 Conclusions; Acknowledgments 3 The Phenomenon of Immunodomination: Speculations on the Nature of Immunodominance3.1 Introduction; 3.2 MHC Binding, Cellular Processing, and T-Cell Repertoire are Major Determinants of Immunodominance; 3.3 Previous Systematic Analysis of Immunodominance by Our Group; 3.4 Cellular and Molecular Events in Immunodomination; 3.5 Speculations on the Mechanism of Immunodomination; 3.5.1 Involvement of APCs; 3.5.2 Possible Involvement of the Immune Synapse in Immunodomination; 3.5.3 The Potential Role of MTOC in Immunodomination; 3.6 Significance of Studying Immunodominance for Vaccine Development 3.7 Conclusions |
| Record Nr. | UNINA-9910144556903321 |
| Weinheim, : Wiley-VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Immunodominance : the choice of the immune system / / edited by Jeffrey A. Frelinger
| Immunodominance : the choice of the immune system / / edited by Jeffrey A. Frelinger |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH |
| Descrizione fisica | 1 online resource (316 p.) |
| Disciplina | 616.079 |
| Altri autori (Persone) | FrelingerJeffrey A |
| Soggetto topico |
Immune response - Regulation
Antigenic determinants - Research |
| ISBN |
1-280-85434-0
9786610854349 3-527-60802-8 3-527-60737-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Immunodominance; Contents; Preface; List of Contributors; Color Plates; I Mechanics of Antigen Processing; 1 Class I MHC Antigen Processing; 1.1 Introduction; 1.2 Properties of MHC; 1.2.1 Structure of MHC; 1.2.2 Polymorphic Residues Generate Specificity Pockets; 1.3 Properties of Peptides; 1.3.1 Peptides That Bind Are Not Random Sequences; 1.3.2 Peptide-binding Motifs; 1.3.3 Peptide Length Is Limited in Class I MHC Peptides; 1.3.4 Binding Affinity; 1.3.5 Molecular Recognition; 1.3.6 Epitope Prediction; 1.4 Cytosolic Processing; 1.4.1 The Proteasome; 1.4.2 The Immunoproteasome
1.4.3 Opening the Immunoproteasome1.4.4 Peptide Trimming; 1.4.5 Association of the Proteasome with the Endoplasmic Reticulum; 1.5 Peptide Transport; 1.5.1 Transport via TAP; 1.5.2 TAP Selectivity; 1.5.3 TAP-independent Peptide Transport; 1.5.3.1 Endogenous Peptides; 1.5.3.2 Exogenous Peptides; 1.6 Class I MHC Maturation and Peptide Loading; 1.6.1 ER Chaperones: Calnexin, Calreticulin, ERp57, and Tapasin; 1.6.1.1 Calnexin; 1.6.1.2 Tapasin; 1.6.1.3 ERp57; 1.6.1.4 Calreticulin; 1.6.2 Peptide Loading; 1.7 Immunodominance and Class I MHC Peptide Processing 2 The Mechanics of Class II Processing: Establishment of a Peptide Class II Hierarchy2.1 General Overview; 2.1.1 Immunodominance and Crypticity; 2.1.2 The Impact of T-Cell Repertoire in the Experimental Analysis of Immunodominance; 2.1.3 Different Antigen-presenting Cells Have Different Functions; 2.1.4 The Phases of Antigen Processing; 2.2 Phase I: MHC Class II Biosynthesis and Delivery to Peptide-loading Compartments; 2.2.1 Invariant Chain Isoforms; 2.2.2 Effects of Cell Signaling on MHC Class II Transport; 2.3 Phase II: Antigen Internalization and Processing 2.3.1 BCR-mediated Antigen Internalization2.3.2 Dendritic Cells and Macrophages; 2.4 Phase III: Formation and Expression of Antigenic Peptide by MHC Class II Molecules; 2.4.1 Proteolytic Antigen Processing; 2.4.2 Class II Peptide Loading; 2.4.2.1 DM; 2.4.2.2 DO; 2.4.2.3 DO-, DM-, and BCR-Mediated Antigen Processing; 2.4.2.4 The Distribution of MHC Class II and Other Proteins Within MIIC; 2.4.3 Cell-surface Delivery of Peptide-Class II Complexes; 2.4.3.1 Exosomes; 2.4.3.2 Signaling Properties of Peptide-Class II Complexes; 2.5 Conclusions; Acknowledgments 3 The Phenomenon of Immunodomination: Speculations on the Nature of Immunodominance3.1 Introduction; 3.2 MHC Binding, Cellular Processing, and T-Cell Repertoire are Major Determinants of Immunodominance; 3.3 Previous Systematic Analysis of Immunodominance by Our Group; 3.4 Cellular and Molecular Events in Immunodomination; 3.5 Speculations on the Mechanism of Immunodomination; 3.5.1 Involvement of APCs; 3.5.2 Possible Involvement of the Immune Synapse in Immunodomination; 3.5.3 The Potential Role of MTOC in Immunodomination; 3.6 Significance of Studying Immunodominance for Vaccine Development 3.7 Conclusions |
| Record Nr. | UNINA-9910677191803321 |
| Weinheim, : Wiley-VCH | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
