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The cholesterol wars [[electronic resource] ] : the skeptics vs. the preponderance of evidence / / Daniel Steinberg
| The cholesterol wars [[electronic resource] ] : the skeptics vs. the preponderance of evidence / / Daniel Steinberg |
| Autore | Steinberg Daniel <1922-> |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | San Diego, Calif., : Academic Press, 2007 |
| Descrizione fisica | 1 online resource (253 p.) |
| Disciplina |
616.1/36
616.136061 |
| Soggetto topico |
Atherosclerosis
Anticholesteremic agents Statins (Cardiovascular agents) |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-11191-0
9786611111915 0-08-055619-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; The Cholesterol Wars: The Skeptics vs. the Preponderance of Evidence; Copyright Page; Contents; Foreword; Preface; Acknowledgments; Chapter 1. Overview; On the nature of medical controversy; An overview of the cholesterol wars; Where we stand today; References; Chapter 2. Animal Models of Atherosclerosis; Nikolai N. Anitschkow and the cholesterol-fed rabbit; Why wasn't Anitschkow's lead followed up?; What led Anitschkow to feed rabbits cholesterol?; Atherosclerosis in other species; Notes; References
Chapter 3. Hypercholesterolemia and Atherosclerosis in Humans: Causally Related? The clinical and genetic evidence; Do more modest degrees of hypercholesterolemia, such as are found in a general population, confer risk of premature coronary heart disease?; The epidemiologic evidence; Dietary fat, blood cholesterol, and coronary heart disease; Do diets rich in saturated fats really raise blood cholesterol?; Experimental findings; Observational studies; The contribution of dietary cholesterol intake; Early clinical trials of dietary intervention; Additional pre-1970 studies Overview of all of the pre-1970's diet intervention studies A brief wrap-up of the case against cholesterol as of 1970; Note; References; Chapter 4. Building the Basic Science Foundation; The biosynthesis of cholesterol and its metabolic regulation; The rate-limiting step, HMGCo A reductase; The birth of the lipoproteins and the John W. Gofman story; Unraveling the complex metabolism and interactions of the plasma lipoproteins; Which lipoproteins are proatherogenic?; The National Heart Institute story; Bringing the lipoprotein package concept into clinical practice Moving from phenotype to genotypeReferences; Chapter 5. In Search of a Pathogenesis; The importance of understanding mechanism in gaining acceptance of a hypothesis; Early attempts to define the pathogenesis of atherosclerosis; The response-to-injury hypothesis and the monoclonal hypothesis; Understanding the role of HDL as an atheroprotective factor; An update on HDL as a target for intervention; Discovery of the LDL receptor: the remarkable partnership of Brown and Goldstein; Goldstein and Brown start their search for the faulty gene in familial hypercholesterolemia Discovery of the scavenger receptor on macrophages Oxidatively modified LDL and atherogenesis; Inflammation in the pathogenesis of atherosclerosis; Weighing the relative importance of inflammation and hyperlipidemia; Regression of atherosclerosis; Status of the lipid hypothesis in the 1980's; Note; References; Chapter 6. The Search for Cholesterol-lowering Drugs; Hypocholesterolemic drugs as a target: cons and pros Nicotinic acid; Bile acid-binding resins; Clofibrate; Probucol; Another blow: the somewhat messy Coronary Drug Project; The cholesterol controversy at its height; References Chapter 7. The 1984 Coronary Primary Prevention Trial |
| Record Nr. | UNINA-9910458813803321 |
Steinberg Daniel <1922->
|
||
| San Diego, Calif., : Academic Press, 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The cholesterol wars [[electronic resource] ] : the skeptics vs. the preponderance of evidence / / Daniel Steinberg
| The cholesterol wars [[electronic resource] ] : the skeptics vs. the preponderance of evidence / / Daniel Steinberg |
| Autore | Steinberg Daniel <1922-> |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | San Diego, Calif., : Academic Press, 2007 |
| Descrizione fisica | 1 online resource (253 p.) |
| Disciplina |
616.1/36
616.136061 |
| Soggetto topico |
Atherosclerosis
Anticholesteremic agents Statins (Cardiovascular agents) |
| ISBN |
1-281-11191-0
9786611111915 0-08-055619-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; The Cholesterol Wars: The Skeptics vs. the Preponderance of Evidence; Copyright Page; Contents; Foreword; Preface; Acknowledgments; Chapter 1. Overview; On the nature of medical controversy; An overview of the cholesterol wars; Where we stand today; References; Chapter 2. Animal Models of Atherosclerosis; Nikolai N. Anitschkow and the cholesterol-fed rabbit; Why wasn't Anitschkow's lead followed up?; What led Anitschkow to feed rabbits cholesterol?; Atherosclerosis in other species; Notes; References
Chapter 3. Hypercholesterolemia and Atherosclerosis in Humans: Causally Related? The clinical and genetic evidence; Do more modest degrees of hypercholesterolemia, such as are found in a general population, confer risk of premature coronary heart disease?; The epidemiologic evidence; Dietary fat, blood cholesterol, and coronary heart disease; Do diets rich in saturated fats really raise blood cholesterol?; Experimental findings; Observational studies; The contribution of dietary cholesterol intake; Early clinical trials of dietary intervention; Additional pre-1970 studies Overview of all of the pre-1970's diet intervention studies A brief wrap-up of the case against cholesterol as of 1970; Note; References; Chapter 4. Building the Basic Science Foundation; The biosynthesis of cholesterol and its metabolic regulation; The rate-limiting step, HMGCo A reductase; The birth of the lipoproteins and the John W. Gofman story; Unraveling the complex metabolism and interactions of the plasma lipoproteins; Which lipoproteins are proatherogenic?; The National Heart Institute story; Bringing the lipoprotein package concept into clinical practice Moving from phenotype to genotypeReferences; Chapter 5. In Search of a Pathogenesis; The importance of understanding mechanism in gaining acceptance of a hypothesis; Early attempts to define the pathogenesis of atherosclerosis; The response-to-injury hypothesis and the monoclonal hypothesis; Understanding the role of HDL as an atheroprotective factor; An update on HDL as a target for intervention; Discovery of the LDL receptor: the remarkable partnership of Brown and Goldstein; Goldstein and Brown start their search for the faulty gene in familial hypercholesterolemia Discovery of the scavenger receptor on macrophages Oxidatively modified LDL and atherogenesis; Inflammation in the pathogenesis of atherosclerosis; Weighing the relative importance of inflammation and hyperlipidemia; Regression of atherosclerosis; Status of the lipid hypothesis in the 1980's; Note; References; Chapter 6. The Search for Cholesterol-lowering Drugs; Hypocholesterolemic drugs as a target: cons and pros Nicotinic acid; Bile acid-binding resins; Clofibrate; Probucol; Another blow: the somewhat messy Coronary Drug Project; The cholesterol controversy at its height; References Chapter 7. The 1984 Coronary Primary Prevention Trial |
| Record Nr. | UNINA-9910784621303321 |
|
Steinberg Daniel <1922->
|
||
| San Diego, Calif., : Academic Press, 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The cholesterol wars : the skeptics vs. the preponderance of evidence / / Daniel Steinberg
| The cholesterol wars : the skeptics vs. the preponderance of evidence / / Daniel Steinberg |
| Autore | Steinberg Daniel <1922-> |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | San Diego, Calif., : Academic Press, 2007 |
| Descrizione fisica | 1 online resource (253 p.) |
| Disciplina |
616.1/36
616.136061 |
| Soggetto topico |
Atherosclerosis
Anticholesteremic agents Statins (Cardiovascular agents) |
| ISBN |
1-281-11191-0
9786611111915 0-08-055619-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; The Cholesterol Wars: The Skeptics vs. the Preponderance of Evidence; Copyright Page; Contents; Foreword; Preface; Acknowledgments; Chapter 1. Overview; On the nature of medical controversy; An overview of the cholesterol wars; Where we stand today; References; Chapter 2. Animal Models of Atherosclerosis; Nikolai N. Anitschkow and the cholesterol-fed rabbit; Why wasn't Anitschkow's lead followed up?; What led Anitschkow to feed rabbits cholesterol?; Atherosclerosis in other species; Notes; References
Chapter 3. Hypercholesterolemia and Atherosclerosis in Humans: Causally Related? The clinical and genetic evidence; Do more modest degrees of hypercholesterolemia, such as are found in a general population, confer risk of premature coronary heart disease?; The epidemiologic evidence; Dietary fat, blood cholesterol, and coronary heart disease; Do diets rich in saturated fats really raise blood cholesterol?; Experimental findings; Observational studies; The contribution of dietary cholesterol intake; Early clinical trials of dietary intervention; Additional pre-1970 studies Overview of all of the pre-1970's diet intervention studies A brief wrap-up of the case against cholesterol as of 1970; Note; References; Chapter 4. Building the Basic Science Foundation; The biosynthesis of cholesterol and its metabolic regulation; The rate-limiting step, HMGCo A reductase; The birth of the lipoproteins and the John W. Gofman story; Unraveling the complex metabolism and interactions of the plasma lipoproteins; Which lipoproteins are proatherogenic?; The National Heart Institute story; Bringing the lipoprotein package concept into clinical practice Moving from phenotype to genotypeReferences; Chapter 5. In Search of a Pathogenesis; The importance of understanding mechanism in gaining acceptance of a hypothesis; Early attempts to define the pathogenesis of atherosclerosis; The response-to-injury hypothesis and the monoclonal hypothesis; Understanding the role of HDL as an atheroprotective factor; An update on HDL as a target for intervention; Discovery of the LDL receptor: the remarkable partnership of Brown and Goldstein; Goldstein and Brown start their search for the faulty gene in familial hypercholesterolemia Discovery of the scavenger receptor on macrophages Oxidatively modified LDL and atherogenesis; Inflammation in the pathogenesis of atherosclerosis; Weighing the relative importance of inflammation and hyperlipidemia; Regression of atherosclerosis; Status of the lipid hypothesis in the 1980's; Note; References; Chapter 6. The Search for Cholesterol-lowering Drugs; Hypocholesterolemic drugs as a target: cons and pros Nicotinic acid; Bile acid-binding resins; Clofibrate; Probucol; Another blow: the somewhat messy Coronary Drug Project; The cholesterol controversy at its height; References Chapter 7. The 1984 Coronary Primary Prevention Trial |
| Record Nr. | UNINA-9910828815503321 |
|
Steinberg Daniel <1922->
|
||
| San Diego, Calif., : Academic Press, 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Statins [[electronic resource] ] : Indications and Uses, Safety and Modes of Action
| Statins [[electronic resource] ] : Indications and Uses, Safety and Modes of Action |
| Autore | Holmqvist Gunnar N |
| Pubbl/distr/stampa | New York, : Nova Science Publishers, Inc., 2008 |
| Descrizione fisica | 1 online resource (219 p.) |
| Disciplina | 615/.718 |
| Soggetto topico |
Anticholesteremic agents
Statins (Cardiovascular agents) Lipoproteins, LDL Anticholesteremic Agents Vascular Diseases Cholesterol Enzyme Inhibitors Heart Diseases Cholesterol, LDL Hydroxymethylglutaryl-CoA Reductase Inhibitors Myocardial Ischemia Sterols Hypolipidemic Agents Lipoproteins Cardiovascular Diseases Molecular Mechanisms of Pharmacological Action Antimetabolites Proteins Lipid Regulating Agents Lipids Diseases Pharmacologic Actions Membrane Lipids Therapeutic Uses Chemical Actions and Uses Chemicals and Drugs Amino Acids, Peptides, and Proteins Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-60876-345-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910460057303321 |
|
Holmqvist Gunnar N
|
||
| New York, : Nova Science Publishers, Inc., 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Statins [[electronic resource] ] : Indications and Uses, Safety and Modes of Action
| Statins [[electronic resource] ] : Indications and Uses, Safety and Modes of Action |
| Autore | Holmqvist Gunnar N |
| Pubbl/distr/stampa | New York, : Nova Science Publishers, Inc., 2008 |
| Descrizione fisica | 1 online resource (219 p.) |
| Disciplina | 615/.718 |
| Soggetto topico |
Anticholesteremic agents
Statins (Cardiovascular agents) Lipoproteins, LDL Anticholesteremic Agents Vascular Diseases Cholesterol Enzyme Inhibitors Heart Diseases Cholesterol, LDL Hydroxymethylglutaryl-CoA Reductase Inhibitors Myocardial Ischemia Sterols Hypolipidemic Agents Lipoproteins Cardiovascular Diseases Molecular Mechanisms of Pharmacological Action Antimetabolites Proteins Lipid Regulating Agents Lipids Diseases Pharmacologic Actions Membrane Lipids Therapeutic Uses Chemical Actions and Uses Amino Acids, Peptides, and Proteins Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN | 1-60876-345-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Statin therapy for coronary artery disease beyond lipid lowering effect / Teruo Inoue, Koichi Node -- Side effects of statins in monotherapy / Helmut Sinzinger, Bernhard A. Peskar -- Preliminary findings about the trends of the renal hemodynamics and the proxies of cardiovascular risk during a short course of atorvastatin therapy in essential hypertensives / Luigi Vernaglione -- Beneficial effects of addition of fenofibrate to statin therapy in patients with acute coronary syndrome after percutaneous coronary interventions / Hetal D. Shah ... [et al.] -- Non-lipid lowering effects of statins / A. Schmidt -- Statins in the therapy of acute coronary syndrome / Petr Ostadal -- Beneficial effects of addition of fenofibrate to statin therapy in patients with acute coronary syndrome after percutaneous coronary interventions / Hetal D. Shah ... [et al.] -- Bad HDL-C responders to statins / Dirk Devroey -- Beneficial effects of statins in systemic lupus erythematosus : molecular mechanism involved / Antonio G. Tristano. |
| Record Nr. | UNINA-9910785176703321 |
|
Holmqvist Gunnar N
|
||
| New York, : Nova Science Publishers, Inc., 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Statins / / Gunnar N. Holmqvist (editor)
| Statins / / Gunnar N. Holmqvist (editor) |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | New York, : Nova Science Publishers, c2008 |
| Descrizione fisica | 1 online resource (219 p.) |
| Disciplina | 615/.718 |
| Altri autori (Persone) | HolmqvistGunnar N |
| Soggetto topico |
Statins (Cardiovascular agents)
Anticholesteremic agents |
| ISBN | 1-60876-345-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Statin therapy for coronary artery disease beyond lipid lowering effect / Teruo Inoue, Koichi Node -- Side effects of statins in monotherapy / Helmut Sinzinger, Bernhard A. Peskar -- Preliminary findings about the trends of the renal hemodynamics and the proxies of cardiovascular risk during a short course of atorvastatin therapy in essential hypertensives / Luigi Vernaglione -- Beneficial effects of addition of fenofibrate to statin therapy in patients with acute coronary syndrome after percutaneous coronary interventions / Hetal D. Shah ... [et al.] -- Non-lipid lowering effects of statins / A. Schmidt -- Statins in the therapy of acute coronary syndrome / Petr Ostadal -- Beneficial effects of addition of fenofibrate to statin therapy in patients with acute coronary syndrome after percutaneous coronary interventions / Hetal D. Shah ... [et al.] -- Bad HDL-C responders to statins / Dirk Devroey -- Beneficial effects of statins in systemic lupus erythematosus : molecular mechanism involved / Antonio G. Tristano. |
| Record Nr. | UNINA-9910818398603321 |
| New York, : Nova Science Publishers, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Triumph of the heart [[electronic resource] ] : the story of statins / / Jie Jack Li
| Triumph of the heart [[electronic resource] ] : the story of statins / / Jie Jack Li |
| Autore | Li Jie Jack |
| Pubbl/distr/stampa | New York, : Oxford University Press, 2009 |
| Descrizione fisica | 1 online resource (220 p.) |
| Disciplina | 615/.718 |
| Collana | Oxford scholarship online |
| Soggetto topico |
Statins (Cardiovascular agents) - History
Anticholesteremic agents |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-19-756250-7
0-19-988665-2 1-281-99848-6 9786611998486 0-19-804351-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Foreword; Contents; 1 Cholesterol; The Janus-Faced Molecule; One of the 10 Greatest Discoveries in Medicine; The Good, the Bad, and the Ugly; Hitler's Gift; The Framingham Heart Study; The Receptor; 2 Genesis of Statins; Early Cholesterol Drugs; Nicotinic acid; Resins; Fibrates; I Refuse to Sign Th is Report!; Birth of Statins; Endo's discovery of the first statin; The fate of mevastatin; Endo's fate; How do statins work?; 3 Merck's Triumph; Merck; Humble beginnings; George W. Merck; Penicillin; Cortisone; Streptomycin; Glorious history; Mevacor and Zocor; The poor Greek immigrant kid
PreludeDiscovery; Halt!; Triumph; The Company, the Drugs, and the Inventors Today; 4 Discovery of Lipitor; Splendid History; Parke, Davis & Company; Dilantin; Chloromycetin; The pill; Lopid; Roger S. Newton; Bruce D. Roth; The Discovery of Lipitor; Shoulders of giants; The first success . . . and disappointment; The second refrain; CI-971; CI-981; 5 Development of Lipitor; Checkered Life; Chiral or Not, You Have to Make It First; Clinical Trials-Divine Providence?; Canter and the FDA; What's in a Name?; A Marketing Partner; 6 To Market, to Market; Pfizer Inc. The small drug firm in Brooklyn made bigPenicillin; Drugs of its own; Windfall: The Era of Blockbusters; Viagra; Zoloft; Diflucan; Zithromax; Norvasc; The Merger; PROVE-IT; The Patent Litigation; 7 Baycol, Crestor, and Cholesterol Drugs beyond Statins; The Story of Baycol; Crestor; Cholesterol Drugs beyond Statins; Zetia and Vytorin; Torcetrapib, a bitter disappointment; ApoA-1 Milano and Newton; 8 Reflections; Triumph of the Heart; Statins set a high standard in efficacy; Statins set a high standard in safety; Statins set a high standard in financial benefits The Drug Industry and the Blockbuster ModelAppendix: Drug Names; Notes and References; Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Y; Z |
| Record Nr. | UNINA-9910454399103321 |
|
Li Jie Jack
|
||
| New York, : Oxford University Press, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Triumph of the heart [[electronic resource] ] : the story of statins / / Jie Jack Li
| Triumph of the heart [[electronic resource] ] : the story of statins / / Jie Jack Li |
| Autore | Li Jie Jack |
| Pubbl/distr/stampa | New York, : Oxford University Press, 2009 |
| Descrizione fisica | 1 online resource (220 p.) |
| Disciplina | 615/.718 |
| Collana | Oxford scholarship online |
| Soggetto topico |
Statins (Cardiovascular agents) - History
Anticholesteremic agents |
| ISBN |
0-19-756250-7
0-19-988665-2 1-281-99848-6 9786611998486 0-19-804351-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Foreword; Contents; 1 Cholesterol; The Janus-Faced Molecule; One of the 10 Greatest Discoveries in Medicine; The Good, the Bad, and the Ugly; Hitler's Gift; The Framingham Heart Study; The Receptor; 2 Genesis of Statins; Early Cholesterol Drugs; Nicotinic acid; Resins; Fibrates; I Refuse to Sign Th is Report!; Birth of Statins; Endo's discovery of the first statin; The fate of mevastatin; Endo's fate; How do statins work?; 3 Merck's Triumph; Merck; Humble beginnings; George W. Merck; Penicillin; Cortisone; Streptomycin; Glorious history; Mevacor and Zocor; The poor Greek immigrant kid
PreludeDiscovery; Halt!; Triumph; The Company, the Drugs, and the Inventors Today; 4 Discovery of Lipitor; Splendid History; Parke, Davis & Company; Dilantin; Chloromycetin; The pill; Lopid; Roger S. Newton; Bruce D. Roth; The Discovery of Lipitor; Shoulders of giants; The first success . . . and disappointment; The second refrain; CI-971; CI-981; 5 Development of Lipitor; Checkered Life; Chiral or Not, You Have to Make It First; Clinical Trials-Divine Providence?; Canter and the FDA; What's in a Name?; A Marketing Partner; 6 To Market, to Market; Pfizer Inc. The small drug firm in Brooklyn made bigPenicillin; Drugs of its own; Windfall: The Era of Blockbusters; Viagra; Zoloft; Diflucan; Zithromax; Norvasc; The Merger; PROVE-IT; The Patent Litigation; 7 Baycol, Crestor, and Cholesterol Drugs beyond Statins; The Story of Baycol; Crestor; Cholesterol Drugs beyond Statins; Zetia and Vytorin; Torcetrapib, a bitter disappointment; ApoA-1 Milano and Newton; 8 Reflections; Triumph of the Heart; Statins set a high standard in efficacy; Statins set a high standard in safety; Statins set a high standard in financial benefits The Drug Industry and the Blockbuster ModelAppendix: Drug Names; Notes and References; Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Y; Z |
| Record Nr. | UNINA-9910782880803321 |
|
Li Jie Jack
|
||
| New York, : Oxford University Press, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Triumph of the heart : the story of statins / / Jie Jack Li
| Triumph of the heart : the story of statins / / Jie Jack Li |
| Autore | Li Jie Jack |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | New York, : Oxford University Press, 2009 |
| Descrizione fisica | 1 online resource (220 p.) |
| Disciplina | 615/.718 |
| Collana | Oxford scholarship online |
| Soggetto topico |
Statins (Cardiovascular agents) - History
Anticholesteremic agents |
| ISBN |
0-19-756250-7
0-19-988665-2 1-281-99848-6 9786611998486 0-19-804351-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Foreword; Contents; 1 Cholesterol; The Janus-Faced Molecule; One of the 10 Greatest Discoveries in Medicine; The Good, the Bad, and the Ugly; Hitler's Gift; The Framingham Heart Study; The Receptor; 2 Genesis of Statins; Early Cholesterol Drugs; Nicotinic acid; Resins; Fibrates; I Refuse to Sign Th is Report!; Birth of Statins; Endo's discovery of the first statin; The fate of mevastatin; Endo's fate; How do statins work?; 3 Merck's Triumph; Merck; Humble beginnings; George W. Merck; Penicillin; Cortisone; Streptomycin; Glorious history; Mevacor and Zocor; The poor Greek immigrant kid
PreludeDiscovery; Halt!; Triumph; The Company, the Drugs, and the Inventors Today; 4 Discovery of Lipitor; Splendid History; Parke, Davis & Company; Dilantin; Chloromycetin; The pill; Lopid; Roger S. Newton; Bruce D. Roth; The Discovery of Lipitor; Shoulders of giants; The first success . . . and disappointment; The second refrain; CI-971; CI-981; 5 Development of Lipitor; Checkered Life; Chiral or Not, You Have to Make It First; Clinical Trials-Divine Providence?; Canter and the FDA; What's in a Name?; A Marketing Partner; 6 To Market, to Market; Pfizer Inc. The small drug firm in Brooklyn made bigPenicillin; Drugs of its own; Windfall: The Era of Blockbusters; Viagra; Zoloft; Diflucan; Zithromax; Norvasc; The Merger; PROVE-IT; The Patent Litigation; 7 Baycol, Crestor, and Cholesterol Drugs beyond Statins; The Story of Baycol; Crestor; Cholesterol Drugs beyond Statins; Zetia and Vytorin; Torcetrapib, a bitter disappointment; ApoA-1 Milano and Newton; 8 Reflections; Triumph of the Heart; Statins set a high standard in efficacy; Statins set a high standard in safety; Statins set a high standard in financial benefits The Drug Industry and the Blockbuster ModelAppendix: Drug Names; Notes and References; Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Y; Z |
| Record Nr. | UNINA-9910824139503321 |
|
Li Jie Jack
|
||
| New York, : Oxford University Press, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
