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Antibody-drug conjugates : fundamentals, drug development, and clinical outcomes to target cancer / / edited by Kenneth J. Olivier Jr. and Sara A. Hurvitz
| Antibody-drug conjugates : fundamentals, drug development, and clinical outcomes to target cancer / / edited by Kenneth J. Olivier Jr. and Sara A. Hurvitz |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : John Wiley & Sons, Incorporated, , [2017] |
| Descrizione fisica | 1 online resource (566 pages) : color illustrations |
| Disciplina | 615.7/98 |
| Soggetto topico |
Antibody-toxin conjugates
Monoclonal antibodies Antineoplastic agents Tumors - Treatment |
| ISBN |
1-119-06084-2
1-119-06080-X 1-119-06072-9 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Typical antibody-drug conjugates / John Lambert -- Selecting optimal ADC targets using indication-dependent or indication-independent approaches / Robert Hollingsworth and Jay Harper -- Antibody drug conjugates : an overview of the CMC and characterization process / Janet Wolfe and Phillip Ross -- Linker and conjugation technology and improvements / Riley Ennis and Sourav Sinha -- Formulation and stability / Kouhei Tsumoto, Anthony Young, and Satoshi Ohtake -- QC assay development / Xiao-Hong Chen and Mate Tolnay -- Occupational health and safety aspects of ADCs and their toxic payloads / Robert Sussman and John Farris -- Bioanalytical strategies enabling successful ADC translation / Xiaogang Han, Lindsay King, and Steve Hansel -- Nonclinical pharmacology and mechanistic modeling of antibody drug conjugates in support of human clinical trials / Brian J. Schmidt, Chin Pan, Heather E. Vezina, Huadong Sun, Douglas D. Leipold, and Manish Gupta -- Pharmacokinetics of antibody-drug conjugates / Amrita Kamath -- Path to market approval : regulatory perspective of ADC nonclinical safety assessments / Stacey Ricci and Natalie Simpson -- Antibody drug conjugates : clinical strategies and applications / Heather E. Vezina, Lucy Lee, Brian J. Schmidt, Manish Gupta -- Antibody-drug conjugates (ADCs) in clinical development / Patricia LoRusso and Joseph McLaughlin -- ADCs approved for use : Trastuzumab emtansine (Kadcyla, T-DM1) in patients with previously treated HER2-positive metastatic breast cancer / Gail Lewis Phillips, Sanne de Hass, Sandhya Girish, and Ellie Guardino -- ADCs approved for use : Brentuximab Vedotin / Sven DeVos and Monica Mead -- Radioimmunotherapy / Jeffrey Wong and Savita Dandapani -- Radiolabeled antibody-based imaging in clinical oncology / Bart Hendriks and Daniel Gaddy -- Antibody-drug conjugates : the next evolution in the cure for cancer -- William C. Olson and Amy Q. Han. |
| Record Nr. | UNINA-9910151742303321 |
| Hoboken, New Jersey : , : John Wiley & Sons, Incorporated, , [2017] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Antibody-drug conjugates : fundamentals, drug development, and clinical outcomes to target cancer / / edited by Kenneth J. Olivier Jr. and Sara A. Hurvitz
| Antibody-drug conjugates : fundamentals, drug development, and clinical outcomes to target cancer / / edited by Kenneth J. Olivier Jr. and Sara A. Hurvitz |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : John Wiley & Sons, Incorporated, , [2017] |
| Descrizione fisica | 1 online resource (566 pages) : color illustrations |
| Disciplina | 615.7/98 |
| Soggetto topico |
Antibody-toxin conjugates
Monoclonal antibodies Antineoplastic agents Tumors - Treatment |
| ISBN |
1-119-06084-2
1-119-06080-X 1-119-06072-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Typical antibody-drug conjugates / John Lambert -- Selecting optimal ADC targets using indication-dependent or indication-independent approaches / Robert Hollingsworth and Jay Harper -- Antibody drug conjugates : an overview of the CMC and characterization process / Janet Wolfe and Phillip Ross -- Linker and conjugation technology and improvements / Riley Ennis and Sourav Sinha -- Formulation and stability / Kouhei Tsumoto, Anthony Young, and Satoshi Ohtake -- QC assay development / Xiao-Hong Chen and Mate Tolnay -- Occupational health and safety aspects of ADCs and their toxic payloads / Robert Sussman and John Farris -- Bioanalytical strategies enabling successful ADC translation / Xiaogang Han, Lindsay King, and Steve Hansel -- Nonclinical pharmacology and mechanistic modeling of antibody drug conjugates in support of human clinical trials / Brian J. Schmidt, Chin Pan, Heather E. Vezina, Huadong Sun, Douglas D. Leipold, and Manish Gupta -- Pharmacokinetics of antibody-drug conjugates / Amrita Kamath -- Path to market approval : regulatory perspective of ADC nonclinical safety assessments / Stacey Ricci and Natalie Simpson -- Antibody drug conjugates : clinical strategies and applications / Heather E. Vezina, Lucy Lee, Brian J. Schmidt, Manish Gupta -- Antibody-drug conjugates (ADCs) in clinical development / Patricia LoRusso and Joseph McLaughlin -- ADCs approved for use : Trastuzumab emtansine (Kadcyla, T-DM1) in patients with previously treated HER2-positive metastatic breast cancer / Gail Lewis Phillips, Sanne de Hass, Sandhya Girish, and Ellie Guardino -- ADCs approved for use : Brentuximab Vedotin / Sven DeVos and Monica Mead -- Radioimmunotherapy / Jeffrey Wong and Savita Dandapani -- Radiolabeled antibody-based imaging in clinical oncology / Bart Hendriks and Daniel Gaddy -- Antibody-drug conjugates : the next evolution in the cure for cancer -- William C. Olson and Amy Q. Han. |
| Record Nr. | UNINA-9910821000603321 |
| Hoboken, New Jersey : , : John Wiley & Sons, Incorporated, , [2017] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Antibody-drug conjugates and immunotoxins : from pre-clinical development to therapeutic applications / / Gail Lewis Phillips, editor
| Antibody-drug conjugates and immunotoxins : from pre-clinical development to therapeutic applications / / Gail Lewis Phillips, editor |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | New York, : Humana Press, 2013 |
| Descrizione fisica | 1 online resource (369 p.) |
| Disciplina |
615.37
615.373 |
| Altri autori (Persone) | PhillipsGail Lewis |
| Collana | Cancer drug discovery and development |
| Soggetto topico |
Antibody-drug conjugates
Antibody-toxin conjugates |
| ISBN |
1-283-93413-2
1-4614-5456-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. I. Introduction and development perspectives -- pt. II. Development of antibody-drug conjugates -- pt. III. Selection of cytotoxic agents -- pt. IV. Antibody-drug conjugates for hematologic malignancies -- pt. V. Antibody-drug conjugates for solid tumors -- pt. VI. Metabolism -- pt. VII. Immunotoxins. |
| Record Nr. | UNINA-9910437996003321 |
| New York, : Humana Press, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Transplantation / / edited by G. E. W. Wolstenholme and Margaret P. Cameron
| Transplantation / / edited by G. E. W. Wolstenholme and Margaret P. Cameron |
| Pubbl/distr/stampa | London, : J. & A. Churchill |
| Descrizione fisica | 1 online resource (464 p.) |
| Disciplina | 617.95 |
| Altri autori (Persone) |
WolstenholmeG. E. W (Gordon Ethelbert Ward)
CameronMargaret P |
| Collana | Novartis Foundation Symposia |
| Soggetto topico |
Transplantation of organs, tissues, etc
Antibody-toxin conjugates |
| ISBN |
1-280-76877-0
9786613679543 0-470-71930-3 0-470-71681-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CIBA FOUNDATION SYMPOSIUM ON TRANSPLANTATION; CONTENTS; Chairman's opening remarks; Studies on transplantation antigens; Discussion; Transplantation antigens, production of haemagglutinins and inhibition of the haemagglutination reaction; Discussion; H-2 histocompatibility antigens of the mouse; Discussion; An isoantigenic lipoprotein from sarcoma I; Discussion; Studies on cheek pouch skin homografts in the Syrian hamster; Discussion; Mother-foetus immunological relationship as an exceptional homograft model; Discussion; Transplantation tolerance and immunity in relation to age; Discussion
Immunogenetica of tumours grown in radiation chimerasDiscussion; The factor of immunization: clonal selection theory investigated by spleen assays of graft-versus-host reaction; Discussion; Further studies on interactions between sessile and hamoral anti- bodies in homograft reactions; Discussion; Immunological competence of small lymphocytes in the graft- versus-host reaction in mice; Discussion; Homograft sensitivity in human beings; Discussion; Protection against runting by specific treatmemt of newborn mice, followed by increased tolerance; Discussion Induction of specific tolerance in adult rats by the method of parabiosisDiscussion; Modification of runt disease in mice by various means; Discussion; Rôle of the thymus in transplantation tolerance and immunity; Discussion; General Discussion; Chairman's closing remarks; Author index; Subject index |
| Record Nr. | UNINA-9910877588203321 |
| London, : J. & A. Churchill | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
