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The antibody enigma / Thomas J. Kindt and J. Donald Capra
| The antibody enigma / Thomas J. Kindt and J. Donald Capra |
| Autore | Kindt, Thomas J. |
| Pubbl/distr/stampa | New York : Plenum Press, c1984 |
| Descrizione fisica | xvi, 270 p. : ill. ; 24 cm |
| Disciplina | 571.968 |
| Altri autori (Persone) | Capra, J. Donaldauthor |
| Soggetto topico | Antibody diversity |
| ISBN | 030641581X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISALENTO-991003422649707536 |
Kindt, Thomas J.
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| New York : Plenum Press, c1984 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. del Salento | ||
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Antibody Fc : linking adaptive and innate immunity / / Margaret E. Ackerman, Falk Nimmerjahn
| Antibody Fc : linking adaptive and innate immunity / / Margaret E. Ackerman, Falk Nimmerjahn |
| Autore | Ackerman Margaret E |
| Pubbl/distr/stampa | London, : Academic Press, c2014 |
| Descrizione fisica | 1 online resource (xii, 363 pages) : illustrations (some color) |
| Disciplina | 616.07/93 |
| Collana | Gale eBooks |
| Soggetto topico |
Immunoglobulins
Antibody diversity |
| ISBN | 0-12-394818-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Antibody Fc: Linking Adaptive and Innate Immunity; Copyright Page; Contents; List of Contributors; 1. EFFECTOR MECHANISMS; 1 Antibody-Dependent Cellular Cytotoxicity (ADCC); Brief History of ADCC; Effector Cells; Receptors Involved; Mechanisms of ADCC; Recognition of the Target Cell and Cross-Linking of the Fc Receptor on the Effector Cell; Downstream Signals in the Effector Cell; Mechanisms of Killing; The Perforin/Granzyme Cell Death Pathway; The FAS-L Pathway; The ROS/ROI Pathway; ADCC Assays in Relation to Killing Mechanisms; ADCC in Monoclonal Antibody Therapy of Cancer
Versatility of Monoclonal Antibodies as Platforms for Cancer TherapyEvidence for ADCC in Cancer Therapy; ADCC in Infectious Disease: A Correlate of Protection?; Studies of Herpes Simplex Virus; Studies of Human and Simian Immunodeficiency Virus; Ongoing Debate and a Possible Consensus; Rational Modification of ADCC Activity; Enhancing the Link between ADCC and Adaptive Immunity; Perspectives: Future Directions; Acknowledgments; References; 2 Antibody-Dependent Cellular Phagocytosis and Its Impact on Pathogen Control; Introduction; Phagocytic Cells and Their Fcγ Receptors Various Receptors for IgGDifferential Expression of Fcγ Receptors on Phagocytic Cells; Fcγ Receptor-Mediated Phagocytosis by Phagocytes; Signaling by Activating FcγRs; Regulation of FcR Signals; Phagosome Maturation; Role of FcγR-Mediated Phagocytosis for Pathogen Uptake, Cellular Localization, and Pathogen Control; Bacteria; Avoiding Uptake into Phagocytes; Establishing an Intracellular Niche; Evasion Strategy of Bacteria: Proteolytic Degradation of Antibodies; Viruses; Targeting of Viruses to FcRs; Antibody-Dependent Enhancement of Infection; FcR-Mediated Uptake of Parasites and Fungi Leishmania-Specific Antibodies Can Shift the Balance between Th1 and Th2 ResponsesToxoplasma is Targeted to Lysosomes in the Presence of Specific Antibody; Antibody-Mediated Phagocytosis of Invasive Fungi; Concluding Remarks; References; 3 Interactions Between the Complement System and Fcγ Receptors; Preliminary Comments; Complement Fragment C3b Mediates Binding of IgG Immune Complexes to Primate Erythrocytes: Immune Adherence; Historical Perspective; Modern Times and Mechanisms: CR1 is Removed from Erythrocytes Complement Fragment C3d Mediates Binding of Substrates to CR2 on B Cells: Antigen Trafficking and Its Significance in HIV D...Similarities and Differences between CR1 and CR2; The Shuttle Mechanism: CR2 and Antigen Presentation; CR1, CR2, and AIDS; A Clue to a Mechanism: Lessons Learned from Dendritic Cells; Cooperation/Synergy between Fcγ Receptors and Complement Receptors on Effector Cells; In Vivo Studies of the Clearance of Opsonized Erythrocytes; In Vitro Evidence for Synergy between Fcγ Receptors and Complement Receptors; Interaction between FcγRIII and CR3; C3b-IgG as a Superopsonin Interaction between FcγR and Complement: Cancer Models |
| Record Nr. | UNINA-9910779973903321 |
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Ackerman Margaret E
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| London, : Academic Press, c2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Antibody Fc : linking adaptive and innate immunity / / Margaret E. Ackerman, Falk Nimmerjahn
| Antibody Fc : linking adaptive and innate immunity / / Margaret E. Ackerman, Falk Nimmerjahn |
| Autore | Ackerman Margaret E |
| Pubbl/distr/stampa | London, : Academic Press, c2014 |
| Descrizione fisica | 1 online resource (xii, 363 pages) : illustrations (some color) |
| Disciplina | 616.07/93 |
| Collana | Gale eBooks |
| Soggetto topico |
Immunoglobulins
Antibody diversity |
| ISBN | 0-12-394818-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Antibody Fc: Linking Adaptive and Innate Immunity; Copyright Page; Contents; List of Contributors; 1. EFFECTOR MECHANISMS; 1 Antibody-Dependent Cellular Cytotoxicity (ADCC); Brief History of ADCC; Effector Cells; Receptors Involved; Mechanisms of ADCC; Recognition of the Target Cell and Cross-Linking of the Fc Receptor on the Effector Cell; Downstream Signals in the Effector Cell; Mechanisms of Killing; The Perforin/Granzyme Cell Death Pathway; The FAS-L Pathway; The ROS/ROI Pathway; ADCC Assays in Relation to Killing Mechanisms; ADCC in Monoclonal Antibody Therapy of Cancer
Versatility of Monoclonal Antibodies as Platforms for Cancer TherapyEvidence for ADCC in Cancer Therapy; ADCC in Infectious Disease: A Correlate of Protection?; Studies of Herpes Simplex Virus; Studies of Human and Simian Immunodeficiency Virus; Ongoing Debate and a Possible Consensus; Rational Modification of ADCC Activity; Enhancing the Link between ADCC and Adaptive Immunity; Perspectives: Future Directions; Acknowledgments; References; 2 Antibody-Dependent Cellular Phagocytosis and Its Impact on Pathogen Control; Introduction; Phagocytic Cells and Their Fcγ Receptors Various Receptors for IgGDifferential Expression of Fcγ Receptors on Phagocytic Cells; Fcγ Receptor-Mediated Phagocytosis by Phagocytes; Signaling by Activating FcγRs; Regulation of FcR Signals; Phagosome Maturation; Role of FcγR-Mediated Phagocytosis for Pathogen Uptake, Cellular Localization, and Pathogen Control; Bacteria; Avoiding Uptake into Phagocytes; Establishing an Intracellular Niche; Evasion Strategy of Bacteria: Proteolytic Degradation of Antibodies; Viruses; Targeting of Viruses to FcRs; Antibody-Dependent Enhancement of Infection; FcR-Mediated Uptake of Parasites and Fungi Leishmania-Specific Antibodies Can Shift the Balance between Th1 and Th2 ResponsesToxoplasma is Targeted to Lysosomes in the Presence of Specific Antibody; Antibody-Mediated Phagocytosis of Invasive Fungi; Concluding Remarks; References; 3 Interactions Between the Complement System and Fcγ Receptors; Preliminary Comments; Complement Fragment C3b Mediates Binding of IgG Immune Complexes to Primate Erythrocytes: Immune Adherence; Historical Perspective; Modern Times and Mechanisms: CR1 is Removed from Erythrocytes Complement Fragment C3d Mediates Binding of Substrates to CR2 on B Cells: Antigen Trafficking and Its Significance in HIV D...Similarities and Differences between CR1 and CR2; The Shuttle Mechanism: CR2 and Antigen Presentation; CR1, CR2, and AIDS; A Clue to a Mechanism: Lessons Learned from Dendritic Cells; Cooperation/Synergy between Fcγ Receptors and Complement Receptors on Effector Cells; In Vivo Studies of the Clearance of Opsonized Erythrocytes; In Vitro Evidence for Synergy between Fcγ Receptors and Complement Receptors; Interaction between FcγRIII and CR3; C3b-IgG as a Superopsonin Interaction between FcγR and Complement: Cancer Models |
| Record Nr. | UNINA-9910820381203321 |
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Ackerman Margaret E
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| London, : Academic Press, c2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Male-mediated developmental toxicity [[electronic resource] /] / edited by Diana Anderson and Martin H. Brinkworth
| Male-mediated developmental toxicity [[electronic resource] /] / edited by Diana Anderson and Martin H. Brinkworth |
| Pubbl/distr/stampa | Cambridge, UK, : Royal Society of Chemistry, c2007 |
| Descrizione fisica | 1 online resource (317 p.) |
| Disciplina | 572.838 |
| Altri autori (Persone) |
BrinkworthMartin H
AndersonDiana |
| Collana | Issues in toxicology |
| Soggetto topico |
Mutagenesis
Antibody diversity |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-84755-764-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Male-mediated Developmental Toxicology; i_iv; v_viii; ix_x; xi_xx; xxi; xxii_xxiv; 001_004; 005_014; 015_027; 028_050; 051_060; 061_076; 077_084; 085_094; 095_113; 114_123; 124_133; 134_148; 149_164; 165_175; 176_188; 189_196; 197_209; 210_223; 224_234; 235_246; 247_258; 259_272; 273_285; 286_288; 289_292 |
| Record Nr. | UNINA-9910455102803321 |
| Cambridge, UK, : Royal Society of Chemistry, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Male-mediated developmental toxicity [[electronic resource] /] / edited by Diana Anderson and Martin H. Brinkworth
| Male-mediated developmental toxicity [[electronic resource] /] / edited by Diana Anderson and Martin H. Brinkworth |
| Pubbl/distr/stampa | Cambridge, UK, : Royal Society of Chemistry, c2007 |
| Descrizione fisica | 1 online resource (317 p.) |
| Disciplina | 572.838 |
| Altri autori (Persone) |
BrinkworthMartin H
AndersonDiana |
| Collana | Issues in toxicology |
| Soggetto topico |
Mutagenesis
Antibody diversity |
| ISBN | 1-84755-764-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Male-mediated Developmental Toxicology; i_iv; v_viii; ix_x; xi_xx; xxi; xxii_xxiv; 001_004; 005_014; 015_027; 028_050; 051_060; 061_076; 077_084; 085_094; 095_113; 114_123; 124_133; 134_148; 149_164; 165_175; 176_188; 189_196; 197_209; 210_223; 224_234; 235_246; 247_258; 259_272; 273_285; 286_288; 289_292 |
| Record Nr. | UNINA-9910778209903321 |
| Cambridge, UK, : Royal Society of Chemistry, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Male-mediated developmental toxicity / / edited by Diana Anderson and Martin H. Brinkworth
| Male-mediated developmental toxicity / / edited by Diana Anderson and Martin H. Brinkworth |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Cambridge, UK, : Royal Society of Chemistry, c2007 |
| Descrizione fisica | 1 online resource (317 p.) |
| Disciplina | 572.838 |
| Altri autori (Persone) |
BrinkworthMartin H
AndersonDiana |
| Collana | Issues in toxicology |
| Soggetto topico |
Mutagenesis
Antibody diversity |
| ISBN | 1-84755-764-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Male-mediated Developmental Toxicology; i_iv; v_viii; ix_x; xi_xx; xxi; xxii_xxiv; 001_004; 005_014; 015_027; 028_050; 051_060; 061_076; 077_084; 085_094; 095_113; 114_123; 124_133; 134_148; 149_164; 165_175; 176_188; 189_196; 197_209; 210_223; 224_234; 235_246; 247_258; 259_272; 273_285; 286_288; 289_292 |
| Record Nr. | UNINA-9910825532603321 |
| Cambridge, UK, : Royal Society of Chemistry, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Antibody diversity
(6)
- Mutagenesis (3)
- Immunoglobulins (2)