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ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
| ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide |
| Autore | Tsaioun Katya |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2012 |
| Descrizione fisica | 1 online resource (524 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) | KatesSteven A |
| Soggetto topico |
Drug Design
Drug Toxicity Drugs - Testing Drugs --Testing --Juvenile literature Pharmaceutical Preparations - chemistry Pharmacokinetics Metabolic Phenomena Drug Discovery Pharmacological Phenomena Natural Science Disciplines Kinetics Chemicals and Drugs Poisoning Biochemical Phenomena Chemistry, Pharmaceutical Substance-Related Disorders Disciplines and Occupations Investigative Techniques Physiological Phenomena Phenomena and Processes Chemical Phenomena Diseases Pharmacology Analytical, Diagnostic and Therapeutic Techniques and Equipment Biological Science Disciplines Chemistry Pharmaceutical Preparations Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN |
1-280-59122-6
9786613621054 0-470-91509-9 0-470-91511-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions
2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs 2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods 2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution 4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools 4.5.7 Tools for Studying Drug Excretion |
| Record Nr. | UNINA-9910133588303321 |
Tsaioun Katya
|
||
| Hoboken, : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
| ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide |
| Autore | Tsaioun Katya |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2012 |
| Descrizione fisica | 1 online resource (524 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) | KatesSteven A |
| Soggetto topico |
Drug Design
Drug Toxicity Drugs - Testing Drugs --Testing --Juvenile literature Pharmaceutical Preparations - chemistry Pharmacokinetics Metabolic Phenomena Drug Discovery Pharmacological Phenomena Natural Science Disciplines Kinetics Chemicals and Drugs Poisoning Biochemical Phenomena Chemistry, Pharmaceutical Substance-Related Disorders Disciplines and Occupations Investigative Techniques Physiological Phenomena Phenomena and Processes Chemical Phenomena Diseases Pharmacology Analytical, Diagnostic and Therapeutic Techniques and Equipment Biological Science Disciplines Chemistry Pharmaceutical Preparations Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN |
1-280-59122-6
9786613621054 0-470-91509-9 0-470-91511-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions
2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs 2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods 2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution 4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools 4.5.7 Tools for Studying Drug Excretion |
| Record Nr. | UNINA-9910830164603321 |
|
Tsaioun Katya
|
||
| Hoboken, : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advances in small animal total joint replacement / / edited by Jeffrey N. Peck, Denis J. Marcellin-Little
| Advances in small animal total joint replacement / / edited by Jeffrey N. Peck, Denis J. Marcellin-Little |
| Pubbl/distr/stampa | Chichester, : Wiley-Blackwell, 2013 |
| Descrizione fisica | 1 online resource (xix, 251 pages) : some col. ill |
| Disciplina | 636.089705 |
| Altri autori (Persone) |
PeckJeffrey N
Marcellin-LittleDenis J <1964-> (Denis Jacques) |
| Collana | AVS Advances in Veterinary Surgery |
| Soggetto topico |
Arthroplasty
Pets - Health Veterinary surgery Prosthesis Implantation Investigative Techniques Animals, Domestic Veterinary Medicine Health Occupations Analytical, Diagnostic and Therapeutic Techniques and Equipment Orthopedic Procedures Animal Population Groups Surgical Procedures, Operative |
| ISBN |
1-118-70477-0
1-283-64426-6 1-118-46271-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910141378903321 |
| Chichester, : Wiley-Blackwell, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advances in small animal total joint replacement / / edited by Jeffrey N. Peck, Denis J. Marcellin-Little
| Advances in small animal total joint replacement / / edited by Jeffrey N. Peck, Denis J. Marcellin-Little |
| Pubbl/distr/stampa | Chichester, : Wiley-Blackwell, 2013 |
| Descrizione fisica | 1 online resource (xix, 251 pages) : some col. ill |
| Disciplina | 636.089705 |
| Altri autori (Persone) |
PeckJeffrey N
Marcellin-LittleDenis J <1964-> (Denis Jacques) |
| Collana | AVS Advances in Veterinary Surgery |
| Soggetto topico |
Arthroplasty
Pets - Health Veterinary surgery Prosthesis Implantation Investigative Techniques Animals, Domestic Veterinary Medicine Health Occupations Analytical, Diagnostic and Therapeutic Techniques and Equipment Orthopedic Procedures Animal Population Groups Surgical Procedures, Operative |
| ISBN |
1-118-70477-0
1-283-64426-6 1-118-46271-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910830143503321 |
| Chichester, : Wiley-Blackwell, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Aesthetic surgery after massive weight loss
| Aesthetic surgery after massive weight loss |
| Pubbl/distr/stampa | [Place of publication not identified], : Saunders Elsevier, 2007 |
| Soggetto topico |
Surgical Procedures, Operative
Obesity Specialties, Surgical Body Weight Changes Overweight Body Weight Analytical, Diagnostic and Therapeutic Techniques and Equipment Medicine Overnutrition Signs and Symptoms Nutrition Disorders Health Occupations Body Size Growth Nutritional and Metabolic Diseases Disciplines and Occupations Pathological Conditions, Signs and Symptoms Growth and Development Diseases Body Weights and Measures Body Constitution Physiological Processes Physiological Phenomena Physical Examination Phenomena and Processes Diagnostic Techniques and Procedures Diagnosis Obesity, Morbid Surgery, Plastic Reconstructive Surgical Procedures Weight Loss |
| ISBN | 1-4160-2952-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996212364203316 |
| [Place of publication not identified], : Saunders Elsevier, 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
AIDS [[electronic resource]]
| AIDS [[electronic resource]] |
| Autore | Aggleton Peter |
| Pubbl/distr/stampa | Hoboken, : Taylor and Francis, 1995 |
| Descrizione fisica | 1 online resource (237 p.) |
| Disciplina | 362.1/969792 |
| Altri autori (Persone) |
DaviesPeter (Peter M.)
HartGraham <1957-> |
| Collana | Social Aspects of AIDS |
| Soggetto topico |
AIDS (Disease)
AIDS (Disease) - Social aspects HIV Infections Sociology Slow Virus Diseases Probability Acquired Immunodeficiency Syndrome Risk Social Environment Virus Diseases Statistics as Topic Lentivirus Infections Sexually Transmitted Diseases, Viral Mathematical Concepts Social Sciences Immunologic Deficiency Syndromes Phenomena and Processes Sexually Transmitted Diseases Anthropology, Education, Sociology and Social Phenomena Diseases Health Care Evaluation Mechanisms Retroviridae Infections Immune System Diseases Epidemiologic Methods Quality of Health Care Investigative Techniques Public Health RNA Virus Infections Environment and Public Health Analytical, Diagnostic and Therapeutic Techniques and Equipment Health Care Quality, Access, and Evaluation Health Care Communicable Diseases Health & Biological Sciences |
| Soggetto genere / forma | Electronic books. |
| ISBN |
9982-19-047-4
0-203-36253-5 1-135-74692-3 1-280-02179-9 9786610021796 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Book Cover; Title; Contents; Preface; Reputedly Effective Risk Reduction Strategies and Gay Men; HIV-Related Discrimination in Medical Teaching Texts; Travel, Sexual Behaviour and Gay Men; Sexual Behaviour in Gay Men: Towards a Sociology of Risk; Framing Difference: Sexuality, AIDS and Organization; Towards Effective Inter vention: Evaluating HIV Prevention and Sexual Health Education Interventions; Communities, Governments and AIDS: Making Partnerships Work; Socially Apart Youth: Priorities for HIV Prevention
Theorizing and Researching 'Risk': Notes on the Social Relations of Risk in Heroin Users' LifestylesSex, Love and Seropositivity: Balancing the Risks; One of Us, One of Them, or One of Those? The Construction of Identity and Sexuality in Relation to HIV/AIDS; Sexuality, Identity and Community; Reflections on the MESMAC Project; Discourses of Power and Empowerment in the Fight Against HIV/AIDS in Africa; Notes on Contributors; Index |
| Record Nr. | UNISA-996207278803316 |
|
Aggleton Peter
|
||
| Hoboken, : Taylor and Francis, 1995 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
AIDS : the making of a chronic disease
| AIDS : the making of a chronic disease |
| Pubbl/distr/stampa | [Place of publication not identified], : University of California Press, 1992 |
| Disciplina | 614.5/993 |
| Soggetto topico |
AIDS (Disease) - History
Financial Support Health Personnel Homosexuality Mass Media Social Control, Formal State Government Substance-Related Disorders Blood Donors Confidentiality Delivery of Health Care Government Acquired Immunodeficiency Syndrome Blood Transfusion Education History Legislation Local Government Health Policy Hemophilia A Human Experimentation Jurisprudence Public Health Minority Groups Federal Government Government Regulation HIV Seropositivity Public Policy International Cooperation Developing Countries Chronic Disease Women Politics AIDS Serodiagnosis Ethics, Medical Internationality Pharmaceutical Preparations Employment Poverty Prejudice Epidemiology Publication Formats Patient Care Management Tissue Donors Environment and Public Health Economics Health Care Facilities, Manpower, and Services Medicine Patient Rights Forensic Psychiatry Diseases Health Sociology Disease Attributes Persons HIV Infections Blood Coagulation Disorders, Inherited Social Control Policies Health Care Quality, Access, and Evaluation Investigative Techniques Biological Therapy Serologic Tests Organizations Social Sciences Sexuality Coagulation Protein Disorders Anthropology, Education, Sociology and Social Phenomena Humanities Psychology, Social Social Problems Hemorrhagic Disorders Socioeconomic Factors Health Care Economics and Organizations Chemicals and Drugs Ethics, Clinical Research Slow Virus Diseases Occupational Groups Biomedical Research Communications Media Mental Disorders Health Care Genetic Diseases, Inborn Policy Behavior and Behavior Mechanisms Immunologic Deficiency Syndromes Human Rights Immunologic Tests Science Sexually Transmitted Diseases, Viral Population Characteristics Therapeutics Virus Diseases Psychiatry and Psychology Publication Characteristics Sexual Behavior Psychiatry Reproductive Physiological Phenomena Health Services Administration Named Groups Information Science Analytical, Diagnostic and Therapeutic Techniques and Equipment Ethics, Professional Blood Coagulation Disorders Pathologic Processes Lentivirus Infections Hematologic Diseases Health Occupations Congenital, Hereditary, and Neonatal Diseases and Abnormalities Ethics Immunologic Techniques Sexually Transmitted Diseases Immune System Diseases Laboratory Techniques and Procedures Behavior Pathological Conditions, Signs and Symptoms Retroviridae Infections Hemic and Lymphatic Diseases Reproductive and Urinary Physiological Phenomena Natural Science Disciplines Disciplines and Occupations Behavioral Sciences RNA Virus Infections Diagnosis Phenomena and Processes Behavioral Disciplines and Activities Communicable Diseases Health & Biological Sciences |
| ISBN | 0-520-07569-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | AIDS |
| Record Nr. | UNINA-9910495891403321 |
| [Place of publication not identified], : University of California Press, 1992 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Alambicchi di parole [[electronic resource] ] : il Ricettario fiorentino e dintorni : Firenze, Biblioteca Riccardiana, 18 ottobre 1999-15 gennaio 2000 / / a cura di Giovanna Lazzi, Mino Gabriele
| Alambicchi di parole [[electronic resource] ] : il Ricettario fiorentino e dintorni : Firenze, Biblioteca Riccardiana, 18 ottobre 1999-15 gennaio 2000 / / a cura di Giovanna Lazzi, Mino Gabriele |
| Pubbl/distr/stampa | Firenze, : Polistampa, 1999 |
| Descrizione fisica | 270 p. : col. ill |
| Disciplina | 016 |
| Soggetto topico |
Prescriptions
Health Occupations Drug Therapy History Therapeutics Humanities Disciplines and Occupations Pharmaceutical Services Analytical, Diagnostic and Therapeutic Techniques and Equipment Health Services Health Care Facilities, Manpower, and Services Health Care Drug Prescriptions History, Modern 1601- Pharmacy General Bibliography - General |
| ISBN | 88-8304-118-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ita |
| Altri titoli varianti | Alambicchi di parole |
| Record Nr. | UNINA-9910146203903321 |
| Firenze, : Polistampa, 1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Un aliment sain dans un corps sain : perspectives historiques
| Un aliment sain dans un corps sain : perspectives historiques |
| Pubbl/distr/stampa | [Place of publication not identified], : Presses universitaires François Rabelais, 2007 |
| Descrizione fisica | 1 online resource (344 p.) |
| Soggetto topico |
Food and Beverages
Nutritional Physiological Phenomena Behavior, Animal Behavior Investigative Techniques Physiological Phenomena Technology, Industry, Agriculture Behavior and Behavior Mechanisms Analytical, Diagnostic and Therapeutic Techniques and Equipment Psychiatry and Psychology Phenomena and Processes Feeding Behavior Diet Food |
| ISBN | 2-86906-338-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | fre |
| Record Nr. | UNINA-9910495897303321 |
| [Place of publication not identified], : Presses universitaires François Rabelais, 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Alimentazione e studenti nella Bologna medievale e moderna [[electronic resource] /] / Alberto Malfitano ; prefazione di Angelo Varni
| Alimentazione e studenti nella Bologna medievale e moderna [[electronic resource] /] / Alberto Malfitano ; prefazione di Angelo Varni |
| Autore | Malfitano Alberto |
| Pubbl/distr/stampa | Bologna, : CLUEB, 1998 |
| Descrizione fisica | 118 p |
| Disciplina | 378 |
| Soggetto topico |
Investigative Techniques
Education, Nonprofessional Habits Persons Feeding Behavior Education Nutritional Physiological Phenomena Named Groups Anthropology, Education, Sociology and Social Phenomena Analytical, Diagnostic and Therapeutic Techniques and Equipment Physiological Phenomena Behavior Phenomena and Processes Behavior and Behavior Mechanisms Psychiatry and Psychology Food Habits Students Diet |
| ISBN | 88-491-1049-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ita |
| Nota di contenuto | (http://www.ilibri.casalini.it/toc/98320939.pdf) |
| Record Nr. | UNINA-9910132986603321 |
|
Malfitano Alberto
|
||
| Bologna, : CLUEB, 1998 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
