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Amino Acids, Peptides and Proteins in Organic Chemistry: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis. Vol. 2
| Amino Acids, Peptides and Proteins in Organic Chemistry: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis. Vol. 2 |
| Autore | Hughes Andrew B |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH Imprint, 2009 |
| Descrizione fisica | 1 online resource (xxii, 683 pages) : illustrations |
| Disciplina | 547.750459 |
| Altri autori (Persone) | HughesAndrew B |
| Soggetto topico |
Amino acids - Synthesis
Amino acids Peptides Proteins |
| ISBN | 3-527-63178-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Synthesis and Chemistry of Modified Amino Acids. Synthesis and Chemistry of [alpha], [beta]- Didehydroamino Acids / Uli Kazmaier -- Synthesis and Chemistry of [alpha]-Hydrazino Acids / Jo︠lle Vidal -- Hydroxamic Acids: Chemistry, Bioactivity, and Solutionand Solid-Phase Synthesis / Darren Griffith, Marc Devocelle, Celine J Marmion -- Chemistry of a-Aminoboronic Acids and their Derivatives / Valery M Dembitsky, Morris Srebnik -- Chemistry of Aminophosphonic Acids and Phosphonopeptides / Valery P Kukhar, Vadim D Romanenko -- Chemistry of Silicon-Containing Amino Acids / Yingmei Qi, Scott Mcn Sieburth -- Amino Acid Organocatalysis. Catalysis of Reactions by Amino Acids / Haibo Xie, Thomas Hayes, Nicholas Gathergood -- Enzymes. Proteases as Powerful Catalysts for Organic Synthesis / Andres Illanes, Fanny Guzman, Sonia Barberis -- Semisynthetic Enzymes / Usama M Hegazy, Bengt Mannervik -- Catalysis by Peptide-Based Enzyme Models / Giovanna Ghirlanda, Leonard J Prins, Paolo Scrimin -- Substrate Recognition / Keith Brocklehurst, Sheraz Gul, Richard W Pickersgill -- Protein Recognition / Robyn E Mansfield, Arwen J Cross, Jacqueline M Matthews, Joel P Mackay -- Mammalian Peptide Hormones: Biosynthesis and Inhibition / Karen Brand, Annette G Beck-sickinger -- Insect Peptide Hormones / R Elwyn Isaac, Neil Audsley -- Plant Peptide Signals / Javier Narvaez-vasquez, Martha L Orozco-c̀rdenas, Gregory Pearce -- Nonribosomal Peptide Synthesis / Sean Doyle. |
| Record Nr. | UNINA-9910830732903321 |
Hughes Andrew B
|
||
| [Place of publication not identified], : Wiley VCH Imprint, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Amino Acids, Peptides and Proteins in Organic Chemistry: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis. Vol. 2
| Amino Acids, Peptides and Proteins in Organic Chemistry: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis. Vol. 2 |
| Autore | Hughes Andrew B |
| Pubbl/distr/stampa | [Place of publication not identified], : Wiley VCH Imprint, 2009 |
| Descrizione fisica | 1 online resource (xxii, 683 pages) : illustrations |
| Disciplina | 547.750459 |
| Altri autori (Persone) | HughesAndrew B |
| Soggetto topico |
Amino acids - Synthesis
Amino acids Peptides Proteins |
| ISBN | 3-527-63178-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Synthesis and Chemistry of Modified Amino Acids. Synthesis and Chemistry of [alpha], [beta]- Didehydroamino Acids / Uli Kazmaier -- Synthesis and Chemistry of [alpha]-Hydrazino Acids / Jo︠lle Vidal -- Hydroxamic Acids: Chemistry, Bioactivity, and Solutionand Solid-Phase Synthesis / Darren Griffith, Marc Devocelle, Celine J Marmion -- Chemistry of a-Aminoboronic Acids and their Derivatives / Valery M Dembitsky, Morris Srebnik -- Chemistry of Aminophosphonic Acids and Phosphonopeptides / Valery P Kukhar, Vadim D Romanenko -- Chemistry of Silicon-Containing Amino Acids / Yingmei Qi, Scott Mcn Sieburth -- Amino Acid Organocatalysis. Catalysis of Reactions by Amino Acids / Haibo Xie, Thomas Hayes, Nicholas Gathergood -- Enzymes. Proteases as Powerful Catalysts for Organic Synthesis / Andres Illanes, Fanny Guzman, Sonia Barberis -- Semisynthetic Enzymes / Usama M Hegazy, Bengt Mannervik -- Catalysis by Peptide-Based Enzyme Models / Giovanna Ghirlanda, Leonard J Prins, Paolo Scrimin -- Substrate Recognition / Keith Brocklehurst, Sheraz Gul, Richard W Pickersgill -- Protein Recognition / Robyn E Mansfield, Arwen J Cross, Jacqueline M Matthews, Joel P Mackay -- Mammalian Peptide Hormones: Biosynthesis and Inhibition / Karen Brand, Annette G Beck-sickinger -- Insect Peptide Hormones / R Elwyn Isaac, Neil Audsley -- Plant Peptide Signals / Javier Narvaez-vasquez, Martha L Orozco-c̀rdenas, Gregory Pearce -- Nonribosomal Peptide Synthesis / Sean Doyle. |
| Record Nr. | UNINA-9910841041703321 |
|
Hughes Andrew B
|
||
| [Place of publication not identified], : Wiley VCH Imprint, 2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Asymmetric synthesis of non-proteinogenic amino acids / / Ashot S. Saghyan and Peter Langer
| Asymmetric synthesis of non-proteinogenic amino acids / / Ashot S. Saghyan and Peter Langer |
| Autore | Saghyan Ashot S. |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , 2016 |
| Descrizione fisica | 1 online resource (376 p.) |
| Disciplina | 547.750459 |
| Soggetto topico | Amino acids - Synthesis |
| ISBN |
3-527-80448-X
3-527-80447-1 3-527-80449-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover ; Title Page ; Copyright ; Contents ; List of Abbreviations ; Introduction ; Chapter 1 Non-Proteinogenic -Amino Acids, Natural Origin, Biological Functions; References ; Part I Natural Synthesis of Amino Acids, Mechanisms, and Modeling; References ; Chapter 2 Some Regularities of Mechanisms for the Natural Synthesis of Amino Acids ; References
Chapter 3 Systems for Modeling Some Aspects of Pyridoxal Enzyme Action References ; Chapter 4 Modeling of Processes Associated with Cleavage of C -H and C -C Bonds; References ; Chapter 5 Modeling of , -Elimination Processes of PP-Catalysis, Kinetics, and Stereochemistry; References Chapter 6 Biomimetic Addition Reaction of Nucleophiles to CoIII Complexes of Dehydroaminobutyric Acid References ; Part II Asymmetric Synthesis of Nonprotein -Amino Acids; Chapter 7 The Main Rules of Asymmetric Synthesis ; References ; Chapter 8 Catalytic Asymmetric Synthesis 8.1 Achiral NiII Complexes of Schiff Bases of Amino Acids 8.1.1 The Alkylation of Achiral NiII Complexes Under Phase-Transfer Catalysis ; 8.1.2 Reactions of 1,4-Michael Addition to Achiral Glycine and Dehydroalanine Complexes ; 8.1.3 Synthesis of Enantiomerically Enriched -Amino Acids 8.1.3.1 The Asymmetric Alkylation of Substrate 65a by Alkyl Halides Under Phase-Transfer Catalysis 8.1.3.2 Asymmetric Aldol Condensation of Achiral NiII Complexes of Amino Acids ; 8.1.3.3 The Asymmetric Michael Addition of Achiral NiII Substrates to Electron-Withdrawing Compounds 8.1.3.4 Catalytic Asymmetric Addition of Nucleophiles to an Achiral Dehydroalanine Substrate |
| Record Nr. | UNINA-9910134851503321 |
|
Saghyan Ashot S.
|
||
| Weinheim, Germany : , : Wiley-VCH, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Asymmetric synthesis of non-proteinogenic amino acids / / Ashot S. Saghyan and Peter Langer
| Asymmetric synthesis of non-proteinogenic amino acids / / Ashot S. Saghyan and Peter Langer |
| Autore | Saghyan Ashot S. |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , 2016 |
| Descrizione fisica | 1 online resource (376 p.) |
| Disciplina | 547.750459 |
| Soggetto topico | Amino acids - Synthesis |
| ISBN |
3-527-80448-X
3-527-80447-1 3-527-80449-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover ; Title Page ; Copyright ; Contents ; List of Abbreviations ; Introduction ; Chapter 1 Non-Proteinogenic -Amino Acids, Natural Origin, Biological Functions; References ; Part I Natural Synthesis of Amino Acids, Mechanisms, and Modeling; References ; Chapter 2 Some Regularities of Mechanisms for the Natural Synthesis of Amino Acids ; References
Chapter 3 Systems for Modeling Some Aspects of Pyridoxal Enzyme Action References ; Chapter 4 Modeling of Processes Associated with Cleavage of C -H and C -C Bonds; References ; Chapter 5 Modeling of , -Elimination Processes of PP-Catalysis, Kinetics, and Stereochemistry; References Chapter 6 Biomimetic Addition Reaction of Nucleophiles to CoIII Complexes of Dehydroaminobutyric Acid References ; Part II Asymmetric Synthesis of Nonprotein -Amino Acids; Chapter 7 The Main Rules of Asymmetric Synthesis ; References ; Chapter 8 Catalytic Asymmetric Synthesis 8.1 Achiral NiII Complexes of Schiff Bases of Amino Acids 8.1.1 The Alkylation of Achiral NiII Complexes Under Phase-Transfer Catalysis ; 8.1.2 Reactions of 1,4-Michael Addition to Achiral Glycine and Dehydroalanine Complexes ; 8.1.3 Synthesis of Enantiomerically Enriched -Amino Acids 8.1.3.1 The Asymmetric Alkylation of Substrate 65a by Alkyl Halides Under Phase-Transfer Catalysis 8.1.3.2 Asymmetric Aldol Condensation of Achiral NiII Complexes of Amino Acids ; 8.1.3.3 The Asymmetric Michael Addition of Achiral NiII Substrates to Electron-Withdrawing Compounds 8.1.3.4 Catalytic Asymmetric Addition of Nucleophiles to an Achiral Dehydroalanine Substrate |
| Record Nr. | UNINA-9910821460103321 |
|
Saghyan Ashot S.
|
||
| Weinheim, Germany : , : Wiley-VCH, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Enantioselective synthesis of [beta]-amino acids / / editors, Eusebio Juaristi, Vadim A. Soloshonok
| Enantioselective synthesis of [beta]-amino acids / / editors, Eusebio Juaristi, Vadim A. Soloshonok |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2005 |
| Descrizione fisica | 1 online resource (658 pages) : illustrations |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
JuaristiEusebio
SoloshonokV. A |
| Soggetto topico |
Beta lactam antibiotics - Synthesis
Amino acids - Synthesis Chiral drugs - Synthesis Enantiomers - Synthesis |
| ISBN |
1-280-27537-5
9786610275373 0-470-31839-2 0-471-69848-2 0-471-69847-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ENANTIOSELECTIVE SYNTHESIS OF b-AMINO ACIDS; CONTENTS; Preface; Preface to the First Edition; Contributors; 1. Structural Types of Relevant b-Amino Acid Targets; 2. b-Amino Acids in Natural Products; 3. Preparation of Enantiopure b-Amino Acids by Homologation of a-Amino Acids; 4. Asymmetric Catalysis in Enantioselective Synthesis of b-Amino Acids; 5. Enantioselective Synthesis of Conformationally Constrained b-Amino Acids; 6. Catalytic Enantioselective Mannich Reactions; 7. Enantioselective Synthesis of b-Amino Acids via Stereoselective Hydrogenation of b-Aminoacrylic Acid Derivatives
8. Asymmetric Synthesis of b-Amino Acids by Enolate Additions to tert-Butanesulfinyl Imines; 9. Organocatalytic Approaches to Enantioenriched b-Amino Acids; 10. Asymmetric Synthesis of Cyclic b-Amino Acids via Cycloaddition Reactions; 11. Enantioselective Synthesis of Novel b-Amino Acids; 12. Asymmetric Synthesis of Phosphonic Analogs of b-Amino Acids; 13. Asymmetric Synthesis of a-Substituted-b-Amino Phosphonates and Phosphinates and b-Amino Sulfur Analogs; 14. Stereoselective Synthesis of Fluorine-Containing b-Amino Acids 15. Enantioselective Synthesis of b-Amino Acids via Conjugate Addition to a,b-Unsaturated Carbonyl Compounds; 16. Preparation of Enantiopure b-Amino Acids via Enantioselective Conjugate Addition; 17. Biocatalytic Entry to Enantiomerically Pure b-Amino Acids; 18. Stereoselective Synthesis of b-Amino Acids via Radical Reactions; 19. Recent Advances in Synthesis of a-Hydroxy-b-amino Acids and Their Use in SAR Studies of Taxane Anticancer Agents; 20. Synthesis of b-Amino Acids and Their Derivatives from b-Lactams: Update 21. Multiple-Component Condensation Methods for Preparation of Combinatorial Libraries of b-Amino Carbonyl Derivatives; 22. Using Constrained b-Amino Acid Residues to Control b-Peptide Shape and Function; 23. b(2)-Amino Acids with Proteinogenic Side Chains and Corresponding Peptides: Synthesis, Secondary Structure, and Biological Activity; Index |
| Record Nr. | UNINA-9910143552803321 |
| Hoboken, N.J., : Wiley, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Enantioselective synthesis of [beta]-amino acids / / editors, Eusebio Juaristi, Vadim A. Soloshonok
| Enantioselective synthesis of [beta]-amino acids / / editors, Eusebio Juaristi, Vadim A. Soloshonok |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2005 |
| Descrizione fisica | 1 online resource (658 pages) : illustrations |
| Disciplina | 615/.19 |
| Altri autori (Persone) |
JuaristiEusebio
SoloshonokV. A |
| Soggetto topico |
Beta lactam antibiotics - Synthesis
Amino acids - Synthesis Chiral drugs - Synthesis Enantiomers - Synthesis |
| ISBN |
1-280-27537-5
9786610275373 0-470-31839-2 0-471-69848-2 0-471-69847-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ENANTIOSELECTIVE SYNTHESIS OF b-AMINO ACIDS; CONTENTS; Preface; Preface to the First Edition; Contributors; 1. Structural Types of Relevant b-Amino Acid Targets; 2. b-Amino Acids in Natural Products; 3. Preparation of Enantiopure b-Amino Acids by Homologation of a-Amino Acids; 4. Asymmetric Catalysis in Enantioselective Synthesis of b-Amino Acids; 5. Enantioselective Synthesis of Conformationally Constrained b-Amino Acids; 6. Catalytic Enantioselective Mannich Reactions; 7. Enantioselective Synthesis of b-Amino Acids via Stereoselective Hydrogenation of b-Aminoacrylic Acid Derivatives
8. Asymmetric Synthesis of b-Amino Acids by Enolate Additions to tert-Butanesulfinyl Imines; 9. Organocatalytic Approaches to Enantioenriched b-Amino Acids; 10. Asymmetric Synthesis of Cyclic b-Amino Acids via Cycloaddition Reactions; 11. Enantioselective Synthesis of Novel b-Amino Acids; 12. Asymmetric Synthesis of Phosphonic Analogs of b-Amino Acids; 13. Asymmetric Synthesis of a-Substituted-b-Amino Phosphonates and Phosphinates and b-Amino Sulfur Analogs; 14. Stereoselective Synthesis of Fluorine-Containing b-Amino Acids 15. Enantioselective Synthesis of b-Amino Acids via Conjugate Addition to a,b-Unsaturated Carbonyl Compounds; 16. Preparation of Enantiopure b-Amino Acids via Enantioselective Conjugate Addition; 17. Biocatalytic Entry to Enantiomerically Pure b-Amino Acids; 18. Stereoselective Synthesis of b-Amino Acids via Radical Reactions; 19. Recent Advances in Synthesis of a-Hydroxy-b-amino Acids and Their Use in SAR Studies of Taxane Anticancer Agents; 20. Synthesis of b-Amino Acids and Their Derivatives from b-Lactams: Update 21. Multiple-Component Condensation Methods for Preparation of Combinatorial Libraries of b-Amino Carbonyl Derivatives; 22. Using Constrained b-Amino Acid Residues to Control b-Peptide Shape and Function; 23. b(2)-Amino Acids with Proteinogenic Side Chains and Corresponding Peptides: Synthesis, Secondary Structure, and Biological Activity; Index |
| Record Nr. | UNINA-9910823942803321 |
| Hoboken, N.J., : Wiley, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Engineering the genetic code [[electronic resource] ] : expanding the amino acid repertoire for the design of novel proteins / / Nediljko Budisa
| Engineering the genetic code [[electronic resource] ] : expanding the amino acid repertoire for the design of novel proteins / / Nediljko Budisa |
| Autore | Budisa Nediljko |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2006 |
| Descrizione fisica | 1 online resource (314 p.) |
| Disciplina | 572.65 |
| Soggetto topico |
Protein engineering
Amino acids - Synthesis |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-85417-0
9786610854172 3-527-60718-8 3-527-60709-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Engineering the Genetic Code; Foreword; Contents; Preface; 1 Introduction; 1.1 Classical Approaches to Protein Modification; 1.2 Peptide Synthesis, Semisynthesis and Chemistry of Total Protein Synthesis; 1.3 Chemoselective Ligations Combined with Biochemical Methods; 1.4 Methods and Approaches of Classical Protein Engineering; 1.5 Genetically Encoded Protein Modifications - Reprogramming Protein Translation; 1.6 Basic Definitions and Taxonomy; References; 2 A Brief History of an Expanded Amino Acid Repertoire; 2.1 The ""Golden Years"" of Molecular Biology and Triplet Code Elucidation
2.2 Early Experiments on the Incorporation of Amino Acid Analogs in Proteins2.3 Test Tube (Cell-free) Synthesis of Proteins and Early Incorporation Experiments; 2.4 Noncanonical Amino Acids as Tools for Studying Cell Metabolism, Physiology, Protein Processing and Turnover; 2.5 Problem of Proofs and Formal Criteria for Noncanonical Amino Acid Incorporation; 2.6 Recent Renaissance - Genetic Code Engineering; References; 3 Basic Features of the Cellular Translation Apparatus; 3.1 Natural Laws, Genetic Information and the ""Central Dogma"" of Molecular Biology 3.2 Cellular Investments in Ribosome-mediated Protein Synthesis3.3 Molecular Architecture of AARS; 3.4 Structure and Function of the tRNA Molecule; 3.5 Aminoacylation Reaction; 3.6 AARS:tRNA Interactions - Identity Sets; 3.7 Translational Proofreading; 3.8 Ribosomal Decoding - A Brief Overview; 3.9 Codon Bias and the Fidelity of Protein Synthesis; 3.10 Preprogrammed Context-dependent Recoding: fMet, Sec, Pyl, etc.; 3.11 Beyond Basic Coding - Posttranslational Modifications; References; 4 Amino Acids and Codons - Code Organization and Protein Structure 4.1 Basic Features and Adaptive Nature of the Universal Genetic Code4.2 Metabolism and Intracellular Uptake of Canonical Amino Acids; 4.3 Physicochemical Properties of Canonical Amino Acids; 4.4 Reasons for the Occurrence of Only 20 Amino Acids in the Genetic Code; 4.5 What Properties of Amino Acids are Best Preserved by the Genetic Code?; 4.6 Evolutionary Legacy: Dual Nature of Conserved Code and Finite Number of Protein Folds; 4.7 Natural Variations in Assignment of Codons of the Universal Genetic Code; 4.7.1 Nucleoside Modifications and Codon Reassignments 4.8 Codon Reassignment Concepts Possibly Relevant to Code Engineering4.8.1 Genome Size, Composition, Complexity and Codon Reassignments; 4.8.2 Stop Codon Takeover, Codon Capture and Codon Ambiguity; References; 5 Reprograming the Cellular Translation Machinery; 5.1 Enzyme Specificity of Aminoacyl-tRNA Synthetases (AARS) and Code Interpretation; 5.1.1 Living Cells as Platforms for Amino Acid Repertoire Expansion; 5.1.2 Uptake, Toxicity and Metabolic Fate of Noncanonical Amino Acids; 5.1.2.1 General Considerations; 5.1.2.2 Amino Acid Transport 5.1.2.3 Metabolic Conversions and Toxicity of Analogs and Surrogates |
| Record Nr. | UNINA-9910143963203321 |
|
Budisa Nediljko
|
||
| Weinheim, : Wiley-VCH, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Engineering the genetic code [[electronic resource] ] : expanding the amino acid repertoire for the design of novel proteins / / Nediljko Budisa
| Engineering the genetic code [[electronic resource] ] : expanding the amino acid repertoire for the design of novel proteins / / Nediljko Budisa |
| Autore | Budisa Nediljko |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2006 |
| Descrizione fisica | 1 online resource (314 p.) |
| Disciplina | 572.65 |
| Soggetto topico |
Protein engineering
Amino acids - Synthesis |
| ISBN |
1-280-85417-0
9786610854172 3-527-60718-8 3-527-60709-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Engineering the Genetic Code; Foreword; Contents; Preface; 1 Introduction; 1.1 Classical Approaches to Protein Modification; 1.2 Peptide Synthesis, Semisynthesis and Chemistry of Total Protein Synthesis; 1.3 Chemoselective Ligations Combined with Biochemical Methods; 1.4 Methods and Approaches of Classical Protein Engineering; 1.5 Genetically Encoded Protein Modifications - Reprogramming Protein Translation; 1.6 Basic Definitions and Taxonomy; References; 2 A Brief History of an Expanded Amino Acid Repertoire; 2.1 The ""Golden Years"" of Molecular Biology and Triplet Code Elucidation
2.2 Early Experiments on the Incorporation of Amino Acid Analogs in Proteins2.3 Test Tube (Cell-free) Synthesis of Proteins and Early Incorporation Experiments; 2.4 Noncanonical Amino Acids as Tools for Studying Cell Metabolism, Physiology, Protein Processing and Turnover; 2.5 Problem of Proofs and Formal Criteria for Noncanonical Amino Acid Incorporation; 2.6 Recent Renaissance - Genetic Code Engineering; References; 3 Basic Features of the Cellular Translation Apparatus; 3.1 Natural Laws, Genetic Information and the ""Central Dogma"" of Molecular Biology 3.2 Cellular Investments in Ribosome-mediated Protein Synthesis3.3 Molecular Architecture of AARS; 3.4 Structure and Function of the tRNA Molecule; 3.5 Aminoacylation Reaction; 3.6 AARS:tRNA Interactions - Identity Sets; 3.7 Translational Proofreading; 3.8 Ribosomal Decoding - A Brief Overview; 3.9 Codon Bias and the Fidelity of Protein Synthesis; 3.10 Preprogrammed Context-dependent Recoding: fMet, Sec, Pyl, etc.; 3.11 Beyond Basic Coding - Posttranslational Modifications; References; 4 Amino Acids and Codons - Code Organization and Protein Structure 4.1 Basic Features and Adaptive Nature of the Universal Genetic Code4.2 Metabolism and Intracellular Uptake of Canonical Amino Acids; 4.3 Physicochemical Properties of Canonical Amino Acids; 4.4 Reasons for the Occurrence of Only 20 Amino Acids in the Genetic Code; 4.5 What Properties of Amino Acids are Best Preserved by the Genetic Code?; 4.6 Evolutionary Legacy: Dual Nature of Conserved Code and Finite Number of Protein Folds; 4.7 Natural Variations in Assignment of Codons of the Universal Genetic Code; 4.7.1 Nucleoside Modifications and Codon Reassignments 4.8 Codon Reassignment Concepts Possibly Relevant to Code Engineering4.8.1 Genome Size, Composition, Complexity and Codon Reassignments; 4.8.2 Stop Codon Takeover, Codon Capture and Codon Ambiguity; References; 5 Reprograming the Cellular Translation Machinery; 5.1 Enzyme Specificity of Aminoacyl-tRNA Synthetases (AARS) and Code Interpretation; 5.1.1 Living Cells as Platforms for Amino Acid Repertoire Expansion; 5.1.2 Uptake, Toxicity and Metabolic Fate of Noncanonical Amino Acids; 5.1.2.1 General Considerations; 5.1.2.2 Amino Acid Transport 5.1.2.3 Metabolic Conversions and Toxicity of Analogs and Surrogates |
| Record Nr. | UNINA-9910830125203321 |
|
Budisa Nediljko
|
||
| Weinheim, : Wiley-VCH, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Engineering the genetic code [[electronic resource] ] : expanding the amino acid repertoire for the design of novel proteins / / Nediljko Budisa
| Engineering the genetic code [[electronic resource] ] : expanding the amino acid repertoire for the design of novel proteins / / Nediljko Budisa |
| Autore | Budisa Nediljko |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2006 |
| Descrizione fisica | 1 online resource (314 p.) |
| Disciplina | 572.65 |
| Soggetto topico |
Protein engineering
Amino acids - Synthesis |
| ISBN |
1-280-85417-0
9786610854172 3-527-60718-8 3-527-60709-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Engineering the Genetic Code; Foreword; Contents; Preface; 1 Introduction; 1.1 Classical Approaches to Protein Modification; 1.2 Peptide Synthesis, Semisynthesis and Chemistry of Total Protein Synthesis; 1.3 Chemoselective Ligations Combined with Biochemical Methods; 1.4 Methods and Approaches of Classical Protein Engineering; 1.5 Genetically Encoded Protein Modifications - Reprogramming Protein Translation; 1.6 Basic Definitions and Taxonomy; References; 2 A Brief History of an Expanded Amino Acid Repertoire; 2.1 The ""Golden Years"" of Molecular Biology and Triplet Code Elucidation
2.2 Early Experiments on the Incorporation of Amino Acid Analogs in Proteins2.3 Test Tube (Cell-free) Synthesis of Proteins and Early Incorporation Experiments; 2.4 Noncanonical Amino Acids as Tools for Studying Cell Metabolism, Physiology, Protein Processing and Turnover; 2.5 Problem of Proofs and Formal Criteria for Noncanonical Amino Acid Incorporation; 2.6 Recent Renaissance - Genetic Code Engineering; References; 3 Basic Features of the Cellular Translation Apparatus; 3.1 Natural Laws, Genetic Information and the ""Central Dogma"" of Molecular Biology 3.2 Cellular Investments in Ribosome-mediated Protein Synthesis3.3 Molecular Architecture of AARS; 3.4 Structure and Function of the tRNA Molecule; 3.5 Aminoacylation Reaction; 3.6 AARS:tRNA Interactions - Identity Sets; 3.7 Translational Proofreading; 3.8 Ribosomal Decoding - A Brief Overview; 3.9 Codon Bias and the Fidelity of Protein Synthesis; 3.10 Preprogrammed Context-dependent Recoding: fMet, Sec, Pyl, etc.; 3.11 Beyond Basic Coding - Posttranslational Modifications; References; 4 Amino Acids and Codons - Code Organization and Protein Structure 4.1 Basic Features and Adaptive Nature of the Universal Genetic Code4.2 Metabolism and Intracellular Uptake of Canonical Amino Acids; 4.3 Physicochemical Properties of Canonical Amino Acids; 4.4 Reasons for the Occurrence of Only 20 Amino Acids in the Genetic Code; 4.5 What Properties of Amino Acids are Best Preserved by the Genetic Code?; 4.6 Evolutionary Legacy: Dual Nature of Conserved Code and Finite Number of Protein Folds; 4.7 Natural Variations in Assignment of Codons of the Universal Genetic Code; 4.7.1 Nucleoside Modifications and Codon Reassignments 4.8 Codon Reassignment Concepts Possibly Relevant to Code Engineering4.8.1 Genome Size, Composition, Complexity and Codon Reassignments; 4.8.2 Stop Codon Takeover, Codon Capture and Codon Ambiguity; References; 5 Reprograming the Cellular Translation Machinery; 5.1 Enzyme Specificity of Aminoacyl-tRNA Synthetases (AARS) and Code Interpretation; 5.1.1 Living Cells as Platforms for Amino Acid Repertoire Expansion; 5.1.2 Uptake, Toxicity and Metabolic Fate of Noncanonical Amino Acids; 5.1.2.1 General Considerations; 5.1.2.2 Amino Acid Transport 5.1.2.3 Metabolic Conversions and Toxicity of Analogs and Surrogates |
| Record Nr. | UNINA-9910840559903321 |
|
Budisa Nediljko
|
||
| Weinheim, : Wiley-VCH, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Methods of non-[alpha]-amino acid synthesis / / Michael Bryant Smith, University of Connecticut, Storrs, USA
| Methods of non-[alpha]-amino acid synthesis / / Michael Bryant Smith, University of Connecticut, Storrs, USA |
| Autore | Smith Michael <1946 October 17, > |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Boca Raton : , : CRC Press, , [2014] |
| Descrizione fisica | 1 online resource (226 p.) |
| Disciplina | 572/.65 |
| Soggetto topico | Amino acids - Synthesis |
| ISBN |
0-429-10221-6
1-4665-7789-4 |
| Classificazione | SCI013040SCI013060SCI049000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Front Cover; Contents; Preface to the Second Edition; Preface to the First Edition; Common Abbreviations; Introduction; Chapter 1: Functional Group Exchanges; Chapter 2: Cyclic Precursors; Chapter 3: Conjugate Addition Reactions; Chapter 4: Enolate Anion and Related Reactions; Chapter 5: Diastereoselective and Enantioselective Syntheses; Chapter 6: Biologically Important Amino Acids; Chapter 7: Aminocyclic and Heterocyclic Amino Acids; Back Cover |
| Record Nr. | UNINA-9910787570003321 |
|
Smith Michael <1946 October 17, >
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| Boca Raton : , : CRC Press, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Soggetto topico
-
Amino acids - Synthesis
(19)
- Peptides (9)
- Amino acids (5)
- Peptide drugs - Design (4)
- Polyamides (4)