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Acute toxicology testing [[electronic resource] /] / Shayne C. Gad, Christopher P. Chengelis
| Acute toxicology testing [[electronic resource] /] / Shayne C. Gad, Christopher P. Chengelis |
| Autore | Gad Shayne C. <1948-> |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | San Diego, : Academic Press, c1998 |
| Descrizione fisica | 1 online resource (561 p.) |
| Disciplina | 615/.704/028 |
| Altri autori (Persone) | ChengelisChristopher P. <1949-> |
| Soggetto topico |
Alternative toxicity testing
Acute toxicity testing |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-03290-5
9786611032906 0-08-052592-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Acute Toxicology Testing; Copyright Page; Contents; Preface to the First Edition; Preface to the Second Edition; Chapter 1. Introduction; Questions of Relevance and Sensitivity; Defining Test Objectives; Display of Study Designs: The Line Chart; Theory and Use of Screens, Innovations, and Alternatives; References; Chapter 2. Acute Toxicology Program: Study Design and Development; Defining the Objective; Defining Exposure Potential; The Data Matrix; Test Selection and Design; Study Design; References; Chapter 3. Tests for Dermal Irritation and Corrosion
Primary Dermal Irritation TestDermal Corrosivity Test; Factors Affecting Responses and Test Outcome; Problems in Testing (and Their Resolutions); Design Alternatives and Innovations; In Vitro Alternatives; Percutaneous Absorption; Intracutaneous Reactivity (Irritation); Intracutaneous Test; References; Chapter 4. Ocular Irritation Testing; History of Ocular Irritation Testing; Current in Vivo Test Protocols; Ocular Irritation Test; 21-Day Eye Irritation Study in Rabbits; Adequacy of Current in Vivo Methods; Limitations of the Rabbit Eye Test; In Vivo vs in Vitro Tests; In Vitro Tests ReferencesChapter 5. Dermal Sensitization; Mechanisms; Objectives and General Features; History; Modified Buehler Procedure; Guinea Pig Maximization Test; Guinea Pig Split Adjuvant Test; Mouse Ear Swelling Test; Local Lymph Node Assay; Test System Manipulation (for all in Vivo Test Systems); Current Test Systems: Practical Problems and Solutions; References; Chapter 6. Photosensitization and Phototoxicity; Theory and Mechanisms; Factors Influencing Phototoxicity/Photosensitization; Predictive Tests for Phototoxicity; Guinea Pig; Mouse Ear Swelling Model; Alternative Designs: In Vivo Systems In Vitro Test SystemsReferences; Chapter 7. Lethality Testing; Historical Perspective; Protocol Designs; Alternatives to Lethality Testing; References; Chapter 8. Safety Considerations for the Administration of Agents by the Parenteral Routes; Parenteral Routes and Rates; Bolus vs Infusion; Test Systems for Parenteral Irritation; Alternatives; Pyrogenicity; Blood Compatibility; Vaginal Irritation; References; Chapter 9. Systemic Acute Toxicity Testing; Screens; Acute Systemic Toxicity Characterization; Acute Toxicity Testing with Nonrodent Species; Acute Mechanistic Studies; References Chapter 10. Routes, Formulations, and VehiclesMechanisms; Common Routes; Mechanisms of Absorption; Techniques; Gavage Procedure (Rat or Mouse); Volume Limitations by Route; Selection of Route; Vehicles and Formulation of Materials; Dosing Calculations; Comparisons and Contrasts of Routes; References; Chapter 11. Considerations Specific to Animal Test Models; Common Model Species and Their Characteristics; Cross-Species Extrapolation; Model Selection; Limitations of Models; Susceptibility Factors; Species Peculiarities; Considerations of Strain; Animal Care, Husbandry, and Welfare; References Chapter 12. Statistical Analysis of Acute Toxicology and Safety Studies |
| Record Nr. | UNINA-9910458377703321 |
Gad Shayne C. <1948->
|
||
| San Diego, : Academic Press, c1998 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Acute toxicology testing [[electronic resource] /] / Shayne C. Gad, Christopher P. Chengelis
| Acute toxicology testing [[electronic resource] /] / Shayne C. Gad, Christopher P. Chengelis |
| Autore | Gad Shayne C. <1948-> |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | San Diego, : Academic Press, c1998 |
| Descrizione fisica | 1 online resource (561 p.) |
| Disciplina | 615/.704/028 |
| Altri autori (Persone) | ChengelisChristopher P. <1949-> |
| Soggetto topico |
Alternative toxicity testing
Acute toxicity testing |
| ISBN |
1-281-03290-5
9786611032906 0-08-052592-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Acute Toxicology Testing; Copyright Page; Contents; Preface to the First Edition; Preface to the Second Edition; Chapter 1. Introduction; Questions of Relevance and Sensitivity; Defining Test Objectives; Display of Study Designs: The Line Chart; Theory and Use of Screens, Innovations, and Alternatives; References; Chapter 2. Acute Toxicology Program: Study Design and Development; Defining the Objective; Defining Exposure Potential; The Data Matrix; Test Selection and Design; Study Design; References; Chapter 3. Tests for Dermal Irritation and Corrosion
Primary Dermal Irritation TestDermal Corrosivity Test; Factors Affecting Responses and Test Outcome; Problems in Testing (and Their Resolutions); Design Alternatives and Innovations; In Vitro Alternatives; Percutaneous Absorption; Intracutaneous Reactivity (Irritation); Intracutaneous Test; References; Chapter 4. Ocular Irritation Testing; History of Ocular Irritation Testing; Current in Vivo Test Protocols; Ocular Irritation Test; 21-Day Eye Irritation Study in Rabbits; Adequacy of Current in Vivo Methods; Limitations of the Rabbit Eye Test; In Vivo vs in Vitro Tests; In Vitro Tests ReferencesChapter 5. Dermal Sensitization; Mechanisms; Objectives and General Features; History; Modified Buehler Procedure; Guinea Pig Maximization Test; Guinea Pig Split Adjuvant Test; Mouse Ear Swelling Test; Local Lymph Node Assay; Test System Manipulation (for all in Vivo Test Systems); Current Test Systems: Practical Problems and Solutions; References; Chapter 6. Photosensitization and Phototoxicity; Theory and Mechanisms; Factors Influencing Phototoxicity/Photosensitization; Predictive Tests for Phototoxicity; Guinea Pig; Mouse Ear Swelling Model; Alternative Designs: In Vivo Systems In Vitro Test SystemsReferences; Chapter 7. Lethality Testing; Historical Perspective; Protocol Designs; Alternatives to Lethality Testing; References; Chapter 8. Safety Considerations for the Administration of Agents by the Parenteral Routes; Parenteral Routes and Rates; Bolus vs Infusion; Test Systems for Parenteral Irritation; Alternatives; Pyrogenicity; Blood Compatibility; Vaginal Irritation; References; Chapter 9. Systemic Acute Toxicity Testing; Screens; Acute Systemic Toxicity Characterization; Acute Toxicity Testing with Nonrodent Species; Acute Mechanistic Studies; References Chapter 10. Routes, Formulations, and VehiclesMechanisms; Common Routes; Mechanisms of Absorption; Techniques; Gavage Procedure (Rat or Mouse); Volume Limitations by Route; Selection of Route; Vehicles and Formulation of Materials; Dosing Calculations; Comparisons and Contrasts of Routes; References; Chapter 11. Considerations Specific to Animal Test Models; Common Model Species and Their Characteristics; Cross-Species Extrapolation; Model Selection; Limitations of Models; Susceptibility Factors; Species Peculiarities; Considerations of Strain; Animal Care, Husbandry, and Welfare; References Chapter 12. Statistical Analysis of Acute Toxicology and Safety Studies |
| Record Nr. | UNINA-9910784636103321 |
|
Gad Shayne C. <1948->
|
||
| San Diego, : Academic Press, c1998 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Acute toxicology testing / / Shayne C. Gad, Christopher P. Chengelis
| Acute toxicology testing / / Shayne C. Gad, Christopher P. Chengelis |
| Autore | Gad Shayne C. <1948-> |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | San Diego, : Academic Press, c1998 |
| Descrizione fisica | 1 online resource (561 p.) |
| Disciplina | 615/.704/028 |
| Altri autori (Persone) | ChengelisChristopher P. <1949-> |
| Soggetto topico |
Alternative toxicity testing
Acute toxicity testing |
| ISBN |
1-281-03290-5
9786611032906 0-08-052592-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Acute Toxicology Testing; Copyright Page; Contents; Preface to the First Edition; Preface to the Second Edition; Chapter 1. Introduction; Questions of Relevance and Sensitivity; Defining Test Objectives; Display of Study Designs: The Line Chart; Theory and Use of Screens, Innovations, and Alternatives; References; Chapter 2. Acute Toxicology Program: Study Design and Development; Defining the Objective; Defining Exposure Potential; The Data Matrix; Test Selection and Design; Study Design; References; Chapter 3. Tests for Dermal Irritation and Corrosion
Primary Dermal Irritation TestDermal Corrosivity Test; Factors Affecting Responses and Test Outcome; Problems in Testing (and Their Resolutions); Design Alternatives and Innovations; In Vitro Alternatives; Percutaneous Absorption; Intracutaneous Reactivity (Irritation); Intracutaneous Test; References; Chapter 4. Ocular Irritation Testing; History of Ocular Irritation Testing; Current in Vivo Test Protocols; Ocular Irritation Test; 21-Day Eye Irritation Study in Rabbits; Adequacy of Current in Vivo Methods; Limitations of the Rabbit Eye Test; In Vivo vs in Vitro Tests; In Vitro Tests ReferencesChapter 5. Dermal Sensitization; Mechanisms; Objectives and General Features; History; Modified Buehler Procedure; Guinea Pig Maximization Test; Guinea Pig Split Adjuvant Test; Mouse Ear Swelling Test; Local Lymph Node Assay; Test System Manipulation (for all in Vivo Test Systems); Current Test Systems: Practical Problems and Solutions; References; Chapter 6. Photosensitization and Phototoxicity; Theory and Mechanisms; Factors Influencing Phototoxicity/Photosensitization; Predictive Tests for Phototoxicity; Guinea Pig; Mouse Ear Swelling Model; Alternative Designs: In Vivo Systems In Vitro Test SystemsReferences; Chapter 7. Lethality Testing; Historical Perspective; Protocol Designs; Alternatives to Lethality Testing; References; Chapter 8. Safety Considerations for the Administration of Agents by the Parenteral Routes; Parenteral Routes and Rates; Bolus vs Infusion; Test Systems for Parenteral Irritation; Alternatives; Pyrogenicity; Blood Compatibility; Vaginal Irritation; References; Chapter 9. Systemic Acute Toxicity Testing; Screens; Acute Systemic Toxicity Characterization; Acute Toxicity Testing with Nonrodent Species; Acute Mechanistic Studies; References Chapter 10. Routes, Formulations, and VehiclesMechanisms; Common Routes; Mechanisms of Absorption; Techniques; Gavage Procedure (Rat or Mouse); Volume Limitations by Route; Selection of Route; Vehicles and Formulation of Materials; Dosing Calculations; Comparisons and Contrasts of Routes; References; Chapter 11. Considerations Specific to Animal Test Models; Common Model Species and Their Characteristics; Cross-Species Extrapolation; Model Selection; Limitations of Models; Susceptibility Factors; Species Peculiarities; Considerations of Strain; Animal Care, Husbandry, and Welfare; References Chapter 12. Statistical Analysis of Acute Toxicology and Safety Studies |
| Record Nr. | UNINA-9910823152203321 |
|
Gad Shayne C. <1948->
|
||
| San Diego, : Academic Press, c1998 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Alternatives to animal testing / / editors, R.E. Hester and R.M. Harrison
| Alternatives to animal testing / / editors, R.E. Hester and R.M. Harrison |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Cambridge, U.K., : Royal Society of Chemistry, c2006 |
| Descrizione fisica | 1 online resource (137 p.) |
| Disciplina | 615.9/07 |
| Altri autori (Persone) |
HesterR. E (Ronald E.)
HarrisonRoy M. <1948-> |
| Collana |
ISSN
Issues in environmental science and technology |
| Soggetto topico |
Alternative toxicity testing
Animal experimentation |
| ISBN | 1-84755-245-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Alternatives to Animal Testing_publicity; i_iv; v_vi; vii_viii; ix_x; xi_xii; 001_027; 028_052; 053_073; 074_094; 095_118; 119_124 |
| Record Nr. | UNINA-9910139801403321 |
| Cambridge, U.K., : Royal Society of Chemistry, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Alternatives to animal testing [[electronic resource] ] : new ways in the biomedical sciences, trends and progress / / edited by Christoph A. Reinhardt on behalf of the Swiss Institute for Alternatives to Animal Testing, SIAT
| Alternatives to animal testing [[electronic resource] ] : new ways in the biomedical sciences, trends and progress / / edited by Christoph A. Reinhardt on behalf of the Swiss Institute for Alternatives to Animal Testing, SIAT |
| Pubbl/distr/stampa | Weinheim ; ; New York, : VCH, c1994 |
| Descrizione fisica | 1 online resource (202 p.) |
| Disciplina | 619 |
| Altri autori (Persone) | ReinhardtChristoph A |
| Soggetto topico |
Alternative toxicity testing
Animal experimentation Tests de toxicitat Experimentació animal |
| Soggetto genere / forma |
Electronic books.
Congressos Llibres electrònics |
| ISBN |
1-282-02538-4
9786612025389 3-527-61605-5 3-527-61604-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Alternatives to Animal Testing; Preface; In memoriam; Foreword; List of contributors; Contents; 1 Looking Back 33 Years to Russell and Burch: The Development of the Concept of the Three Rs (Alternatives); 2 The OECD and International Regulatory Acceptance of the Three Rs; 3 The European Centre for the Validation of Alternative Methods (ECVAM); 4 A Timetable for Replacing, Reducing and Refining Animal Use with the Help of in Vitro Tests: The Limulus Amebocyte Lysate Test (LAL) as an Example
5 The Fund for the Replacement of Animals in Medical Experiments (FRAME): 23 Years of Campaigning for the Three Rs6 Animal Use and Alternatives: Developments in the Netherlands; 7 The RIVM Center for Alternatives to Animal Testing and the Concept of the Three Rs in the Quality Control of Vaccines; 8 ZEBET: Three Years of the National German Center for Documentation and Evaluation of Alternatives to Animal Experiments at the Federal Health Office (BGA) in Berlin; 9 Reviewed Literature Databank for Alternatives to Animal Experiments - "Gelbe Liste" 10 The SIAT Research, Teaching and Consulting Program in the Area of in Vitro Toxicology. Experimental Research, Screening and Validation11 Computer-Aided Drug Design and the Three Rs; 12 Computer-Aided Programs in Biomedical Education; 13 Alternatives to Experiments with Animals in Medical Education: A TEMPUS Joint European Project; 14 Replacement of Laboratory Animals in the Management of Blood- Sucking Arthropods; 15 Maintenance of Filarial Cycles in the Laboratory: Approaches to Replacing the Vertebrate Host 16 Improved Drug Metabolizing Capacity of Hepatocytes Co-Cultured with Epithelial Cells and Maintained in a Perifusion System17 Characterization and Use of Long-Term Liver Cultures to Evaluate the Toxicity of Cyclophosphamide or Benzene to Bone Marrow Cultures; 18 European Interlaboratory Evaluation of an in Vitro Ocular Irritation Model (Skin2TM Model ZK1100) Using 18 Chemicals and Formulated Products; 19 Cellular Assays for Testing Peritoneal Dialysis Bags; 20 The Position of the Authorities; Subject index |
| Record Nr. | UNINA-9910144389703321 |
| Weinheim ; ; New York, : VCH, c1994 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Alternatives to animal testing [[electronic resource] ] : new ways in the biomedical sciences, trends and progress / / edited by Christoph A. Reinhardt on behalf of the Swiss Institute for Alternatives to Animal Testing, SIAT
| Alternatives to animal testing [[electronic resource] ] : new ways in the biomedical sciences, trends and progress / / edited by Christoph A. Reinhardt on behalf of the Swiss Institute for Alternatives to Animal Testing, SIAT |
| Pubbl/distr/stampa | Weinheim ; ; New York, : VCH, c1994 |
| Descrizione fisica | 1 online resource (202 p.) |
| Disciplina | 619 |
| Altri autori (Persone) | ReinhardtChristoph A |
| Soggetto topico |
Alternative toxicity testing
Animal experimentation Tests de toxicitat Experimentació animal |
| Soggetto genere / forma |
Congressos
Llibres electrònics |
| ISBN |
1-282-02538-4
9786612025389 3-527-61605-5 3-527-61604-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Alternatives to Animal Testing; Preface; In memoriam; Foreword; List of contributors; Contents; 1 Looking Back 33 Years to Russell and Burch: The Development of the Concept of the Three Rs (Alternatives); 2 The OECD and International Regulatory Acceptance of the Three Rs; 3 The European Centre for the Validation of Alternative Methods (ECVAM); 4 A Timetable for Replacing, Reducing and Refining Animal Use with the Help of in Vitro Tests: The Limulus Amebocyte Lysate Test (LAL) as an Example
5 The Fund for the Replacement of Animals in Medical Experiments (FRAME): 23 Years of Campaigning for the Three Rs6 Animal Use and Alternatives: Developments in the Netherlands; 7 The RIVM Center for Alternatives to Animal Testing and the Concept of the Three Rs in the Quality Control of Vaccines; 8 ZEBET: Three Years of the National German Center for Documentation and Evaluation of Alternatives to Animal Experiments at the Federal Health Office (BGA) in Berlin; 9 Reviewed Literature Databank for Alternatives to Animal Experiments - "Gelbe Liste" 10 The SIAT Research, Teaching and Consulting Program in the Area of in Vitro Toxicology. Experimental Research, Screening and Validation11 Computer-Aided Drug Design and the Three Rs; 12 Computer-Aided Programs in Biomedical Education; 13 Alternatives to Experiments with Animals in Medical Education: A TEMPUS Joint European Project; 14 Replacement of Laboratory Animals in the Management of Blood- Sucking Arthropods; 15 Maintenance of Filarial Cycles in the Laboratory: Approaches to Replacing the Vertebrate Host 16 Improved Drug Metabolizing Capacity of Hepatocytes Co-Cultured with Epithelial Cells and Maintained in a Perifusion System17 Characterization and Use of Long-Term Liver Cultures to Evaluate the Toxicity of Cyclophosphamide or Benzene to Bone Marrow Cultures; 18 European Interlaboratory Evaluation of an in Vitro Ocular Irritation Model (Skin2TM Model ZK1100) Using 18 Chemicals and Formulated Products; 19 Cellular Assays for Testing Peritoneal Dialysis Bags; 20 The Position of the Authorities; Subject index |
| Record Nr. | UNINA-9910830431203321 |
| Weinheim ; ; New York, : VCH, c1994 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Alternatives to animal testing : new ways in the biomedical sciences, trends and progress / / edited by Christoph A. Reinhardt on behalf of the Swiss Institute for Alternatives to Animal Testing, SIAT
| Alternatives to animal testing : new ways in the biomedical sciences, trends and progress / / edited by Christoph A. Reinhardt on behalf of the Swiss Institute for Alternatives to Animal Testing, SIAT |
| Pubbl/distr/stampa | Weinheim ; ; New York, : VCH, c1994 |
| Descrizione fisica | 1 online resource (202 p.) |
| Disciplina | 619 |
| Altri autori (Persone) | ReinhardtChristoph A |
| Soggetto topico |
Alternative toxicity testing
Animal experimentation Tests de toxicitat Experimentació animal |
| Soggetto genere / forma |
Congressos
Llibres electrònics |
| ISBN |
1-282-02538-4
9786612025389 3-527-61605-5 3-527-61604-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Alternatives to Animal Testing; Preface; In memoriam; Foreword; List of contributors; Contents; 1 Looking Back 33 Years to Russell and Burch: The Development of the Concept of the Three Rs (Alternatives); 2 The OECD and International Regulatory Acceptance of the Three Rs; 3 The European Centre for the Validation of Alternative Methods (ECVAM); 4 A Timetable for Replacing, Reducing and Refining Animal Use with the Help of in Vitro Tests: The Limulus Amebocyte Lysate Test (LAL) as an Example
5 The Fund for the Replacement of Animals in Medical Experiments (FRAME): 23 Years of Campaigning for the Three Rs6 Animal Use and Alternatives: Developments in the Netherlands; 7 The RIVM Center for Alternatives to Animal Testing and the Concept of the Three Rs in the Quality Control of Vaccines; 8 ZEBET: Three Years of the National German Center for Documentation and Evaluation of Alternatives to Animal Experiments at the Federal Health Office (BGA) in Berlin; 9 Reviewed Literature Databank for Alternatives to Animal Experiments - "Gelbe Liste" 10 The SIAT Research, Teaching and Consulting Program in the Area of in Vitro Toxicology. Experimental Research, Screening and Validation11 Computer-Aided Drug Design and the Three Rs; 12 Computer-Aided Programs in Biomedical Education; 13 Alternatives to Experiments with Animals in Medical Education: A TEMPUS Joint European Project; 14 Replacement of Laboratory Animals in the Management of Blood- Sucking Arthropods; 15 Maintenance of Filarial Cycles in the Laboratory: Approaches to Replacing the Vertebrate Host 16 Improved Drug Metabolizing Capacity of Hepatocytes Co-Cultured with Epithelial Cells and Maintained in a Perifusion System17 Characterization and Use of Long-Term Liver Cultures to Evaluate the Toxicity of Cyclophosphamide or Benzene to Bone Marrow Cultures; 18 European Interlaboratory Evaluation of an in Vitro Ocular Irritation Model (Skin2TM Model ZK1100) Using 18 Chemicals and Formulated Products; 19 Cellular Assays for Testing Peritoneal Dialysis Bags; 20 The Position of the Authorities; Subject index |
| Record Nr. | UNISA-996204168503316 |
| Weinheim ; ; New York, : VCH, c1994 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Alternatives to animal testing : new ways in the biomedical sciences, trends and progress / / edited by Christoph A. Reinhardt on behalf of the Swiss Institute for Alternatives to Animal Testing, SIAT
| Alternatives to animal testing : new ways in the biomedical sciences, trends and progress / / edited by Christoph A. Reinhardt on behalf of the Swiss Institute for Alternatives to Animal Testing, SIAT |
| Pubbl/distr/stampa | Weinheim ; ; New York, : VCH, c1994 |
| Descrizione fisica | 1 online resource (202 p.) |
| Disciplina | 619 |
| Altri autori (Persone) | ReinhardtChristoph A |
| Soggetto topico |
Alternative toxicity testing
Animal experimentation |
| ISBN |
1-282-02538-4
9786612025389 3-527-61605-5 3-527-61604-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Alternatives to Animal Testing; Preface; In memoriam; Foreword; List of contributors; Contents; 1 Looking Back 33 Years to Russell and Burch: The Development of the Concept of the Three Rs (Alternatives); 2 The OECD and International Regulatory Acceptance of the Three Rs; 3 The European Centre for the Validation of Alternative Methods (ECVAM); 4 A Timetable for Replacing, Reducing and Refining Animal Use with the Help of in Vitro Tests: The Limulus Amebocyte Lysate Test (LAL) as an Example
5 The Fund for the Replacement of Animals in Medical Experiments (FRAME): 23 Years of Campaigning for the Three Rs6 Animal Use and Alternatives: Developments in the Netherlands; 7 The RIVM Center for Alternatives to Animal Testing and the Concept of the Three Rs in the Quality Control of Vaccines; 8 ZEBET: Three Years of the National German Center for Documentation and Evaluation of Alternatives to Animal Experiments at the Federal Health Office (BGA) in Berlin; 9 Reviewed Literature Databank for Alternatives to Animal Experiments - "Gelbe Liste" 10 The SIAT Research, Teaching and Consulting Program in the Area of in Vitro Toxicology. Experimental Research, Screening and Validation11 Computer-Aided Drug Design and the Three Rs; 12 Computer-Aided Programs in Biomedical Education; 13 Alternatives to Experiments with Animals in Medical Education: A TEMPUS Joint European Project; 14 Replacement of Laboratory Animals in the Management of Blood- Sucking Arthropods; 15 Maintenance of Filarial Cycles in the Laboratory: Approaches to Replacing the Vertebrate Host 16 Improved Drug Metabolizing Capacity of Hepatocytes Co-Cultured with Epithelial Cells and Maintained in a Perifusion System17 Characterization and Use of Long-Term Liver Cultures to Evaluate the Toxicity of Cyclophosphamide or Benzene to Bone Marrow Cultures; 18 European Interlaboratory Evaluation of an in Vitro Ocular Irritation Model (Skin2TM Model ZK1100) Using 18 Chemicals and Formulated Products; 19 Cellular Assays for Testing Peritoneal Dialysis Bags; 20 The Position of the Authorities; Subject index |
| Record Nr. | UNINA-9910876804603321 |
| Weinheim ; ; New York, : VCH, c1994 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biodefense research methodology and animal models / / edited by James R. Swearengen
| Biodefense research methodology and animal models / / edited by James R. Swearengen |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Boca Raton : , : CRC Press, , 2012 |
| Descrizione fisica | 1 online resource (415 p.) |
| Disciplina | 363.325/3 |
| Altri autori (Persone) | SwearengenJames R |
| Soggetto topico |
Bioterrorism - Prevention - Research
Infection - Animal models Communicable diseases - Research Biological weapons Alternative toxicity testing Toxins - Research |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-429-15227-2
1-280-12193-9 9786613525796 1-4398-3633-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | History of biological agents as weapons / James W. Martin -- Bioterrorism and biowarfare : similarities and differences / Nelson W. Rebert -- Scientific and ethical importance of animal models in biodefense research / James R. Swearengen and Arthur O. Anderson -- Development and validation of animal models / Jaime B. Anderson and Kenneth Tucker -- Infectious disease aerobiology : aerosol challenge methods / Chad J. Roy and Louise M. Pitt -- Characterization of new and advancement of existing animal models of bacillus anthracis infection / Elizabeth K. Leffel and Louise M. Pitt -- Glanders / David L. Fritz and David M. Waag -- Plague / Jeffery J. Adamovicz and Patricia L. Worsham -- Tularemia / Jeffery J. Adamovicz and David M. Waag -- Q fever / David M. Waag and David L. Fritz -- Brucellosis / Bret K. Purcell and Robert Rivard -- Alphaviruses / William D. Pratt ... [et al.] -- Orthopoxviruses / Peter B. Jahrling and Victoria Wahl-Jensen -- Animal models for viral hemorrhagic fevers / Kelly l. Warfield and Thomas W. Geisbert -- Botulinum toxins / Stephen B. Greenbaum, Jaime B. Anderson, and Frank J. Lebeda -- Ricin / Stephen B. Greenbaum and Jaime B. Anderson -- Staphylococcal and streptococcal superantigens : in vitro and in vivo assays / Teresa Krakauer and Bradley G. Stiles. |
| Record Nr. | UNINA-9910457835803321 |
| Boca Raton : , : CRC Press, , 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biodefense research methodology and animal models / / edited by James R. Swearengen
| Biodefense research methodology and animal models / / edited by James R. Swearengen |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Boca Raton : , : CRC Press, , 2012 |
| Descrizione fisica | 1 online resource (415 p.) |
| Disciplina | 363.325/3 |
| Altri autori (Persone) | SwearengenJames R |
| Soggetto topico |
Bioterrorism - Prevention - Research
Infection - Animal models Communicable diseases - Research Biological weapons Alternative toxicity testing Toxins - Research |
| ISBN |
0-429-15227-2
1-280-12193-9 9786613525796 1-4398-3633-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | History of biological agents as weapons / James W. Martin -- Bioterrorism and biowarfare : similarities and differences / Nelson W. Rebert -- Scientific and ethical importance of animal models in biodefense research / James R. Swearengen and Arthur O. Anderson -- Development and validation of animal models / Jaime B. Anderson and Kenneth Tucker -- Infectious disease aerobiology : aerosol challenge methods / Chad J. Roy and Louise M. Pitt -- Characterization of new and advancement of existing animal models of bacillus anthracis infection / Elizabeth K. Leffel and Louise M. Pitt -- Glanders / David L. Fritz and David M. Waag -- Plague / Jeffery J. Adamovicz and Patricia L. Worsham -- Tularemia / Jeffery J. Adamovicz and David M. Waag -- Q fever / David M. Waag and David L. Fritz -- Brucellosis / Bret K. Purcell and Robert Rivard -- Alphaviruses / William D. Pratt ... [et al.] -- Orthopoxviruses / Peter B. Jahrling and Victoria Wahl-Jensen -- Animal models for viral hemorrhagic fevers / Kelly l. Warfield and Thomas W. Geisbert -- Botulinum toxins / Stephen B. Greenbaum, Jaime B. Anderson, and Frank J. Lebeda -- Ricin / Stephen B. Greenbaum and Jaime B. Anderson -- Staphylococcal and streptococcal superantigens : in vitro and in vivo assays / Teresa Krakauer and Bradley G. Stiles. |
| Record Nr. | UNINA-9910779058303321 |
| Boca Raton : , : CRC Press, , 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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