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Acute toxicology testing [[electronic resource] /] / Shayne C. Gad, Christopher P. Chengelis
| Acute toxicology testing [[electronic resource] /] / Shayne C. Gad, Christopher P. Chengelis |
| Autore | Gad Shayne C. <1948-> |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | San Diego, : Academic Press, c1998 |
| Descrizione fisica | 1 online resource (561 p.) |
| Disciplina | 615/.704/028 |
| Altri autori (Persone) | ChengelisChristopher P. <1949-> |
| Soggetto topico |
Alternative toxicity testing
Acute toxicity testing |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-03290-5
9786611032906 0-08-052592-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Acute Toxicology Testing; Copyright Page; Contents; Preface to the First Edition; Preface to the Second Edition; Chapter 1. Introduction; Questions of Relevance and Sensitivity; Defining Test Objectives; Display of Study Designs: The Line Chart; Theory and Use of Screens, Innovations, and Alternatives; References; Chapter 2. Acute Toxicology Program: Study Design and Development; Defining the Objective; Defining Exposure Potential; The Data Matrix; Test Selection and Design; Study Design; References; Chapter 3. Tests for Dermal Irritation and Corrosion
Primary Dermal Irritation TestDermal Corrosivity Test; Factors Affecting Responses and Test Outcome; Problems in Testing (and Their Resolutions); Design Alternatives and Innovations; In Vitro Alternatives; Percutaneous Absorption; Intracutaneous Reactivity (Irritation); Intracutaneous Test; References; Chapter 4. Ocular Irritation Testing; History of Ocular Irritation Testing; Current in Vivo Test Protocols; Ocular Irritation Test; 21-Day Eye Irritation Study in Rabbits; Adequacy of Current in Vivo Methods; Limitations of the Rabbit Eye Test; In Vivo vs in Vitro Tests; In Vitro Tests ReferencesChapter 5. Dermal Sensitization; Mechanisms; Objectives and General Features; History; Modified Buehler Procedure; Guinea Pig Maximization Test; Guinea Pig Split Adjuvant Test; Mouse Ear Swelling Test; Local Lymph Node Assay; Test System Manipulation (for all in Vivo Test Systems); Current Test Systems: Practical Problems and Solutions; References; Chapter 6. Photosensitization and Phototoxicity; Theory and Mechanisms; Factors Influencing Phototoxicity/Photosensitization; Predictive Tests for Phototoxicity; Guinea Pig; Mouse Ear Swelling Model; Alternative Designs: In Vivo Systems In Vitro Test SystemsReferences; Chapter 7. Lethality Testing; Historical Perspective; Protocol Designs; Alternatives to Lethality Testing; References; Chapter 8. Safety Considerations for the Administration of Agents by the Parenteral Routes; Parenteral Routes and Rates; Bolus vs Infusion; Test Systems for Parenteral Irritation; Alternatives; Pyrogenicity; Blood Compatibility; Vaginal Irritation; References; Chapter 9. Systemic Acute Toxicity Testing; Screens; Acute Systemic Toxicity Characterization; Acute Toxicity Testing with Nonrodent Species; Acute Mechanistic Studies; References Chapter 10. Routes, Formulations, and VehiclesMechanisms; Common Routes; Mechanisms of Absorption; Techniques; Gavage Procedure (Rat or Mouse); Volume Limitations by Route; Selection of Route; Vehicles and Formulation of Materials; Dosing Calculations; Comparisons and Contrasts of Routes; References; Chapter 11. Considerations Specific to Animal Test Models; Common Model Species and Their Characteristics; Cross-Species Extrapolation; Model Selection; Limitations of Models; Susceptibility Factors; Species Peculiarities; Considerations of Strain; Animal Care, Husbandry, and Welfare; References Chapter 12. Statistical Analysis of Acute Toxicology and Safety Studies |
| Record Nr. | UNINA-9910458377703321 |
Gad Shayne C. <1948->
|
||
| San Diego, : Academic Press, c1998 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Acute toxicology testing [[electronic resource] /] / Shayne C. Gad, Christopher P. Chengelis
| Acute toxicology testing [[electronic resource] /] / Shayne C. Gad, Christopher P. Chengelis |
| Autore | Gad Shayne C. <1948-> |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | San Diego, : Academic Press, c1998 |
| Descrizione fisica | 1 online resource (561 p.) |
| Disciplina | 615/.704/028 |
| Altri autori (Persone) | ChengelisChristopher P. <1949-> |
| Soggetto topico |
Alternative toxicity testing
Acute toxicity testing |
| ISBN |
1-281-03290-5
9786611032906 0-08-052592-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Acute Toxicology Testing; Copyright Page; Contents; Preface to the First Edition; Preface to the Second Edition; Chapter 1. Introduction; Questions of Relevance and Sensitivity; Defining Test Objectives; Display of Study Designs: The Line Chart; Theory and Use of Screens, Innovations, and Alternatives; References; Chapter 2. Acute Toxicology Program: Study Design and Development; Defining the Objective; Defining Exposure Potential; The Data Matrix; Test Selection and Design; Study Design; References; Chapter 3. Tests for Dermal Irritation and Corrosion
Primary Dermal Irritation TestDermal Corrosivity Test; Factors Affecting Responses and Test Outcome; Problems in Testing (and Their Resolutions); Design Alternatives and Innovations; In Vitro Alternatives; Percutaneous Absorption; Intracutaneous Reactivity (Irritation); Intracutaneous Test; References; Chapter 4. Ocular Irritation Testing; History of Ocular Irritation Testing; Current in Vivo Test Protocols; Ocular Irritation Test; 21-Day Eye Irritation Study in Rabbits; Adequacy of Current in Vivo Methods; Limitations of the Rabbit Eye Test; In Vivo vs in Vitro Tests; In Vitro Tests ReferencesChapter 5. Dermal Sensitization; Mechanisms; Objectives and General Features; History; Modified Buehler Procedure; Guinea Pig Maximization Test; Guinea Pig Split Adjuvant Test; Mouse Ear Swelling Test; Local Lymph Node Assay; Test System Manipulation (for all in Vivo Test Systems); Current Test Systems: Practical Problems and Solutions; References; Chapter 6. Photosensitization and Phototoxicity; Theory and Mechanisms; Factors Influencing Phototoxicity/Photosensitization; Predictive Tests for Phototoxicity; Guinea Pig; Mouse Ear Swelling Model; Alternative Designs: In Vivo Systems In Vitro Test SystemsReferences; Chapter 7. Lethality Testing; Historical Perspective; Protocol Designs; Alternatives to Lethality Testing; References; Chapter 8. Safety Considerations for the Administration of Agents by the Parenteral Routes; Parenteral Routes and Rates; Bolus vs Infusion; Test Systems for Parenteral Irritation; Alternatives; Pyrogenicity; Blood Compatibility; Vaginal Irritation; References; Chapter 9. Systemic Acute Toxicity Testing; Screens; Acute Systemic Toxicity Characterization; Acute Toxicity Testing with Nonrodent Species; Acute Mechanistic Studies; References Chapter 10. Routes, Formulations, and VehiclesMechanisms; Common Routes; Mechanisms of Absorption; Techniques; Gavage Procedure (Rat or Mouse); Volume Limitations by Route; Selection of Route; Vehicles and Formulation of Materials; Dosing Calculations; Comparisons and Contrasts of Routes; References; Chapter 11. Considerations Specific to Animal Test Models; Common Model Species and Their Characteristics; Cross-Species Extrapolation; Model Selection; Limitations of Models; Susceptibility Factors; Species Peculiarities; Considerations of Strain; Animal Care, Husbandry, and Welfare; References Chapter 12. Statistical Analysis of Acute Toxicology and Safety Studies |
| Record Nr. | UNINA-9910784636103321 |
|
Gad Shayne C. <1948->
|
||
| San Diego, : Academic Press, c1998 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Acute toxicology testing [[electronic resource] /] / Shayne C. Gad, Christopher P. Chengelis
| Acute toxicology testing [[electronic resource] /] / Shayne C. Gad, Christopher P. Chengelis |
| Autore | Gad Shayne C. <1948-> |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | San Diego, : Academic Press, c1998 |
| Descrizione fisica | 1 online resource (561 p.) |
| Disciplina | 615/.704/028 |
| Altri autori (Persone) | ChengelisChristopher P. <1949-> |
| Soggetto topico |
Alternative toxicity testing
Acute toxicity testing |
| ISBN |
1-281-03290-5
9786611032906 0-08-052592-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Acute Toxicology Testing; Copyright Page; Contents; Preface to the First Edition; Preface to the Second Edition; Chapter 1. Introduction; Questions of Relevance and Sensitivity; Defining Test Objectives; Display of Study Designs: The Line Chart; Theory and Use of Screens, Innovations, and Alternatives; References; Chapter 2. Acute Toxicology Program: Study Design and Development; Defining the Objective; Defining Exposure Potential; The Data Matrix; Test Selection and Design; Study Design; References; Chapter 3. Tests for Dermal Irritation and Corrosion
Primary Dermal Irritation TestDermal Corrosivity Test; Factors Affecting Responses and Test Outcome; Problems in Testing (and Their Resolutions); Design Alternatives and Innovations; In Vitro Alternatives; Percutaneous Absorption; Intracutaneous Reactivity (Irritation); Intracutaneous Test; References; Chapter 4. Ocular Irritation Testing; History of Ocular Irritation Testing; Current in Vivo Test Protocols; Ocular Irritation Test; 21-Day Eye Irritation Study in Rabbits; Adequacy of Current in Vivo Methods; Limitations of the Rabbit Eye Test; In Vivo vs in Vitro Tests; In Vitro Tests ReferencesChapter 5. Dermal Sensitization; Mechanisms; Objectives and General Features; History; Modified Buehler Procedure; Guinea Pig Maximization Test; Guinea Pig Split Adjuvant Test; Mouse Ear Swelling Test; Local Lymph Node Assay; Test System Manipulation (for all in Vivo Test Systems); Current Test Systems: Practical Problems and Solutions; References; Chapter 6. Photosensitization and Phototoxicity; Theory and Mechanisms; Factors Influencing Phototoxicity/Photosensitization; Predictive Tests for Phototoxicity; Guinea Pig; Mouse Ear Swelling Model; Alternative Designs: In Vivo Systems In Vitro Test SystemsReferences; Chapter 7. Lethality Testing; Historical Perspective; Protocol Designs; Alternatives to Lethality Testing; References; Chapter 8. Safety Considerations for the Administration of Agents by the Parenteral Routes; Parenteral Routes and Rates; Bolus vs Infusion; Test Systems for Parenteral Irritation; Alternatives; Pyrogenicity; Blood Compatibility; Vaginal Irritation; References; Chapter 9. Systemic Acute Toxicity Testing; Screens; Acute Systemic Toxicity Characterization; Acute Toxicity Testing with Nonrodent Species; Acute Mechanistic Studies; References Chapter 10. Routes, Formulations, and VehiclesMechanisms; Common Routes; Mechanisms of Absorption; Techniques; Gavage Procedure (Rat or Mouse); Volume Limitations by Route; Selection of Route; Vehicles and Formulation of Materials; Dosing Calculations; Comparisons and Contrasts of Routes; References; Chapter 11. Considerations Specific to Animal Test Models; Common Model Species and Their Characteristics; Cross-Species Extrapolation; Model Selection; Limitations of Models; Susceptibility Factors; Species Peculiarities; Considerations of Strain; Animal Care, Husbandry, and Welfare; References Chapter 12. Statistical Analysis of Acute Toxicology and Safety Studies |
| Record Nr. | UNINA-9910823152203321 |
|
Gad Shayne C. <1948->
|
||
| San Diego, : Academic Press, c1998 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Doubts, Problems and Certainties about Acute Appendicitis / / edited by Angelo Guttadauro
| Doubts, Problems and Certainties about Acute Appendicitis / / edited by Angelo Guttadauro |
| Pubbl/distr/stampa | London : , : IntechOpen, , 2022 |
| Descrizione fisica | 1 online resource (106 pages) : illustrations |
| Disciplina | 615.9 |
| Soggetto topico | Acute toxicity testing |
| ISBN | 1-83968-856-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910586664003321 |
| London : , : IntechOpen, , 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Doubts, Problems and Certainties about Acute Appendicitis / / edited by Angelo Guttadauro
| Doubts, Problems and Certainties about Acute Appendicitis / / edited by Angelo Guttadauro |
| Pubbl/distr/stampa | London : , : IntechOpen, , 2022 |
| Descrizione fisica | 1 online resource (xiii, 106 pages) : illustrations |
| Disciplina | 616.34 |
| Soggetto topico |
Acute toxicity testing
Gastroenterology Appendicitis |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910688359003321 |
| London : , : IntechOpen, , 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
