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Calculating the secrets of life : applications of the mathematical sciences in molecular biology / / Eric S. Lander and Michael S. Waterman, editors
| Calculating the secrets of life : applications of the mathematical sciences in molecular biology / / Eric S. Lander and Michael S. Waterman, editors |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1995 |
| Descrizione fisica | 1 online resource (299 p.) |
| Disciplina | 574.8/8/0151 |
| Altri autori (Persone) |
LanderEric S
WatermanMichael S |
| Soggetto topico |
Genetics - Mathematical models
Genetics - Statistical methods Molecular biology - Mathematical models Molecular biology - Statistical methods |
| ISBN |
9786610211388
9781280211386 1280211385 9780309556163 0309556163 9780585037233 058503723X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Calculating the Secrets of Life -- Copyright -- Preface -- Contents -- Calculating the Secrets of Life -- Chapter 1 The Secrets of Life: A Mathematician's Introduction to Molecular Biology -- BIOCHEMISTRY -- CLASSICAL GENETICS -- MOLECULAR BIOLOGY -- THE RECOMBINANT DNA REVOLUTION -- MOLECULAR GENETICS IN THE 1990S -- THE HUMAN GENOME PROJECT -- COMING ATTRACTIONS -- REFERENCES -- Chapter 2 Mapping Heredity: Using Probabilistic Models and Algorithms to Map Genes and Genomes -- GENETIC MAPPING -- The Concept of Genetic Maps -- Challenges of Genetic Mapping: Human Families and Complex Traits -- MAXIMUM LIKELIHOOD ESTIMATION -- Efficient Algorithms -- Statistical Significance -- Excursion: Susceptibility to Colon Cancer in Mice and the Large Deviation Theory of Diffusion Processes -- PHYSICAL MAPPING -- Assembling Physical Maps by "Fingerprinting" Random Clones -- Excursion: Designing a Strategy to Map the Human Genome -- CONCLUSION -- REFERENCES -- Chapter 3 Seeing Conserved Signals: Using Algorithms to Detect Similarities between Biosequences -- FINDING GLOBAL SIMILARITIES -- Visualizing Alignments: Edit Graphs -- The Basic Dynamic Programming Algorithm -- FINDING LOCAL SIMILARITIES -- VARIATIONS ON SEQUENCE COMPARISON -- Variations in Gap Cost Penalties -- The Duality Between Similarity and Difference Measures -- Aligning More Than Two Sequences at a Time -- K-Best Alignments -- Approximate Pattern Matching -- Parallel Computing -- COMPARING ONE SEQUENCE AGAINST A DATABASE -- Heuristic Algorithms -- Sublinear Similarity Searches -- OPEN PROBLEMS -- REFERENCES -- Chapter 4 Hearing Distant Echoes: Using Extremal Statistics to Probe Evolutionary Origins -- GLOBAL SEQUENCE COMPARISONS -- Sequence Alignment -- Alignment Given -- Alignment Unknown -- LOCAL SEQUENCE COMPARISONS -- Alignment Given -- Alignment Unknown -- APPLICATION TO RNA EVOLUTION.
TWO BEHAVIORS SUFFICE -- RNA EVOLUTION REVISITED -- REFERENCES -- Chapter 5 Calibrating the Clock: Using Stochastic Processes to Measure the Rate of Evolution -- OVERVIEW -- THE COALESCENT AND MUTATION -- The Ewens Sampling Formula -- Forwards and Backwards in the Tree -- Top-down -- Bottom-up -- The Infinitely-Many-Sites Model -- K-Allele Models -- The Finitely-Many-Sites Models -- MATHEMATICAL VIGNETTE: APPROXIMATING COMBINATORIAL STRUCTURES -- Approximations for the Ewens Sampling Formula -- Combinatorial Assemblies -- Other Combinatorial Structures -- The Large Components -- WHERE TO NEXT? -- Likelihood Methods -- Discussion -- REFERENCES -- General-Purpose References -- Detailed References -- Chapter 6 Winding the Double Helix: Using Geometry, Topology, and Mechanics of DNA -- DNA GEOMETRY AND TOPOLOGY: LINKING, TWISTING, AND WRITHING -- APPLICATIONS TO DNA TOPOISOMERASE REACTIONS -- DNA ON PROTEIN COMPLEXES -- THE SURFACE LINKING NUMBER -- THE WINDING NUMBER AND HELICAL REPEAT -- RELATIONSHIP BETWEEN LINKING, SURFACE LINKING, AND WINDING -- APPLICATION TO THE STUDY OF THE MINICHROMOSOME -- REFERENCES -- Chapter 7 Unwinding the Double Helix: Using Differential Mechanics to Probe Conformational Changes... -- DNA SUPERHELICITY-MATHEMATICS AND BIOLOGY -- STATEMENT OF THE PROBLEM -- THE ENERGETICS OF A STATE -- ANALYSIS OF SUPERHELICAL EQUILIBRIA -- Evaluation of Free-Energy Parameters -- Accuracy of the Calculated Results -- APPLYING THE METHOD TO STUDY INTERESTING GENES -- DISCUSSION AND OPEN PROBLEMS -- REFERENCES -- Chapter 8 Lifting the Curtain: Using Topology to Probe the Hidden Action of Enzymes -- THE TOPOLOGY OF DNA -- SITE-SPECIFIC RECOMBINATION -- TOPOLOGICAL TOOLS FOR DNA ANALYSIS -- THE TANGLE MODEL FOR SITE-SPECIFIC RECOMBINATION -- THE TOPOLOGY OF TN3 RESOLVASE -- SOME UNSOLVED PROBLEMS -- ANNOTATED BIBLIOGRAPHY -- Knot Theory. Application of Geometry and Topology to Biology -- REFERENCES -- Chapter 9 Folding the Sheets: Using Computational Methods to Predict the Structure of Proteins -- A PRIMER ON PROTEIN STRUCTURE -- BASIC INSIGHTS ABOUT PROTEIN STRUCTURE -- THREADING METHODS -- PREDICTING HIV PROTEASE STRUCTURE:AN EXCURSION -- HIERARCHICAL APPROACHES -- PREDICTING MYOGLOBIN STRUCTURE:AN EXCURSION -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Appendix-Chapter Authors -- Index. |
| Altri titoli varianti | Life |
| Record Nr. | UNINA-9910957259103321 |
| Washington, D.C., : National Academy Press, 1995 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
IUBMB life
| IUBMB life |
| Pubbl/distr/stampa | Philadelphia, PA, : Taylor & Francis, Inc., ©1999- |
| Disciplina | 572 |
| Soggetto topico |
Biochemistry
Molecular biology Histology Molecular Biology |
| Soggetto genere / forma | Periodicals. |
| Soggetto non controllato | Animal Biochemistry |
| ISSN | 1521-6551 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
International Union of Biochemistry and Molecular Biology life
Life |
| Record Nr. | UNISA-996213430603316 |
| Philadelphia, PA, : Taylor & Francis, Inc., ©1999- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
IUBMB life
| IUBMB life |
| Pubbl/distr/stampa | Philadelphia, PA, : Taylor & Francis, Inc., ©1999- |
| Disciplina | 572 |
| Soggetto topico |
Biochemistry
Molecular biology Histology Molecular Biology |
| Soggetto genere / forma | Periodicals. |
| ISSN | 1521-6551 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
International Union of Biochemistry and Molecular Biology life
Life |
| Record Nr. | UNINA-9910132890603321 |
| Philadelphia, PA, : Taylor & Francis, Inc., ©1999- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Life : das Magazin für die ETH-Community / ETH Zürich
| Life : das Magazin für die ETH-Community / ETH Zürich |
| Pubbl/distr/stampa | Zürich, : ETH, 2013- |
| Descrizione fisica | Online-Ressource |
| Disciplina | 370 |
| Soggetto genere / forma | Zeitschrift |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | ger |
| Altri titoli varianti | Life |
| Record Nr. | UNINA-9910747601103321 |
| Zürich, : ETH, 2013- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Life: the excitement of biology
| Life: the excitement of biology |
| Pubbl/distr/stampa | [York, Pa.] : , : Blay Publishers LLC, , 2013- |
| Disciplina | 570 |
| ISSN | 2325-0828 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
Life
LEB |
| Record Nr. | UNINA-9910139243503321 |
| [York, Pa.] : , : Blay Publishers LLC, , 2013- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||