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A handbook of alkaloids and alkaloid-containing plants
| A handbook of alkaloids and alkaloid-containing plants |
| Autore | Raffauf, Robert F. |
| Pubbl/distr/stampa | New York : Wiley-interscience, copyr. 1970 |
| Descrizione fisica | 1 v. 23 cm |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ita |
| Record Nr. | UNINA-990002212420403321 |
Raffauf, Robert F.
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| New York : Wiley-interscience, copyr. 1970 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Biochemical applications of mass spectrometry : first supplementary volume / edited by George R. Waller, Otis C. Dermer
| Biochemical applications of mass spectrometry : first supplementary volume / edited by George R. Waller, Otis C. Dermer |
| Pubbl/distr/stampa | New York : Wiley-interscience, 1980- |
| Descrizione fisica | xvii, 1279 p. : ill. ; 28 cm |
| Disciplina | 574.1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-990002220040403321 |
| New York : Wiley-interscience, 1980- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Categorical Data Analysis / Alan Agresti
| Categorical Data Analysis / Alan Agresti |
| Autore | Agresti, Alan |
| Edizione | [3. ed] |
| Pubbl/distr/stampa | New York : Wiley-interscience, 2013 |
| Descrizione fisica | XI, 714 p. : ill. ; 24 cm. |
| Soggetto topico | Analisi dei dati - Metodi statistici |
| ISBN | 978-04-7046-363-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNICAMPANIA-SUN0102602 |
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Agresti, Alan
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| New York : Wiley-interscience, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Vanvitelli | ||
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Categorical Data Analysis / Alan Agresti
| Categorical Data Analysis / Alan Agresti |
| Autore | Agresti, Alan |
| Edizione | [3. ed] |
| Pubbl/distr/stampa | Hobocken, NJ, : Wiley-interscience, 2013 |
| Descrizione fisica | XVI, 714 p. : 24 cm. |
| Disciplina | 519.535 |
| Collana | Wiley series in probability and statistics |
| Soggetto topico | Dati categorici - Analisi statistica |
| ISBN | 9780470463635 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Titolo uniforme | |
| Record Nr. | UNISANNIO-PUV1363506 |
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Agresti, Alan
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| Hobocken, NJ, : Wiley-interscience, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. del Sannio | ||
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Chemical reactor design and control / William L. Luyben
| Chemical reactor design and control / William L. Luyben |
| Autore | LUYBEN, William L. |
| Pubbl/distr/stampa | Hoboken : Wiley-interscience, copyr. 2007 |
| Descrizione fisica | XVI, 419 p. ; 24 cm |
| Disciplina | 600.2832 |
| Soggetto topico | Reattori chimici - Costruzione [e] disegno* - BNCF |
| ISBN | 978-0-470-09770-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-990003092160203316 |
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LUYBEN, William L.
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| Hoboken : Wiley-interscience, copyr. 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Creating more effective graphs / Naomi B. Robbins
| Creating more effective graphs / Naomi B. Robbins |
| Autore | ROBBINS, Naomi B. |
| Pubbl/distr/stampa | Hoboken ( (NJ), : Wiley-interscience, 2005 |
| Descrizione fisica | XVIII, 402 p. ; 23 cm. |
| Disciplina | 519.5(Statistica matematica) |
| Soggetto topico | STATISTICA - Metodologia |
| ISBN | 04-7127-402-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNIOR-UON00273621 |
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ROBBINS, Naomi B.
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| Hoboken ( (NJ), : Wiley-interscience, 2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. L'Orientale | ||
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Design methods : seeds of human futures / J. Christopher Jones. -
| Design methods : seeds of human futures / J. Christopher Jones. - |
| Autore | Jones, Christopher J. |
| Pubbl/distr/stampa | London : Wiley-interscience, copyr.1970 |
| Descrizione fisica | xiii, 407 p. : ill. ; 23 cm |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ita |
| Record Nr. | UNINA-990000672670403321 |
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Jones, Christopher J.
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| London : Wiley-interscience, copyr.1970 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Digital image processing / William K. Pratt
| Digital image processing / William K. Pratt |
| Autore | Pratt, William K. |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | New York : Wiley-interscience, ©1991 |
| Descrizione fisica | 698 p. : ill. ; 24 cm |
| Disciplina | 621.36'7 |
| Soggetto non controllato | Elaborazione delle immagini |
| ISBN | 0-471-85766-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-990000520140403321 |
| Pratt, William K. | ||
| New York : Wiley-interscience, ©1991 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Drug-drug interactions in pharmaceutical development [[electronic resource] /] / edited by Albert P. Li
| Drug-drug interactions in pharmaceutical development [[electronic resource] /] / edited by Albert P. Li |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-interscience, c2008 |
| Descrizione fisica | 1 online resource (261 p.) |
| Disciplina |
615.7045
615/.7045 |
| Altri autori (Persone) | LiA. P |
| Collana | Wiley series in drug discovery and development |
| Soggetto topico |
Drug interactions
Drug development |
| ISBN |
1-282-02206-7
9786612022067 0-470-18792-1 0-470-18791-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DRUG-DRUG INTERACTIONS IN PHARMACEUTICAL DEVELOPMENT; CONTENTS; Preface; Contributors; 1 In Vitro Evaluation of Metabolic Drug-Drug Interactions: Concepts and Practice; 1.1 Introduction; 1.2 Mechanisms of Adverse Drug-Drug Interactions; 1.2.1 Pharmacological Interactions; 1.2.2 Pharmacokinetic Interactions; 1.3 Drug Metabolism; 1.3.1 Phase I Oxidation; 1.3.2 Phase II Conjugation; 1.4 CYP Isoforms; 1.5 Human In Vitro Experimental Systems for Drug Metabolism; 1.5.1 Hepatocytes; 1.5.2 Liver Postmitochondrial Supernatant (PMS); 1.5.3 Human Liver Microsomes; 1.5.4 Recombinant P450 Isoforms (rCYP)
1.5.5 Cytosol1.6 Mechanisms of Metabolic Drug-Drug Interactions; 1.7 Mechanism-Based Approach for Evaluation of Drug-Drug Interaction Potential; 1.7.1 Metabolic Phenotyping; 1.7.2 Evaluation of Inhibitory Potential for Drug-Metabolizing Enzymes; 1.7.3 Induction Potential for Drug-Metabolizing Enzymes; 1.8 Experimental Approaches for In Vitro Evaluation of Drug-Drug Interaction Potential; 1.8.1 Study 1: Metabolic Phenotyping 1-Metabolite Identification; 1.8.2 Study 2: Metabolic Phenotyping 2-Identification of Major Metabolic Pathways 1.8.3 Study 3: Metabolic Phenotyping 3-Identification of P450 Isoform Pathways (P450 Phenotyping)1.8.4 Study 4: CYP Inhibitory Potential; 1.8.5 Study 5: Enzyme Induction Potential; 1.8.6 Study 6: In Vitro Empirical Drug-Drug Interactions; 1.9 Data Interpretation; 1.9.1 Pathway Evaluation; 1.9.2 P450 Inhibition; 1.9.3 P450 Induction; 1.10 Conclusion; References; 2 In Vitro Approaches to Anticipating Clinical Drug Interactions; 2.1 In Vitro Systems for Human CYP450 Metabolism; 2.1.1 Incubation Buffer (pH and Ionic Strength); 2.1.2 MgCl(2) and Cytochrome b(5); 2.1.3 Nonspecific Binding 2.1.4 Organic Solvents and Excipients2.2 Analysis of Data from In Vitro Systems; 2.2.1 Linear Transformation of Michaelis-Menten Equation (Lineweaver-Burk and Eadie-Hofstee); 2.2.2 Nonlinear Regression Analysis of Hyperbolic Kinetic Data; 2.2.3 Consideration of Non-Michaelis-Menten Kinetics; 2.3 Use of In Vitro Kinetic Data to Predict In Vivo Clearance; 2.3.1 Calculation of In Vitro (Predicted) Hepatic Clearance; 2.3.2 Comparison of In Vitro (Predicted) with In Vivo Hepatic Clearance; 2.4 Use of In Vitro Kinetic Data to Predict Drug-Drug Interactions 2.4.1 Choice of Probe Substrates for Inhibition Studies2.4.2 Determining the Mechanism of CYP450 Inhibition; 2.4.3 Prediction of In Vivo Drug-Drug Inhibition Interactions from In Vitro Data; 2.5 Consideration of Non-CYP Enzymatic Systems; 2.5.1 Flavin-Containing Monooxygenase (FMO); 2.5.2 UDP-glucuronosyltransferase (UGT); 2.5.3 Sulfotransferase (SULT); 2.5.4 N-Acetyltransferase (NAT); 2.5.5 Methyltransferase; 2.5.6 Epoxidase Hydrolase; 2.5.7 Aldehyde Oxidase and Dehydrogenase; 2.5.8 Glutathione-S-transferase (GST); 2.6 Summary; 2.7 Acknowledgments; References 3 Inhibition of Drug-Metabolizing Enzymes and Drug-Drug Interactions in Drug Discovery and Development |
| Record Nr. | UNINA-9910143982103321 |
| Hoboken, N.J., : Wiley-interscience, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Drug-drug interactions in pharmaceutical development / / edited by Albert P. Li
| Drug-drug interactions in pharmaceutical development / / edited by Albert P. Li |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-interscience, c2008 |
| Descrizione fisica | 1 online resource (261 p.) |
| Disciplina |
615.7045
615/.7045 |
| Altri autori (Persone) | LiA. P |
| Collana | Wiley series in drug discovery and development |
| Soggetto topico |
Drug interactions
Drug development |
| ISBN |
1-282-02206-7
9786612022067 0-470-18792-1 0-470-18791-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DRUG-DRUG INTERACTIONS IN PHARMACEUTICAL DEVELOPMENT; CONTENTS; Preface; Contributors; 1 In Vitro Evaluation of Metabolic Drug-Drug Interactions: Concepts and Practice; 1.1 Introduction; 1.2 Mechanisms of Adverse Drug-Drug Interactions; 1.2.1 Pharmacological Interactions; 1.2.2 Pharmacokinetic Interactions; 1.3 Drug Metabolism; 1.3.1 Phase I Oxidation; 1.3.2 Phase II Conjugation; 1.4 CYP Isoforms; 1.5 Human In Vitro Experimental Systems for Drug Metabolism; 1.5.1 Hepatocytes; 1.5.2 Liver Postmitochondrial Supernatant (PMS); 1.5.3 Human Liver Microsomes; 1.5.4 Recombinant P450 Isoforms (rCYP)
1.5.5 Cytosol1.6 Mechanisms of Metabolic Drug-Drug Interactions; 1.7 Mechanism-Based Approach for Evaluation of Drug-Drug Interaction Potential; 1.7.1 Metabolic Phenotyping; 1.7.2 Evaluation of Inhibitory Potential for Drug-Metabolizing Enzymes; 1.7.3 Induction Potential for Drug-Metabolizing Enzymes; 1.8 Experimental Approaches for In Vitro Evaluation of Drug-Drug Interaction Potential; 1.8.1 Study 1: Metabolic Phenotyping 1-Metabolite Identification; 1.8.2 Study 2: Metabolic Phenotyping 2-Identification of Major Metabolic Pathways 1.8.3 Study 3: Metabolic Phenotyping 3-Identification of P450 Isoform Pathways (P450 Phenotyping)1.8.4 Study 4: CYP Inhibitory Potential; 1.8.5 Study 5: Enzyme Induction Potential; 1.8.6 Study 6: In Vitro Empirical Drug-Drug Interactions; 1.9 Data Interpretation; 1.9.1 Pathway Evaluation; 1.9.2 P450 Inhibition; 1.9.3 P450 Induction; 1.10 Conclusion; References; 2 In Vitro Approaches to Anticipating Clinical Drug Interactions; 2.1 In Vitro Systems for Human CYP450 Metabolism; 2.1.1 Incubation Buffer (pH and Ionic Strength); 2.1.2 MgCl(2) and Cytochrome b(5); 2.1.3 Nonspecific Binding 2.1.4 Organic Solvents and Excipients2.2 Analysis of Data from In Vitro Systems; 2.2.1 Linear Transformation of Michaelis-Menten Equation (Lineweaver-Burk and Eadie-Hofstee); 2.2.2 Nonlinear Regression Analysis of Hyperbolic Kinetic Data; 2.2.3 Consideration of Non-Michaelis-Menten Kinetics; 2.3 Use of In Vitro Kinetic Data to Predict In Vivo Clearance; 2.3.1 Calculation of In Vitro (Predicted) Hepatic Clearance; 2.3.2 Comparison of In Vitro (Predicted) with In Vivo Hepatic Clearance; 2.4 Use of In Vitro Kinetic Data to Predict Drug-Drug Interactions 2.4.1 Choice of Probe Substrates for Inhibition Studies2.4.2 Determining the Mechanism of CYP450 Inhibition; 2.4.3 Prediction of In Vivo Drug-Drug Inhibition Interactions from In Vitro Data; 2.5 Consideration of Non-CYP Enzymatic Systems; 2.5.1 Flavin-Containing Monooxygenase (FMO); 2.5.2 UDP-glucuronosyltransferase (UGT); 2.5.3 Sulfotransferase (SULT); 2.5.4 N-Acetyltransferase (NAT); 2.5.5 Methyltransferase; 2.5.6 Epoxidase Hydrolase; 2.5.7 Aldehyde Oxidase and Dehydrogenase; 2.5.8 Glutathione-S-transferase (GST); 2.6 Summary; 2.7 Acknowledgments; References 3 Inhibition of Drug-Metabolizing Enzymes and Drug-Drug Interactions in Drug Discovery and Development |
| Record Nr. | UNINA-9910818381003321 |
| Hoboken, N.J., : Wiley-interscience, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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