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Advanced therapeutics
| Advanced therapeutics |
| Pubbl/distr/stampa | Weinheim : , : WILEY-VCH Verlag GmbH & Co. KGaA, , [2018]- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Therapeutics
Nanomedicine Pharmacological Phenomena |
| Soggetto genere / forma |
Periodical
Periodicals. |
| ISSN | 2366-3987 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996326243203316 |
| Weinheim : , : WILEY-VCH Verlag GmbH & Co. KGaA, , [2018]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Advanced therapeutics
| Advanced therapeutics |
| Pubbl/distr/stampa | Weinheim : , : WILEY-VCH Verlag GmbH & Co. KGaA, , [2018]- |
| Descrizione fisica | 1 online resource |
| Soggetto topico |
Therapeutics
Nanomedicine Pharmacological Phenomena Farmacologia Medicina |
| Soggetto genere / forma |
Periodical
Periodicals. Revistes electròniques. |
| ISSN | 2366-3987 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910329440303321 |
| Weinheim : , : WILEY-VCH Verlag GmbH & Co. KGaA, , [2018]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Analytische Chemie : grundlagen, Methoden und praxis / / Georg Schwedt, Torsten C. Schmidt, Oliver J. Schmitz
| Analytische Chemie : grundlagen, Methoden und praxis / / Georg Schwedt, Torsten C. Schmidt, Oliver J. Schmitz |
| Autore | Schwedt Georg |
| Edizione | [Dritte, überarbeitete und aktualisierte Auflage.] |
| Pubbl/distr/stampa | Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2017 |
| Descrizione fisica | 1 online resource (563 pages) : color illustrations |
| Disciplina | 543 |
| Collana | Leadership und Angewandte Psychologie |
| Soggetto topico | Chemistry, Analytic |
| ISBN | 3-527-69877-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ger |
| Record Nr. | UNINA-9910155273903321 |
Schwedt Georg
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| Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Anomalous transport : foundations and applications / / edited by Rainer Klages, Günter Radons, and Igor M. Sokolov
| Anomalous transport : foundations and applications / / edited by Rainer Klages, Günter Radons, and Igor M. Sokolov |
| Pubbl/distr/stampa | Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 |
| Descrizione fisica | 1 online resource (610 p.) |
| Disciplina | 530.44 |
| Soggetto topico |
Plasma turbulence
Transport theory |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-94708-3
9786611947088 3-527-62297-7 3-527-62298-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Anomalous Transport; Contents; Preface; List of Contributors; 1 In Memoriam: Radu Balescu; 1.1 Radu Balescu's Abstract for the Conference on Anomalous Transport in Bad Honnef; 1.2 The Scientific Career of Radu Balescu by Boris Weyssow; 1.3 My Memory of Radu Balescu by Angelo Vulpiani; 1.4 My Memory of Radu Balescu by Francesco Mainardi; 1.5 In Memoriam: Radu Balescu by Raul Sánchez; 1.6 Remembering Radu Balescu by Diego del-Castillo-Negrete; References; Part I Fractional Calculus and Stochastic Theory; Introduction to Part I; 2 Threefold Introduction to Fractional Derivatives
2.1 Historical Introduction to Fractional Derivatives2.1.1 Leibniz; 2.1.2 Euler; 2.1.3 Paradoxa and Problems; 2.1.4 Liouville; 2.1.5 Fourier; 2.1.6 Grünwald; 2.1.7 Riemann; 2.2 Mathematical Introduction to Fractional Derivatives; 2.2.1 Fractional Integrals; 2.2.2 Fractional Derivatives; 2.2.3 Eigenfunctions; 2.3 Physical Introduction to Fractional Derivatives; 2.3.1 Basic Questions; 2.3.2 Fractional Space; 2.3.3 Fractional Time; 2.3.4 Identification of α from Models; Appendix A: Tables; Appendix B: Function Spaces; Appendix C: Distributions; References 3 Random Processes with Infinite Moments3.1 St. Petersburg Paradox; 3.2 Holtsmark Distribution; 3.3 Activated Hopping; 3.4 Deterministic Examples of Long Tail Distributions; 3.5 RandomWalks and Master Equations; 3.6 RandomWalks and Upper Critical Dimensions; 3.7 Weierstrass Random Walk; 3.8 Fractal Time Random Walk; 3.9 Coupled Memory Random Walks: Diffusion or Telegraph Equation; 3.10 Random Walks: Coupled Memory Lévy Walks: Turbulent and Relativistic; References; 4 Continuous Time Random Walk, Mittag-Leffler Waiting Time and Fractional Diffusion: Mathematical Aspects; 4.1 Introduction 4.2 An Outline of the Gnedenko-Kovalenko Theory of Thinning4.3 The Continuous Time Random Walk (CTRW); 4.4 Manipulations: Rescaling and Respeeding; 4.5 Power Laws and Asymptotic Universality of the Mittag-Leffler Waiting-Time Density; 4.6 Passage to the Diffusion Limit in Space; 4.7 The Time-Fractional Drift Process; 4.8 Conclusions; Appendix A: The Time-Fractional Derivatives; Appendix B: The Space-Fractional Derivatives; Appendix C: The Mittag-Leffler Function; References; 5 Introduction to the Theory of Lévy Flights; 5.1 Lévy Stable Distributions; 5.2 Underlying Random Walk Processes 5.3 Space Fractional Fokker-Planck Equation5.4 Free Lévy Flights in the Semi-Infinite Domain; 5.4.1 First Passage Time and Leapover Properties; 5.4.2 Lévy Flights and the Method of Images; 5.5 Lévy Flights in External Fields; 5.5.1 Reminder: Stationary Solution of the Fokker-Planck Equation, α = 2; 5.5.2 Lévy Flights in an Harmonic Potential; 5.5.3 Lévy Flights in a Quartic Potential, 1 < 2; 5.5.4 Lévy Flights in a More General Potential Well; 5.5.5 Kramers Problem for Lévy Flights; 5.6 Lévy Flights in Phase Space; 5.6.1 Langevin Description; 5.6.2 Velocity-Fractional Klein-Kramers Equation 5.6.3 Space-Homogeneous Relaxation in Absence of External Field |
| Record Nr. | UNINA-9910144118503321 |
| Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Anomalous transport : foundations and applications / / edited by Rainer Klages, Günter Radons, and Igor M. Sokolov
| Anomalous transport : foundations and applications / / edited by Rainer Klages, Günter Radons, and Igor M. Sokolov |
| Pubbl/distr/stampa | Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 |
| Descrizione fisica | 1 online resource (610 p.) |
| Disciplina | 530.44 |
| Soggetto topico |
Plasma turbulence
Transport theory |
| ISBN |
1-281-94708-3
9786611947088 3-527-62297-7 3-527-62298-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Anomalous Transport; Contents; Preface; List of Contributors; 1 In Memoriam: Radu Balescu; 1.1 Radu Balescu's Abstract for the Conference on Anomalous Transport in Bad Honnef; 1.2 The Scientific Career of Radu Balescu by Boris Weyssow; 1.3 My Memory of Radu Balescu by Angelo Vulpiani; 1.4 My Memory of Radu Balescu by Francesco Mainardi; 1.5 In Memoriam: Radu Balescu by Raul Sánchez; 1.6 Remembering Radu Balescu by Diego del-Castillo-Negrete; References; Part I Fractional Calculus and Stochastic Theory; Introduction to Part I; 2 Threefold Introduction to Fractional Derivatives
2.1 Historical Introduction to Fractional Derivatives2.1.1 Leibniz; 2.1.2 Euler; 2.1.3 Paradoxa and Problems; 2.1.4 Liouville; 2.1.5 Fourier; 2.1.6 Grünwald; 2.1.7 Riemann; 2.2 Mathematical Introduction to Fractional Derivatives; 2.2.1 Fractional Integrals; 2.2.2 Fractional Derivatives; 2.2.3 Eigenfunctions; 2.3 Physical Introduction to Fractional Derivatives; 2.3.1 Basic Questions; 2.3.2 Fractional Space; 2.3.3 Fractional Time; 2.3.4 Identification of α from Models; Appendix A: Tables; Appendix B: Function Spaces; Appendix C: Distributions; References 3 Random Processes with Infinite Moments3.1 St. Petersburg Paradox; 3.2 Holtsmark Distribution; 3.3 Activated Hopping; 3.4 Deterministic Examples of Long Tail Distributions; 3.5 RandomWalks and Master Equations; 3.6 RandomWalks and Upper Critical Dimensions; 3.7 Weierstrass Random Walk; 3.8 Fractal Time Random Walk; 3.9 Coupled Memory Random Walks: Diffusion or Telegraph Equation; 3.10 Random Walks: Coupled Memory Lévy Walks: Turbulent and Relativistic; References; 4 Continuous Time Random Walk, Mittag-Leffler Waiting Time and Fractional Diffusion: Mathematical Aspects; 4.1 Introduction 4.2 An Outline of the Gnedenko-Kovalenko Theory of Thinning4.3 The Continuous Time Random Walk (CTRW); 4.4 Manipulations: Rescaling and Respeeding; 4.5 Power Laws and Asymptotic Universality of the Mittag-Leffler Waiting-Time Density; 4.6 Passage to the Diffusion Limit in Space; 4.7 The Time-Fractional Drift Process; 4.8 Conclusions; Appendix A: The Time-Fractional Derivatives; Appendix B: The Space-Fractional Derivatives; Appendix C: The Mittag-Leffler Function; References; 5 Introduction to the Theory of Lévy Flights; 5.1 Lévy Stable Distributions; 5.2 Underlying Random Walk Processes 5.3 Space Fractional Fokker-Planck Equation5.4 Free Lévy Flights in the Semi-Infinite Domain; 5.4.1 First Passage Time and Leapover Properties; 5.4.2 Lévy Flights and the Method of Images; 5.5 Lévy Flights in External Fields; 5.5.1 Reminder: Stationary Solution of the Fokker-Planck Equation, α = 2; 5.5.2 Lévy Flights in an Harmonic Potential; 5.5.3 Lévy Flights in a Quartic Potential, 1 < 2; 5.5.4 Lévy Flights in a More General Potential Well; 5.5.5 Kramers Problem for Lévy Flights; 5.6 Lévy Flights in Phase Space; 5.6.1 Langevin Description; 5.6.2 Velocity-Fractional Klein-Kramers Equation 5.6.3 Space-Homogeneous Relaxation in Absence of External Field |
| Record Nr. | UNINA-9910830711703321 |
| Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Asymmetric organic synthesis with enzymes / / edited by Vicente Gotor, Ignacio Alfonso, and Eduardo García-Urdiales
| Asymmetric organic synthesis with enzymes / / edited by Vicente Gotor, Ignacio Alfonso, and Eduardo García-Urdiales |
| Pubbl/distr/stampa | Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 |
| Descrizione fisica | 1 online resource (341 p.) |
| Disciplina | 572.745 |
| Soggetto topico |
Enzymes - Synthesis
Asymmetric synthesis Organic compounds - Synthesis |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-94689-3
9786611946890 3-527-62248-9 3-527-62249-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Asymmetric Organic Synthesis with Enzymes; Contents; Preface; List of Contributors; I Methodology; 1 Medium Engineering; 1.1 Introduction; 1.2 Modulation of Enzyme Enantioselectivity by Medium Engineering; 1.2.1 Selectivity Enhancement by Addition of Water-Miscible Organic Cosolvents; 1.2.2 Selectivity Enhancement in Organic Media with Low Water Activity; 1.2.2.1 Organic Solvent Systems; 1.2.2.2 Enzyme Properties in Organic Solvents; 1.2.2.3 Medium Engineering; 1.2.3 Rationales; 1.2.4 Modulation of Enzyme Selectivity: New Trends of Research; 1.2.4.1 Ionic Liquids; 1.2.4.2 Additives
1.3 Conclusions and OutlooksReferences; 2 Directed Evolution as a Means to Engineer Enantioselective Enzymes; 2.1 Introduction; 2.2 Molecular Biological Methods for Mutagenesis; 2.3 High-throughput Screening Methods for Enantioselectivity; 2.4 Examples of Enhancing the Enantioselectivity of Enzymes by Directed Evolution; 2.4.1 Lipase from Pseudomonas aeruginosa (PAL); 2.4.2 Other Lipases; 2.4.3 Esterases; 2.4.4 Hydantoinases; 2.4.5 Nitrilases; 2.4.6 Epoxide Hydrolases; 2.4.7 Phosphotriesterases; 2.4.8 Aminotransferases; 2.4.9 Aldolases 2.4.10 Cyclohexanone and Cyclopentanone Monooxygenases as Baeyer-Villigerases and Sulfoxidation Catalysts2.4.11 Monoamine Oxidases; 2.4.12 Cytochrome P450 Enzymes; 2.4.13 Other Enzymes; 2.5 Conclusions and Perspectives; References; 3 The Search for New Enzymes; 3.1 Introduction; 3.2 Mechanism-based Enzyme Design; 3.2.1 Catalytic Antibodies; 3.2.2 Rational Design of New Catalysts on Enzyme and Protein Basis; 3.2.3 Synthetic Enzyme Models; 3.3 Metagenomics; 3.3.1 Construction of Metagenome-derived DNA Libraries; 3.3.1.1 Selection of the Environment; 3.3.1.2 Cloning Strategies 3.3.1.3 Screening and Detection Technologies3.3.1.4 Major Problems that Need to be Addressed; 3.3.2 The Genomes of Not Yet Cultured Microbes as Resources for Novel Genes; 3.3.2.1 Polysaccharide Degrading/Modifying Enzymes; 3.3.2.2 Lipolytic Biocatalysts; 3.3.2.3 Vitamin Biosynthesis; 3.3.2.4 Nitrilases, Nitrile Hydratases, and Amidases; 3.3.2.5 Oxidoreductases/Dehydrogenases; 3.3.2.6 Proteases; 3.3.2.7 Glycerol Hydratases; 3.3.2.8 Antibiotics and Pharmaceuticals; 3.4 Conclusion; References; II Synthetic Applications; 4 Dynamic Kinetic Resolutions; 4.1 Introduction 4.1.1 Synthesis of Enantiomerically Pure Compounds4.1.2 Kinetic Resolution (KR) and Dynamic Kinetic Resolution (DKR); 4.1.3 Enzymes in Organic Chemistry; 4.2 Metal-Catalyzed Racemization; 4.2.1 DKR of Allylic Acetates and Allylic Alcohols; 4.2.2 DKR of sec-alcohols; 4.2.3 DKR of Amines; 4.3 Base-Catalyzed Racemization; 4.3.1 DKR of Thioesters; 4.3.2 DKR of Activated Esters; 4.3.3 DKR of Oxazolones; 4.3.4 DKR of Hydantoins; 4.3.5 DKR of Acyloins; 4.4 Acid-Catalyzed Racemization; 4.5 Racemization through Continuous Reversible Formation-Cleavage of the Substrate; 4.5.1 DKR of Cyanohydrins 4.5.2 DKR of Hemithioathetals |
| Record Nr. | UNINA-9910144229803321 |
| Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Asymmetric organic synthesis with enzymes / / edited by Vicente Gotor, Ignacio Alfonso, and Eduardo García-Urdiales
| Asymmetric organic synthesis with enzymes / / edited by Vicente Gotor, Ignacio Alfonso, and Eduardo García-Urdiales |
| Pubbl/distr/stampa | Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 |
| Descrizione fisica | 1 online resource (341 p.) |
| Disciplina | 572.745 |
| Soggetto topico |
Enzymes - Synthesis
Asymmetric synthesis Organic compounds - Synthesis |
| ISBN |
1-281-94689-3
9786611946890 3-527-62248-9 3-527-62249-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Asymmetric Organic Synthesis with Enzymes; Contents; Preface; List of Contributors; I Methodology; 1 Medium Engineering; 1.1 Introduction; 1.2 Modulation of Enzyme Enantioselectivity by Medium Engineering; 1.2.1 Selectivity Enhancement by Addition of Water-Miscible Organic Cosolvents; 1.2.2 Selectivity Enhancement in Organic Media with Low Water Activity; 1.2.2.1 Organic Solvent Systems; 1.2.2.2 Enzyme Properties in Organic Solvents; 1.2.2.3 Medium Engineering; 1.2.3 Rationales; 1.2.4 Modulation of Enzyme Selectivity: New Trends of Research; 1.2.4.1 Ionic Liquids; 1.2.4.2 Additives
1.3 Conclusions and OutlooksReferences; 2 Directed Evolution as a Means to Engineer Enantioselective Enzymes; 2.1 Introduction; 2.2 Molecular Biological Methods for Mutagenesis; 2.3 High-throughput Screening Methods for Enantioselectivity; 2.4 Examples of Enhancing the Enantioselectivity of Enzymes by Directed Evolution; 2.4.1 Lipase from Pseudomonas aeruginosa (PAL); 2.4.2 Other Lipases; 2.4.3 Esterases; 2.4.4 Hydantoinases; 2.4.5 Nitrilases; 2.4.6 Epoxide Hydrolases; 2.4.7 Phosphotriesterases; 2.4.8 Aminotransferases; 2.4.9 Aldolases 2.4.10 Cyclohexanone and Cyclopentanone Monooxygenases as Baeyer-Villigerases and Sulfoxidation Catalysts2.4.11 Monoamine Oxidases; 2.4.12 Cytochrome P450 Enzymes; 2.4.13 Other Enzymes; 2.5 Conclusions and Perspectives; References; 3 The Search for New Enzymes; 3.1 Introduction; 3.2 Mechanism-based Enzyme Design; 3.2.1 Catalytic Antibodies; 3.2.2 Rational Design of New Catalysts on Enzyme and Protein Basis; 3.2.3 Synthetic Enzyme Models; 3.3 Metagenomics; 3.3.1 Construction of Metagenome-derived DNA Libraries; 3.3.1.1 Selection of the Environment; 3.3.1.2 Cloning Strategies 3.3.1.3 Screening and Detection Technologies3.3.1.4 Major Problems that Need to be Addressed; 3.3.2 The Genomes of Not Yet Cultured Microbes as Resources for Novel Genes; 3.3.2.1 Polysaccharide Degrading/Modifying Enzymes; 3.3.2.2 Lipolytic Biocatalysts; 3.3.2.3 Vitamin Biosynthesis; 3.3.2.4 Nitrilases, Nitrile Hydratases, and Amidases; 3.3.2.5 Oxidoreductases/Dehydrogenases; 3.3.2.6 Proteases; 3.3.2.7 Glycerol Hydratases; 3.3.2.8 Antibiotics and Pharmaceuticals; 3.4 Conclusion; References; II Synthetic Applications; 4 Dynamic Kinetic Resolutions; 4.1 Introduction 4.1.1 Synthesis of Enantiomerically Pure Compounds4.1.2 Kinetic Resolution (KR) and Dynamic Kinetic Resolution (DKR); 4.1.3 Enzymes in Organic Chemistry; 4.2 Metal-Catalyzed Racemization; 4.2.1 DKR of Allylic Acetates and Allylic Alcohols; 4.2.2 DKR of sec-alcohols; 4.2.3 DKR of Amines; 4.3 Base-Catalyzed Racemization; 4.3.1 DKR of Thioesters; 4.3.2 DKR of Activated Esters; 4.3.3 DKR of Oxazolones; 4.3.4 DKR of Hydantoins; 4.3.5 DKR of Acyloins; 4.4 Acid-Catalyzed Racemization; 4.5 Racemization through Continuous Reversible Formation-Cleavage of the Substrate; 4.5.1 DKR of Cyanohydrins 4.5.2 DKR of Hemithioathetals |
| Record Nr. | UNINA-9910830044503321 |
| Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Aufgabensammlung Chemie für Dummies / / Heather Hattori und Richard H. Langley ; Übersetzung aus dem Amerikanischen von Susanne Hemschemeier
| Aufgabensammlung Chemie für Dummies / / Heather Hattori und Richard H. Langley ; Übersetzung aus dem Amerikanischen von Susanne Hemschemeier |
| Autore | Hattori Heather |
| Edizione | [1. Auflage.] |
| Pubbl/distr/stampa | Weinheim an der Bergstrasse, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2016 |
| Descrizione fisica | 1 online resource (489 p.) |
| Disciplina | 540 |
| Collana | Für Dummies |
| Soggetto topico | Chemistry |
| ISBN |
3-527-81060-9
3-527-80236-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ger |
| Nota di contenuto | Redox- und Säure-Base-Reaktionen (569-584) |
| Record Nr. | UNINA-9910157476403321 |
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Hattori Heather
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| Weinheim an der Bergstrasse, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biosimulation in drug development / / edited by Martin Bertau, Erik Mosekilde, and Hans V. Westerhoff
| Biosimulation in drug development / / edited by Martin Bertau, Erik Mosekilde, and Hans V. Westerhoff |
| Pubbl/distr/stampa | Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 |
| Descrizione fisica | 1 online resource (542 p.) |
| Disciplina | 615.580724 |
| Soggetto topico |
Drug development
Drug development - Simulation methods |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-94698-2
9786611946982 3-527-62267-5 3-527-62268-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Biosimulation in Drug Development; Contents; Preface; List of Contributors; Part I Introduction; 1 Simulation in Clinical Drug Development; 1.1 Introduction; 1.2 Models for Simulations; 1.3 Simulations in Clinical Drug Development: Practical Examples; 1.3.1 Predicting the Outcome of Phase I Studies of Erythropoietin Receptor Agonists; 1.3.2 Simulations for Antimicrobial Dose Selection; 1.3.3 Optimizing the Design of Phase II Dose Finding Studies; 1.3.4 Predicting the Outcome of Phase III Trials Using Phase II Data; 1.4 Conclusions; 2 Modeling of Complex Biomedical Systems; 2.1 Introduction
2.2 Pulsatile Secretion of Insulin2.3 Subcutaneous Absorption of Insulin; 2.4 Bursting Pancreatic β-Cells; 2.5 Conclusions; 3 Biosimulation of Drug Metabolism; 3.1 Introduction; 3.2 Experimental Approaches; 3.2.1 Animal Test Models; 3.2.2 Microbial Models; 3.3 The Biosimulation Approach; 3.4 Ethical Issues; 3.5 PharmBiosim - a Computer Model of Drug Metabolism in Yeast; 3.5.1 General Concept; 3.5.1.1 Chemical Abstraction; 3.5.1.2 Biological Abstraction; 3.5.2 Initial Steps - Experimental Results; 3.5.2.1 Dehalogenation (Pathways II and III); 3.5.2.2 Retro-Claisen Condensation (Pathway IV) 3.5.2.3 Ester Hydrolysis (Pathway VI)3.5.2.4 Competing Pathways and Stereoselectivity; 3.6 Computational Modeling; 3.6.1 Selection of the Modeling Software; 3.6.2 SBML-compatible Software; 3.6.2.1 Cellware; 3.6.2.2 Copasi; 3.6.2.3 Ecell; 3.6.2.4 JigCell; 3.6.2.5 JSim; 3.6.2.6 Systems Biology Workbench; 3.6.2.7 Virtual Cell; 3.6.2.8 XPPAUT; 3.6.3 CellML-compatible Software; 3.6.4 Kinetic Model; 3.6.4.1 Methods; 3.6.4.2 Model Derivation; 3.6.4.3 Results; 3.6.5 Stoichiometric Model; 3.6.5.1 Methods; 3.6.5.2 Model Derivation; 3.6.5.3 Results 3.7 Application of the Model to Predict Drug Metabolism3.8 Conclusions; Part II Simulating Cells and Tissues; 4 Correlation Between In Vitro, In Situ, and In Vivo Models; 4.1 Introduction; 4.2 Biophysical Models of Intestinal Absorption; 4.2.1 Colon; 4.2.2 Small Intestine; 4.2.3 Stomach; 4.3 Influence of Surfactants on Intestinal Permeability; 4.3.1 Absorption Experiments in Presence of Surfactants; 4.3.1.1 Colon; 4.3.1.2 Intestine; 4.3.1.3 Stomach; 4.4 Modeling and Predicting Fraction Absorbed from Permeability Values; 4.4.1 Mass Balance, Time-independent Models 4.4.2 Prediction of the Fraction of Dose Absorbed from In Vitro and In Situ Data4.4.3 Prediction from In Situ Absorption Rate Constant Determined with Closed Loop Techniques; 4.4.4 Prediction from Permeabilities Through Caco-2 Cell Lines; 4.4.5 Prediction from the PAMPA In Vitro System; 4.5 Characterization of Active Transport Parameters; 4.5.1 In Situ Parameter Estimation; 4.5.2 In Vitro-In Situ Correlation; 5 Core-Box Modeling in the Biosimulation of Drug Action; 5.1 Introduction; 5.2 Core-Box Modeling; 5.2.1 Shortcomings of Gray-Box and Minimal Modeling 5.2.1.1 Full-Scale Mechanistic Gray-Box Modeling |
| Record Nr. | UNINA-9910144228403321 |
| Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biosimulation in drug development / / edited by Martin Bertau, Erik Mosekilde, and Hans V. Westerhoff
| Biosimulation in drug development / / edited by Martin Bertau, Erik Mosekilde, and Hans V. Westerhoff |
| Pubbl/distr/stampa | Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 |
| Descrizione fisica | 1 online resource (542 p.) |
| Disciplina | 615.580724 |
| Soggetto topico |
Drug development
Drug development - Simulation methods |
| ISBN |
1-281-94698-2
9786611946982 3-527-62267-5 3-527-62268-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Biosimulation in Drug Development; Contents; Preface; List of Contributors; Part I Introduction; 1 Simulation in Clinical Drug Development; 1.1 Introduction; 1.2 Models for Simulations; 1.3 Simulations in Clinical Drug Development: Practical Examples; 1.3.1 Predicting the Outcome of Phase I Studies of Erythropoietin Receptor Agonists; 1.3.2 Simulations for Antimicrobial Dose Selection; 1.3.3 Optimizing the Design of Phase II Dose Finding Studies; 1.3.4 Predicting the Outcome of Phase III Trials Using Phase II Data; 1.4 Conclusions; 2 Modeling of Complex Biomedical Systems; 2.1 Introduction
2.2 Pulsatile Secretion of Insulin2.3 Subcutaneous Absorption of Insulin; 2.4 Bursting Pancreatic β-Cells; 2.5 Conclusions; 3 Biosimulation of Drug Metabolism; 3.1 Introduction; 3.2 Experimental Approaches; 3.2.1 Animal Test Models; 3.2.2 Microbial Models; 3.3 The Biosimulation Approach; 3.4 Ethical Issues; 3.5 PharmBiosim - a Computer Model of Drug Metabolism in Yeast; 3.5.1 General Concept; 3.5.1.1 Chemical Abstraction; 3.5.1.2 Biological Abstraction; 3.5.2 Initial Steps - Experimental Results; 3.5.2.1 Dehalogenation (Pathways II and III); 3.5.2.2 Retro-Claisen Condensation (Pathway IV) 3.5.2.3 Ester Hydrolysis (Pathway VI)3.5.2.4 Competing Pathways and Stereoselectivity; 3.6 Computational Modeling; 3.6.1 Selection of the Modeling Software; 3.6.2 SBML-compatible Software; 3.6.2.1 Cellware; 3.6.2.2 Copasi; 3.6.2.3 Ecell; 3.6.2.4 JigCell; 3.6.2.5 JSim; 3.6.2.6 Systems Biology Workbench; 3.6.2.7 Virtual Cell; 3.6.2.8 XPPAUT; 3.6.3 CellML-compatible Software; 3.6.4 Kinetic Model; 3.6.4.1 Methods; 3.6.4.2 Model Derivation; 3.6.4.3 Results; 3.6.5 Stoichiometric Model; 3.6.5.1 Methods; 3.6.5.2 Model Derivation; 3.6.5.3 Results 3.7 Application of the Model to Predict Drug Metabolism3.8 Conclusions; Part II Simulating Cells and Tissues; 4 Correlation Between In Vitro, In Situ, and In Vivo Models; 4.1 Introduction; 4.2 Biophysical Models of Intestinal Absorption; 4.2.1 Colon; 4.2.2 Small Intestine; 4.2.3 Stomach; 4.3 Influence of Surfactants on Intestinal Permeability; 4.3.1 Absorption Experiments in Presence of Surfactants; 4.3.1.1 Colon; 4.3.1.2 Intestine; 4.3.1.3 Stomach; 4.4 Modeling and Predicting Fraction Absorbed from Permeability Values; 4.4.1 Mass Balance, Time-independent Models 4.4.2 Prediction of the Fraction of Dose Absorbed from In Vitro and In Situ Data4.4.3 Prediction from In Situ Absorption Rate Constant Determined with Closed Loop Techniques; 4.4.4 Prediction from Permeabilities Through Caco-2 Cell Lines; 4.4.5 Prediction from the PAMPA In Vitro System; 4.5 Characterization of Active Transport Parameters; 4.5.1 In Situ Parameter Estimation; 4.5.2 In Vitro-In Situ Correlation; 5 Core-Box Modeling in the Biosimulation of Drug Action; 5.1 Introduction; 5.2 Core-Box Modeling; 5.2.1 Shortcomings of Gray-Box and Minimal Modeling 5.2.1.1 Full-Scale Mechanistic Gray-Box Modeling |
| Record Nr. | UNINA-9910830717703321 |
| Weinheim, Germany : , : WILEY-VCH Verlag GmbH & Co. KGaA, , 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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