| Autore |
Passarge Eberhard
|
| Edizione | [5th ed., rev. and updated.] |
| Pubbl/distr/stampa |
Stuttgart, Germany ; ; New York, NY, : Georg Thieme Verlag KG, 2018
|
| Descrizione fisica |
1 online resource (474 p.) : col. ill
|
| Disciplina |
576.5022/2
|
| Altri autori (Persone) |
WirthJèurgen
|
| Collana |
Flexibook
|
| Soggetto topico |
Genetics, Medical
Medical genetics
|
| Soggetto genere / forma |
Atlas.
Handbook
|
| ISBN |
9783132414419
3132414417
|
| Formato |
Materiale a stampa  |
| Livello bibliografico |
Monografia |
| Lingua di pubblicazione |
eng
|
| Nota di contenuto |
Color Atlas of Genetics -- At a Glance -- Dedication -- Title Page -- Copyright -- Preface -- Acknowledgments -- About the Author -- Table of Contents -- Introduction -- Chronology -- Important Advances that Contributed to the Development of Genetics -- Fundamentals -- Prologue -- Phylogenetic Tree of Living Organisms -- Origins of Humans -- Out of Africa: Toward Modern Humans -- The Cell and Its Components -- Genetic Background of Aging Processes -- Molecular Basis of Genetics -- Carbohydrates -- Lipids (Fatty Acids) -- Amino Acids -- Nucleotides and Nucleic Acids -- DNA and Its Components -- DNA as a Carrier of Genetic Information -- DNA Structure -- DNA Replication -- The Flow of Genetic Information: Transcription and Translation -- Genetic Code -- Eukaryotic Gene Structure -- Analysis of DNA -- Restriction Enzymes -- DNA Amplification (PCR) -- DNA Sequencing -- Parallel DNA Sequencing (Next-Generation Sequencing) -- DNA Cloning -- DNA Libraries -- Southern Blot Hybridization -- Variability of DNA -- DNA Variants -- Genes and Mutation -- Mutations Due to Base Modifications -- Mutations Due to Errors in Replication -- Processing of DNA -- DNA Repair Systems -- Transposition -- Trinucleotide Repeat Expansion -- Eukaryotic Cells -- Cell Communication -- Haploid and Diploid Yeast Cells -- Cell Cycle Control -- Cell Division: Mitosis -- Meiosis in Germ Cells -- Meiosis Prophase I -- Formation of Gametes -- Programmed Cell Death -- Cultured Cells -- Formal Genetics -- The Mendelian Traits -- Transmission to the Next Generation -- Independent Distribution -- Phenotype and Genotype: Application in Genetic Counseling -- Segregation of Parental Genotypes -- Monogenic Inheritance -- Genetic Linkage and Recombination -- Genetic Linkage and Association Analysis -- Quantitative Differences in Genetic Traits -- Distribution of Alleles in a Population.
Hardy-Weinberg Equilibrium Principle -- Geographical Differences in Allelic Distribution -- Inbreeding -- Twins and Twinning -- Chromosomes -- Chromosomes and Genes -- Chromosome Organization -- Functional Elements of Chromosomes -- Nucleosomes -- Packing DNA in Chromosomes -- The Telomere -- Chromosomes in Metaphase -- The Banding Patterns of Human Chromosomes -- Karyotype of Man and Mouse -- Preparation of Metaphase Chromosomes for Analysis -- Fluorescence in Situ Hybridization -- Multicolor Fluorescence In Situ Hybridization (FISH) Identification of Chromosomes -- Aneuploidy -- Chromosome Translocation -- Structural Chromosomal Aberrations -- Regulation of Gene Function -- Ribosomal RNA and Protein Assembly -- Stages of Transcription -- Basic Principles of Gene Control -- Regulation of Gene Expression in Eukaryotes -- DNA-Protein Interactions -- Other Forms of Transcription Control -- Noncoding RNAs -- Targeted Gene Disruption -- Epigenetic Modifications -- DNA Methylation -- Reversible Changes in Chromatin Structure -- Genomic Imprinting -- Mammalian X Chromosome Inactivation -- Genetic Signal Pathways -- Cellular Signal Transduction -- Heterotrimeric G Proteins -- TGF ß and Wnt/ß-Catenin Signaling Pathways -- Hedgehog and TNF Signal Pathways -- The Notch/Delta Signaling Pathway -- Genes in Embryonic Development -- Embryonic Development Genes in Drosophila melanogaster -- Hox Genes -- Zebrafish: A Translucent Vertebrate -- Cell Lineage in a Nematode, Caenorhabditis elegans -- Genomics -- Genomics -- Genomics: The Study of the Organization of Genomes -- Genomes of Microorganisms -- Architecture of the Human Genome -- Regulatory Architecture of the Human Genome -- Genome Analysis with DNA Microarrays -- Genome Scan and Array-Comparative Genomic Hybridization -- Comparative Genomic Hybridization -- Genome-Wide Association Study.
The Dynamic Genome: Mobile Genetic Elements -- Genome Editing by the CRISPR-Cas System -- Evolution of Genes and Genomes -- Comparative Genomics -- Genomic Structure of the Human X and Y Chromosomes -- The Mitochondrial Genome of Man -- Genetics in Medicine -- Genetic Classification of Diseases -- Genomic Disorders -- Disorders due to Dysregulated Chromatin Structure -- Disorders Resulting from Rearrangement of Cis-Regulatory Elements -- Disorders Resulting from Defects in Telomeres -- Disorders Resulting from Defective Lamins -- Disorders Resulting from Dysfunctional Cohesin -- Disorders due to Dysfunctional Cilia (Ciliopathies) -- Neurocristopathies -- Dysregulated RAS-MAPK Signaling Pathway -- Unstable Repeat Expansion -- Fragile X Syndrome -- Imprinting Disorders -- Imbalanced Homeostasis -- Mitochondrial Diseases -- Chloride Channel Defects: Cystic Fibrosis -- Genetic Defects in Ion Channels: LQT Syndromes -- a1-Antitrypsin Deficiency -- Hemophilia A and B -- von Willebrand Bleeding Disease -- Pharmacogenetics -- Cytochrome P450 (CYP) Genes -- Metabolic Disorders -- Genetics of Diabetes Mellitus -- Amino Acid Degradation and Urea Cycle Disorders -- Cholesterol Biosynthesis Pathway -- Distal Cholesterol Biosynthesis Pathway -- Familial Hypercholesterolemia -- LDL Receptor Mutations -- Lysosomal Storage Disorders -- Lysosomal Enzyme Defects -- Mucopolysaccharide Storage Diseases -- Peroxisomal Disorders -- Immune System -- Components of the Immune System -- Immunoglobulin Molecules -- Generation of Antibody Diversity -- Immunoglobulin Gene Rearrangement -- T-cell Receptor -- The MHC Region -- Evolution of the Immunoglobulin Superfamily -- Primary Immunodeficiency Diseases -- Origins of Cancer -- Genetic Causes of Cancer -- Categories of Cancer Genes -- Cancer Genomes -- The TP53 Tumor Suppressor Gene -- The APC Gene and Polyposis Coli.
Breast and Ovarian Cancer Susceptibility Genes -- Oncogenic Chromosome Translocations -- Retinoblastoma -- Neurofibromatosis -- Genomic Instability Diseases -- DNA Excision Repair Disorders -- Impaired Cell and Tissue Structure -- Cytoskeletal Proteins in Erythrocytes -- Hereditary Muscular Dystrophies -- Duchenne's Muscular Dystrophy -- FGF Receptor Mutations in Skeletal Dysplasias -- Marfan's and Loeys-Dietz Syndromes -- Collagen Molecule Disorders -- Osteogenesis Imperfecta -- Molecular Basis of Bone Development -- Hemoglobin Disorders -- Hemoglobin -- Hemoglobin Genes -- Sickle Cell Disease -- Mutations in Globin Genes -- The Thalassemias -- Hereditary Persistence of Fetal Hemoglobin (HPFH) -- Sex Determination and Differentiation -- Mammalian Sex Determination -- Sex Differentiation -- Disorders of Sexual Development -- Congenital Adrenal Hyperplasia -- Sensory Perception -- Rhodopsin, a Photoreceptor -- Pigmentary Retinal Degeneration -- Color Vision -- Auditory System -- Odorant Receptors -- Mammalian Taste Receptors -- Chromosomal Aberrations -- Numerical Chromosomal Aberrations -- Triploidy, Monosomy X, Additional X or Y Chromosome -- Microdeletion Syndromes -- A Brief Guide to Genetic Diagnosis -- A Brief Guide to Genetic Diagnosis -- Gene and Stem Cell Therapy -- Morbid Anatomy of the Human Genome -- Chromosomal Locations of Human Genetic Diseases -- Chromosomal Locations-Alphabetical List -- Appendix -- Glossary -- Index.
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| Record Nr. | UNINA-9910993975903321 |
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