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Analysis of chemical warfare degradation products / / Karolin K. Kroening [et al.]
Analysis of chemical warfare degradation products / / Karolin K. Kroening [et al.]
Autore Kroening Karolin K. <1974->
Pubbl/distr/stampa Chichester, UK, : Wiley, 2011
Descrizione fisica 1 online resource (xiv, 146 pages)
Disciplina 623.4/592
Soggetto topico Organophosphorus compounds - Deterioration
Chemical agents (Munitions) - Deterioration
Chemical agents (Munitions) - Analysis
Decomposition (Chemistry)
ISBN 1-283-40551-2
9786613405517
1-119-97019-9
1-119-99369-5
1-119-99368-7
Classificazione SCI013010
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Analysis of Chemical Warfare Degradation Products; Contents; Preface; 1 Historical Milieu; 1.1 Organophosphorus Nerve Agents; 1.2 Blister Agents; 1.3 Sternutator Agents; 1.4 Chemical Weapons Convention (CWC); 1.4.1 Schedule of Chemicals; 1.4.2 Destruction of Chemical Weapons; References; 2 Toxicity of Chemical Warfare Agents and their Degradation Products; 2.1 Organophosphorus Nerve Agent Toxicity; 2.1.1 Toxicity Mechanism - Acetylcholinesterase Inhibition; 2.1.2 Exposure; 2.1.3 Response, Treatment and Prevention; 2.2 Toxicity of Nerve Agent Degradation Products
2.2.1 Toxicity of GA (Tabun) Degradation Products2.2.2 Toxicity of GB (Sarin) Degradation Products; 2.2.3 Toxicity of GD (Soman) Degradation Products; 2.2.4 Toxicity of GF (Cyclosarin) Degradation Products; 2.2.5 Toxicity of VX Degradation Products; 2.3 Toxicity of Blister Agents; 2.4 Toxicity of Sternutator Agents; 2.4.1 Toxicity of Degradation Products of Sternutator Agents; References; 3 Analysis of Chemical Warfare Agents; 3.1 Introduction; 3.2 Minimally Invasive Detection Techniques; 3.3 Separation and Detection Techniques; 3.3.1 Capillary Electrophoresis; 3.3.2 Ion Mobility Spectrometry
3.3.3 Gas Chromatography (GC)/Gas Chromatography-Mass Spectrometry (GC-MS)3.3.4 Liquid Chromatography (LC)/Liquid Chromatography-Mass Spectrometry (LC-MS); 3.3.5 Desorption Electrospray Ionization and Direct Analysis in Real Time Mass Spectrometry; References; 4 Chemical Warfare Agent Degradation Products; 4.1 Analysis of Nerve Agent Degradation Products; 4.1.1 Sample Preparation; 4.1.2 Liquid-Liquid Extraction (Pre-concentration); 4.1.3 Solid Phase Extraction (SPE); 4.1.4 Solid Phase Microextraction (SPME); 4.1.5 Stir Bar Sorptive Extraction (SBSE); 4.1.6 Derivatization
4.2 Analytical Techniques4.2.1 Gas Chromatography (GC); 4.2.2 Liquid Chromatography (LC); 4.2.3 Elemental Speciation; 4.2.4 Ion Mobility; 4.2.5 Capillary Electrophoresis; 4.3 Analysis of Sulfur Mustard Degradation Products; 4.4 Analysis of Sternutator Degradation Products; References; Appendix; Index
Record Nr. UNINA-9910130879003321
Kroening Karolin K. <1974->  
Chichester, UK, : Wiley, 2011
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Analysis of Chemical Warfare Degradation Products / / Karolin K. Kroening ...[et. al.]
Analysis of Chemical Warfare Degradation Products / / Karolin K. Kroening ...[et. al.]
Autore Kroening Karolin K. <1974->
Edizione [1st ed.]
Pubbl/distr/stampa Chichester, West Sussex, United Kingdom, : Wiley, 2011
Descrizione fisica 1 online resource (xiv, 146 pages)
Disciplina 623.4/592
Soggetto topico Organophosphorus compounds - Deterioration
Chemical agents (Munitions) - Deterioration
Chemical agents (Munitions) - Analysis
Decomposition (Chemistry)
ISBN 1-283-40551-2
9786613405517
1-119-97019-9
1-119-99369-5
1-119-99368-7
Classificazione SCI013010
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Analysis of Chemical Warfare Degradation Products; Contents; Preface; 1 Historical Milieu; 1.1 Organophosphorus Nerve Agents; 1.2 Blister Agents; 1.3 Sternutator Agents; 1.4 Chemical Weapons Convention (CWC); 1.4.1 Schedule of Chemicals; 1.4.2 Destruction of Chemical Weapons; References; 2 Toxicity of Chemical Warfare Agents and their Degradation Products; 2.1 Organophosphorus Nerve Agent Toxicity; 2.1.1 Toxicity Mechanism - Acetylcholinesterase Inhibition; 2.1.2 Exposure; 2.1.3 Response, Treatment and Prevention; 2.2 Toxicity of Nerve Agent Degradation Products
2.2.1 Toxicity of GA (Tabun) Degradation Products2.2.2 Toxicity of GB (Sarin) Degradation Products; 2.2.3 Toxicity of GD (Soman) Degradation Products; 2.2.4 Toxicity of GF (Cyclosarin) Degradation Products; 2.2.5 Toxicity of VX Degradation Products; 2.3 Toxicity of Blister Agents; 2.4 Toxicity of Sternutator Agents; 2.4.1 Toxicity of Degradation Products of Sternutator Agents; References; 3 Analysis of Chemical Warfare Agents; 3.1 Introduction; 3.2 Minimally Invasive Detection Techniques; 3.3 Separation and Detection Techniques; 3.3.1 Capillary Electrophoresis; 3.3.2 Ion Mobility Spectrometry
3.3.3 Gas Chromatography (GC)/Gas Chromatography-Mass Spectrometry (GC-MS)3.3.4 Liquid Chromatography (LC)/Liquid Chromatography-Mass Spectrometry (LC-MS); 3.3.5 Desorption Electrospray Ionization and Direct Analysis in Real Time Mass Spectrometry; References; 4 Chemical Warfare Agent Degradation Products; 4.1 Analysis of Nerve Agent Degradation Products; 4.1.1 Sample Preparation; 4.1.2 Liquid-Liquid Extraction (Pre-concentration); 4.1.3 Solid Phase Extraction (SPE); 4.1.4 Solid Phase Microextraction (SPME); 4.1.5 Stir Bar Sorptive Extraction (SBSE); 4.1.6 Derivatization
4.2 Analytical Techniques4.2.1 Gas Chromatography (GC); 4.2.2 Liquid Chromatography (LC); 4.2.3 Elemental Speciation; 4.2.4 Ion Mobility; 4.2.5 Capillary Electrophoresis; 4.3 Analysis of Sulfur Mustard Degradation Products; 4.4 Analysis of Sternutator Degradation Products; References; Appendix; Index
Record Nr. UNINA-9910813763903321
Kroening Karolin K. <1974->  
Chichester, West Sussex, United Kingdom, : Wiley, 2011
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Analytical characterization of biotherapeutics / / edited by Jennie R. Lill, Wendy N. Sandoval
Analytical characterization of biotherapeutics / / edited by Jennie R. Lill, Wendy N. Sandoval
Pubbl/distr/stampa Hoboken, New Jersey : , : Wiley, , 2017
Descrizione fisica 1 online resource
Disciplina 615.7
Soggetto topico Proteins - Therapeutic use
Proteins - Analysis
Soggetto genere / forma Electronic books.
ISBN 1-119-38440-0
1-119-38442-7
1-119-38443-5
Classificazione SCI013010
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Machine generated contents note: Dedication Chapter 1: Introduction to Biotherapeutics Jennie R. Lill Chapter 2: Mass Spectrometric Characterization of Recombinant Proteins Corey E Bakalarski, Wendy N Sandoval & Jennie R Lill Chapter 3: Characterizing the Termini of Recombinant Proteins Nestor Solis, Christopher M. Overall Chapter 4: Assessing activity & conformation of recombinant proteins Diego Ellerman, Till Maurer, Justin M. Scheer Chapter 5: Structural Characterization of Recombinant Proteins & Antibodies Paola Di Lello and Patrick Lupardus Chapter 6: Antibody de novo sequencing Natalie Castellana, Adrian Guthals Chapter 7: Characterization of Antibody Drug Conjugates Yichin Liu Chapter 8: Characterization of Bi-Specific or other Hybrid molecules T. Noelle Lombana and Christoph Spiess Chapter 9: Bio-Repository Anne Baldwin, Kurt Schroeder, Lovejit Singh, Karen Billeci Chapter 10: Characterization of Manufacturing Host-Cell Contaminant Proteins Denise Krawitz, Jason Rouse, Justin Sperry, Wendy Sandoval, Martin Vanderlaan Chapter 11: Analytical Tools for Biologics Molecular Assessment Wilson Phung , Wendy Sandoval, Robert F Kelley & Jennie R Lill Chapter 12: Glycan Characterization: Determining the Structure, Distribution, and Localization of Glycoprotein Glycans John Briggs INDEX.
Record Nr. UNINA-9910271008203321
Hoboken, New Jersey : , : Wiley, , 2017
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Analytical characterization of biotherapeutics / / edited by Jennie R. Lill, Wendy N. Sandoval
Analytical characterization of biotherapeutics / / edited by Jennie R. Lill, Wendy N. Sandoval
Pubbl/distr/stampa Hoboken, New Jersey : , : Wiley, , 2017
Descrizione fisica 1 online resource
Disciplina 615.7
Soggetto topico Proteins - Therapeutic use
Proteins - Analysis
ISBN 1-119-38440-0
1-119-38442-7
1-119-38443-5
Classificazione SCI013010
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Machine generated contents note: Dedication Chapter 1: Introduction to Biotherapeutics Jennie R. Lill Chapter 2: Mass Spectrometric Characterization of Recombinant Proteins Corey E Bakalarski, Wendy N Sandoval & Jennie R Lill Chapter 3: Characterizing the Termini of Recombinant Proteins Nestor Solis, Christopher M. Overall Chapter 4: Assessing activity & conformation of recombinant proteins Diego Ellerman, Till Maurer, Justin M. Scheer Chapter 5: Structural Characterization of Recombinant Proteins & Antibodies Paola Di Lello and Patrick Lupardus Chapter 6: Antibody de novo sequencing Natalie Castellana, Adrian Guthals Chapter 7: Characterization of Antibody Drug Conjugates Yichin Liu Chapter 8: Characterization of Bi-Specific or other Hybrid molecules T. Noelle Lombana and Christoph Spiess Chapter 9: Bio-Repository Anne Baldwin, Kurt Schroeder, Lovejit Singh, Karen Billeci Chapter 10: Characterization of Manufacturing Host-Cell Contaminant Proteins Denise Krawitz, Jason Rouse, Justin Sperry, Wendy Sandoval, Martin Vanderlaan Chapter 11: Analytical Tools for Biologics Molecular Assessment Wilson Phung , Wendy Sandoval, Robert F Kelley & Jennie R Lill Chapter 12: Glycan Characterization: Determining the Structure, Distribution, and Localization of Glycoprotein Glycans John Briggs INDEX.
Record Nr. UNINA-9910830599403321
Hoboken, New Jersey : , : Wiley, , 2017
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Forensic analytical techniques / / Barbara Stuart
Forensic analytical techniques / / Barbara Stuart
Autore Stuart Barbara (Barbara H.)
Pubbl/distr/stampa Chichester, West Sussex, England : , : Wiley, , [2013]
Descrizione fisica 1 online resource (235 p.)
Disciplina 543
Collana Analytical techniques in the sciences
Soggetto topico Analytical chemistry
Forensic sciences
Chemistry, Forensic
ISBN 1-118-49687-6
1-299-18837-0
1-118-49741-4
Classificazione SCI013010
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Forensic Analytical Techniques; Contents; Series Preface; Preface; About the Author; Acronyms, Abbreviations and Symbols; Chapter 1 The Chemistry of Forensic Evidence; 1.1 Introduction; 1.2 Evidence Types; 1.2.1 Polymers; 1.2.2 Fibres; 1.2.3 Paint; 1.2.4 Documents; 1.2.5 Glass; 1.2.6 Soil; 1.2.7 Explosives; 1.2.8 Firearms; 1.2.9 Arson; 1.2.10 Body Fluids; 1.2.11 Drugs and Toxicology; 1.2.12 Fingerprints; 1.3 Introduction to Data Analysis; 1.4 Summary; References; Chapter 2 Preliminary Tests; 2.1 Introduction; 2.2 Chemical Tests; 2.2.1 Methods; 2.2.2 Drugs and Toxicology; 2.2.3 Body Fluids
2.2.4 Gunshot Residue2.2.5 Explosives; 2.2.6 Paint; 2.2.7 Documents; 2.3 Density; 2.3.1 Methods; 2.3.2 Glass; 2.3.3 Soil; 2.3.4 Polymers; 2.4 Light Examination; 2.4.1 Methods; 2.4.2 Fingerprints; 2.4.3 Body fluids; 2.4.4 Documents; 2.5 Summary; References; Chapter 3 Microscopic Techniques; 3.1 Introduction; 3.2 Optical Microscopy; 3.2.1 Methods; 3.2.2 Interpretation; 3.2.3 Fibres; 3.2.4 Paint; 3.2.5 Drugs; 3.2.6 Glass; 3.2.7 Soil; 3.2.8 Documents; 3.2.9 Firearms; 3.3 Transmission Electron Microscopy; 3.3.1 Method; 3.3.2 Interpretation; 3.3.3 Paint; 3.4 Scanning Electron Microscopy
3.4.1 Methods3.4.2 Interpretation; 3.4.3 Gunshot Residue; 3.4.4 Paint; 3.4.5 Fibres; 3.4.6 Documents; 3.4.7 Glass; 3.5 Atomic Force Microscopy; 3.5.1 Methods; 3.5.2 Interpretation; 3.5.3 Documents; 3.6 X-Ray Diffraction; 3.6.1 Methods; 3.6.2 Interpretation; 3.6.3 Explosives; 3.6.4 Paint; 3.6.5 Drugs; 3.6.6 Documents; 3.6.7 Soil; 3.7 Summary; References; Chapter 4 Molecular Spectroscopy; 4.1 Introduction; 4.2 Infrared Spectroscopy; 4.2.1 Methods; 4.2.2 Interpretation; 4.2.3 Paint; 4.2.4 Fibres; 4.2.5 Polymers; 4.2.6 Documents; 4.2.7 Explosives; 4.2.8 Drugs; 4.3 Raman Spectroscopy
4.3.1 Methods4.3.2 Interpretation; 4.3.3 Drugs; 4.3.4 Paint; 4.3.5 Fibres; 4.3.6 Documents; 4.3.7 Explosives; 4.4 Ultraviolet-visible Spectroscopy; 4.4.1 Methods; 4.4.2 Interpretation; 4.4.3 Fibres; 4.4.4 Paint; 4.4.5 Documents; 4.4.6 Drugs; 4.4.7 Toxicology; 4.5 Fluorescence Spectroscopy; 4.5.1 Methods; 4.5.2 Interpretation; 4.5.3 Body Fluids; 4.5.4 Toxicology; 4.5.5 Fibres; 4.6 Nuclear Magnetic Resonance Spectroscopy; 4.6.1 Methods; 4.6.2 Interpretation; 4.6.3 Drugs; 4.6.4 Explosives; 4.7 Summary; References; Chapter 5 Elemental Analysis; 5.1 Introduction; 5.2 Atomic Spectrometry
5.2.1 Methods5.2.2 Interpretation; 5.2.3 Glass; 5.2.4 Gunshot Residue; 5.2.5 Toxicology; 5.3 Inductively Coupled Plasma-Mass Spectrometry; 5.3.1 Methods; 5.3.2 Interpretation; 5.3.3 Glass; 5.3.4 Paint; 5.3.5 Gunshot Residue; 5.4 X-Ray Fluorescence Spectroscopy; 5.4.1 Methods; 5.4.2 Interpretation; 5.4.3 Glass; 5.4.4 Gunshot Residue; 5.4.5 Paint; 5.5 Particle-Induced X-Ray Emission Spectroscopy; 5.5.1 Methods; 5.5.2 Interpretation; 5.5.3 Glass; 5.6 Neutron Activation Analysis; 5.7 Summary; References; Chapter 6 Mass Spectrometry; 6.1 Introduction; 6.2 Molecular Mass Spectrometry; 6.2.1 Methods
6.2.2 Interpretation
Record Nr. UNINA-9910141500003321
Stuart Barbara (Barbara H.)  
Chichester, West Sussex, England : , : Wiley, , [2013]
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Forensic analytical techniques / / Barbara Stuart
Forensic analytical techniques / / Barbara Stuart
Autore Stuart Barbara (Barbara H.)
Pubbl/distr/stampa Chichester, West Sussex, England : , : Wiley, , [2013]
Descrizione fisica 1 online resource (235 p.)
Disciplina 543
Collana Analytical techniques in the sciences
Soggetto topico Analytical chemistry
Forensic sciences
Chemistry, Forensic
ISBN 1-118-49687-6
1-299-18837-0
1-118-49741-4
Classificazione SCI013010
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Forensic Analytical Techniques; Contents; Series Preface; Preface; About the Author; Acronyms, Abbreviations and Symbols; Chapter 1 The Chemistry of Forensic Evidence; 1.1 Introduction; 1.2 Evidence Types; 1.2.1 Polymers; 1.2.2 Fibres; 1.2.3 Paint; 1.2.4 Documents; 1.2.5 Glass; 1.2.6 Soil; 1.2.7 Explosives; 1.2.8 Firearms; 1.2.9 Arson; 1.2.10 Body Fluids; 1.2.11 Drugs and Toxicology; 1.2.12 Fingerprints; 1.3 Introduction to Data Analysis; 1.4 Summary; References; Chapter 2 Preliminary Tests; 2.1 Introduction; 2.2 Chemical Tests; 2.2.1 Methods; 2.2.2 Drugs and Toxicology; 2.2.3 Body Fluids
2.2.4 Gunshot Residue2.2.5 Explosives; 2.2.6 Paint; 2.2.7 Documents; 2.3 Density; 2.3.1 Methods; 2.3.2 Glass; 2.3.3 Soil; 2.3.4 Polymers; 2.4 Light Examination; 2.4.1 Methods; 2.4.2 Fingerprints; 2.4.3 Body fluids; 2.4.4 Documents; 2.5 Summary; References; Chapter 3 Microscopic Techniques; 3.1 Introduction; 3.2 Optical Microscopy; 3.2.1 Methods; 3.2.2 Interpretation; 3.2.3 Fibres; 3.2.4 Paint; 3.2.5 Drugs; 3.2.6 Glass; 3.2.7 Soil; 3.2.8 Documents; 3.2.9 Firearms; 3.3 Transmission Electron Microscopy; 3.3.1 Method; 3.3.2 Interpretation; 3.3.3 Paint; 3.4 Scanning Electron Microscopy
3.4.1 Methods3.4.2 Interpretation; 3.4.3 Gunshot Residue; 3.4.4 Paint; 3.4.5 Fibres; 3.4.6 Documents; 3.4.7 Glass; 3.5 Atomic Force Microscopy; 3.5.1 Methods; 3.5.2 Interpretation; 3.5.3 Documents; 3.6 X-Ray Diffraction; 3.6.1 Methods; 3.6.2 Interpretation; 3.6.3 Explosives; 3.6.4 Paint; 3.6.5 Drugs; 3.6.6 Documents; 3.6.7 Soil; 3.7 Summary; References; Chapter 4 Molecular Spectroscopy; 4.1 Introduction; 4.2 Infrared Spectroscopy; 4.2.1 Methods; 4.2.2 Interpretation; 4.2.3 Paint; 4.2.4 Fibres; 4.2.5 Polymers; 4.2.6 Documents; 4.2.7 Explosives; 4.2.8 Drugs; 4.3 Raman Spectroscopy
4.3.1 Methods4.3.2 Interpretation; 4.3.3 Drugs; 4.3.4 Paint; 4.3.5 Fibres; 4.3.6 Documents; 4.3.7 Explosives; 4.4 Ultraviolet-visible Spectroscopy; 4.4.1 Methods; 4.4.2 Interpretation; 4.4.3 Fibres; 4.4.4 Paint; 4.4.5 Documents; 4.4.6 Drugs; 4.4.7 Toxicology; 4.5 Fluorescence Spectroscopy; 4.5.1 Methods; 4.5.2 Interpretation; 4.5.3 Body Fluids; 4.5.4 Toxicology; 4.5.5 Fibres; 4.6 Nuclear Magnetic Resonance Spectroscopy; 4.6.1 Methods; 4.6.2 Interpretation; 4.6.3 Drugs; 4.6.4 Explosives; 4.7 Summary; References; Chapter 5 Elemental Analysis; 5.1 Introduction; 5.2 Atomic Spectrometry
5.2.1 Methods5.2.2 Interpretation; 5.2.3 Glass; 5.2.4 Gunshot Residue; 5.2.5 Toxicology; 5.3 Inductively Coupled Plasma-Mass Spectrometry; 5.3.1 Methods; 5.3.2 Interpretation; 5.3.3 Glass; 5.3.4 Paint; 5.3.5 Gunshot Residue; 5.4 X-Ray Fluorescence Spectroscopy; 5.4.1 Methods; 5.4.2 Interpretation; 5.4.3 Glass; 5.4.4 Gunshot Residue; 5.4.5 Paint; 5.5 Particle-Induced X-Ray Emission Spectroscopy; 5.5.1 Methods; 5.5.2 Interpretation; 5.5.3 Glass; 5.6 Neutron Activation Analysis; 5.7 Summary; References; Chapter 6 Mass Spectrometry; 6.1 Introduction; 6.2 Molecular Mass Spectrometry; 6.2.1 Methods
6.2.2 Interpretation
Record Nr. UNINA-9910830476403321
Stuart Barbara (Barbara H.)  
Chichester, West Sussex, England : , : Wiley, , [2013]
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
HPLC and UHPLC for practicing scientists / / Michael W. Dong
HPLC and UHPLC for practicing scientists / / Michael W. Dong
Autore Dong M. W.
Edizione [Second edition.]
Pubbl/distr/stampa Hoboken, New Jersey : , : Wiley, , [2019]
Descrizione fisica 1 online resource (411 pages)
Disciplina 615.1901
Soggetto topico High performance liquid chromatography
Drugs - Analysis
ISBN 1-5231-2826-7
1-119-31379-1
1-119-31377-5
1-119-31378-3
Classificazione SCI013010
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910831062703321
Dong M. W.  
Hoboken, New Jersey : , : Wiley, , [2019]
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Hydrophilic interaction chromatography [[electronic resource] ] : a guide for practitioners / / edited by Bernard A. Olsen, Brian W. Pack
Hydrophilic interaction chromatography [[electronic resource] ] : a guide for practitioners / / edited by Bernard A. Olsen, Brian W. Pack
Pubbl/distr/stampa Hoboken, N.J., : John Wiley & Sons, Inc., 2013
Descrizione fisica 1 online resource (337 p.)
Disciplina 543/.84
Altri autori (Persone) OlsenBernard A. <1953->
PackBrian W. <1970->
Collana Chemical analysis : a series of monographs on analytical chemistry and its applications
Soggetto topico Hydrophilic interaction liquid chromatography
ISBN 1-118-49524-1
1-283-97811-3
1-118-49521-7
1-118-49523-3
Classificazione SCI013010
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Machine generated contents note: Chapter 1. Separation Mechanisms in Hydrophilic Interaction Chromatography 1.1 Introduction 1.2 Historical Background. Recognition of the contribution of partition, ion exchange and reversed-phase interactions to the retention process 1.3 Recent studies on the contributory mechanisms to HILIC retention 1.3.1 Overview 1.3.2 Contribution of adsorption and partition to HILIC separations 1.3.3 Further studies on the contribution of ionic retention in HILIC 1.3.3.1 Introduction 1.3.3.2 Mobile phase considerations for the separation of ionogenic compounds 1.3.3.3. Ionisation state of the column as a function of pH 1.3.3.4 Quantitation of ionic retention effects on different columns 1.3.4 Reversed-phase retention on bare silica 1.3.5 Electrostatic Repulsion Hydrophilic Interaction Chromatography (ERLIC)- a new separation mode in HILIC. 1.4 Conclusions Chapter 2. Stationary Phases for HILIC 2.1 Introduction 2.2 HILIC stationary phases 2.2.1 Underivatized silica 2.2.1.1 Totally porous silica particles 2.2.1.2 Superficially porous (core shell) silica particles 2.2.1.3 Monolithic silica 2.2.1.4 Ethylene Bridged Hybrids (BEH) 2.2.2 Derivatized silica 2.2.2.1 Neutral derivatized silica 2.2.2.2 Zwitterionic derivatized silica 2.2.2.3 Positively charged derivatized silica 2.2.2.4 Negatively charged derivatized silica 2.2.3 Non-silica phases 2.2.3.1 Amino phases 2.2.3.2 Sulfonated S-DVB phases 2.3 Commercial HILIC phases 2.3.1 Efficiency comparison 2.3.2 Retention and selectivity comparisons 2.4 Conclusions Chapter 3. HILIC Method Development 3.1 Introduction 3.2 General method development considerations 3.2.1 Method objectives 3.2.2 Sample consideration 3.2.3 Systematic method development 3.3 Method development strategies 3.3.1 Systematic approach to column screening 3.3.2 Optimization of method parameters 3.3.2.1 Final column selection 3.3.2.2 Organic solvents 3.3.2.3 Mobile phase pH 3.3.2.4 Buffer types and concentration 3.3.2.5 Column temperature 3.3.2.6 Sample solvents 3.4 Detection for HILIC methods 3.4.1 Mass Spectrometry detector (MS) 3.4.2 Charged aerosol detector (CAD) 3.5 Conclusions Chapter 4. Pharmaceutical Applications of Hydrophilic Interaction Chromatography 4.1 Introduction 4.1.1 Definition of the problem 4.1.2 Selection of conditions 4.1.3 Validation of the method 4.1.4 General references 4.2 Determination of Counterions 4.2.1 Salt selection and options for counterion determination 4.2.2 Specific counterion analysis 4.2.3 Counterion screening with gradient elution 4.2.4 Suitable reference standards for counterion analysis 4.3 Main Component Methods 4.3.1 Potency/assay methods 4.3.2 Equipment cleaning verification assays 4.3.3 Dissolution methods 4.4 Determination of Impurities 4.4.1 Impurity screening and orthogonal separations 4.4.2 Impurity identification 4.4.3 Specific impurity determination 4.4.3.1 Pyrimidines, purines, nucleosides 4.4.3.2 Hydrazines with ethanol as weak solvent 4.4.3.3 Neutral and charged polar impurities in a drug substance 4.4.3.4 Polar basic compounds and impurities 4.4.4 Statistical design of experiments (DOE) for optimization 4.5 Excipients 4.5.1 Parenteral and solution formulations 4.5.2 Tablets, capsules and inhalation products 4.5.3 Sugars 4.5.4 Stabilizers and antioxidants 4.6 Chiral Applications 4.6.1 Chiral selectors and HILIC 4.6.1.1 Cyclodextrins 4.6.1.2 Macrocyclic antibiotics 4.6.1.3 Chiral crown ethers 4.6.1.4 Cyclofructans 4.6.2 Conclusions for chiral separations 4.7 Conclusions Chapter 5. Hydrophilic Interaction Chromatography (HILIC) for Drug Discovery 5.1 Drug Discovery Model 5.2 HILIC Applications for in vitro Biology 5.2.1 Biological screening and hit finding 5.2.1.1 Target selection and assay validation 5.2.1.2 High-throughput screening 5.2.2 New drug discovery strategies 5.3 HILIC Applications and Advances for Discovery Chemistry 5.3.1 Lead identification 5.3.2 Lead optimization 5.3.2.1 ADME profile 5.3.2.2 Biopharmaceutics 5.3.2.3 Chiral purity 5.3.3 Candidate selection 5.4 Practical Considerations 5.5 Conclusions Chapter 6. Advances in Hydrophilic Interaction Chromatography (HILIC) for Biochemical Applications 6.1 Introduction 6.2 Carbohydrates 6.2.1 Mono- and disaccharides 6.2.2 Oligosaccharides and polysaccharides 6.2.3 Glycans 6.2.3.1 Glycan and glycopeptide analysis 6.2.3.2 HILIC for sample enrichment 6.3 Nucleobases and Nucleosides 6.4 Oligonucleotides 6.5 Amino Acids and Peptides 6.6 Proteins 6.7 Phospholipids 6.8 Conclusions Chapter 7. HILIC-MS for Targeted Metabolomics and Small Molecule Bioanalysis 7.1 Introduction 7.2 The role of HILIC-MS in targeted metabolomics versus other LC modes 7.3 Strategies for method development based on retention behavior of targeted metabolites on HILIC stationary phases 7.3.1 Retention behavior of metabolites on HILIC stationary phases 7.3.2 Robustness, mobile phase compositions, and matrix effects 7.4 Summary Chapter 8. HILIC for Food, Environmental, and Other Applications 8.1 Introduction 8.2 Food applications for HILIC 8.2.1 Review of HILIC analytical methods for food analysis 8.2.1.1 Sample preparation in HILIC methods applied to food matrices 8.2.1.2 HILIC methods applied to food matrices: chromatographic parameters and detection 8.2.2 Selected detailed examples of HILIC applications in food analysis 8.2.2.1 Melamine (MEL) and cyanuric acid (CYA) 8.2.2.2 Water soluble vitamins 8.2.2.3 Seafood and other toxins 8.3 Environmental and other applications of HILIC 8.3.1 Review of environmental applications based on the stages of method development 8.3.2 Selected detailed examples of environmental and other HILIC applications 8.3.2.1 Metals and their related organic compounds 8.3.2.2 Pharmaceutical compounds in aqueous environmental samples 8.3.2.3 Other applications 8.4 Conclusions Chapter 9. Theory and Practice of Two-Dimensional Liquid Chromatography Separations Involving the HILIC Mode of Separation 9.1 Fundamentals of multi-dimensional liquid chromatography 9.1.1 Scope 9.1.2 Potential advantages of two-dimensional separations over conventional separations 9.1.3 Modes of 2D separation 9.1.3.1 Offline fraction transfer 9.1.3.2 Online fraction transfer 9.1.3.3 Conceptual comparison of different 2D separation modes 9.1.4 Undersampling 9.1.5 Orthogonality 9.2 Complementarity of HILIC selectivity to other separation modes 9.3 Instrumentation and Experimental Considerations 9.3.1 Online versus offline 2DLC 9.3.1.1 Offline 2DLC 9.3.1.2 Online 2DLC 9.3.2 Dealing with solvent incompatibility 9.3.2.1 Partial mobile phase evaporation 9.3.2.2 Consideration of fraction transfer volume relative to the second dimension column volume 9.3.2.3 On-column focusing 9.3.3 Fast Separations 9.3.3.1 General considerations for fast LC separations 9.3.3.2 Fast HILIC separations 9.4 Applications 9.5 The future of HILIC separations in 2DLC.
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Hoboken, N.J., : John Wiley & Sons, Inc., 2013
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Hydrophilic interaction chromatography : a guide for practitioners / / edited by Bernard A. Olsen, Brian W. Pack
Hydrophilic interaction chromatography : a guide for practitioners / / edited by Bernard A. Olsen, Brian W. Pack
Edizione [1st ed.]
Pubbl/distr/stampa Hoboken, N.J., : John Wiley & Sons, Inc., 2013
Descrizione fisica 1 online resource (337 p.)
Disciplina 543/.84
Altri autori (Persone) OlsenBernard A. <1953->
PackBrian W. <1970->
Collana Chemical analysis : a series of monographs on analytical chemistry and its applications
Soggetto topico Hydrophilic interaction liquid chromatography
ISBN 1-118-49524-1
1-283-97811-3
1-118-49521-7
1-118-49523-3
Classificazione SCI013010
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Machine generated contents note: Chapter 1. Separation Mechanisms in Hydrophilic Interaction Chromatography 1.1 Introduction 1.2 Historical Background. Recognition of the contribution of partition, ion exchange and reversed-phase interactions to the retention process 1.3 Recent studies on the contributory mechanisms to HILIC retention 1.3.1 Overview 1.3.2 Contribution of adsorption and partition to HILIC separations 1.3.3 Further studies on the contribution of ionic retention in HILIC 1.3.3.1 Introduction 1.3.3.2 Mobile phase considerations for the separation of ionogenic compounds 1.3.3.3. Ionisation state of the column as a function of pH 1.3.3.4 Quantitation of ionic retention effects on different columns 1.3.4 Reversed-phase retention on bare silica 1.3.5 Electrostatic Repulsion Hydrophilic Interaction Chromatography (ERLIC)- a new separation mode in HILIC. 1.4 Conclusions Chapter 2. Stationary Phases for HILIC 2.1 Introduction 2.2 HILIC stationary phases 2.2.1 Underivatized silica 2.2.1.1 Totally porous silica particles 2.2.1.2 Superficially porous (core shell) silica particles 2.2.1.3 Monolithic silica 2.2.1.4 Ethylene Bridged Hybrids (BEH) 2.2.2 Derivatized silica 2.2.2.1 Neutral derivatized silica 2.2.2.2 Zwitterionic derivatized silica 2.2.2.3 Positively charged derivatized silica 2.2.2.4 Negatively charged derivatized silica 2.2.3 Non-silica phases 2.2.3.1 Amino phases 2.2.3.2 Sulfonated S-DVB phases 2.3 Commercial HILIC phases 2.3.1 Efficiency comparison 2.3.2 Retention and selectivity comparisons 2.4 Conclusions Chapter 3. HILIC Method Development 3.1 Introduction 3.2 General method development considerations 3.2.1 Method objectives 3.2.2 Sample consideration 3.2.3 Systematic method development 3.3 Method development strategies 3.3.1 Systematic approach to column screening 3.3.2 Optimization of method parameters 3.3.2.1 Final column selection 3.3.2.2 Organic solvents 3.3.2.3 Mobile phase pH 3.3.2.4 Buffer types and concentration 3.3.2.5 Column temperature 3.3.2.6 Sample solvents 3.4 Detection for HILIC methods 3.4.1 Mass Spectrometry detector (MS) 3.4.2 Charged aerosol detector (CAD) 3.5 Conclusions Chapter 4. Pharmaceutical Applications of Hydrophilic Interaction Chromatography 4.1 Introduction 4.1.1 Definition of the problem 4.1.2 Selection of conditions 4.1.3 Validation of the method 4.1.4 General references 4.2 Determination of Counterions 4.2.1 Salt selection and options for counterion determination 4.2.2 Specific counterion analysis 4.2.3 Counterion screening with gradient elution 4.2.4 Suitable reference standards for counterion analysis 4.3 Main Component Methods 4.3.1 Potency/assay methods 4.3.2 Equipment cleaning verification assays 4.3.3 Dissolution methods 4.4 Determination of Impurities 4.4.1 Impurity screening and orthogonal separations 4.4.2 Impurity identification 4.4.3 Specific impurity determination 4.4.3.1 Pyrimidines, purines, nucleosides 4.4.3.2 Hydrazines with ethanol as weak solvent 4.4.3.3 Neutral and charged polar impurities in a drug substance 4.4.3.4 Polar basic compounds and impurities 4.4.4 Statistical design of experiments (DOE) for optimization 4.5 Excipients 4.5.1 Parenteral and solution formulations 4.5.2 Tablets, capsules and inhalation products 4.5.3 Sugars 4.5.4 Stabilizers and antioxidants 4.6 Chiral Applications 4.6.1 Chiral selectors and HILIC 4.6.1.1 Cyclodextrins 4.6.1.2 Macrocyclic antibiotics 4.6.1.3 Chiral crown ethers 4.6.1.4 Cyclofructans 4.6.2 Conclusions for chiral separations 4.7 Conclusions Chapter 5. Hydrophilic Interaction Chromatography (HILIC) for Drug Discovery 5.1 Drug Discovery Model 5.2 HILIC Applications for in vitro Biology 5.2.1 Biological screening and hit finding 5.2.1.1 Target selection and assay validation 5.2.1.2 High-throughput screening 5.2.2 New drug discovery strategies 5.3 HILIC Applications and Advances for Discovery Chemistry 5.3.1 Lead identification 5.3.2 Lead optimization 5.3.2.1 ADME profile 5.3.2.2 Biopharmaceutics 5.3.2.3 Chiral purity 5.3.3 Candidate selection 5.4 Practical Considerations 5.5 Conclusions Chapter 6. Advances in Hydrophilic Interaction Chromatography (HILIC) for Biochemical Applications 6.1 Introduction 6.2 Carbohydrates 6.2.1 Mono- and disaccharides 6.2.2 Oligosaccharides and polysaccharides 6.2.3 Glycans 6.2.3.1 Glycan and glycopeptide analysis 6.2.3.2 HILIC for sample enrichment 6.3 Nucleobases and Nucleosides 6.4 Oligonucleotides 6.5 Amino Acids and Peptides 6.6 Proteins 6.7 Phospholipids 6.8 Conclusions Chapter 7. HILIC-MS for Targeted Metabolomics and Small Molecule Bioanalysis 7.1 Introduction 7.2 The role of HILIC-MS in targeted metabolomics versus other LC modes 7.3 Strategies for method development based on retention behavior of targeted metabolites on HILIC stationary phases 7.3.1 Retention behavior of metabolites on HILIC stationary phases 7.3.2 Robustness, mobile phase compositions, and matrix effects 7.4 Summary Chapter 8. HILIC for Food, Environmental, and Other Applications 8.1 Introduction 8.2 Food applications for HILIC 8.2.1 Review of HILIC analytical methods for food analysis 8.2.1.1 Sample preparation in HILIC methods applied to food matrices 8.2.1.2 HILIC methods applied to food matrices: chromatographic parameters and detection 8.2.2 Selected detailed examples of HILIC applications in food analysis 8.2.2.1 Melamine (MEL) and cyanuric acid (CYA) 8.2.2.2 Water soluble vitamins 8.2.2.3 Seafood and other toxins 8.3 Environmental and other applications of HILIC 8.3.1 Review of environmental applications based on the stages of method development 8.3.2 Selected detailed examples of environmental and other HILIC applications 8.3.2.1 Metals and their related organic compounds 8.3.2.2 Pharmaceutical compounds in aqueous environmental samples 8.3.2.3 Other applications 8.4 Conclusions Chapter 9. Theory and Practice of Two-Dimensional Liquid Chromatography Separations Involving the HILIC Mode of Separation 9.1 Fundamentals of multi-dimensional liquid chromatography 9.1.1 Scope 9.1.2 Potential advantages of two-dimensional separations over conventional separations 9.1.3 Modes of 2D separation 9.1.3.1 Offline fraction transfer 9.1.3.2 Online fraction transfer 9.1.3.3 Conceptual comparison of different 2D separation modes 9.1.4 Undersampling 9.1.5 Orthogonality 9.2 Complementarity of HILIC selectivity to other separation modes 9.3 Instrumentation and Experimental Considerations 9.3.1 Online versus offline 2DLC 9.3.1.1 Offline 2DLC 9.3.1.2 Online 2DLC 9.3.2 Dealing with solvent incompatibility 9.3.2.1 Partial mobile phase evaporation 9.3.2.2 Consideration of fraction transfer volume relative to the second dimension column volume 9.3.2.3 On-column focusing 9.3.3 Fast Separations 9.3.3.1 General considerations for fast LC separations 9.3.3.2 Fast HILIC separations 9.4 Applications 9.5 The future of HILIC separations in 2DLC.
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Hoboken, N.J., : John Wiley & Sons, Inc., 2013
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Immunoassays in agricultural biotechnology [[electronic resource] /] / edited by Guomin Shan
Immunoassays in agricultural biotechnology [[electronic resource] /] / edited by Guomin Shan
Pubbl/distr/stampa Hoboken, N.J., : Wiley, 2011
Descrizione fisica 1 online resource (364 p.)
Disciplina 616.07/56
Altri autori (Persone) ShanGuomin
Soggetto topico Immunoassay - Methodology
Agricultural biotechnology
ISBN 0-470-92268-0
1-283-10045-2
9786613100450
0-470-90993-5
0-470-90992-7
Classificazione SCI013010
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto IMMUNOASSAYS IN AGRICULTURAL BIOTECHNOLOGY; CONTENTS; FOREWORD; PREFACE; CONTRIBUTORS; 1 INTRODUCTION; 2 PRINCIPLES OF IMMUNOASSAYS; 3 ANTIBODY ENGINEERING IN AGRICULTURAL BIOTECHNOLOGY; 4 MICROTITER PLATE ELISA; 5 LATERAL FLOW DEVICES; 6 IMMUNOASSAY METHOD VALIDATION; 7 REFERENCE MATERIALS AND CONSIDERATIONS; 8 AUTOMATION OF IMMUNOASSAYS; 9 DATA INTERPRETATION AND SOURCES OF ERROR; 10 IMMUNOASSAY APPLICATIONS IN TRAIT DISCOVERY, PRODUCT DEVELOPMENT, AND REGISTRATION; 11 IMMUNOASSAY APPLICATIONS IN GRAIN PRODUCTS AND FOOD PROCESSING; 12 IMMUNOASSAY APPLICATIONS IN SOIL MONITORING
13 IMMUNOASSAY APPLICATIONS IN PLANT-BASED BIOPHARMA14 IMMUNOASSAYS IN VETERINARY PLANT-MADE VACCINES; 15 IMMUNOASSAY AS A GM DETECTION METHOD IN INTERNATIONAL TRADE; 16 FUTURE PERSPECTIVES AND CHALLENGES; INDEX
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Hoboken, N.J., : Wiley, 2011
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