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Biomedical engineering challenges : a chemical engineering insight / / edited by Vincenzo Piemonte [and three others]
| Biomedical engineering challenges : a chemical engineering insight / / edited by Vincenzo Piemonte [and three others] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2018 |
| Descrizione fisica | 1 online resource (276 pages) : color illustrations |
| Disciplina | 610.28 |
| Soggetto topico |
Biomedical engineering
Biochemical engineering |
| ISBN |
1-119-29602-1
1-119-29601-3 1-119-29603-X |
| Classificazione | SCI010000 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910270879403321 |
| Hoboken, New Jersey : , : Wiley, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biomedical engineering challenges : a chemical engineering insight / / edited by Vincenzo Piemonte [and three others]
| Biomedical engineering challenges : a chemical engineering insight / / edited by Vincenzo Piemonte [and three others] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2018 |
| Descrizione fisica | 1 online resource (276 pages) : color illustrations |
| Disciplina | 610.28 |
| Soggetto topico |
Biomedical engineering
Biochemical engineering |
| ISBN |
1-119-29602-1
1-119-29601-3 1-119-29603-X |
| Classificazione | SCI010000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910815319003321 |
| Hoboken, New Jersey : , : Wiley, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Downstream industrial biotechnology [[electronic resource] ] : recovery and purification / / edited by Michael C. Flickinger
| Downstream industrial biotechnology [[electronic resource] ] : recovery and purification / / edited by Michael C. Flickinger |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons Inc., 2013 |
| Descrizione fisica | 1 online resource (875 p.) |
| Disciplina | 660.6 |
| Altri autori (Persone) | FlickingerMichael C |
| Soggetto topico | Biotechnology |
| ISBN |
1-118-61898-X
1-118-61912-9 |
| Classificazione | SCI010000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. I. Introduction -- pt. II. Downstream recovery of cells and protein capture -- pt. III. Process development in downstream purification -- pt. IV. Equipment design for downstream recovery and protein purification -- pt. V. Downstream cGMP operations -- pt. VI. Biopharmaceutical facility validation -- pt. VII. FDA cGMP regulatory compliance. |
| Record Nr. | UNINA-9910787324103321 |
| Hoboken, N.J., : John Wiley & Sons Inc., 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Downstream industrial biotechnology : recovery and purification / / edited by Michael C. Flickinger
| Downstream industrial biotechnology : recovery and purification / / edited by Michael C. Flickinger |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons Inc., 2013 |
| Descrizione fisica | 1 online resource (875 p.) |
| Disciplina | 660.6 |
| Altri autori (Persone) | FlickingerMichael C |
| Soggetto topico | Biotechnology |
| ISBN |
1-118-61898-X
1-118-61912-9 |
| Classificazione | SCI010000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. I. Introduction -- pt. II. Downstream recovery of cells and protein capture -- pt. III. Process development in downstream purification -- pt. IV. Equipment design for downstream recovery and protein purification -- pt. V. Downstream cGMP operations -- pt. VI. Biopharmaceutical facility validation -- pt. VII. FDA cGMP regulatory compliance. |
| Record Nr. | UNINA-9910828663303321 |
| Hoboken, N.J., : John Wiley & Sons Inc., 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Enzyme technologies : pluripotent players in discovering therapeutic agents / / edited by Hsiu-Chiung Yang, Wu-Kuang Yeh, James R. McCarthy
| Enzyme technologies : pluripotent players in discovering therapeutic agents / / edited by Hsiu-Chiung Yang, Wu-Kuang Yeh, James R. McCarthy |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (366 p.) |
| Disciplina | 615.3 |
| Altri autori (Persone) |
YangHsiu-Chiung
YehWu-Kuang <1942-> McCarthyJ. R |
| Collana | Chemical Biology of Enzymes for Biotechnology and Pharmaceutical Applications |
| Soggetto topico |
Enzyme inhibitors
Enzymes - Pharmacokinetics Drugs - Design |
| ISBN |
1-118-73990-6
1-118-73989-2 |
| Classificazione | SCI010000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Enzyme Technologies: Pluripotent Players in Discovering Therapeutic Agents; Copyright; Contents; Contributors; Preface; PART A ENZYMES - ESSENTIAL WORKHORSES IN PHARMACEUTICAL RESEARCH; 1 ASSAY TECHNOLOGIES FOR PROTEASES; I. INTRODUCTION; II. PROTEASE ACTIVITY ASSAYS; III. ASSAYS FOR SOME CLINICALLY SIGNIFICANT PROTEASES; IV. COMPUTATIONAL APPROACHES FOR PROTEASE IDENTIFICATION AND CHARACTERIZATION; 2 DISCOVERY AND DEVELOPMENT OF ISOZYME-SELECTIVE INHIBITORS INVOLVED IN LIPID METABOLISM; I. INTRODUCTION; II. DIACYLGLYCEROL ACYLTRANSFERASE (DGAT)
III. ACYL-COA: CHOLESTEROL ACYLTRANSFERASE (ACAT)IV. CONCLUSIONS AND FUTURE PERSPECTIVES; References; 3 COVALENT ENZYME INHIBITION IN DRUG DISCOVERY AND DEVELOPMENT; I. INTRODUCTION; II. MECHANISM OF INHIBITION: MECHANISTIC TYPES BY PRINCIPLE OF INHIBITION; III. KINETICS: CONCEPTUAL AND EXPERIMENTAL CONSIDERATIONS; IV. SPECIFIC EXAMPLES OF COVALENT INHIBITORS; V. COVALENT ADDUCT WITH COFACTOR ALONE; VI. FULLY IRREVERSIBLE NONCOVALENT INHIBITION; VII. REVERSIBILITY AND DRUG RESISTANCE; VIII. PSEUDO-IRREVERSIBLE INHIBITION; IX. IRREVERSIBLE INHIBITORS AS TOOLS: ACTIVITY-BASED PROTEOMICS (ABP) X. MBI OF CYPsXI. THE PROBLEM OF HAPTENATION; XII. CONCLUSION; References; 4 PRECLINOMICS: ENZYME ASSAYS AND RODENT MODELS FOR METABOLIC DISEASES; I. INTRODUCTION; II. EVOLVING ENZYME ASSAYS; III. DEVELOPING NEW RAT MODEL FOR METABOLIC DISEASES; IV. ZDSD RAT: EVALUATING CURRENT DRUGS; V. EXISTING RODENT MODELS: ESTABLISHING POSITIVE CONTROLS; VI. EXISTING RODENT MODELS AND ONE CANCER PATIENT: TESTING NUTRITIONAL SUPPLEMENT (ALKA VITA); VII. CONCLUDING REMARKS; References; PART B ENZYMES - INDISPENSABLE TOOLS FOR IMPROVING DRUGGABILITY; 5 ENZYMES AND TARGETED ACTIVATION OF PRODRUGS I. INTRODUCTIONII. ENDOGENOUS ENZYMES; III. NONENDOGENOUS ENZYMES; IV. CONCLUDING REMARKS; References; 6 EVOLUTION OF AN ORALLY ACTIVE PRODRUG OF GEMCITABINE; I. INTRODUCTION; II. PREPARATION OF GEMCITABINE PRODRUGS; III. ADVANTAGE OF CYCLOPROPYL ESTER PRODRUGS; IV. ISSUES WITH CYCLOPROPYL ESTERS OF GEMCITABINE; V. ALTERNATIVE PRODRUGS OF GEMCITABINE; VI. CO-CRYSTALS OF VALPROATE AMIDE OF GEMCITABINE; VII. STABILITY OF VALPROATE AMIDE PRODRUG; VIII. BIOAVAILABILITY OF AMIDE PRODRUG; IX. ANTITUMOR ACTIVITY OF PRODRUG; X. SUMMARY; References 7 ENZYMATICALLY ACTIVATED PHOSPHATE AND PHOSPHONATE PRODRUGSI. INTRODUCTION; II. PHOSPHATE GROUP USED FOR SOLUBILITY ENHANCEMENT; III. PHOSPHATE AND PHOSPHONATE PRODRUGS; IV. CONCLUSIONS; References; PART C ENZYMES - POWERFUL WEAPONS FOR CORRECTING NATURE ' S ERRORS; 8 TREATMENT OPTIONS FOR MUCOPOLYSACCHARIDOSIS TYPE II (HUNTER'S SYNDROME); I. INTRODUCTION; II. HISTORY; III. BIOCHEMISTRY; IV. GENETICS; V. CLINICAL MANIFESTATION; VI. MANAGEMENT AND TREATMENT; VII. FUTURE PERSPECTIVES; References; 9 ENZYME REPLACEMENT THERAPY FOR FABRY DISEASE; I. INTRODUCTION II. THE STRUCTURE AND CATALYTIC MECHANISMS OF HUMAN ALPHA-GALACTOSIDASE A |
| Record Nr. | UNINA-9910138987203321 |
| Hoboken, New Jersey : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Enzyme technologies : pluripotent players in discovering therapeutic agents / / edited by Hsiu-Chiung Yang, Wu-Kuang Yeh, James R. McCarthy
| Enzyme technologies : pluripotent players in discovering therapeutic agents / / edited by Hsiu-Chiung Yang, Wu-Kuang Yeh, James R. McCarthy |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (366 p.) |
| Disciplina | 615.3 |
| Altri autori (Persone) |
YangHsiu-Chiung
YehWu-Kuang <1942-> McCarthyJ. R |
| Collana | Chemical Biology of Enzymes for Biotechnology and Pharmaceutical Applications |
| Soggetto topico |
Enzyme inhibitors
Enzymes - Pharmacokinetics Drugs - Design |
| ISBN |
1-118-73990-6
1-118-73989-2 |
| Classificazione | SCI010000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Enzyme Technologies: Pluripotent Players in Discovering Therapeutic Agents; Copyright; Contents; Contributors; Preface; PART A ENZYMES - ESSENTIAL WORKHORSES IN PHARMACEUTICAL RESEARCH; 1 ASSAY TECHNOLOGIES FOR PROTEASES; I. INTRODUCTION; II. PROTEASE ACTIVITY ASSAYS; III. ASSAYS FOR SOME CLINICALLY SIGNIFICANT PROTEASES; IV. COMPUTATIONAL APPROACHES FOR PROTEASE IDENTIFICATION AND CHARACTERIZATION; 2 DISCOVERY AND DEVELOPMENT OF ISOZYME-SELECTIVE INHIBITORS INVOLVED IN LIPID METABOLISM; I. INTRODUCTION; II. DIACYLGLYCEROL ACYLTRANSFERASE (DGAT)
III. ACYL-COA: CHOLESTEROL ACYLTRANSFERASE (ACAT)IV. CONCLUSIONS AND FUTURE PERSPECTIVES; References; 3 COVALENT ENZYME INHIBITION IN DRUG DISCOVERY AND DEVELOPMENT; I. INTRODUCTION; II. MECHANISM OF INHIBITION: MECHANISTIC TYPES BY PRINCIPLE OF INHIBITION; III. KINETICS: CONCEPTUAL AND EXPERIMENTAL CONSIDERATIONS; IV. SPECIFIC EXAMPLES OF COVALENT INHIBITORS; V. COVALENT ADDUCT WITH COFACTOR ALONE; VI. FULLY IRREVERSIBLE NONCOVALENT INHIBITION; VII. REVERSIBILITY AND DRUG RESISTANCE; VIII. PSEUDO-IRREVERSIBLE INHIBITION; IX. IRREVERSIBLE INHIBITORS AS TOOLS: ACTIVITY-BASED PROTEOMICS (ABP) X. MBI OF CYPsXI. THE PROBLEM OF HAPTENATION; XII. CONCLUSION; References; 4 PRECLINOMICS: ENZYME ASSAYS AND RODENT MODELS FOR METABOLIC DISEASES; I. INTRODUCTION; II. EVOLVING ENZYME ASSAYS; III. DEVELOPING NEW RAT MODEL FOR METABOLIC DISEASES; IV. ZDSD RAT: EVALUATING CURRENT DRUGS; V. EXISTING RODENT MODELS: ESTABLISHING POSITIVE CONTROLS; VI. EXISTING RODENT MODELS AND ONE CANCER PATIENT: TESTING NUTRITIONAL SUPPLEMENT (ALKA VITA); VII. CONCLUDING REMARKS; References; PART B ENZYMES - INDISPENSABLE TOOLS FOR IMPROVING DRUGGABILITY; 5 ENZYMES AND TARGETED ACTIVATION OF PRODRUGS I. INTRODUCTIONII. ENDOGENOUS ENZYMES; III. NONENDOGENOUS ENZYMES; IV. CONCLUDING REMARKS; References; 6 EVOLUTION OF AN ORALLY ACTIVE PRODRUG OF GEMCITABINE; I. INTRODUCTION; II. PREPARATION OF GEMCITABINE PRODRUGS; III. ADVANTAGE OF CYCLOPROPYL ESTER PRODRUGS; IV. ISSUES WITH CYCLOPROPYL ESTERS OF GEMCITABINE; V. ALTERNATIVE PRODRUGS OF GEMCITABINE; VI. CO-CRYSTALS OF VALPROATE AMIDE OF GEMCITABINE; VII. STABILITY OF VALPROATE AMIDE PRODRUG; VIII. BIOAVAILABILITY OF AMIDE PRODRUG; IX. ANTITUMOR ACTIVITY OF PRODRUG; X. SUMMARY; References 7 ENZYMATICALLY ACTIVATED PHOSPHATE AND PHOSPHONATE PRODRUGSI. INTRODUCTION; II. PHOSPHATE GROUP USED FOR SOLUBILITY ENHANCEMENT; III. PHOSPHATE AND PHOSPHONATE PRODRUGS; IV. CONCLUSIONS; References; PART C ENZYMES - POWERFUL WEAPONS FOR CORRECTING NATURE ' S ERRORS; 8 TREATMENT OPTIONS FOR MUCOPOLYSACCHARIDOSIS TYPE II (HUNTER'S SYNDROME); I. INTRODUCTION; II. HISTORY; III. BIOCHEMISTRY; IV. GENETICS; V. CLINICAL MANIFESTATION; VI. MANAGEMENT AND TREATMENT; VII. FUTURE PERSPECTIVES; References; 9 ENZYME REPLACEMENT THERAPY FOR FABRY DISEASE; I. INTRODUCTION II. THE STRUCTURE AND CATALYTIC MECHANISMS OF HUMAN ALPHA-GALACTOSIDASE A |
| Record Nr. | UNINA-9910814431703321 |
| Hoboken, New Jersey : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Ionic liquids in biotransformations and organocatalysis [[electronic resource] ] : solvents and beyond / / edited by Pablo Domínguez de María
| Ionic liquids in biotransformations and organocatalysis [[electronic resource] ] : solvents and beyond / / edited by Pablo Domínguez de María |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2012 |
| Descrizione fisica | 1 online resource (455 p.) |
| Disciplina | 572.6 |
| Altri autori (Persone) | Domínguez de MaríaPablo <1974-> |
| Soggetto topico |
Proteins - Biotechnology
Ionic solutions Catalysis |
| ISBN |
1-299-31449-X
1-118-15874-1 1-118-15875-X 1-118-15872-5 |
| Classificazione | SCI010000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. I. Fundamentals -- pt. II. Ionic liquids in biotransformations -- pt. III. Ionic liquids in organocatalysis. |
| Record Nr. | UNINA-9910141296903321 |
| Hoboken, N.J., : Wiley, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Ionic liquids in biotransformations and organocatalysis : solvents and beyond / / edited by Pablo Domínguez de María
| Ionic liquids in biotransformations and organocatalysis : solvents and beyond / / edited by Pablo Domínguez de María |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2012 |
| Descrizione fisica | 1 online resource (455 p.) |
| Disciplina | 572.6 |
| Altri autori (Persone) | Domínguez de MaríaPablo <1974-> |
| Soggetto topico |
Proteins - Biotechnology
Ionic solutions Catalysis |
| ISBN |
1-299-31449-X
1-118-15874-1 1-118-15875-X 1-118-15872-5 |
| Classificazione | SCI010000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. I. Fundamentals -- pt. II. Ionic liquids in biotransformations -- pt. III. Ionic liquids in organocatalysis. |
| Record Nr. | UNINA-9910825351903321 |
| Hoboken, N.J., : Wiley, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Medical devices [[electronic resource] ] : surgical and image-guided technologies / / edited by Martin Culjat, Rahul Singh, Hua Lee
| Medical devices [[electronic resource] ] : surgical and image-guided technologies / / edited by Martin Culjat, Rahul Singh, Hua Lee |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, 2013 |
| Descrizione fisica | 1 online resource (453 p.) |
| Disciplina |
610.28
610.284 |
| Altri autori (Persone) |
CuljatMartin
Rahul Singh LeeHula |
| Soggetto topico |
Medical instruments and apparatus
Surgical instruments and apparatus |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-283-71516-3
1-118-45279-8 |
| Classificazione | SCI010000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. 1. Introduction to medical devices -- pt. 2. Minimally invasive devices and techniques -- pt. 3. Energy delivery devices and systems -- pt. 4. Implantable devices and systems -- pt. 5. Imaging and image-guided techniques. |
| Record Nr. | UNINA-9910462281703321 |
| Hoboken, N.J., : Wiley, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Medical devices [[electronic resource] ] : surgical and image-guided technologies / / edited by Martin Culjat, Rahul Singh, Hua Lee
| Medical devices [[electronic resource] ] : surgical and image-guided technologies / / edited by Martin Culjat, Rahul Singh, Hua Lee |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, 2013 |
| Descrizione fisica | 1 online resource (453 p.) |
| Disciplina |
610.28
610.284 |
| Altri autori (Persone) |
CuljatMartin
Rahul Singh LeeHula |
| Soggetto topico |
Medical instruments and apparatus
Surgical instruments and apparatus |
| ISBN |
1-118-45353-0
1-283-71516-3 1-118-45279-8 |
| Classificazione | SCI010000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | pt. 1. Introduction to medical devices -- pt. 2. Minimally invasive devices and techniques -- pt. 3. Energy delivery devices and systems -- pt. 4. Implantable devices and systems -- pt. 5. Imaging and image-guided techniques. |
| Record Nr. | UNINA-9910785722703321 |
| Hoboken, N.J., : Wiley, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
