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Antineoplastic drugs : organic synthesis / / Daniel Lednicer
Antineoplastic drugs : organic synthesis / / Daniel Lednicer
Autore Lednicer Daniel
Pubbl/distr/stampa Chichester, England : , : Wiley, , 2015
Descrizione fisica 1 online resource (230 p.)
Disciplina 616.994061
Soggetto topico Antineoplastic agents
ISBN 1-118-89256-9
1-118-89255-0
1-118-89257-7
Classificazione SCI007000
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Title Page; Copyright Page; Contents; Preface; Introduction; Chapter 1 Alkylating Agents; 1.1 bis-Chloroethyl Amines; 1.2 Several Other Chloroethyl Agents; 1.3 Platinum-Based Antineoplastic Agents; 1.4 Miscellaneous Alkylating Agents; References; Chapter 2 Antimetabolites; 2.1 Introduction; 2.2 Folate Antagonists; 2.2.1 Compounds with Glutamate Side Chain; 2.2.2 Compounds Lacking the Glutamate Moiety; 2.2.3 Methoxylated Benzenes; 2.3 Pyrimidines and Purines; 2.3.1 Aglycones; 2.3.2 Saccharide-Linked Compounds; References; Chapter 3 Hormone Blocking Anticancer Drugs; 3.1 Introduction
3.2 Estrogen Antagonists3.2.1 Estrogen Antagonists; 3.2.2 Aromatase Inhibitors; 3.3 Androgen Antagonists; 3.3.1 Non-steroidal Antian drogens; 3.3.2 Steroid Androgen Antagonists; References; Chapter 4 Topoisomerase Inhibitors; 4.1 Introduction; 4.2 Anthracyclines; 4.3 Anthraquinones and Anthrapyrazoles; 4.3.1 Anthraquinones with Two Aminoalkyl Side Chains; 4.3.2 Anthraquinones with a Fused Pyrazole Ring; 4.3.3 Heterocyclic Anthraquinones; 4.4 Camptothecins; 4.4.1 Compounds from Modified Camptothecin; 4.4.2 Camptothecins by Total Synthesis; 4.5 Miscellaneous Topoisomerase Inhibitors; References
Chapter 5 Mitotic Inhibitors5.1 Introduction; 5.2 Taxanes; 5.3 Wholly Synthetic Compounds; 5.3.1 Carbocyclic Compounds; 5.3.2 Peptide-Like Inhibitors; 5.3.3 Monocyclic Heterocyclic Inhibitors; 5.3.4 Bicyclic 5:6 Heterocyclic Inhibitors; 5.3.5 Bicyclic 6:6 Heterocyclic Tubulin Inhibitors; References; Chapter 6 Matrix Metalloproteinase Inhibitors; 6.1 Introduction; 6.2 Hydroxamates; 6.2.1 Agents with an Isobutyl Moiety; 6.2.2 A Thiomorpholine; 6.2.3 Sulfamates; 6.2.4 Miscellaneous Compounds; References; Chapter 7 Histone Deacetylase Inhibitors; 7.1 Introduction; 7.2 Hydroxamates
7.3 PhenylenediaminesReferences; Chapter 8 Enzyme Inhibitor, Part I, Tyrosine Kinases; 8.1 Introduction; 8.2 Epidermal Growth Factor Inhibitors; 8.3 VEGF; 8.3.1 Fused Ring Compounds; 8.3.2 Linear Arrays; 8.4 SRC Nonreceptor Tyrosine Kinase; 8.5 PDGF; 8.6 EGF; 8.7 Other TKI; 8.7.1 Linear Arrays; 8.7.2 Compounds with Two Fused Rings; 8.8 Janus Kinase Inhibitors; References; Chapter 9 Enzyme Inhibitors: Part II Additional Targets; 9.1 Serine-Threonine Kinase Inhibitors; 9.2 Additional Enzyme Inhibitors; 9.2.1 Farnesyl Transferase Inhibitors; 9.2.2 Cyclin-Dependent Kinase Inhibitors
9.2.3 Proteasome Inhibitors9.2.4 PARP Inhibitors; 9.2.5 Various Other Enzyme Inhibitors; References; Chapter 10 Miscellaneous Antineoplastic Agents; 10.1 Acyclic; 10.2 Monocyclic; 10.3 Two Linked Rings; 10.4 Rings on a Chain; 10.4.1 Two Rings; 10.4.2 Four and More Rings; 10.5 Fused Rings; 10.5.1 Indoles; 10.5.2 Purine-Like; 10.5.3 Tetralins and a Naphthalene; 10.5.4 Etc.; References; Appendix A; Index of Heterocycle Syntheses; Subject Index; EULA
Record Nr. UNINA-9910131339603321
Lednicer Daniel  
Chichester, England : , : Wiley, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Antineoplastic drugs : organic synthesis / / Daniel Lednicer
Antineoplastic drugs : organic synthesis / / Daniel Lednicer
Autore Lednicer Daniel
Pubbl/distr/stampa Chichester, England : , : Wiley, , 2015
Descrizione fisica 1 online resource (230 p.)
Disciplina 616.994061
Soggetto topico Antineoplastic agents
ISBN 1-118-89256-9
1-118-89255-0
1-118-89257-7
Classificazione SCI007000
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Title Page; Copyright Page; Contents; Preface; Introduction; Chapter 1 Alkylating Agents; 1.1 bis-Chloroethyl Amines; 1.2 Several Other Chloroethyl Agents; 1.3 Platinum-Based Antineoplastic Agents; 1.4 Miscellaneous Alkylating Agents; References; Chapter 2 Antimetabolites; 2.1 Introduction; 2.2 Folate Antagonists; 2.2.1 Compounds with Glutamate Side Chain; 2.2.2 Compounds Lacking the Glutamate Moiety; 2.2.3 Methoxylated Benzenes; 2.3 Pyrimidines and Purines; 2.3.1 Aglycones; 2.3.2 Saccharide-Linked Compounds; References; Chapter 3 Hormone Blocking Anticancer Drugs; 3.1 Introduction
3.2 Estrogen Antagonists3.2.1 Estrogen Antagonists; 3.2.2 Aromatase Inhibitors; 3.3 Androgen Antagonists; 3.3.1 Non-steroidal Antian drogens; 3.3.2 Steroid Androgen Antagonists; References; Chapter 4 Topoisomerase Inhibitors; 4.1 Introduction; 4.2 Anthracyclines; 4.3 Anthraquinones and Anthrapyrazoles; 4.3.1 Anthraquinones with Two Aminoalkyl Side Chains; 4.3.2 Anthraquinones with a Fused Pyrazole Ring; 4.3.3 Heterocyclic Anthraquinones; 4.4 Camptothecins; 4.4.1 Compounds from Modified Camptothecin; 4.4.2 Camptothecins by Total Synthesis; 4.5 Miscellaneous Topoisomerase Inhibitors; References
Chapter 5 Mitotic Inhibitors5.1 Introduction; 5.2 Taxanes; 5.3 Wholly Synthetic Compounds; 5.3.1 Carbocyclic Compounds; 5.3.2 Peptide-Like Inhibitors; 5.3.3 Monocyclic Heterocyclic Inhibitors; 5.3.4 Bicyclic 5:6 Heterocyclic Inhibitors; 5.3.5 Bicyclic 6:6 Heterocyclic Tubulin Inhibitors; References; Chapter 6 Matrix Metalloproteinase Inhibitors; 6.1 Introduction; 6.2 Hydroxamates; 6.2.1 Agents with an Isobutyl Moiety; 6.2.2 A Thiomorpholine; 6.2.3 Sulfamates; 6.2.4 Miscellaneous Compounds; References; Chapter 7 Histone Deacetylase Inhibitors; 7.1 Introduction; 7.2 Hydroxamates
7.3 PhenylenediaminesReferences; Chapter 8 Enzyme Inhibitor, Part I, Tyrosine Kinases; 8.1 Introduction; 8.2 Epidermal Growth Factor Inhibitors; 8.3 VEGF; 8.3.1 Fused Ring Compounds; 8.3.2 Linear Arrays; 8.4 SRC Nonreceptor Tyrosine Kinase; 8.5 PDGF; 8.6 EGF; 8.7 Other TKI; 8.7.1 Linear Arrays; 8.7.2 Compounds with Two Fused Rings; 8.8 Janus Kinase Inhibitors; References; Chapter 9 Enzyme Inhibitors: Part II Additional Targets; 9.1 Serine-Threonine Kinase Inhibitors; 9.2 Additional Enzyme Inhibitors; 9.2.1 Farnesyl Transferase Inhibitors; 9.2.2 Cyclin-Dependent Kinase Inhibitors
9.2.3 Proteasome Inhibitors9.2.4 PARP Inhibitors; 9.2.5 Various Other Enzyme Inhibitors; References; Chapter 10 Miscellaneous Antineoplastic Agents; 10.1 Acyclic; 10.2 Monocyclic; 10.3 Two Linked Rings; 10.4 Rings on a Chain; 10.4.1 Two Rings; 10.4.2 Four and More Rings; 10.5 Fused Rings; 10.5.1 Indoles; 10.5.2 Purine-Like; 10.5.3 Tetralins and a Naphthalene; 10.5.4 Etc.; References; Appendix A; Index of Heterocycle Syntheses; Subject Index; EULA
Record Nr. UNINA-9910808374903321
Lednicer Daniel  
Chichester, England : , : Wiley, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Biochemical pathways [[electronic resource] ] : an atlas of biochemistry and molecular biology / / edited by Dietmar Schomburg, Gerhard Michal
Biochemical pathways [[electronic resource] ] : an atlas of biochemistry and molecular biology / / edited by Dietmar Schomburg, Gerhard Michal
Edizione [2nd ed.]
Pubbl/distr/stampa Hoboken, N.J., : John Wiley & Sons, c2012
Descrizione fisica 1 online resource (414 p.)
Disciplina 572
612.3/9
612.39
Altri autori (Persone) SchomburgD (Dietmar)
MichalGerhard
Soggetto topico Metabolism
ISBN 1-118-65707-1
1-118-65690-3
Classificazione SCI007000
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Machine generated contents note: Chapter 1. Introduction and general aspects, chemistry and physical chemistry Gerhard Michael and Dietmar Schomburg Chapter 2. The cell and its contents: Enzymes, nucleic acids, and polymeric carbohydrates and lipids Gerhard Michal and Dietmar Schomburg Chapter 3. General metabolism in animals, plants and bacteria 3.1 Carbohydrate Metabolism and Citrate Cycle 3.2 Amino Acids and Derivatives 3.3 Tetrapyrroles 3.4 Lipids amd Glycolipids 3.5 Steriods and Isopreniods 3.6 Nucleotides and Nucleosides 3.7 Cofactors and Vitamins 3.8 Nucleic Acid Metabolism in Bacteria 3.9 Nucleic Acid Metabolism in Eukarya 3.10 Special Bacterial Metabolism and Biosynthesis of Antimicrobials 3.11 Electron Transfer Reactions and Oxidative Phosphorylation 3.12 Photosynthesis 3.13 Plant Secondary Metabolism Chapter 4. Protein biosynthesis, modification and degradation 4.1 Protein Synthesis in Bacteria 4.2 Protein Biosynthesis in Eukarya 4.3 Cell Cycle in Eukarya 4.4 Posttranslational Modification of Proteins 4.5 Protein Folding, Transport / Targeting and Degradation Chapter 5. Viruses Klaus Klumpp Chapter 6. Transport systems 6.1 Transport Through Membranes 6.2 Transport of Lipids in Plasma 6.3 Oxygen Transport by Hemoglobin Chapter 7. Signal transduction and cellular communication Gerhard Niederfellner Chapter 8. Immune system 8.1 Components of the Immune System 8.2 Generation of a Specific Immune Response 8.3 Pathologic Immune responses 8.4 Adhesion of Leukocytes Chapter 9. Blood coagulation and fibrinolysis P. Mueller Chapter 10. Biochemical networks, bioinformatics and systems biology Dietmar Schomburg.
Record Nr. UNINA-9910141499503321
Hoboken, N.J., : John Wiley & Sons, c2012
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Biochemical pathways [[electronic resource] ] : an atlas of biochemistry and molecular biology / / edited by Dietmar Schomburg, Gerhard Michal
Biochemical pathways [[electronic resource] ] : an atlas of biochemistry and molecular biology / / edited by Dietmar Schomburg, Gerhard Michal
Edizione [2nd ed.]
Pubbl/distr/stampa Hoboken, N.J., : John Wiley & Sons, c2012
Descrizione fisica 1 online resource (414 p.)
Disciplina 572
612.3/9
612.39
Altri autori (Persone) SchomburgD (Dietmar)
MichalGerhard
Soggetto topico Metabolism
ISBN 1-118-65707-1
1-118-65690-3
Classificazione SCI007000
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Machine generated contents note: Chapter 1. Introduction and general aspects, chemistry and physical chemistry Gerhard Michael and Dietmar Schomburg Chapter 2. The cell and its contents: Enzymes, nucleic acids, and polymeric carbohydrates and lipids Gerhard Michal and Dietmar Schomburg Chapter 3. General metabolism in animals, plants and bacteria 3.1 Carbohydrate Metabolism and Citrate Cycle 3.2 Amino Acids and Derivatives 3.3 Tetrapyrroles 3.4 Lipids amd Glycolipids 3.5 Steriods and Isopreniods 3.6 Nucleotides and Nucleosides 3.7 Cofactors and Vitamins 3.8 Nucleic Acid Metabolism in Bacteria 3.9 Nucleic Acid Metabolism in Eukarya 3.10 Special Bacterial Metabolism and Biosynthesis of Antimicrobials 3.11 Electron Transfer Reactions and Oxidative Phosphorylation 3.12 Photosynthesis 3.13 Plant Secondary Metabolism Chapter 4. Protein biosynthesis, modification and degradation 4.1 Protein Synthesis in Bacteria 4.2 Protein Biosynthesis in Eukarya 4.3 Cell Cycle in Eukarya 4.4 Posttranslational Modification of Proteins 4.5 Protein Folding, Transport / Targeting and Degradation Chapter 5. Viruses Klaus Klumpp Chapter 6. Transport systems 6.1 Transport Through Membranes 6.2 Transport of Lipids in Plasma 6.3 Oxygen Transport by Hemoglobin Chapter 7. Signal transduction and cellular communication Gerhard Niederfellner Chapter 8. Immune system 8.1 Components of the Immune System 8.2 Generation of a Specific Immune Response 8.3 Pathologic Immune responses 8.4 Adhesion of Leukocytes Chapter 9. Blood coagulation and fibrinolysis P. Mueller Chapter 10. Biochemical networks, bioinformatics and systems biology Dietmar Schomburg.
Record Nr. UNINA-9910830112203321
Hoboken, N.J., : John Wiley & Sons, c2012
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Biochemical pathways [[electronic resource] ] : an atlas of biochemistry and molecular biology / / edited by Dietmar Schomburg, Gerhard Michal
Biochemical pathways [[electronic resource] ] : an atlas of biochemistry and molecular biology / / edited by Dietmar Schomburg, Gerhard Michal
Edizione [2nd ed.]
Pubbl/distr/stampa Hoboken, N.J., : John Wiley & Sons, c2012
Descrizione fisica 1 online resource (414 p.)
Disciplina 572
612.3/9
612.39
Altri autori (Persone) SchomburgD (Dietmar)
MichalGerhard
Soggetto topico Metabolism
ISBN 1-118-65707-1
1-118-65690-3
Classificazione SCI007000
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Machine generated contents note: Chapter 1. Introduction and general aspects, chemistry and physical chemistry Gerhard Michael and Dietmar Schomburg Chapter 2. The cell and its contents: Enzymes, nucleic acids, and polymeric carbohydrates and lipids Gerhard Michal and Dietmar Schomburg Chapter 3. General metabolism in animals, plants and bacteria 3.1 Carbohydrate Metabolism and Citrate Cycle 3.2 Amino Acids and Derivatives 3.3 Tetrapyrroles 3.4 Lipids amd Glycolipids 3.5 Steriods and Isopreniods 3.6 Nucleotides and Nucleosides 3.7 Cofactors and Vitamins 3.8 Nucleic Acid Metabolism in Bacteria 3.9 Nucleic Acid Metabolism in Eukarya 3.10 Special Bacterial Metabolism and Biosynthesis of Antimicrobials 3.11 Electron Transfer Reactions and Oxidative Phosphorylation 3.12 Photosynthesis 3.13 Plant Secondary Metabolism Chapter 4. Protein biosynthesis, modification and degradation 4.1 Protein Synthesis in Bacteria 4.2 Protein Biosynthesis in Eukarya 4.3 Cell Cycle in Eukarya 4.4 Posttranslational Modification of Proteins 4.5 Protein Folding, Transport / Targeting and Degradation Chapter 5. Viruses Klaus Klumpp Chapter 6. Transport systems 6.1 Transport Through Membranes 6.2 Transport of Lipids in Plasma 6.3 Oxygen Transport by Hemoglobin Chapter 7. Signal transduction and cellular communication Gerhard Niederfellner Chapter 8. Immune system 8.1 Components of the Immune System 8.2 Generation of a Specific Immune Response 8.3 Pathologic Immune responses 8.4 Adhesion of Leukocytes Chapter 9. Blood coagulation and fibrinolysis P. Mueller Chapter 10. Biochemical networks, bioinformatics and systems biology Dietmar Schomburg.
Record Nr. UNINA-9910841611803321
Hoboken, N.J., : John Wiley & Sons, c2012
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Biomimetic, bioresponsive, and bioactive materials [[electronic resource] ] : an introduction to integrating materials with tissues / / edited by Matteo Santin, Gary Phillips
Biomimetic, bioresponsive, and bioactive materials [[electronic resource] ] : an introduction to integrating materials with tissues / / edited by Matteo Santin, Gary Phillips
Pubbl/distr/stampa Hoboken, N.J., : Wiley, c2012
Descrizione fisica 1 online resource (249 p.)
Disciplina 660.6
Altri autori (Persone) SantinMatteo
PhillipsGary
Soggetto topico Biomimetic polymers
Biomimetics
Tissues - Mechanical properties
ISBN 1-280-58945-0
9786613619280
1-118-12989-X
1-118-12990-3
1-118-12987-3
Classificazione SCI007000
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Biomimetic, Bioresponsive, and Bioactive Materials; CONTENTS; PREFACE; CONTRIBUTORS; 1: HISTORY OF BIOMIMETIC, BIOACTIVE, AND BIORESPONSIVE BIOMATERIALS; 1.1 THE FIRST GENERATION OF BIOMATERIALS: THE SEARCH FOR "THE BIOINERT"; 1.1.1 Bioinert: Myth, Reality, or Utopia?; 1.2 THE SECOND GENERATION OF BIOMATERIALS: BIOMIMETIC, BIORESPONSIVE, BIOACTIVE; 1.2.1 Hydroxyapatite (HA) and Bioglass®: Cell Adhesion and Stimulation; 1.2.2 Collagen, Fibrin Glue, and Hyaluronic Acid Hydrogels: Presenting the ECM; 1.2.3 Chitosan and Alginate: Replacing the ECM
1.2.4 Poly(Lactic/Glycolic) Acid Copolymers: Encouraging Tissue Remodeling by Safe Biodegradation1.2.5 Porous Metals: Favoring Mechanical Integration; 1.3 THE THIRD-GENERATION BIOMATERIALS: BIOMIMICKING NATURAL BIOACTIVE AND BIORESPONSIVE PROCESSES; 1.3.1 Principal Phases of Tissue Regeneration; 1.3.1.1 Cell Adhesion: The Cornerstone of Tissue Regeneration; 1.3.1.2 Mechanisms of Tissue Mineralization; 1.4 PRINCIPLES OF BIOMIMESIS AND BIOACTIVITY; 1.4.1 Biomimicking of the ECM; 1.4.2 Biomimicking of Cell Membrane Components; 1.4.3 Biomimicking Cell Signaling Pathways
1.4.3.1 Modulation of the Growth Factor Signaling by Gene Expression: Bioactive Gene Delivery Systems1.5 BIOACTIVE BIOMATERIALS FROM DIFFERENT NATURAL SOURCES; 1.5.1 Silk Fibroin; 1.5.2 Soybean-Based Biomaterials; 1.6 SCOPE OF THIS BOOK; REFERENCES; 2: SOFT TISSUE STRUCTURE AND FUNCTIONALITY; 2.1 OVERVIEW; 2.2 EPITHELIAL TISSUE; 2.2.1 Background; 2.3 THE SKIN; 2.3.1 Structure and Functionality; 2.3.2 Repair, Healing, and Renewal; 2.4 MUSCLE TISSUE; 2.4.1 Background; 2.4.2 Skeletal Muscle; 2.4.2.1 Structure and Functionality; 2.4.2.2 Repair, Healing, and Renewal; 2.4.3 Smooth Muscle
2.4.3.1 Structure and Functionality2.4.3.2 Repair, Healing, and Renewal; 2.4.4 Cardiac Muscle; 2.4.4.1 Structure and Functionality; 2.4.4.2 Repair, Healing, and Renewal; 2.5 CONNECTIVE TISSUE; 2.5.1 Background; 2.5.2 Embryonic Connective Tissue; 2.5.3 Connective Tissue Proper; 2.5.3.1 Cells of the Connective Tissue Proper; 2.5.3.2 Connective Tissue Proper Fibers; 2.5.3.3 Ground Substance; 2.5.4 Specialized Connective Tissues; 2.5.4.1 Structure and Function; 2.5.4.2 Repair, Healing, and Renewal of Hyaline Cartilage; 2.6 THE FOREIGN BODY RESPONSE; EXERCISES/QUESTIONS FOR CHAPTER 2; REFERENCES
3: HARD TISSUE STRUCTURE AND FUNCTIONALITY3.1 DEFINITION OF HARD TISSUES; 3.2 ARTICULAR CARTILAGE; 3.2.1 Structure of the Articular Cartilage; 3.2.2 Specific Mechanism Repair of the Articular Cartilage; 3.3 BONE TISSUE; 3.3.1 The Structure of the Bony Tissues; 3.3.2 The Functions of Bone Tissue; 3.3.3 Cell Types Involved in Bone Homeostasis: The Osteoblasts and the Osteoclasts; 3.3.4 Ossification, Turnover, and Remodeling; 3.3.5 Bone Composite Structure and Its Effect on Mechanical Performance; 3.4 CONCLUDING REMARKS; EXERCISES/QUESTIONS FOR CHAPTER 3; REFERENCES
4: BIOMEDICAL APPLICATIONS OF BIOMIMETIC POLYMERS: THE PHOSPHORYLCHOLINE-CONTAINING POLYMERS
Record Nr. UNINA-9910141298103321
Hoboken, N.J., : Wiley, c2012
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Chemical biology [[electronic resource] ] : approaches to drug discovery and development to targeting disease / / edited by Natanya Civjan
Chemical biology [[electronic resource] ] : approaches to drug discovery and development to targeting disease / / edited by Natanya Civjan
Autore Civjan Natanya
Edizione [1st edition]
Pubbl/distr/stampa Hoboken, N.J., : Wiley, 2012
Descrizione fisica 1 online resource (525 p.)
Disciplina 572
Soggetto topico Biochemistry
ISBN 1-283-57605-8
9786613888501
1-118-43576-1
1-118-43450-1
1-118-43767-5
Classificazione SCI007000
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto pt. 1. Drug discovery and development -- pt. 2. Chemical biology to understand and target disease.
Record Nr. UNINA-9910141434203321
Civjan Natanya  
Hoboken, N.J., : Wiley, 2012
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Chemical biology [[electronic resource] ] : approaches to drug discovery and development to targeting disease / / edited by Natanya Civjan
Chemical biology [[electronic resource] ] : approaches to drug discovery and development to targeting disease / / edited by Natanya Civjan
Autore Civjan Natanya
Edizione [1st edition]
Pubbl/distr/stampa Hoboken, N.J., : Wiley, 2012
Descrizione fisica 1 online resource (525 p.)
Disciplina 572
Soggetto topico Biochemistry
ISBN 1-283-57605-8
9786613888501
1-118-43576-1
1-118-43450-1
1-118-43767-5
Classificazione SCI007000
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto pt. 1. Drug discovery and development -- pt. 2. Chemical biology to understand and target disease.
Record Nr. UNINA-9910812578003321
Civjan Natanya  
Hoboken, N.J., : Wiley, 2012
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Chemistry and Biochemistry of Oxygen Therapeutics [[electronic resource] ] : From Transfusion to Artificial Blood
Chemistry and Biochemistry of Oxygen Therapeutics [[electronic resource] ] : From Transfusion to Artificial Blood
Autore Mozzarelli Andrea
Pubbl/distr/stampa Hoboken, : Wiley, 2011
Descrizione fisica 1 online resource (476 p.)
Disciplina 615.8/36
615.836
Altri autori (Persone) BettatiStefano
Soggetto topico Hemoglobins - therapeutic use
Hemoglobins -- therapeutic use
Nitric oxide - Physiological effect
Nitric oxide -- Physiological effect
Oxigen - Physiological effect
Oxigen -- Physiological effect
Oxygen - blood
Oxygen -- blood
Oxygen Consumption
Oxygen Inhalation Therapy - methods
Oxygen Inhalation Therapy -- methods
Oxygen therapy
SCIENCE / Life Sciences / Biochemistry
Oxygen therapy - Physiological effect
Oxygen - Physiological effect
Nitric oxide
Metabolic Phenomena
Respiratory Therapy
Investigative Techniques
Body Fluids
Globins
Chalcogens
Blood Proteins
Gases
Therapeutics
Fluids and Secretions
Elements
Hemeproteins
Inorganic Chemicals
Proteins
Amino Acids, Peptides, and Proteins
Anatomy
Oxygen
Blood
Hemoglobins
Methods
Oxygen Inhalation Therapy
Health & Biological Sciences
Pharmacy, Therapeutics, & Pharmacology
ISBN 1-283-17785-4
9786613177858
1-119-97542-5
1-119-97543-3
Classificazione SCI007000
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Chemistry and Biochemistry of Oxygen Therapeutics; Contents; List of Contributors; Preface; 1. Introduction; References; Part I. Oxygen: Chemistry, Biochemistry, Physiology and Toxicity; 2. Hemoglobin Reactivity and Regulation; 2.1 Introduction; 2.2 Oxygen Loading and Transport; 2.3 NO Reactivity with Hb; 2.4 Hb Oxidation; 2.5 Nitrite Reactivity with Hb; 2.6 Amino-acid Determinants of Hb Reactivity: Natural and Engineered Hbs; 2.6.1 Modulation of Oxygen Affinity and Cooperativity; 2.6.2 NO Reactivity and Oxidation; 2.7 Conclusion; Acknowledgments; References
3. The Major Physiological Control Mechanisms of Blood Flow and Oxygen Delivery3.1 Introduction; 3.2 Autoregulation of Blood Flow to Changes in Perfusion Pressure; 3.3 Metabolic Regulation of Blood Flow; 3.4 O2 Transport; 3.5 O2 Delivery; 3.6 Endothelial Control of Vasomotor Tone; 3.7 Effect of Cell-free Hb on Endothelial Function; 3.8 Hypoxic Hypoxia; 3.9 Carbon Monoxide Hypoxia; 3.10 Anemia; 3.11 Conclusion; References; 4. The Main Players: Hemoglobin and Myoglobin; Nitric Oxide and Oxygen; 4.1 Introduction; 4.2 Role of Mammalian Mb in O2 Homeostasis
4.3 WhatLfs Missing in the Mb Knockout Mouse4.4 Evolutionary Origins of Mb and the Nitrogen Cycle; 4.5 Human Hb: Evolved Sensor of pO2 and Redox; 4.6 Broad Reactivity and Influence of NO: Lessons from the Microcosm Hb; 4.7 Some Fish Demonstrate a Fundamental "Need" for Hb-dependent NO Cycling, as in Humans; 4.8 Reactions of NO with Hb that Preserve NO Bioactivity; 4.9 Mammalian RBC/Hb.NO Interactions; 4.10 A Mutant Mouse Challenges the SNO-Hb Hypothesis, but does not Overthrow it; 4.11 Signaling by Hb-derived SNO: A Metabolically Responsive, Regulated Pathway
4.12 Signaling by Hb-derived SNO: Pathway Complexity Revealed by Multiple Defects in Disease States4.13 Therapeutic Implications of the Hb.NO Signaling System; 4.14 HBOCs, NO, and SNO; 4.15 Other Gaseous Hb Ligands of Potential Therapeutic Significance; 4.16 NO-related Enzymatic Activities of Hb: Reconciling Nitrite Reductase and SNO Synthase Functions; 4.17 Measuring Biologically Relevant Hb.NO Adducts; 4.18 Conclusion; Acknowledgments; References; 5. The Role of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury; 5.1 Introduction
5.2 Redox System and Free Radicals in Biological Systems5.3 Pathophysiology of Ischemia/Reperfusion Injury; 5.3.1 Cell Death; 5.3.2 The Inflammatory Response; 5.4 Protection Against I/R Injury; 5.4.1 Ischemic Pre- and Post-conditioning; 5.4.2 Pharmacological Conditioning; 5.4.2.1 The Protective Role of ROS and Antioxidants; 5.4.2.2 The Protective Role of NO; 5.4.2.3 NO-based Therapies for I/R Injury; 5.5 Conclusion; Acknowledgments; References; Part II. Medical Needs for Oxygen Supply; 6. Acute Traumatic Hemorrhage and Anemia; 6.1 Introduction; 6.2 Blood Transfusion in Trauma
6.2.1 Massive Transfusion
Record Nr. UNINA-9910139631203321
Mozzarelli Andrea  
Hoboken, : Wiley, 2011
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Chemistry and Biochemistry of Oxygen Therapeutics [[electronic resource] ] : From Transfusion to Artificial Blood
Chemistry and Biochemistry of Oxygen Therapeutics [[electronic resource] ] : From Transfusion to Artificial Blood
Autore Mozzarelli Andrea
Pubbl/distr/stampa Hoboken, : Wiley, 2011
Descrizione fisica 1 online resource (476 p.)
Disciplina 615.8/36
615.836
Altri autori (Persone) BettatiStefano
Soggetto topico Hemoglobins - therapeutic use
Hemoglobins -- therapeutic use
Nitric oxide - Physiological effect
Nitric oxide -- Physiological effect
Oxigen - Physiological effect
Oxigen -- Physiological effect
Oxygen - blood
Oxygen -- blood
Oxygen Consumption
Oxygen Inhalation Therapy - methods
Oxygen Inhalation Therapy -- methods
Oxygen therapy
SCIENCE / Life Sciences / Biochemistry
Oxygen therapy - Physiological effect
Oxygen - Physiological effect
Nitric oxide
Metabolic Phenomena
Respiratory Therapy
Investigative Techniques
Body Fluids
Globins
Chalcogens
Blood Proteins
Gases
Therapeutics
Fluids and Secretions
Elements
Hemeproteins
Inorganic Chemicals
Proteins
Amino Acids, Peptides, and Proteins
Anatomy
Oxygen
Blood
Hemoglobins
Methods
Oxygen Inhalation Therapy
Health & Biological Sciences
Pharmacy, Therapeutics, & Pharmacology
ISBN 1-283-17785-4
9786613177858
1-119-97542-5
1-119-97543-3
Classificazione SCI007000
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Chemistry and Biochemistry of Oxygen Therapeutics; Contents; List of Contributors; Preface; 1. Introduction; References; Part I. Oxygen: Chemistry, Biochemistry, Physiology and Toxicity; 2. Hemoglobin Reactivity and Regulation; 2.1 Introduction; 2.2 Oxygen Loading and Transport; 2.3 NO Reactivity with Hb; 2.4 Hb Oxidation; 2.5 Nitrite Reactivity with Hb; 2.6 Amino-acid Determinants of Hb Reactivity: Natural and Engineered Hbs; 2.6.1 Modulation of Oxygen Affinity and Cooperativity; 2.6.2 NO Reactivity and Oxidation; 2.7 Conclusion; Acknowledgments; References
3. The Major Physiological Control Mechanisms of Blood Flow and Oxygen Delivery3.1 Introduction; 3.2 Autoregulation of Blood Flow to Changes in Perfusion Pressure; 3.3 Metabolic Regulation of Blood Flow; 3.4 O2 Transport; 3.5 O2 Delivery; 3.6 Endothelial Control of Vasomotor Tone; 3.7 Effect of Cell-free Hb on Endothelial Function; 3.8 Hypoxic Hypoxia; 3.9 Carbon Monoxide Hypoxia; 3.10 Anemia; 3.11 Conclusion; References; 4. The Main Players: Hemoglobin and Myoglobin; Nitric Oxide and Oxygen; 4.1 Introduction; 4.2 Role of Mammalian Mb in O2 Homeostasis
4.3 WhatLfs Missing in the Mb Knockout Mouse4.4 Evolutionary Origins of Mb and the Nitrogen Cycle; 4.5 Human Hb: Evolved Sensor of pO2 and Redox; 4.6 Broad Reactivity and Influence of NO: Lessons from the Microcosm Hb; 4.7 Some Fish Demonstrate a Fundamental "Need" for Hb-dependent NO Cycling, as in Humans; 4.8 Reactions of NO with Hb that Preserve NO Bioactivity; 4.9 Mammalian RBC/Hb.NO Interactions; 4.10 A Mutant Mouse Challenges the SNO-Hb Hypothesis, but does not Overthrow it; 4.11 Signaling by Hb-derived SNO: A Metabolically Responsive, Regulated Pathway
4.12 Signaling by Hb-derived SNO: Pathway Complexity Revealed by Multiple Defects in Disease States4.13 Therapeutic Implications of the Hb.NO Signaling System; 4.14 HBOCs, NO, and SNO; 4.15 Other Gaseous Hb Ligands of Potential Therapeutic Significance; 4.16 NO-related Enzymatic Activities of Hb: Reconciling Nitrite Reductase and SNO Synthase Functions; 4.17 Measuring Biologically Relevant Hb.NO Adducts; 4.18 Conclusion; Acknowledgments; References; 5. The Role of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury; 5.1 Introduction
5.2 Redox System and Free Radicals in Biological Systems5.3 Pathophysiology of Ischemia/Reperfusion Injury; 5.3.1 Cell Death; 5.3.2 The Inflammatory Response; 5.4 Protection Against I/R Injury; 5.4.1 Ischemic Pre- and Post-conditioning; 5.4.2 Pharmacological Conditioning; 5.4.2.1 The Protective Role of ROS and Antioxidants; 5.4.2.2 The Protective Role of NO; 5.4.2.3 NO-based Therapies for I/R Injury; 5.5 Conclusion; Acknowledgments; References; Part II. Medical Needs for Oxygen Supply; 6. Acute Traumatic Hemorrhage and Anemia; 6.1 Introduction; 6.2 Blood Transfusion in Trauma
6.2.1 Massive Transfusion
Record Nr. UNINA-9910806996303321
Mozzarelli Andrea  
Hoboken, : Wiley, 2011
Materiale a stampa
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