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Advances in statistical bioinformatics : models and integrative inference for high-throughput data / / edited by Kim-Anh Do, The University of Texas M.D. Anderson Cancer Center, Zhaohui Steven Qin, Emory University, Atlanta, GA, Marina Vannucci, Rice University, Houston, TX [[electronic resource]]
| Advances in statistical bioinformatics : models and integrative inference for high-throughput data / / edited by Kim-Anh Do, The University of Texas M.D. Anderson Cancer Center, Zhaohui Steven Qin, Emory University, Atlanta, GA, Marina Vannucci, Rice University, Houston, TX [[electronic resource]] |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2013 |
| Descrizione fisica | 1 online resource (xv, 481 pages) : digital, PDF file(s) |
| Disciplina | 572.80285 |
| Soggetto topico |
Bioinformatics - Statistical methods
Biometry Genetics - Technique |
| ISBN |
1-139-89118-9
1-107-24941-4 1-107-24858-2 1-299-70751-3 1-107-25107-9 1-107-25024-2 1-139-22644-4 1-107-24775-6 |
| Classificazione | MED090000 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
""Contents""; ""List of Contributors""; ""Preface""; ""1 An Introduction to Next-Generation Biological Platforms""; ""Virginia Mohlere, Wenting Wang, and Ganiraju Manyam""; ""1.1 Introduction""; ""1.2 The Biology of Gene Silencing""; ""1.2.1 DNA Methylation""; ""1.2.2 RNA Interference""; ""1.3 High-Throughput Profiling""; ""1.3.1 Molecular Inversion Probe Arrays""; ""1.3.2 Array Comparative Genomic Hybridization (aCGH)""; ""1.3.3 Genome-Wide Association Studies""; ""1.3.4 Reverse-Phase Protein Array""; ""1.4 Next-Generation Sequencing""; ""1.4.1 Whole-Genome and Whole-Exome Sequencing""
""1.4.2 ChIP-Seq""""1.4.3 RNA-Seq""; ""1.4.4 BS-seq""; ""1.5 NGS Data Management and Analysis""; ""1.6 Platform Integration""; ""Acknowledgments""; ""References""; ""References""; ""2 An Introduction to The Cancer Genome Atlas""; ""Bradley M. Broom and Rehan Akbani""; ""2.1 Introduction""; ""2.2 History and Goals of the TCGA Project""; ""2.3 Sample Collection and Processing""; ""2.3.1 Step 1: Tissue Collection""; ""2.3.2 Step 2: Quality Control and DNA/RNA Extraction""; ""2.3.3 Step 3: Molecular Profiling and Sequencing""; ""2.3.4 Step 4: Data Collection and Public Distribution"" ""2.3.5 Step 5: Data Analysis""""2.4 Data Processing, Storage, and Access""; ""2.4.1 TCGA Barcodes and UUIDs""; ""2.4.2 The Data Coordinating Center""; ""2.4.3 Data Access Matrix""; ""2.4.4 Bulk Download""; ""2.4.5 HTTP""; ""2.4.6 CGHub""; ""2.4.7 Sample and Data Relationship Format (SDRF) and Investigation Description Format (IDF) Files""; ""2.4.8 File Format""; ""2.4.9 Version""; ""2.5 Tools for Visualizing and Analyzing TCGA Data""; ""2.5.1 cBio Cancer Genomics Portal""; ""2.5.2 MBatch Portal""; ""2.5.3 Next-Generation Clustered Heat Maps""; ""2.5.4 Regulome Explorer"" ""2.5.5 Integrative Genome Viewer""""2.5.6 Cancer Genomics Browser""; ""2.6 Summary""; ""Acknowledgments""; ""References""; ""References""; ""3 DNA Variant Calling in Targeted Sequencing Data""; ""Wenyi Wang, Yu Fan, and Terence P. Speed""; ""3.1 Introduction""; ""3.2 Background""; ""3.2.1 Single-Nucleotide Variation""; ""3.2.2 Long Padlock Probes""; ""3.2.3 Array-Based Resequencing""; ""3.3 Sequence Robust Multiarray Analysis""; ""3.3.1 Quality Control""; ""3.3.2 Variant Calling""; ""3.4 Application of SRMA""; ""3.4.1 Candidate Gene Study for Mitochondrial Diseases"" ""3.4.2 Validation Results""""3.4.3 Biological Findings""; ""3.5 Conclusion""; ""Appendix""; ""References""; ""References""; ""4 Statistical Analysis of Mapped Reads from mRNA-Seq Data""; ""Ernest Turro and Alex Lewin""; ""4.1 Background""; ""4.1.1 RNA Biology""; ""4.1.2 RNA Technology""; ""4.2 Mapping and Assembly Strategies""; ""4.2.1 De Novo Assembly of the Transcriptome""; ""4.2.2 Genome-Guided Assembly of the Transcriptome""; ""4.2.3 Alignment to a Reference Transcriptome""; ""4.3 Modeling Expression Levels""; ""4.3.1 Poisson Model for Expression Quantification""; ""4.4 Normalization"" ""4.4.1 RPKM Normalization"" |
| Record Nr. | UNINA-9910789313903321 |
| Cambridge : , : Cambridge University Press, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Advances in statistical bioinformatics : models and integrative inference for high-throughput data / / edited by Kim-Anh Do, The University of Texas M.D. Anderson Cancer Center, Zhaohui Steven Qin, Emory University, Atlanta, GA, Marina Vannucci, Rice University, Houston, TX [[electronic resource]]
| Advances in statistical bioinformatics : models and integrative inference for high-throughput data / / edited by Kim-Anh Do, The University of Texas M.D. Anderson Cancer Center, Zhaohui Steven Qin, Emory University, Atlanta, GA, Marina Vannucci, Rice University, Houston, TX [[electronic resource]] |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2013 |
| Descrizione fisica | 1 online resource (xv, 481 pages) : digital, PDF file(s) |
| Disciplina | 572.80285 |
| Soggetto topico |
Bioinformatics - Statistical methods
Biometry Genetics - Technique |
| ISBN |
1-139-89118-9
1-107-24941-4 1-107-24858-2 1-299-70751-3 1-107-25107-9 1-107-25024-2 1-139-22644-4 1-107-24775-6 |
| Classificazione | MED090000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
""Contents""; ""List of Contributors""; ""Preface""; ""1 An Introduction to Next-Generation Biological Platforms""; ""Virginia Mohlere, Wenting Wang, and Ganiraju Manyam""; ""1.1 Introduction""; ""1.2 The Biology of Gene Silencing""; ""1.2.1 DNA Methylation""; ""1.2.2 RNA Interference""; ""1.3 High-Throughput Profiling""; ""1.3.1 Molecular Inversion Probe Arrays""; ""1.3.2 Array Comparative Genomic Hybridization (aCGH)""; ""1.3.3 Genome-Wide Association Studies""; ""1.3.4 Reverse-Phase Protein Array""; ""1.4 Next-Generation Sequencing""; ""1.4.1 Whole-Genome and Whole-Exome Sequencing""
""1.4.2 ChIP-Seq""""1.4.3 RNA-Seq""; ""1.4.4 BS-seq""; ""1.5 NGS Data Management and Analysis""; ""1.6 Platform Integration""; ""Acknowledgments""; ""References""; ""References""; ""2 An Introduction to The Cancer Genome Atlas""; ""Bradley M. Broom and Rehan Akbani""; ""2.1 Introduction""; ""2.2 History and Goals of the TCGA Project""; ""2.3 Sample Collection and Processing""; ""2.3.1 Step 1: Tissue Collection""; ""2.3.2 Step 2: Quality Control and DNA/RNA Extraction""; ""2.3.3 Step 3: Molecular Profiling and Sequencing""; ""2.3.4 Step 4: Data Collection and Public Distribution"" ""2.3.5 Step 5: Data Analysis""""2.4 Data Processing, Storage, and Access""; ""2.4.1 TCGA Barcodes and UUIDs""; ""2.4.2 The Data Coordinating Center""; ""2.4.3 Data Access Matrix""; ""2.4.4 Bulk Download""; ""2.4.5 HTTP""; ""2.4.6 CGHub""; ""2.4.7 Sample and Data Relationship Format (SDRF) and Investigation Description Format (IDF) Files""; ""2.4.8 File Format""; ""2.4.9 Version""; ""2.5 Tools for Visualizing and Analyzing TCGA Data""; ""2.5.1 cBio Cancer Genomics Portal""; ""2.5.2 MBatch Portal""; ""2.5.3 Next-Generation Clustered Heat Maps""; ""2.5.4 Regulome Explorer"" ""2.5.5 Integrative Genome Viewer""""2.5.6 Cancer Genomics Browser""; ""2.6 Summary""; ""Acknowledgments""; ""References""; ""References""; ""3 DNA Variant Calling in Targeted Sequencing Data""; ""Wenyi Wang, Yu Fan, and Terence P. Speed""; ""3.1 Introduction""; ""3.2 Background""; ""3.2.1 Single-Nucleotide Variation""; ""3.2.2 Long Padlock Probes""; ""3.2.3 Array-Based Resequencing""; ""3.3 Sequence Robust Multiarray Analysis""; ""3.3.1 Quality Control""; ""3.3.2 Variant Calling""; ""3.4 Application of SRMA""; ""3.4.1 Candidate Gene Study for Mitochondrial Diseases"" ""3.4.2 Validation Results""""3.4.3 Biological Findings""; ""3.5 Conclusion""; ""Appendix""; ""References""; ""References""; ""4 Statistical Analysis of Mapped Reads from mRNA-Seq Data""; ""Ernest Turro and Alex Lewin""; ""4.1 Background""; ""4.1.1 RNA Biology""; ""4.1.2 RNA Technology""; ""4.2 Mapping and Assembly Strategies""; ""4.2.1 De Novo Assembly of the Transcriptome""; ""4.2.2 Genome-Guided Assembly of the Transcriptome""; ""4.2.3 Alignment to a Reference Transcriptome""; ""4.3 Modeling Expression Levels""; ""4.3.1 Poisson Model for Expression Quantification""; ""4.4 Normalization"" ""4.4.1 RPKM Normalization"" |
| Record Nr. | UNINA-9910810575303321 |
| Cambridge : , : Cambridge University Press, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Preventing and treating missing data in longitudinal clinical trials : a practical guide / / Craig H. Mallinckrodt [[electronic resource]]
| Preventing and treating missing data in longitudinal clinical trials : a practical guide / / Craig H. Mallinckrodt [[electronic resource]] |
| Autore | Mallinckrodt Craig H. <1958-> |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2013 |
| Descrizione fisica | 1 online resource (xviii, 165 pages) : digital, PDF file(s) |
| Disciplina | 610.72/4 |
| Collana | Practical guides to biostatistics and epidemiology |
| Soggetto topico |
Clinical trials
Medical sciences - Statistical methods Regression analysis - Data processing |
| ISBN |
1-107-23773-4
1-107-30590-X 1-107-30692-2 1-107-30912-3 1-107-30183-1 1-107-31467-4 1-139-38166-0 1-107-31247-7 1-299-00912-3 |
| Classificazione | MED090000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: Part I. Background and Setting: 1. Why missing data matter; 2. Missing data mechanisms; 3. Estimands; Part II. Preventing Missing Data: 4. Trial design considerations; 5. Trial conduct considerations; Part III. Analytic Considerations: 6. Methods of estimation; 7. Models and modeling considerations; 8. Methods of dealing with missing data; Part IV. Analyses and the Analytic Road Map: 9. Analyses of incomplete data; 10. MNAR analyses; 11. Choosing primary estimands and analyses; 12. The analytic road map; 13. Analyzing incomplete categorical data; 14. Example; 15. Putting principles into practice. |
| Altri titoli varianti | Preventing & Treating Missing Data in Longitudinal Clinical Trials |
| Record Nr. | UNINA-9910779589803321 |
Mallinckrodt Craig H. <1958->
|
||
| Cambridge : , : Cambridge University Press, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Preventing and treating missing data in longitudinal clinical trials : a practical guide / / Craig H. Mallinckrodt [[electronic resource]]
| Preventing and treating missing data in longitudinal clinical trials : a practical guide / / Craig H. Mallinckrodt [[electronic resource]] |
| Autore | Mallinckrodt Craig H. <1958-> |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2013 |
| Descrizione fisica | 1 online resource (xviii, 165 pages) : digital, PDF file(s) |
| Disciplina | 610.72/4 |
| Collana | Practical guides to biostatistics and epidemiology |
| Soggetto topico |
Clinical trials
Medical sciences - Statistical methods Regression analysis - Data processing |
| ISBN |
1-107-23773-4
1-107-30590-X 1-107-30692-2 1-107-30912-3 1-107-30183-1 1-107-31467-4 1-139-38166-0 1-107-31247-7 1-299-00912-3 |
| Classificazione | MED090000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Machine generated contents note: Part I. Background and Setting: 1. Why missing data matter; 2. Missing data mechanisms; 3. Estimands; Part II. Preventing Missing Data: 4. Trial design considerations; 5. Trial conduct considerations; Part III. Analytic Considerations: 6. Methods of estimation; 7. Models and modeling considerations; 8. Methods of dealing with missing data; Part IV. Analyses and the Analytic Road Map: 9. Analyses of incomplete data; 10. MNAR analyses; 11. Choosing primary estimands and analyses; 12. The analytic road map; 13. Analyzing incomplete categorical data; 14. Example; 15. Putting principles into practice. |
| Altri titoli varianti | Preventing & Treating Missing Data in Longitudinal Clinical Trials |
| Record Nr. | UNINA-9910826704803321 |
|
Mallinckrodt Craig H. <1958->
|
||
| Cambridge : , : Cambridge University Press, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||