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Basic principles of drug discovery and development / / Benjamin E. Blass
Basic principles of drug discovery and development / / Benjamin E. Blass
Autore Benjamin Blass
Pubbl/distr/stampa Amsterdam, [Netherlands] : , : Academic Press, , 2015
Descrizione fisica 1 online resource (591 p.)
Disciplina 615.19
Soggetto topico Drug development
Drugs - Design
ISBN 1-78539-787-7
Classificazione 44.38
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Front Cover; Basic Principles of Drug Discovery and Development; Copyright; Dedication; Contents; Foreword; Chapter 1 - Drug Discovery and Development: An Overview of Modern Methods and Principles; DRUG DISCOVERY AND DEVELOPMENT FROM 20,000FEET (FIGURE 1.7); TARGET SELECTION: THE FIRST STEP FORWARD; HIT IDENTIFICATION: FINDING A STARTING POINT; IDENTIFY A CLINICAL CANDIDATE: JUGGLING THE PROPERTIES; QUESTIONS; References; Chapter 2 - The Drug Discovery Process: From Ancient Times to the Present Day; THE AGE OF BOTANICALS: PREINDUSTRIAL DRUG DISCOVERY
PAUL EHRLICH: THE FATHER OF MODERN DRUG DISCOVERY10MILESTONES IN DRUG DISCOVERY; THE RISE OF BIOLOGICS AND MACROMOLECULAR THERAPEUTICS; SOCIETAL AND GOVERNMENTAL IMPACTS; REGULATORY MILESTONES; FUTURE DEVELOPMENTS IN DRUG DISCOVERY; QUESTIONS; References; Chapter 3 - Classical Targets in Drug Discovery; PROTEIN STRUCTURE; ENZYMES; INHIBITION OF ENZYMES; G-PROTEIN-COUPLED RECEPTORS (GPCRS); ION CHANNELS; MEMBRANE TRANSPORT PROTEINS (TRANSPORTERS); EMERGING TARGETS; QUESTIONS; References; Chapter 4 - In vitro Screening Systems; THE LANGUAGE OF SCREENING: BASIC TERMS; STREPTAVIDIN AND BIOTIN
BIOCHEMICAL VERSUS CELLULAR ASSAYSASSAY SYSTEMS AND METHODS OF DETECTION; RADIOLIGAND ASSAY SYSTEMS; ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA); FLUORESCENCE-BASED ASSAY SYSTEMS; REPORTER GENE ASSAYS; KINETIC FLUORESCENT MEASUREMENT SYSTEMS; LABEL-FREE ASSAY SYSTEMS; ELECTROPHYSIOLOGICAL PATCH CLAMP; GENERAL CONSIDERATION FOR ALL SCREENING METHODS; QUESTIONS; References; Chapter 5 - Medicinal Chemistry; STRUCTURE-ACTIVITY RELATIONSHIPS AND STRUCTURE-PROPERTY RELATIONSHIPS; THE ROLE OF CHIRALITY; PUSH AND PULL IN STRUCTURE-ACTIVITY RELATIONSHIPS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS
EXEMPLARY ANIMAL MODELS BY DISEASE CATEGORYANIMAL MODELS OF INFECTIOUS DISEASE; ANIMAL MODELS OF ONCOLOGY; QUESTIONS; References; Chapter 8 - Safety and Toxicology; SOURCES OF TOXICITY; ACUTE VERSUS CHRONIC TOXICITY; CYTOTOXICITY; CARCINOGENICITY, GENOTOXICITY, AND MUTAGENICITY; DRUG-DRUG INTERACTIONS; CARDIOVASCULAR SAFETY AND TOXICOLOGY STUDIES; CENTRAL NERVOUS SYSTEM SAFETY AND TOXICOLOGY STUDIES; IMMUNE SYSTEM MEDIATED SAFETY ISSUES; TERATOGENICITY; IN VIVO TOXICITY AND SAFETY STUDIES; QUESTIONS; References; Chapter 9 - Basics of Clinical Trials; BEFORE THE CLINIC; DRUG SUPPLY
DELIVERY METHODS
Record Nr. UNINA-9910788115403321
Benjamin Blass  
Amsterdam, [Netherlands] : , : Academic Press, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Basic principles of drug discovery and development / / Benjamin E. Blass
Basic principles of drug discovery and development / / Benjamin E. Blass
Autore Benjamin Blass
Pubbl/distr/stampa Amsterdam, [Netherlands] : , : Academic Press, , 2015
Descrizione fisica 1 online resource (591 p.)
Disciplina 615.19
Soggetto topico Drug development
Drugs - Design
ISBN 1-78539-787-7
Classificazione 44.38
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Front Cover; Basic Principles of Drug Discovery and Development; Copyright; Dedication; Contents; Foreword; Chapter 1 - Drug Discovery and Development: An Overview of Modern Methods and Principles; DRUG DISCOVERY AND DEVELOPMENT FROM 20,000FEET (FIGURE 1.7); TARGET SELECTION: THE FIRST STEP FORWARD; HIT IDENTIFICATION: FINDING A STARTING POINT; IDENTIFY A CLINICAL CANDIDATE: JUGGLING THE PROPERTIES; QUESTIONS; References; Chapter 2 - The Drug Discovery Process: From Ancient Times to the Present Day; THE AGE OF BOTANICALS: PREINDUSTRIAL DRUG DISCOVERY
PAUL EHRLICH: THE FATHER OF MODERN DRUG DISCOVERY10MILESTONES IN DRUG DISCOVERY; THE RISE OF BIOLOGICS AND MACROMOLECULAR THERAPEUTICS; SOCIETAL AND GOVERNMENTAL IMPACTS; REGULATORY MILESTONES; FUTURE DEVELOPMENTS IN DRUG DISCOVERY; QUESTIONS; References; Chapter 3 - Classical Targets in Drug Discovery; PROTEIN STRUCTURE; ENZYMES; INHIBITION OF ENZYMES; G-PROTEIN-COUPLED RECEPTORS (GPCRS); ION CHANNELS; MEMBRANE TRANSPORT PROTEINS (TRANSPORTERS); EMERGING TARGETS; QUESTIONS; References; Chapter 4 - In vitro Screening Systems; THE LANGUAGE OF SCREENING: BASIC TERMS; STREPTAVIDIN AND BIOTIN
BIOCHEMICAL VERSUS CELLULAR ASSAYSASSAY SYSTEMS AND METHODS OF DETECTION; RADIOLIGAND ASSAY SYSTEMS; ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA); FLUORESCENCE-BASED ASSAY SYSTEMS; REPORTER GENE ASSAYS; KINETIC FLUORESCENT MEASUREMENT SYSTEMS; LABEL-FREE ASSAY SYSTEMS; ELECTROPHYSIOLOGICAL PATCH CLAMP; GENERAL CONSIDERATION FOR ALL SCREENING METHODS; QUESTIONS; References; Chapter 5 - Medicinal Chemistry; STRUCTURE-ACTIVITY RELATIONSHIPS AND STRUCTURE-PROPERTY RELATIONSHIPS; THE ROLE OF CHIRALITY; PUSH AND PULL IN STRUCTURE-ACTIVITY RELATIONSHIPS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS
EXEMPLARY ANIMAL MODELS BY DISEASE CATEGORYANIMAL MODELS OF INFECTIOUS DISEASE; ANIMAL MODELS OF ONCOLOGY; QUESTIONS; References; Chapter 8 - Safety and Toxicology; SOURCES OF TOXICITY; ACUTE VERSUS CHRONIC TOXICITY; CYTOTOXICITY; CARCINOGENICITY, GENOTOXICITY, AND MUTAGENICITY; DRUG-DRUG INTERACTIONS; CARDIOVASCULAR SAFETY AND TOXICOLOGY STUDIES; CENTRAL NERVOUS SYSTEM SAFETY AND TOXICOLOGY STUDIES; IMMUNE SYSTEM MEDIATED SAFETY ISSUES; TERATOGENICITY; IN VIVO TOXICITY AND SAFETY STUDIES; QUESTIONS; References; Chapter 9 - Basics of Clinical Trials; BEFORE THE CLINIC; DRUG SUPPLY
DELIVERY METHODS
Record Nr. UNINA-9910811820003321
Benjamin Blass  
Amsterdam, [Netherlands] : , : Academic Press, , 2015
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
High-throughput screening in drug discovery [[e-book] /] / edited by Jörg Hüser
High-throughput screening in drug discovery [[e-book] /] / edited by Jörg Hüser
Pubbl/distr/stampa Weinheim, : Wiley-VCH
Descrizione fisica 1 online resource (371 p.)
Disciplina 615.19
615.1900285
Altri autori (Persone) HüserJörg
Collana Methods and principles in medicinal chemistry
Soggetto topico High throughput screening (Drug development)
Pharmaceutical chemistry
Soggetto genere / forma Electronic books.
ISBN 1-280-72366-1
9786610723669
3-527-60932-6
3-527-60936-9
Classificazione 44.38
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto High-Throughput Screening in Drug Discovery; Foreword; List of Contents; Preface; List of Contributors; Part I Concept of Screening; 1 Chemical Genetics: Use of High-throughput Screening to Identify Small-molecule Modulators of Proteins Involved in Cellular Pathways with the Aim of Uncovering Protein Function; 1.1 Introduction; 1.2 Classical and Chemical Genetics; 1.2.1 Forward and Reverse Screens; 1.3 Identifying Bioactive Molecules; 1.4 Target Identification; 1.4.1 Hypothesis-driven Target Identification; 1.4.2 Affinity-based Target Identification
1.4.3 Genomic Methods of Target Identification1.4.4 Proteomic Methods; 1.5 Discovery for Basic Research Versus Pharmacotherapy Goals; 1.6 Chemical Genetic Screens in the Academic Setting; 1.7 Conclusions; 2 High-throughput Screening for Targeted Lead Discovery; 2.1 Chemical Libraries for High-throughput Screening; 2.2 Properties of Lead Structures; 2.3 Challenges to High-throughput Screening; 2.4 Assay Technologies for High-throughput Screening; 2.5 Laboratory Automation; 2.6 From Target Selection to Confirmed Hits - the HTS Workflow and its Vocabulary
2.7 Separating Specific Modulators from Off-Target Effects2.8 Data Analysis and Screening Results; 2.9 Conclusions; Part II Automation Technologies; 3 Tools and Technologies that Facilitate Automated Screening; 3.1 Introduction - the Necessity to Automate; 3.1.1 Compound Libraries; 3.1.2 Targets and Data Points; 3.1.3 Main Issues Facing HTS Groups Today; 3.1.4 Benefits of Miniaturization; 3.1.5 Benefits of Automated HTS; 3.1.6 Screening Strategies; 3.1.7 Ultra HTS (UHTS); 3.2 Sample Carriers; 3.2.1 A Brief History of the Microplate; 3.2.2 Microplate Usage Today; 3.2.3 Microplate Arrays
3.2.4 Non-microplate Alternatives3.2.4.1 Labchips; 3.2.4.2 LabCDs; 3.2.4.3 LabBrick; 3.2.4.4 Arrayed Compound Screening; 3.3 Liquid Handling Tools; 3.3.1 Main Microplate Dispense Mechanisms; 3.3.1.1 Pin Tools; 3.3.1.2 Air and Positive Displacement; 3.3.1.3 Peristaltic; 3.3.1.4 Solenoid-syringe; 3.3.1.5 Solenoid-pressure bottle; 3.3.1.6 Capillary Sipper; 3.3.1.7 Piezoelectric; 3.3.1.8 Acoustic Transducer; 3.3.2 HTS Liquid Handling Applications and Dispensing Technologies Used; 3.3.2.1 Bulk Reagent and Cell Addition; 3.3.2.2 Compound Reformatting and Nanoliter Dispensing
3.3.2.3 Cherry Picking and Serial Dilution3.3.2.4 Microplate Washing; 3.4 Detection Technologies; 3.4.1 Main Detection Modalities Used in HTS; 3.4.2 Plate Readers; 3.4.3 Plate Imagers; 3.4.3.1 Macro-imaging; 3.4.3.2 Micro-imaging; 3.4.4 Dispense and Read Devices; 3.4.5 Other Detection Technologies; 3.4.6 Automation of Detection Technologies; 3.4.7 Potential Sources of Reading Error; 3.5 Laboratory Robotics; 3.5.1 Traditional Workstations; 3.5.2 Robotic Sample Processors; 3.5.3 Plate Storage Devices; 3.5.4 Plate Moving Devices; 3.5.5 Fully Integrated Robotic Systems; 3.5.6 Turnkey Workstations
3.5.7 Automated Cell Culture Systems
Record Nr. UNINA-9910143983303321
Weinheim, : Wiley-VCH
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
High-throughput screening in drug discovery [[e-book] /] / edited by Jörg Hüser
High-throughput screening in drug discovery [[e-book] /] / edited by Jörg Hüser
Pubbl/distr/stampa Weinheim, : Wiley-VCH
Descrizione fisica 1 online resource (371 p.)
Disciplina 615.19
615.1900285
Altri autori (Persone) HüserJörg
Collana Methods and principles in medicinal chemistry
Soggetto topico High throughput screening (Drug development)
Pharmaceutical chemistry
ISBN 1-280-72366-1
9786610723669
3-527-60932-6
3-527-60936-9
Classificazione 44.38
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto High-Throughput Screening in Drug Discovery; Foreword; List of Contents; Preface; List of Contributors; Part I Concept of Screening; 1 Chemical Genetics: Use of High-throughput Screening to Identify Small-molecule Modulators of Proteins Involved in Cellular Pathways with the Aim of Uncovering Protein Function; 1.1 Introduction; 1.2 Classical and Chemical Genetics; 1.2.1 Forward and Reverse Screens; 1.3 Identifying Bioactive Molecules; 1.4 Target Identification; 1.4.1 Hypothesis-driven Target Identification; 1.4.2 Affinity-based Target Identification
1.4.3 Genomic Methods of Target Identification1.4.4 Proteomic Methods; 1.5 Discovery for Basic Research Versus Pharmacotherapy Goals; 1.6 Chemical Genetic Screens in the Academic Setting; 1.7 Conclusions; 2 High-throughput Screening for Targeted Lead Discovery; 2.1 Chemical Libraries for High-throughput Screening; 2.2 Properties of Lead Structures; 2.3 Challenges to High-throughput Screening; 2.4 Assay Technologies for High-throughput Screening; 2.5 Laboratory Automation; 2.6 From Target Selection to Confirmed Hits - the HTS Workflow and its Vocabulary
2.7 Separating Specific Modulators from Off-Target Effects2.8 Data Analysis and Screening Results; 2.9 Conclusions; Part II Automation Technologies; 3 Tools and Technologies that Facilitate Automated Screening; 3.1 Introduction - the Necessity to Automate; 3.1.1 Compound Libraries; 3.1.2 Targets and Data Points; 3.1.3 Main Issues Facing HTS Groups Today; 3.1.4 Benefits of Miniaturization; 3.1.5 Benefits of Automated HTS; 3.1.6 Screening Strategies; 3.1.7 Ultra HTS (UHTS); 3.2 Sample Carriers; 3.2.1 A Brief History of the Microplate; 3.2.2 Microplate Usage Today; 3.2.3 Microplate Arrays
3.2.4 Non-microplate Alternatives3.2.4.1 Labchips; 3.2.4.2 LabCDs; 3.2.4.3 LabBrick; 3.2.4.4 Arrayed Compound Screening; 3.3 Liquid Handling Tools; 3.3.1 Main Microplate Dispense Mechanisms; 3.3.1.1 Pin Tools; 3.3.1.2 Air and Positive Displacement; 3.3.1.3 Peristaltic; 3.3.1.4 Solenoid-syringe; 3.3.1.5 Solenoid-pressure bottle; 3.3.1.6 Capillary Sipper; 3.3.1.7 Piezoelectric; 3.3.1.8 Acoustic Transducer; 3.3.2 HTS Liquid Handling Applications and Dispensing Technologies Used; 3.3.2.1 Bulk Reagent and Cell Addition; 3.3.2.2 Compound Reformatting and Nanoliter Dispensing
3.3.2.3 Cherry Picking and Serial Dilution3.3.2.4 Microplate Washing; 3.4 Detection Technologies; 3.4.1 Main Detection Modalities Used in HTS; 3.4.2 Plate Readers; 3.4.3 Plate Imagers; 3.4.3.1 Macro-imaging; 3.4.3.2 Micro-imaging; 3.4.4 Dispense and Read Devices; 3.4.5 Other Detection Technologies; 3.4.6 Automation of Detection Technologies; 3.4.7 Potential Sources of Reading Error; 3.5 Laboratory Robotics; 3.5.1 Traditional Workstations; 3.5.2 Robotic Sample Processors; 3.5.3 Plate Storage Devices; 3.5.4 Plate Moving Devices; 3.5.5 Fully Integrated Robotic Systems; 3.5.6 Turnkey Workstations
3.5.7 Automated Cell Culture Systems
Record Nr. UNINA-9910830771703321
Weinheim, : Wiley-VCH
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
High-throughput screening in drug discovery / / edited by Jorg Huser
High-throughput screening in drug discovery / / edited by Jorg Huser
Pubbl/distr/stampa Weinheim, : Wiley-VCH
Descrizione fisica 1 online resource (371 p.)
Disciplina 615.19
615.1900285
Altri autori (Persone) HuserJorg
Collana Methods and principles in medicinal chemistry
Soggetto topico High throughput screening (Drug development)
Pharmaceutical chemistry
ISBN 1-280-72366-1
9786610723669
3-527-60932-6
3-527-60936-9
Classificazione 44.38
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto High-Throughput Screening in Drug Discovery; Foreword; List of Contents; Preface; List of Contributors; Part I Concept of Screening; 1 Chemical Genetics: Use of High-throughput Screening to Identify Small-molecule Modulators of Proteins Involved in Cellular Pathways with the Aim of Uncovering Protein Function; 1.1 Introduction; 1.2 Classical and Chemical Genetics; 1.2.1 Forward and Reverse Screens; 1.3 Identifying Bioactive Molecules; 1.4 Target Identification; 1.4.1 Hypothesis-driven Target Identification; 1.4.2 Affinity-based Target Identification
1.4.3 Genomic Methods of Target Identification1.4.4 Proteomic Methods; 1.5 Discovery for Basic Research Versus Pharmacotherapy Goals; 1.6 Chemical Genetic Screens in the Academic Setting; 1.7 Conclusions; 2 High-throughput Screening for Targeted Lead Discovery; 2.1 Chemical Libraries for High-throughput Screening; 2.2 Properties of Lead Structures; 2.3 Challenges to High-throughput Screening; 2.4 Assay Technologies for High-throughput Screening; 2.5 Laboratory Automation; 2.6 From Target Selection to Confirmed Hits - the HTS Workflow and its Vocabulary
2.7 Separating Specific Modulators from Off-Target Effects2.8 Data Analysis and Screening Results; 2.9 Conclusions; Part II Automation Technologies; 3 Tools and Technologies that Facilitate Automated Screening; 3.1 Introduction - the Necessity to Automate; 3.1.1 Compound Libraries; 3.1.2 Targets and Data Points; 3.1.3 Main Issues Facing HTS Groups Today; 3.1.4 Benefits of Miniaturization; 3.1.5 Benefits of Automated HTS; 3.1.6 Screening Strategies; 3.1.7 Ultra HTS (UHTS); 3.2 Sample Carriers; 3.2.1 A Brief History of the Microplate; 3.2.2 Microplate Usage Today; 3.2.3 Microplate Arrays
3.2.4 Non-microplate Alternatives3.2.4.1 Labchips; 3.2.4.2 LabCDs; 3.2.4.3 LabBrick; 3.2.4.4 Arrayed Compound Screening; 3.3 Liquid Handling Tools; 3.3.1 Main Microplate Dispense Mechanisms; 3.3.1.1 Pin Tools; 3.3.1.2 Air and Positive Displacement; 3.3.1.3 Peristaltic; 3.3.1.4 Solenoid-syringe; 3.3.1.5 Solenoid-pressure bottle; 3.3.1.6 Capillary Sipper; 3.3.1.7 Piezoelectric; 3.3.1.8 Acoustic Transducer; 3.3.2 HTS Liquid Handling Applications and Dispensing Technologies Used; 3.3.2.1 Bulk Reagent and Cell Addition; 3.3.2.2 Compound Reformatting and Nanoliter Dispensing
3.3.2.3 Cherry Picking and Serial Dilution3.3.2.4 Microplate Washing; 3.4 Detection Technologies; 3.4.1 Main Detection Modalities Used in HTS; 3.4.2 Plate Readers; 3.4.3 Plate Imagers; 3.4.3.1 Macro-imaging; 3.4.3.2 Micro-imaging; 3.4.4 Dispense and Read Devices; 3.4.5 Other Detection Technologies; 3.4.6 Automation of Detection Technologies; 3.4.7 Potential Sources of Reading Error; 3.5 Laboratory Robotics; 3.5.1 Traditional Workstations; 3.5.2 Robotic Sample Processors; 3.5.3 Plate Storage Devices; 3.5.4 Plate Moving Devices; 3.5.5 Fully Integrated Robotic Systems; 3.5.6 Turnkey Workstations
3.5.7 Automated Cell Culture Systems
Record Nr. UNINA-9910877559103321
Weinheim, : Wiley-VCH
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
International journal of clinical pharmacy
International journal of clinical pharmacy
Pubbl/distr/stampa New York, : Springer
Soggetto topico Pharmacy
Drugs
Geneesmiddelen
Farmacotherapie
Soggetto genere / forma Periodical
Periodicals.
Soggetto non controllato Pharmacy, Therapeutics, & Pharmacology
ISSN 2210-7711
Classificazione 44.42
44.38
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Altri titoli varianti IJCP
Clinical pharmacy
Record Nr. UNISA-996201458203316
New York, : Springer
Materiale a stampa
Lo trovi qui: Univ. di Salerno
Opac: Controlla la disponibilità qui
International journal of clinical pharmacy
International journal of clinical pharmacy
Pubbl/distr/stampa New York, : Springer
Soggetto topico Pharmacy
Drugs
Geneesmiddelen
Farmacotherapie
Farmàcia
Soggetto genere / forma Periodical
Periodicals.
Revistes electròniques.
ISSN 2210-7711
Classificazione 44.42
44.38
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Altri titoli varianti IJCP
Clinical pharmacy
Record Nr. UNINA-9910154525103321
New York, : Springer
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Novel compounds from natural products in the new millennium : potential and challenges / / editors, Benny K-H Tan, Boon-Huat Bay, Yi-Zhun Zhu
Novel compounds from natural products in the new millennium : potential and challenges / / editors, Benny K-H Tan, Boon-Huat Bay, Yi-Zhun Zhu
Pubbl/distr/stampa Hackensack, N.J. ; ; Hong Kong : , : World Scientific, , 2004
Descrizione fisica 1 online resource (xv, 319 pages) : illustrations
Disciplina 547.7
660.6
Altri autori (Persone) TanBenny K-H
BayBoon-Huat
ZhuYi-Zhun
Soggetto topico Natural products
Natural products - Therapeutic use
Pharmacognosy
ISBN 1-281-34759-0
9786611347598
981-256-221-4
Classificazione 44.38
42.42
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto 1. Plants in drug discovery creating a new vision / Geoffrey Alan Cordell 2. The Bio-extraction industry in Jamaica: potential and challenges / Trevor Herbert Yee 3. Structural studies of drug metabolising enzymes and the relevance to natural product development / Rupika Delgoda 4. Bioi nformaticsspecies diversity databases: tools for facilitating natural product research / Sudershan Kumar and V idhi Gupta5. From genomes to drugs with bioinformatics / Kuo-Bin Li6. Yeast-based technologies for high through put screening of natural anti-viral agents / Rashi Srivastava and Sunil Kumar Lal7. Use of high-density oligonucleotide microarrays for gene expression profiling in natural product research / George Wai-Cheong Yip8. Limitations of natural pesticides: a challenge to scientists / Ajai Mansingh9. Bioactivity of hexane extract of blighia sapida Konig. on the cattle tick, boophilus microplus and the sweet potato weevil, cylas formicarius elegantulus / Arlene Wilson and Ajai Mansingh10. Antibacterial screening of tragia involucrata L. (Euphorbiaceae)a tribal used medicinal plant / Ramar Perumal Samy [and others]11. Effect of crude papaya latex on rats' pregnancy / Adebowale Adebiyi and P Ganesan Adaikan12. 1-cyano-2-hydroxy-3-butene: a plant nitrile that induces apoptosis in pancreatic acinar cells and reduces the severity of acute pancreatitis / Madhav Bhatia and Matthew A Wallig13. The liver protective effect of sesamin / Yasuo Kiso and Takatoshi Ishikawa14. Endothelium-dependent vascular relaxation induced by extracts of some Chinese medicinal herbs traditionally used to remove circulatory stagnation: an update / Chiu-Yin Kwan and Paul Chan15. Effect of chronic administration of aqueous azadirachta indica (neem) leaf extract on the cardiovascular system in the rat / Idongesit Obiefuna and Ronald Young. 16. The anti-hypertensive effect of sesamin / Yasuo Matsumura17. Effects of salvia miltiorrhiza after acute myocardial infarction in rats / Xin-Yan Ji [and others]18. The antioxidant and free radical scavenging effects of sesamin / Toshio Moritani19. Anticancer and immunomodulatory potential of DRF-3188, an analogue of andrographolide / Ajaya R Kumar [and others]20. Immunomodulating property of astragalus membranaceus and curcuma aromatica / Agnes Slater and Benny Kwong-Huat Tan21. Induction of breast tumours in rats for assaying natural products for anti-tumour properties / Janet Marlene Menzie22. Cancer diagnosis using the novel photosensitizer, hypericin / Malini Olivo23. Chemopreventive efficacy of apigenin against N-nitrosodiethylamine-induced and phenobarbital-promoted experimental hepatoma / Dhanapal Sakthisekaran and Jeyapal Prince Vijeya Singh24. The effects of saponin from sea cucumber (holothuria atra Jaeger) on CEM-SS T-lymphoblastic cells / Hi ang-Lian Hing [and others]25. Lentinana medically valuable glucan / Ann-Teck Yap and Mah-Lee Ng26. Turmeric and colon cancer / Devasena Thiyagarajan [and others]27. Immunotherapy of bladder cancer using microbes / Ratha Mahendran [and others]28. Modulation of hypericin-based phototoxicity in nasopharyngeal cancer / Hong-Yan Du [and others]29. Research and development of natural products in developing countries: need for venture capital / Victor Hugo Rhone30. Protection of ideas, inventions, trade marks, copyrights and products under the intellectual property law / Catherine Swee-Kian Toy
Record Nr. UNINA-9910783218603321
Hackensack, N.J. ; ; Hong Kong : , : World Scientific, , 2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Novel compounds from natural products in the new millennium : potential and challenges / / editors, Benny K-H Tan, Boon-Huat Bay, Yi-Zhun Zhu
Novel compounds from natural products in the new millennium : potential and challenges / / editors, Benny K-H Tan, Boon-Huat Bay, Yi-Zhun Zhu
Edizione [1st ed.]
Pubbl/distr/stampa Hackensack, N.J. ; ; Hong Kong, : World Scientific, c2004
Descrizione fisica 1 online resource (xv, 319 pages) : illustrations
Disciplina 547.7
660.6
Altri autori (Persone) TanBenny K-H
BayBoon-Huat
ZhuYi-Zhun
Soggetto topico Natural products
Natural products - Therapeutic use
Pharmacognosy
ISBN 1-281-34759-0
9786611347598
981-256-221-4
Classificazione 44.38
42.42
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto 1. Plants in drug discovery creating a new vision / Geoffrey Alan Cordell 2. The Bio-extraction industry in Jamaica: potential and challenges / Trevor Herbert Yee 3. Structural studies of drug metabolising enzymes and the relevance to natural product development / Rupika Delgoda 4. Bioi nformaticsspecies diversity databases: tools for facilitating natural product research / Sudershan Kumar and V idhi Gupta5. From genomes to drugs with bioinformatics / Kuo-Bin Li6. Yeast-based technologies for high through put screening of natural anti-viral agents / Rashi Srivastava and Sunil Kumar Lal7. Use of high-density oligonucleotide microarrays for gene expression profiling in natural product research / George Wai-Cheong Yip8. Limitations of natural pesticides: a challenge to scientists / Ajai Mansingh9. Bioactivity of hexane extract of blighia sapida Konig. on the cattle tick, boophilus microplus and the sweet potato weevil, cylas formicarius elegantulus / Arlene Wilson and Ajai Mansingh10. Antibacterial screening of tragia involucrata L. (Euphorbiaceae)a tribal used medicinal plant / Ramar Perumal Samy [and others]11. Effect of crude papaya latex on rats' pregnancy / Adebowale Adebiyi and P Ganesan Adaikan12. 1-cyano-2-hydroxy-3-butene: a plant nitrile that induces apoptosis in pancreatic acinar cells and reduces the severity of acute pancreatitis / Madhav Bhatia and Matthew A Wallig13. The liver protective effect of sesamin / Yasuo Kiso and Takatoshi Ishikawa14. Endothelium-dependent vascular relaxation induced by extracts of some Chinese medicinal herbs traditionally used to remove circulatory stagnation: an update / Chiu-Yin Kwan and Paul Chan15. Effect of chronic administration of aqueous azadirachta indica (neem) leaf extract on the cardiovascular system in the rat / Idongesit Obiefuna and Ronald Young. 16. The anti-hypertensive effect of sesamin / Yasuo Matsumura17. Effects of salvia miltiorrhiza after acute myocardial infarction in rats / Xin-Yan Ji [and others]18. The antioxidant and free radical scavenging effects of sesamin / Toshio Moritani19. Anticancer and immunomodulatory potential of DRF-3188, an analogue of andrographolide / Ajaya R Kumar [and others]20. Immunomodulating property of astragalus membranaceus and curcuma aromatica / Agnes Slater and Benny Kwong-Huat Tan21. Induction of breast tumours in rats for assaying natural products for anti-tumour properties / Janet Marlene Menzie22. Cancer diagnosis using the novel photosensitizer, hypericin / Malini Olivo23. Chemopreventive efficacy of apigenin against N-nitrosodiethylamine-induced and phenobarbital-promoted experimental hepatoma / Dhanapal Sakthisekaran and Jeyapal Prince Vijeya Singh24. The effects of saponin from sea cucumber (holothuria atra Jaeger) on CEM-SS T-lymphoblastic cells / Hi ang-Lian Hing [and others]25. Lentinana medically valuable glucan / Ann-Teck Yap and Mah-Lee Ng26. Turmeric and colon cancer / Devasena Thiyagarajan [and others]27. Immunotherapy of bladder cancer using microbes / Ratha Mahendran [and others]28. Modulation of hypericin-based phototoxicity in nasopharyngeal cancer / Hong-Yan Du [and others]29. Research and development of natural products in developing countries: need for venture capital / Victor Hugo Rhone30. Protection of ideas, inventions, trade marks, copyrights and products under the intellectual property law / Catherine Swee-Kian Toy
Record Nr. UNINA-9910822687003321
Hackensack, N.J. ; ; Hong Kong, : World Scientific, c2004
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Pharmacometrics : the science of quantitative pharmacology / / edited by Ene I. Ette, Anoixis Corporation, Paul J. Williams, University of the Pacific and Anoixis Corporation
Pharmacometrics : the science of quantitative pharmacology / / edited by Ene I. Ette, Anoixis Corporation, Paul J. Williams, University of the Pacific and Anoixis Corporation
Pubbl/distr/stampa Hoboken, New Jersey : , : Wiley-Interscience, , [2007]
Descrizione fisica 1 online resource (1227 p.)
Disciplina 615.1
615/.1
Soggetto topico Pharmacology
Pharmacokinetics
ISBN 1-118-67951-2
1-280-82698-3
9786610826988
0-470-08797-8
0-470-08796-X
Classificazione 44.38
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto PHARMACOMETRICS; CONTENTS; CONTRIBUTORS; PREFACE; ACKNOWLEDGMENTS; 1. Pharmacometrics: Impacting Drug Development and Pharmacotherapy; PART I GENERAL PRINCIPLES; 2. General Principles of Programming: Computer and Statistical; 3. Validation of Software for Pharmacometric Analysis; 4. Linear, Generalized Linear, and Nonlinear Mixed Effects Models; 5. Bayesian Hierarchical Modeling with Markov Chain Monte Carlo Methods; 6. Estimating the Dynamics of Drug Regimen Compliance; 7. Graphical Displays for Modeling Population Data; 8. The Epistemology of Pharmacometrics; 9. Data Imputation
PART II POPULATION PHARMACOKINETIC BASIS OF PHARMACOMETRICS10. Population Pharmacokinetic Estimation Methods; 11. Timing and Efficiency in Population Pharmacokinetic/Pharmacodynamic Data Analysis Projects; 12. Designing Population Pharmacokinetic Studies for Efficient Parameter Estimation; 13. Population Models for Drug Absorption and Enterohepatic Recycling; 14. Pharmacometric Knowledge Discovery from Clinical Trial Data Sets; 15. Resampling Techniques and Their Application to Pharmacometrics; 16. Population Modeling Approach in Bioequivalence Assessment
PART III PHARMACOKINETICS / PHARMACODYNAMICS RELATIONSHIP: BIOMARKERS AND PHARMACOGENOMICS, PK/PD MODELS FOR CONTINUOUS DATA, AND PK/PD MODELS FOR OUTCOMES DATA17. Biomarkers in Drug Development and Pharmacometric Modeling; 18. Analysis of Gene Expression Data; 19. Pharmacogenomics and Pharmacokinetic/Pharmacodynamic Modeling; 20. Empirical Pharmacokinetic/Pharmacodynamic Models; 21. Developing Models of Disease Progression; 22. Mechanistic Pharmacokinetic/Pharmacodynamic Models I; 23. Mechanistic Pharmacokinetic/Pharmacodynamic Models II; 24. PK/PD Analysis of Binary (Logistic) Outcome Data
25. Population Pharmacokinetic/Pharmacodynamic Modeling of Ordered Categorical Longitudinal Data26. Transition Models in Pharmacodynamics; 27. Mixed Effects Modeling Analysis of Count Data; 28. Mixture Modeling with NONMEM V; PART IV CLINICAL TRIAL DESIGNS; 29. Designs for First-Time-in-Human Studies in Nononcology Indications; 30. Design of Phase 1 Studies in Oncology; 31. Design and Analysis of Clinical Exposure: Response Trials; PART V PHARMACOMETRIC KNOWLEDGE CREATION; 32. Pharmacometric/Pharmacodynamic Knowledge Creation: Toward Characterizing an Unexplored Region of the Response Surface
33. Clinical Trial Simulation: Theory34. Modeling and Simulation: Planning and Execution; 35. Clinical Trial Simulation: Efficacy Trials; PART VI PHARMACOMETRIC SERVICE AND COMMUNICATION; 36. Engineering a Pharmacometrics Enterprise; 37. Communicating Pharmacometric Analysis Outcome; PART VII SPECIFIC APPLICATION EXAMPLES; 38. Pharmacometrics Applications in Population Exposure-Response Data for New Drug Development and Evaluation; 39. Pharmacometrics in Pharmacotherapy and Drug Development: Pediatric Application
40. Pharmacometric Methods for Assessing Drug-Induced QT and QTc Prolongations for Non-antiarrhythmic Drugs
Record Nr. UNINA-9910143578003321
Hoboken, New Jersey : , : Wiley-Interscience, , [2007]
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui