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Introduction to cancer metastasis / / edited by Aamir Ahmad
| Introduction to cancer metastasis / / edited by Aamir Ahmad |
| Pubbl/distr/stampa | Amsterdam, [Netherlands] : , : Academic Press, , 2017 |
| Descrizione fisica | 1 online resource (418 pages) : illustrations, tables |
| Disciplina | 616.994072 |
| Collana | Cancer Metastasis |
| Soggetto topico | Metastasis - Diagnosis |
| ISBN | 0-12-804033-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | List of contributors -- Preface -- I CANCER METASTASIS FROM PRIMARY ORGANS -- 1 CANCER METASTASIS: AN INTRODUCTION -- 1. Introduction -- 2. Disruption of Cell Adhesion: Initiation of Metastasis -- 3. Matrix Metalloproteinases in Cancer Metastasis -- 4. EMT in Cancer Metastasis -- 5. Organ-Specific Metastasis -- 6. microRNAs and Cancer Stem Cells in Cancer Metastasis -- 7. Conclusions and Perspectives -- 2. BREAST CANCER METASTASIS -- 1. Introduction -- 2. Biology -- 3. Metastatic Dissemination -- 4. Prognostic Factors After Recurrence -- 5. Treatment for Metastatic Breast Cancer -- 6. Conclusions -- 3. PROSTATE CANCER METASTASIS -1. Epidemiology and Overview of Metastatic Prostate Cancer -- 2. Cellular Biology of Prostate Cancer Metastases -- 3. The Metastatic Cascade -- 4. Conclusions -- 4. LUNG CANCER METASTASIS -- 1. General Information -- 2. Mechanism of Metastasis -- 3. Molecular Mechanism in the Regulation of Lung Cancer Metastasis -- 4. Epithelial to Mesenchymal Transition in Lung Cancer -- 5. Cancer Stem Cells -- 6. Concluding Remarks -- 5. CERVICAL CANCER METASTASIS -- 1. Introduction -- 2. Risk Factors -- 3. Pathogenesis -- 4. Histopathology -- 5. Routes of Dissemination -- 6. Major Molecular Factors -- 7. Conclusion -- 6. COLORECTAL CANCER METASTASIS -- 1. Introduction -- 2. Molecular Aspects of Colorectal Cancer Metastasis -- 3. Main Sites of Colorectal Cancer Metastasis -- 4. Therapeutic Options for Metastatic Colorectal Cancer -- 5. Challenges and Probable Solutions -- 6. Conclusions -- 7. METASTATIC PANCREATIC CANCER: CURRENT STATE AND FUTURE DIRECTIONS -- 1 Introduction -- 2 Management of pancreatic ductal adenocarcinoma -- 3 Molecular mechanisms driving metastasis -- 4 In vivo experimental models -- 5 Open question: onset and dynamics of metastasis -- 6 Conclusions -- 8 GASTRIC CANCER METASTASIS -- 1 Epidemiology and screening programs -- 2 Metastatic GC -- clinical aspects -- 3 Diagnosis of metastatic GC with a particular focus on 18-F-FDG PET/CT -- 4 Prognostic and predictive factors -- 5 Biomarkers -- 6 Treatment methods of metastatic GC -- 7 Conclusion -- 9 HEPATOCELLULAR CARCINOMA: METASTATIC DISEASE -- 1 Introduction -- 2 Epidemiology -- 3 Diagnosis -- 4 Prognosis and staging -- 5 Treatment -- 6 Conclusions -- 10 METASTATIC BLADDER CANCER -- 1 Introduction -- 2 Epidemiology -- 3 Staging -- 4 Grading -- 5 Staging tools -- 6 Emerging biomarkers -- 7 Prognostic factors -- 8 Clinical presentation of metastatic bladder disease -- 9 Management of clinically localized bladder cancer, positive pelvic nodes and metastatic disease -- 10 Clinical prognosticators -- 11 Management of metastatic bladder cancer -- 12 New agents -- 13 Immunotherapy -- 14 Role of surgery in metastatic bladder cancer -- 15 Conclusions -- 11 METASTATIC CUTANEOUS SQUAMOUS CELL CARCINOMAS -- 1 Introduction -- 2 Defining the high-risk variant -- 3 Staging systems -- 4 Treating high-risk cutaneous squamous cell carcinoma -- 5 Sentinel node biopsy -- 6 Treatment of locally advanced or metastatic cutaneous squamous cell carcinoma -- 7 Concluding remarks -- 12 OSTEOSARCOMA METASTASIS-PROGNOSTIC FACTORS AND TREATMENT STRATEGIES -- 1 Introduction -- 2 Clinical features of metastasis from osteosarcoma -- 3 Treatment for metastasis from osteosarcoma -- 4 Conclusion -- II CANCER METASTASIS TO DISTANT ORGANS -- 13 LYMPH NODE METASTASIS -- 1 Introduction -- 2 History -- 3 Mechanisms-how tumors metastasize to lymph nodes -- 4 Clinical aspects of lymph node metastasis -- 5 Pathology -- 6 Conclusions and summary -- 14 MOLECULAR INVOLVEMENT OF THE BONE MARROW MICROENVIRONMENT IN BONE METASTASIS -- 1 Introduction -- 2 Types of bone metastasis -- 3 Pathophysiology of bone metastasis -- 4 Treatment options for bone metastasis -- 5 Discussion/conclusion -- 15 AN OVERVIEW ON HEPATIC METASTASIS -- 1 Introduction -- 2 Hepatic physiology and cancer biology -- 3 Hepatic functional and surgical anatomy -- 4 Clinical presentation and diagnosis -- 5 Treatment of hepatic metastasis -- 6 Conclusions -- 16 PULMONARY METASTASIS -- 1 Development of pulmonary metastasis -- 2 Rationale for local treatment of pulmonary metastases -- 3 Diagnosis of pulmonary metastases -- 4 Preoperative exams -- 5 Surgical resection -- 6 Radiological ablation -- 7 Radiotherapy -- 8 Lymph node involvement -- 9 Resection of recurrent metastases -- 10 Lung metastasis in given tumor types -- 11 Conclusion -- 17 BRAIN METASTASIS: BASIC BIOLOGY, CLINICAL MANAGEMENT, AND INSIGHT FROM EXPERIMENTAL MODEL SYSTEMS -- 1 Introduction -- 2 Biology -- 3 Clinical management -- 4 Experimental model systems -- 5 Preclinical findings -- 6 Conclusions -- III EMERGING TARGETS FOR CANCER METASTASIS -- 18 DEVELOPMENTAL PATHWAYS: EMERGING THERAPEUTIC TARGETS FOR CANCER METASTASIS -- 1 Introduction -- 2 Prometastatic changes and developmental pathways -- 3 Notch signaling and metastasis -- 4 Antimetastatic potential of Wnt and hedgehog targeting -- 5 Concluding remarks -- 19 EMERGING THERAPEUTIC TARGETS FOR CANCER METASTASIS: FROM THE PERSPECTIVE OF EMBRYO IMPLANTATION -- 1 Introduction -- 2 The similarity between embryo implantation and tumor metastasis -- 3 Trophoblast invasion inhibitory factors derived from the maternal endometrium during embryo implantation and their implications in cancer metastasis -- 4 Conclusions and perspectives -- 20 WNT SIGNALING AS A THERAPEUTIC TARGET IN CANCER AND METASTASIS -- 1 Introduction -- 2 Wnt signaling and cancer -- 3 The role of Wnt signaling in epithelial-mesenchymal transition and cancer stem cells -- 4 Therapeutic strategies targeting Wnt signaling -- 5 Protein knockdown strategies -- 6 Viral-based therapies -- 7 Conclusion -- Index |
| Record Nr. | UNINA-9910583007903321 |
| Amsterdam, [Netherlands] : , : Academic Press, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
MicroRNA in cancer / / Suresh Alahari, editor
| MicroRNA in cancer / / Suresh Alahari, editor |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | Dordrecht ; ; New York, : Springer, 2012, c2013 |
| Descrizione fisica | 1 online resource (148 p.) |
| Disciplina | 616.994072 |
| Altri autori (Persone) | AlahariSuresh |
| Collana | Advances in experimental medicine and biology |
| Soggetto topico |
Small interfering RNA
Cancer |
| ISBN |
1-283-93808-1
94-007-4655-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Preface; Contents; MicroRNAs and Other Non-Coding RNAs: Implications for Cancer Patients; 1 Introduction; 2 MiRNAs in Selected Malignancies; 2.1 Chronic Lymphocytic Leukemia; 2.2 Multiple Myeloma; 2.3 Cutaneous T-Cell Lymphoma; 2.4 Mantle Cell Lymphoma; 3 Soluble MiRNAs; 4 Other Non-coding RNAs; 4.1 MALAT-1; 4.2 HOTAIR; 4.3 H19; 4.4 XIST; 4.5 SnaR Family Members; 4.6 Other Transcribed Ultraconserved Regions; 5 Implications for the Treatment of Cancer; References; Function of miRNAs in Tumor Cell Proliferation; 1 Introduction; 2 Aberrant miRNA Expression in Cancer
3 miRNA Regulation of Tumor Cell Division3.1 Cell Division Cycle; 3.2 miRNAs Inhibiting Tumor Cell Proliferation; 3.2.1 miR-15a and miR-16-1; 3.2.2 miR-17/20; 3.2.3 miR-221/222; 3.2.4 Let-7; 3.2.5 miR-29; 3.2.6 miR-34, miR-192 and miR-215; 3.3 miRNAs Enhancing Tumor Cell Proliferation; 3.3.1 miR-21; 3.3.2 miR-27a; 3.3.3 miR-155; 4 miRNA Regulation of Cancer Stem Cells; 5 miRNA Regulation of Tumor Microenvironment and Cancer Metastasis; 6 Therapeutic Application of miRNA in Cancer; 6.1 Restoring the Expression of Tumor Suppressor miRNAs; 6.2 Blocking the Function of Oncogenic miRNAs ReferencesMicroRNAs in Cancer Stem Cells; 1 The Cancer Stem Cell Hypothesis; 2 Links between EMT and the CSC phenotype; 3 microRNAs in CSCs; 4 The cell of origin for Cancer Stem Cells; 5 microRNAs in Normal Stem Cells and Development; 6 Regulation of CSC-Associated microRNAs; 7 Conclusions; References; MicroRNAs in the Pathogenesis of Viral Infections and Cancer; 1 Introduction; 2 Viral miRNAs; 3 Viral miRNAs Targeting Viral Messages; 4 Viral miRNAs that Regulate Host Genes; 5 Cancer and miRNAs; 6 Conclusions; References; Oncogenic microRNAs in Cancer; 1 Introduction 2 Role of Oncogenic microRNAs in Normal Cellular Processes3 Oncogenic microRNAs vs Tumor Suppressive microRNAs; 4 Oncogenic microRNA-Mediated Tumor Growth; 5 Oncogenic microRNA-Mediated Invasion and Metastasis; 6 Cell Type Specific Effect of microRNAs; 7 Oncogenic microRNA-Mediated Resistance to Chemotherapy and Radiation Therapy; 8 Oncogenic microRNAs as a Biomarker for Cancer Diagnosis and Prognosis, and as Therapeutic Targets; 9 Summary; References; Regulation of Metastasis by miRNAs; 1 MiRNAs: The Basics; 1.1 Discovery; 1.2 Biogenesis; 1.3 Mechanism of miRNA Gene Regulation 2 MicroRNAs and Metastasis2.1 Function of Specific miRNAs in EMT; 2.2 miRNAs Drive the Cancer Metastasis; 2.2.1 miR-21; 2.2.2 miR-10b; 2.2.3 miR-182, miR-183, miR-380-5p and miR-211; 2.2.4 Others (miR-1, miR-126, let-7, miR-29c and miR-214); 2.3 miRNAs Suppress Tumor Metastasis; 2.3.1 miR-335, miR-206 and miR-126; 2.3.2 miR-31; 2.3.3 miR-146a and miR-146b; 2.3.4 miR-205; 2.3.5 Others (miR-29b, miR-198, miR-34a, let-7f); 3 Conclusion and Future Perspective; References; MicroRNA in Leukemias; 1 Introduction; 1.1 MicroRNAs in ALL; 1.1.1 MicroRNA Expression Profiling ; 1.1.2 MiRNA Regulation, Cellular Function and Prognostic Significance |
| Record Nr. | UNINA-9910437622303321 |
| Dordrecht ; ; New York, : Springer, 2012, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||