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A Contagious Cause : The American Hunt for Cancer Viruses and the Rise of Molecular Medicine / / Robin Wolfe Scheffler
| A Contagious Cause : The American Hunt for Cancer Viruses and the Rise of Molecular Medicine / / Robin Wolfe Scheffler |
| Autore | Scheffler Robin Wolfe |
| Pubbl/distr/stampa | Chicago : , : University of Chicago Press, , [2019] |
| Descrizione fisica | 1 online resource (391 pages) |
| Disciplina | 616.994019 |
| Collana | Chicago scholarship online |
| Soggetto topico |
Oncogenic viruses - Research - United States - History
Cancer - Etiology - Research - United States - History Virology - Research - United States - History Molecular biology - United States - History |
| Soggetto non controllato |
biomedicine
cancer chronic disease contagion germ theory health policy infrastructure molecular biology public health virus |
| ISBN | 0-226-62840-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Frontmatter -- Contents -- Acronyms -- Introduction: "An Infectious Disease-A Virus" -- Chapter 1. Cancer and Contagion -- Chapter 2. Cancer as a Viral Disease -- Chapter 3. Policymakers and Philanthropists Define the Cancer Problem -- Chapter 4. The Biomedical Settlement and the Federalization of the Cancer Problem -- Chapter 5. Managing the Future at the Special Virus Leukemia Program -- Chapter 6. Administrative Objects and the Infrastructure of Cancer Virus Research -- Chapter 7. Viruses as a Central Front in the War on Cancer -- Chapter 8. Molecular Biology's Resistance to the War on Cancer -- Chapter 9. The West Coast Retrovirus Rush and the Discovery of Oncogenes -- Chapter 10. Momentum for Molecular Medicine -- Conclusion: Afterlife, Memory, and Failure in Biomedical Research -- Time Line -- Acknowledgments -- Notes -- Bibliography -- Bibliography |
| Record Nr. | UNINA-9910861017103321 |
Scheffler Robin Wolfe
|
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| Chicago : , : University of Chicago Press, , [2019] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Human oncogenic viruses [[electronic resource] /] / editors, Jing-Hsiung James Ou, T. S. Benedict Yen
| Human oncogenic viruses [[electronic resource] /] / editors, Jing-Hsiung James Ou, T. S. Benedict Yen |
| Pubbl/distr/stampa | New Jersey, : World Scientific, c2010 |
| Descrizione fisica | 1 online resource (352 p.) |
| Disciplina |
616.9101
616.99/4019 616.994019 |
| Altri autori (Persone) |
OuJ.-H. James <1954-> (Jing-hsiung James)
YenT. S. Benedict <1953-2009.> (Tien-Sze Benedict) |
| Soggetto topico |
Oncogenic viruses
Hepatitis viruses Herpesviruses |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-76042-4
9786612760426 981-283-347-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Foreword; Preface; Chapter 1 Oncogenic Viruses, Cellular Transformation and Human Cancers Yanyan Zheng and Jing-hsiung James Ou; 1. Introduction and Historical Aspects; 2. Human Oncogenic Viruses; 2.1. Hepatitis B Virus (HBV); 2.2. Hepatitis C Virus (HCV); 2.3. Human Papilloma Virus (HPV); 2.4. Epstein-Barr Virus (EBV); 2.5. Kaposi's Sarcoma-associated Herpesvirus (KSHV); 2.6. Human T-cell Leukemia Virus-1 (HTLV-1); 3. Mechanisms of Virus-induced Cellular Transformation; 3.1. Perturbation of Signaling Pathways; 3.1.1. Mimicking the signaling ligands
3.1.2. Mimicking the cellular signaling receptors3.1.3. Mimicking the intracellular signaling adaptors; 3.1.4. Activation of cell surface receptors; 3.2. Deregulation of the Cell Cycle; 3.2.1. Abrogation of the RB function; 3.2.2. Enhancement of CDK activities; 3.2.3. Targeting of cyclin; 3.3. Escape of Apoptosis; 3.3.1. Inactivation of the "gatekeeper" p53; 3.3.2. Expression of viral version of Bcl-2 (vBcl-2); 3.4. Immortalization of Cells; 3.5. Induction of Genetic Instability; 3.6. Insertional Mutagenesis; 3.7. Induction of Chronic Inflammation; 4. Concluding Remarks; Bibliography Chapter 2 Hepatitis B Virus and Hepatocellular Carcinogenesis T. S. Benedict Yen1. Hepatitis B Virus and Hepatocellular Carcinoma; 2. Biology and Epidemiology of HBV; 3. HBV Virology; 4. Prevention and Treatment of HBV; 5. Mechanisms of HBV Carcinogenesis; 5.1. Overview; 5.2. HBV-specific Factors; 5.2.1. X protein; 5.2.1.1. Function of X protein in the HBV life cycle; 5.2.1.2. Effect of X protein on transcription; 5.2.1.3. Effect of X protein on viral replication; 5.2.1.4. X protein and DDB1; 5.2.1.5. X-protein carcinogenesis; 5.2.2. Other viral proteins potentially involved in carcinogenesis 5.2.2.1. Truncated MSP5.2.2.2. preS2 mutants; 5.2.2.3. Core gene mutants; 5.2.3. Insertional mutagenesis; 5.3. Role of Liver Injury and Inflammation; 5.4. Dietary Carcinogens; 5.5. Other Aspects of HBV Oncogenesis; 5.5.1. Role of genotypes; 5.5.2. Role of sex hormones; 6. Summary; Note; References; Chapter 3 Molecular Mechanism of Hepatitis C Virus Carcinogenesis Keigo Machida, Jing-hsiung James Ou and Michael M. C. Lai; 1. Introduction; 2. Molecular Carcinogenesis of HCV; 2.1. Induction of Mutator Phenotype; 2.2. Chromosome Translocation; 2.3. Reactive Oxygen Species (ROS); 2.4. Nitric Oxide 2.5. Inhibition of DNA Damage Repair2.6. Oncogenic Activities of the HCV Core Protein; 2.6.1. TNF-α; 2.6.2. MAPK and AP-1; 2.6.3. NF-κB; 2.6.4. Oxidative stress; 2.6.5. Insulin resistance; 2.6.6. PPARα; 2.6.7. Proteasome activator PA28γ; 2.6.8. SOCS-1; 2.6.9. p53; 2.7. Oncogenic Activities of the HCV NS5A Protein; 3. Other Causative Factors in HCV-associated HCC; 3.1. Chronic Liver Inflammation; 3.2. Alcohol; 4. Endoplasmic Reticulum Stress and HCV Pathogenesis; 5. Gene Expression Profile of HCC; 6. HCV and Lymphomagenesis; 6.1. Induction of IgHypermutation by HCV 6.2. Induction of DNA Translocation between IgGenes and Proto-Oncogenes by HCV |
| Record Nr. | UNINA-9910456103403321 |
| New Jersey, : World Scientific, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Human oncogenic viruses [[electronic resource] /] / editors, Jing-Hsiung James Ou, T. S. Benedict Yen
| Human oncogenic viruses [[electronic resource] /] / editors, Jing-Hsiung James Ou, T. S. Benedict Yen |
| Pubbl/distr/stampa | New Jersey, : World Scientific, c2010 |
| Descrizione fisica | 1 online resource (352 p.) |
| Disciplina |
616.9101
616.99/4019 616.994019 |
| Altri autori (Persone) |
OuJ.-H. James <1954-> (Jing-hsiung James)
YenT. S. Benedict <1953-2009.> (Tien-Sze Benedict) |
| Soggetto topico |
Oncogenic viruses
Hepatitis viruses Herpesviruses |
| ISBN |
1-282-76042-4
9786612760426 981-283-347-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Foreword; Preface; Chapter 1 Oncogenic Viruses, Cellular Transformation and Human Cancers Yanyan Zheng and Jing-hsiung James Ou; 1. Introduction and Historical Aspects; 2. Human Oncogenic Viruses; 2.1. Hepatitis B Virus (HBV); 2.2. Hepatitis C Virus (HCV); 2.3. Human Papilloma Virus (HPV); 2.4. Epstein-Barr Virus (EBV); 2.5. Kaposi's Sarcoma-associated Herpesvirus (KSHV); 2.6. Human T-cell Leukemia Virus-1 (HTLV-1); 3. Mechanisms of Virus-induced Cellular Transformation; 3.1. Perturbation of Signaling Pathways; 3.1.1. Mimicking the signaling ligands
3.1.2. Mimicking the cellular signaling receptors3.1.3. Mimicking the intracellular signaling adaptors; 3.1.4. Activation of cell surface receptors; 3.2. Deregulation of the Cell Cycle; 3.2.1. Abrogation of the RB function; 3.2.2. Enhancement of CDK activities; 3.2.3. Targeting of cyclin; 3.3. Escape of Apoptosis; 3.3.1. Inactivation of the "gatekeeper" p53; 3.3.2. Expression of viral version of Bcl-2 (vBcl-2); 3.4. Immortalization of Cells; 3.5. Induction of Genetic Instability; 3.6. Insertional Mutagenesis; 3.7. Induction of Chronic Inflammation; 4. Concluding Remarks; Bibliography Chapter 2 Hepatitis B Virus and Hepatocellular Carcinogenesis T. S. Benedict Yen1. Hepatitis B Virus and Hepatocellular Carcinoma; 2. Biology and Epidemiology of HBV; 3. HBV Virology; 4. Prevention and Treatment of HBV; 5. Mechanisms of HBV Carcinogenesis; 5.1. Overview; 5.2. HBV-specific Factors; 5.2.1. X protein; 5.2.1.1. Function of X protein in the HBV life cycle; 5.2.1.2. Effect of X protein on transcription; 5.2.1.3. Effect of X protein on viral replication; 5.2.1.4. X protein and DDB1; 5.2.1.5. X-protein carcinogenesis; 5.2.2. Other viral proteins potentially involved in carcinogenesis 5.2.2.1. Truncated MSP5.2.2.2. preS2 mutants; 5.2.2.3. Core gene mutants; 5.2.3. Insertional mutagenesis; 5.3. Role of Liver Injury and Inflammation; 5.4. Dietary Carcinogens; 5.5. Other Aspects of HBV Oncogenesis; 5.5.1. Role of genotypes; 5.5.2. Role of sex hormones; 6. Summary; Note; References; Chapter 3 Molecular Mechanism of Hepatitis C Virus Carcinogenesis Keigo Machida, Jing-hsiung James Ou and Michael M. C. Lai; 1. Introduction; 2. Molecular Carcinogenesis of HCV; 2.1. Induction of Mutator Phenotype; 2.2. Chromosome Translocation; 2.3. Reactive Oxygen Species (ROS); 2.4. Nitric Oxide 2.5. Inhibition of DNA Damage Repair2.6. Oncogenic Activities of the HCV Core Protein; 2.6.1. TNF-α; 2.6.2. MAPK and AP-1; 2.6.3. NF-κB; 2.6.4. Oxidative stress; 2.6.5. Insulin resistance; 2.6.6. PPARα; 2.6.7. Proteasome activator PA28γ; 2.6.8. SOCS-1; 2.6.9. p53; 2.7. Oncogenic Activities of the HCV NS5A Protein; 3. Other Causative Factors in HCV-associated HCC; 3.1. Chronic Liver Inflammation; 3.2. Alcohol; 4. Endoplasmic Reticulum Stress and HCV Pathogenesis; 5. Gene Expression Profile of HCC; 6. HCV and Lymphomagenesis; 6.1. Induction of IgHypermutation by HCV 6.2. Induction of DNA Translocation between IgGenes and Proto-Oncogenes by HCV |
| Record Nr. | UNINA-9910780891803321 |
| New Jersey, : World Scientific, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Human oncogenic viruses / / editors, Jing-Hsiung James Ou, T. S. Benedict Yen
| Human oncogenic viruses / / editors, Jing-Hsiung James Ou, T. S. Benedict Yen |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | New Jersey, : World Scientific, c2010 |
| Descrizione fisica | 1 online resource (352 p.) |
| Disciplina |
616.9101
616.99/4019 616.994019 |
| Altri autori (Persone) |
OuJ.-H. James <1954-> (Jing-hsiung James)
YenT. S. Benedict <1953-2009.> (Tien-Sze Benedict) |
| Soggetto topico |
Oncogenic viruses
Hepatitis viruses Herpesviruses |
| ISBN |
1-282-76042-4
9786612760426 981-283-347-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Contents; Foreword; Preface; Chapter 1 Oncogenic Viruses, Cellular Transformation and Human Cancers Yanyan Zheng and Jing-hsiung James Ou; 1. Introduction and Historical Aspects; 2. Human Oncogenic Viruses; 2.1. Hepatitis B Virus (HBV); 2.2. Hepatitis C Virus (HCV); 2.3. Human Papilloma Virus (HPV); 2.4. Epstein-Barr Virus (EBV); 2.5. Kaposi's Sarcoma-associated Herpesvirus (KSHV); 2.6. Human T-cell Leukemia Virus-1 (HTLV-1); 3. Mechanisms of Virus-induced Cellular Transformation; 3.1. Perturbation of Signaling Pathways; 3.1.1. Mimicking the signaling ligands
3.1.2. Mimicking the cellular signaling receptors3.1.3. Mimicking the intracellular signaling adaptors; 3.1.4. Activation of cell surface receptors; 3.2. Deregulation of the Cell Cycle; 3.2.1. Abrogation of the RB function; 3.2.2. Enhancement of CDK activities; 3.2.3. Targeting of cyclin; 3.3. Escape of Apoptosis; 3.3.1. Inactivation of the "gatekeeper" p53; 3.3.2. Expression of viral version of Bcl-2 (vBcl-2); 3.4. Immortalization of Cells; 3.5. Induction of Genetic Instability; 3.6. Insertional Mutagenesis; 3.7. Induction of Chronic Inflammation; 4. Concluding Remarks; Bibliography Chapter 2 Hepatitis B Virus and Hepatocellular Carcinogenesis T. S. Benedict Yen1. Hepatitis B Virus and Hepatocellular Carcinoma; 2. Biology and Epidemiology of HBV; 3. HBV Virology; 4. Prevention and Treatment of HBV; 5. Mechanisms of HBV Carcinogenesis; 5.1. Overview; 5.2. HBV-specific Factors; 5.2.1. X protein; 5.2.1.1. Function of X protein in the HBV life cycle; 5.2.1.2. Effect of X protein on transcription; 5.2.1.3. Effect of X protein on viral replication; 5.2.1.4. X protein and DDB1; 5.2.1.5. X-protein carcinogenesis; 5.2.2. Other viral proteins potentially involved in carcinogenesis 5.2.2.1. Truncated MSP5.2.2.2. preS2 mutants; 5.2.2.3. Core gene mutants; 5.2.3. Insertional mutagenesis; 5.3. Role of Liver Injury and Inflammation; 5.4. Dietary Carcinogens; 5.5. Other Aspects of HBV Oncogenesis; 5.5.1. Role of genotypes; 5.5.2. Role of sex hormones; 6. Summary; Note; References; Chapter 3 Molecular Mechanism of Hepatitis C Virus Carcinogenesis Keigo Machida, Jing-hsiung James Ou and Michael M. C. Lai; 1. Introduction; 2. Molecular Carcinogenesis of HCV; 2.1. Induction of Mutator Phenotype; 2.2. Chromosome Translocation; 2.3. Reactive Oxygen Species (ROS); 2.4. Nitric Oxide 2.5. Inhibition of DNA Damage Repair2.6. Oncogenic Activities of the HCV Core Protein; 2.6.1. TNF-α; 2.6.2. MAPK and AP-1; 2.6.3. NF-κB; 2.6.4. Oxidative stress; 2.6.5. Insulin resistance; 2.6.6. PPARα; 2.6.7. Proteasome activator PA28γ; 2.6.8. SOCS-1; 2.6.9. p53; 2.7. Oncogenic Activities of the HCV NS5A Protein; 3. Other Causative Factors in HCV-associated HCC; 3.1. Chronic Liver Inflammation; 3.2. Alcohol; 4. Endoplasmic Reticulum Stress and HCV Pathogenesis; 5. Gene Expression Profile of HCC; 6. HCV and Lymphomagenesis; 6.1. Induction of IgHypermutation by HCV 6.2. Induction of DNA Translocation between IgGenes and Proto-Oncogenes by HCV |
| Record Nr. | UNINA-9910816046903321 |
| New Jersey, : World Scientific, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Tumour viruses [[electronic resource] /] / Joanna Parish (ed.)
| Tumour viruses [[electronic resource] /] / Joanna Parish (ed.) |
| Pubbl/distr/stampa | Basel, Switzerland : , : MDPI AG, , 2015 |
| Descrizione fisica | 1 online resource (453 pages) : illustrations; digital, PDF file(s) |
| Disciplina | 616.994019 |
| Soggetto topico |
Oncogenic viruses
Tumors - Virology Virus diseases Epstein-Barr virus diseases Kaposi's sarcoma Papillomaviruses Virology |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910136935903321 |
| Basel, Switzerland : , : MDPI AG, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Tumour viruses [[electronic resource] /] / Joanna Parish (ed.)
| Tumour viruses [[electronic resource] /] / Joanna Parish (ed.) |
| Pubbl/distr/stampa | Basel, Switzerland : , : MDPI AG, , 2015 |
| Descrizione fisica | 1 online resource (453 pages) : illustrations; digital, PDF file(s) |
| Disciplina | 616.994019 |
| Soggetto topico |
Oncogenic viruses
Tumors - Virology Virus diseases Epstein-Barr virus diseases Kaposi's sarcoma Papillomaviruses Virology |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910674363503321 |
| Basel, Switzerland : , : MDPI AG, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Viruses and Human Cancer : From Basic Science to Clinical Prevention / / edited by Mei Hwei Chang, Kuan-Teh Jeang
| Viruses and Human Cancer : From Basic Science to Clinical Prevention / / edited by Mei Hwei Chang, Kuan-Teh Jeang |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (293 p.) |
| Disciplina |
610
616.99 616.994019 |
| Collana | Recent Results in Cancer Research |
| Soggetto topico |
Oncology
Cancer research Communicable diseases Microbiology Cancer Research Infectious Diseases |
| ISBN | 3-642-38965-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Virus infection and human cancer – An overview -- Epidemiology of virus infection and human cancer -- Viral oncogenes and human cancer -- Virus infection, inflammation and cancer prevention -- The oncogenic role of hepatitis B virus -- Prevention of hepatitis B virus infection and liver cancer -- The oncogenic role of hepatitis C virus -- Prevention of hepatitis C virus infection and liver cancer -- The oncogenic role of Human Papilloma virus -- Prevention of Human Papilloma virus and related cancers -- The oncogenic role of Epstein-Barr virus -- Prevention of Epstein-Barr virus infection and related cancers.- The oncogenic role of Human T-Cell Lymphotropic virus -- Prevention of Human T-Cell Lymphotropic virus infection and adult T-Cell leukemia -- The oncogenic role of Kaposi sarcoma-associated herpes virus (HHV-8).- Prevention of Kaposi sarcoma-associated herpes virus (HHV-8) and Kaposi’s sarcoma.- Merkel cell polyomavirus (MCV) and human Merkel cell carcinoma.- Infection-associated cancer after transplantation – Prevention and cure.- Viral infection and cancer prevention – Future prospects. |
| Record Nr. | UNINA-9910300088303321 |
| Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||