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Univ. Federico II (18)

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Advances in biology and therapy of multiple myeloma . Volume 1 Basic science / / Nikhil C. Munshi, Kenneth C. Anderson, editors

New York, : Springer, c2013

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Cancer Consult . Volume 2. : Expertise in Clinical Practice / / edited by Syed A. Abutalib [and three others]

Chichester, England : , : John Wiley & Sons Ltd, , [2024]

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Current & Emerging Therapeutics for Multiple Myeloma [[electronic resource]]

Jagannath Sundar

London, : Future Medicine Ltd, 2013

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Flow Cytometry of Hematological Malignancies

Ortolani Claudio

Hoboken, : Wiley, 2011

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Hematologic malignancies in adults / / edited by MiKaela Olsen, Laura J. Zitella

Pittsburgh, Pennsylvania : , : Oncology Nursing Society, , 2013

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Hematologic malignancies in adults / / edited by MiKaela Olsen, Laura J. Zitella

Pittsburgh, Pennsylvania : , : Oncology Nursing Society, , 2013

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Hematologic malignancies in adults / / edited by MiKaela Olsen, Laura J. Zitella

Pittsburgh, Pennsylvania : , : Oncology Nursing Society, , 2013

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Hoffbrand's Postgraduate Haematology

Mead Adam J

Newark : , : John Wiley & Sons, Incorporated, , 2025

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Multiple myeloma : a new era of treatment strategies / / editors, Klaus Podar, Kenneth C. Anderson

Podar Klaus

[U.S.A.], : Bentham Science Publishers, [2012]

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Multiple myeloma : a textbook for nurses / / edited by Joseph D. Tariman, Beth Faiman

[Place of publication not identified] : , : Oncology Nursing Society, , 2015

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Multiple Myeloma (1)
Multiple myeloma (1)
Multiple myeloma (1)
Hematologic malignancies in adults (1)
Treatment of multiple myeloma and related disorders (1)
Current & Emerging Therapeutics for Multiple Myeloma (1)

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Inglese (18)

Data

Data di pubblicazione

2013 (5)
2009 (4)
2012 (3)
2016 (2)
2011 (1)
2015 (1)
2024 (1)
2025 (1)

Pubbl/distr/stampa	New York, : Springer, c2013
Descrizione fisica	1 online resource (321 p.)
Disciplina	616.99/418 616.9941806
Altri autori (Persone)	MunshiNikhil C AndersonKenneth C
Soggetto topico	Bone marrow - Diseases Myelodysplastic syndromes
ISBN	1-283-84894-5 1-4614-4666-X
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Genomic strategies determining progressions from MGUS to Multiple Myeloma -- Prognostic implication of Genetic changes (Cytogenetics, and FISH, gains and losses of DNA by SNP array and aCGH) in risk stratification in myeloma -- Advances in MM gene expression profiling -- Growth factors in MM -- Role of Wnt signaling pathways in multiple myeloma pathogenesis -- mTOR pathway in multiple myeloma -- Jak/STAT signaling in the pathogenesis and treatment of multiple myeloma -- Role of extracellular matrix in myeloma biology -- Osteoclasts: Potential target for blocking microenvironmental support of myeloma -- Targeting the BAFF/APRIL cytokine network in multiple myeloma -- Role of Osteoblast in myeloma pathology -- Migration and homing in Multiple Myeloma -- Genes and proteins of myeloma endothelial cells to search specific targets of the tumor vasculature -- Epigenetic regulation of myeloma within its bone marrow microenvironment -- Targeting mulitple myeloma tumor angiogenesis: focus on VEGF -- Novel in vivo model in myeloma -- Index.
Record Nr.	UNINA-9910437850803321

Edizione	[Second edition.]
Pubbl/distr/stampa	Chichester, England : , : John Wiley & Sons Ltd, , [2024]
Descrizione fisica	1 online resource (863 pages)
Disciplina	616.99/418
Soggetto topico	Hematopoietic system - Cancer Hematological oncology Cellular therapy
ISBN	1-119-82319-6 1-119-82320-X
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Intro -- Cancer Consult -- Contents -- Editors Volume 2 -- Preface -- Author Bios -- Acknowledgement -- Part 1 Acute Lymphoblastic Leukemia in Adults -- 1 Prognostic Markers and Models in Acute Lymphoblastic Leukemia -- 2 Acute Lymphoblastic Leukemia-Treatment and Outcomes in B-ALL -- 3 T Cell Acute Lymphoblastic Leukemia and Acute Lymphoblastic Lymphoma -- 4 Minimal Residual Disease in Acute Lymphoblastic Leukemia -- 5 Hematopoietic Transplantation and Cellular Therapy in Acute Lymphoblastic Leukemia -- Part 2 Acute Myeloid Leukemia in Adults -- 6 Prognosis in Acute Myeloid Leukemia: Beyond Cytogenetics -- 7 Young Adults with Acute Myeloid Leukemia -- 8 Older Adults with Acute Myeloid Leukemia -- 9 Acute Promyelocytic Leukemia -- 10 Measurable Residual Disease in Acute Myeloid Leukemia -- 11 Hematopoietic Cell Transplantation and Cellular Therapy in Acute Myeloid Leukemia -- Part 3 Myelodysplastic Syndromes and Familial Myeloid Neoplasms -- 12 Diagnosis of Myelodysplastic Syndromes -- 13 Treatment of Myelodysplastic Syndromes -- 14 Hematopoietic Cell Transplantation and Cellular Therapy in Myelodysplastic Syndromes -- 15 Familial Myeloid Neoplasms-When to Suspect and What to Do? -- Part 4 Myeloproliferative Neoplasms -- 16 Chronic Myeloid Leukemia: Chronic Phase Disease -- 17 Chronic Myeloid Leukemia: Advance Phases of the Disease -- 18 Chronic Myeloid Leukemia: Treatment Safety During Reproductive Age and Pregnancy -- 19 Chronic Myeloid Leukemia: Cessation of Therapy -- 20 Hematopoietic Cell Transplantation in Chronic Myeloid Leukemia -- 21 Polycythemia Vera -- 22 Essential Thrombocythemia -- 23 Primary Myelofibrosis -- 24 Hematopoietic Cell Transplantation and Cellular Therapy in Primary and Post ET/PV Myelofibrosis -- 25 Chronic Myelomonocytic Leukemia -- 26 Eosinophilic Myeloproliferative Disorders. Part 5 Chronic Lymphocytic and Other Leukemias -- 27 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma -- 28 Hematopoietic Cell Transplantation and Cellular Therapy in Chronic Lymphocytic Leukemia -- 29 Prolymphocytic Leukemia -- 30 Hairy Cell Leukemia -- Part 6 Hodgkin Lymphoma -- 31 Classic Hodgkin Lymphoma -- 32 Nodular Lymphocyte-Predominant Hodgkin Lymphoma -- 33 Hematopoietic Cell Transplantation and Cellular Therapy in Hodgkin Lymphoma -- Part 7 Non-Hodgkin's Lymphomas -- 34 Pitfalls in the Diagnosis of Non-Hodgkin's Lymphomas -- 35 Follicular Lymphoma -- 36 Mantle Cell Lymphoma -- 37 Marginal Zone Lymphoma -- 38 Hematopoietic Cell Transplantation and Cellular Therapy in Indolent Non-Hodgkin's Lymphomas -- 39 Diffuse Large B Cell Lymphoma -- 40 Hematopoietic Cell Transplantation and Cellular Therapy in Diffuse Large B Cell Lymphoma -- 41 Primary Mediastinal Large B Cell Lymphoma -- 42 Double-Hit and Double-Expressor Lymphomas -- 43 Transformed Lymphoma -- 44 Burkitt Lymphoma -- 45 Primary and Secondary CNS Lymphomas -- 46 HIV-Associated Lymphoma -- 47 Waldenström's Macroglobulinemia -- 48 Primary Cutaneous Lymphomas -- 49 Mycosis Fungoides and Sézary Syndrome -- 50 Peripheral T-Cell Lymphoma -- Part 8 Plasma Cell Neoplasms and Related Disorders -- 51 Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma -- 52 Risk Stratification Including Measurable Residual Disease in Multiple Myeloma -- 53 Newly Diagnosed Multiple Myeloma: Transplant Eligible -- 54 Newly Diagnosed Multiple Myeloma: Transplant Ineligible -- 55 Relapsed/Refractory Multiple Myeloma -- 56 Light-chain (AL) Amyloidosis -- 57 Bispecific T Cell Engager and Cell Based Immune Therapy in Multiple Myeloma -- Part 9 Special Issues in Neoplastic Hematology and Cellular Therapy -- 58 Treatment of Lymphomas During Pregnancy. 59 Complications and Management of CAR T Cell Therapy -- 60 Acute Graft-versus-Host Disease -- 61 Chronic Graft-versus-Host Disease -- Index -- EULA.
Record Nr.	UNINA-9910829819503321

Autore	Jagannath Sundar
Edizione	[1st ed.]
Pubbl/distr/stampa	London, : Future Medicine Ltd, 2013
Descrizione fisica	1 online resource (141 p.)
Disciplina	616.99/418
Soggetto topico	Multiple myelom Multiple myeloma -- Chemotherarpy Multiple myeloma -- Treatment
Soggetto genere / forma	Electronic books.
ISBN	1-78084-228-7
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Title page; Copyright page; Contents; Foreword. Current and emerging therapeutics for multiple myeloma; 1. Current standard treatment of myeloma; 2. Stem cell transplantation; 3. New immune modulators; 4. Histone deacetylase inhibitors; 5. Targeted treatment of multiple myeloma: proteasome inhibitors; 6. AKT inhibitors in multiple myeloma; 7. Future directions; Index
Record Nr.	UNINA-9910465459303321

Autore	Ortolani Claudio
Edizione	[1st ed.]
Pubbl/distr/stampa	Hoboken, : Wiley, 2011
Descrizione fisica	1 online resource (327 p.)
Disciplina	616.99/418 616.99418 616.9941807582
Soggetto topico	Flow cytometry Flow Cytometry - methods Flow Cytometry -- methods Hematologic Neoplasms - diagnosis Hematologic Neoplasms -- diagnosis Hematological oncology Investigative Techniques Neoplasms by Site Cytophotometry Hematologic Diseases Fluorometry Cytological Techniques Neoplasms Hemic and Lymphatic Diseases Disease Clinical Laboratory Techniques Luminescent Measurements Photometry Chemistry Techniques, Analytical Methods Diagnosis Hematologic Neoplasms Flow Cytometry Medicine Health & Biological Sciences Oncology
ISBN	1-283-17847-8 9786613178473 1-4443-9806-7 1-4443-9804-0
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Flow Cytometry of Hematological Malignancies; Contents; Foreword by Maryalice Stetler-Stevenson; Foreword by Bruno Brando; Preface and acknowledgments; Abbreviations; 1 Antigens; CD1 Antigens; CD2 Antigen; CD3 Antigen; CD4 Antigen; CD5 Antigen; CD7 Antigen; CD8 Antigen; CD10 Antigen; CD11b Antigen; CD11c Antigen; CD13 Antigen; CD14 Antigen; CD15 Antigen; CD16 Antigen; CD19 Antigen; CD20 Antigen; CD22 Antigen; CD23 Antigen; CD24 Antigen; CD25 Antigen; CD30 Antigen; CD33 Antigen; CD34 Antigen; CD38 Antigen; CD45 Antigen; CD45 Isoforms; CD56 Antigen; CD57 Antigen; CD61 Antigen; CD64 Antigen CD65 AntigenCD66c Antigen; CD71 Antigen; CD79 Antigen; CD103 Antigen; CD117 Antigen; CD138 Antigen; HLA-DR Antigen; NG2 Antigen; Immunoglobulins; Myeloperoxidase; Cytotoxic Proteins; KIR, CD158 Isoforms; T Cell Receptor; Terminal Deoxy-nucleotidyl Transferase; Bcl-2 Protein; ZAP-70 Protein; References; 2 Diseases; Myeloproliferative Neoplasms; Myelodysplastic/Myeloproliferative Neoplasms; Myelodysplastic Syndromes; Acute Myeloid Leukemias; Acute Leukemias of Ambigous Lineage Attribution; Acute Leukemias not Recognized by the WHO Classification Neoplastic Diseases of T and B Lymphatic PrecursorsNeoplastic Diseases of Mature B Cells; Neoplastic Diseases of Mature T and NK Cells; Appendix; References; Index; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; R; S; T; U; V; W; X; Z
Record Nr.	UNINA-9910139629903321

Pubbl/distr/stampa	Pittsburgh, Pennsylvania : , : Oncology Nursing Society, , 2013
Descrizione fisica	1 online resource (730 p.)
Disciplina	616.99/418
Soggetto topico	Lymphoproliferative disorders Hematopoietic system - Cancer
Soggetto genere / forma	Electronic books.
ISBN	1-935864-50-5
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	""Hematologic Malignancies in Adults""; ""List of Abbreviations""; ""Preface""; ""Chapter 1. Overview of Hematologic Malignancies""; ""Chapter 2. Myeloproliferative Neoplasms (Ph-) and Chronic Myeloid Leukemias""; ""Chapter 3. Myelodysplastic Syndromes""; ""Chapter 4. Myelodysplastic/Myeloproliferative Neoplasms""; ""Chapter 5. Acute Myeloid Leukemia and Acute Leukemias of Ambiguous Lineage""; ""Chapter 6. Precursor Lymphoid Neoplasms""; ""Chapter 7. Mature B-Cell Neoplasms""; ""Chapter 8. Hodgkin Lymphoma""; ""Chapter 9. Mature T-Cell and NK-Cell Neoplasms""; ""Chapter 10. Multiple Myeloma"" ""Chapter 11. Hematopoietic Cell Transplantation""""Chapter 12. Management of the Complications of Hematologic Malignancy and Treatment""; ""Chapter 13. Vascular Access""; ""Chapter 14. Patient Education""; ""Appendices""; ""Index""
Record Nr.	UNINA-9910154965003321

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Autore	Mead Adam J
Edizione	[8th ed.]
Pubbl/distr/stampa	Newark : , : John Wiley & Sons, Incorporated, , 2025
Descrizione fisica	1 online resource (1107 pages)
Disciplina	616.99/418
Altri autori (Persone)	LaffanMichael A CollinsGraham P HayDeborah HoffbrandA. Victor
Soggetto topico	Blood Physiological Phenomena Hematologic Diseases Leukemia - blood Thrombosis - blood
ISBN	9781119706687 1119706688 9781119706670 111970667X 9781119706663 1119706661
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Cover -- Title Page -- Copyright Page -- Contents -- About the editors -- Contributor's list -- Preface to the eighth edition by Adam J Mead -- Preface to the eighth edition by A Victor Hoffbrand -- Preface to the first edition -- About the companion website -- Part I General principles of haematology -- Chapter 1 Human stem cells and haemopoiesis -- Introduction -- Human haemopoietic stem cells and the haemopoietic differentiation hierarchy -- Human haemopoietic stem cell characteristics -- Assays for human haemopoiesis -- Short-term in vitro assays -- Long-term in vitro assays -- Xenotransplantation assay -- Fate-mapping -- Identification of human haemopoietic stem cells -- Development of haemopoietic stem cells -- Regulation of haemopoietic stem cells -- Fate-mapping human haemopoiesis -- Clinical relevance of haemopoietic stem cells -- Selected bibliography -- Chapter 2 Phagocytes -- Introduction -- The phagocyte lineage at a glance -- Phagocyte identification and quantification -- General phagocyte molecules and functions -- Phagocytosis -- Adhesion and chemotaxis -- Pattern recognition receptors and inflammation -- Killing via lytic enzymes and production of reactive radicals -- Phagocyte Particulars -- Neutrophils -- Eosinophils, basophils and mast cells -- Basophils and mast cells -- MPS-Monocytes, macrophages, DCs and multinucleated cells -- Disorders of the phagocyte system -- Neutrophil congenital disorders (Table 2.9) -- Disorders of monocyte/macrophages: a genetic perspective -- Conclusion -- Acknowledgements -- Selected bibliography -- Chapter 3 Erythropoiesis in the human -- Introduction -- The developmental origins of erythropoiesis -- The cellular and molecular pathways leading to definitive erythropoiesis -- Differentiation and terminal maturation. Changes in the expression of key erythroid proteins during terminal differentiation -- The erythroid niche -- The regulation of erythropoiesis by cytokines and cell signalling -- The regulation of apoptosis in erythropoiesis -- The coordination of erythropoiesis and iron metabolism -- The control of erythropoiesis via the oxygen-sensing system -- The mature red cell, senescence and clearance -- Assessing erythropoiesis -- Concluding remarks -- Selected bibliography -- Chapter 4 Lymphocyte development and function -- Introduction -- B cells -- Development -- Antibodies -- Antibody function -- Fc-Fc receptor-mediated interactions -- Complement fixation -- Neutralising activity -- The B cell receptor -- T cells -- T-cell development -- Antigen recognition by the TCR -- CD4+ and CD8+ T cells and their functions -- Differentiation of primed T cells into effector cells -- Regulatory CD4+ T cells -- The role of co-stimulatory and inhibitory molecules -- Natural killer cells -- Natural killer T cells -- The immune response in cancer and its therapy -- Interpretation of blood lymphocyte counts -- Selected bibliography -- Chapter 5 The spleen -- Structure and function of the spleen -- Splenic blood flow and the red pulp -- Blood pooling within the spleen -- Role of the spleen in ensuring quality control of red cells -- Immunological function of the spleen -- Splenomegaly and hypersplenism -- Spleen size -- Causes of splenomegaly -- Extramedullary haemopoiesis -- Haemolytic anaemia and immune cytopenias -- Infections -- Infiltration by haematological malignancies -- Non-Hodgkin lymphoma -- Hodgkin lymphoma -- Myeloid stem cell disorders -- Infiltration by non-haematological malignancies and tumour-like lesions -- Vascular congestion -- Diagnostic evaluation of splenomegaly and splenic lesions -- Management of splenomegaly -- Post splenectomy sepsis. Patient education -- Vaccination -- Antibiotics -- Changes in peripheral blood following splenectomy -- Leucocyte changes -- Platelet changes -- Hyposplenism -- Selected bibliography -- Chapter 6 Cancer immunotherapy -- Introduction -- Immune evasion and subversion in cancer -- The immune system and tumour microenvironment -- Types of immunotherapy -- Antibody therapy -- Adoptive T cell therapy -- Cancer vaccines -- Cytokine therapy -- Emerging types of immunotherapy -- Allogeneic cell therapies -- Future of immunotherapy -- Selected bibliography -- Chapter 7 Clinical applications of gene editing and therapy -- Introduction -- General principles of gene therapy -- Gene therapy in haemopoietic stem cells -- Gene therapy for thalassaemia -- Gene therapy for sickle cell disease -- Safety and efficacy concerns -- Gene therapy for haemophilia -- Genome editing -- General principles of genome editing -- Delivery of genome editing technology -- Genome editing for the -thalassaemias and sickle cell disease -- Approaches for treating haemoglobinopathies through elevation of fetal haemoglobin levels -- Approaches for treating haemoglobinopathies through direct correction of the gene -- Safety of genome editing -- Conclusion -- Selected bibliography -- Chapter 8 Application of next-generation sequencing in haematology -- Introduction -- NGS technology -- Choice of input substrate -- Choice of assay breadth and depth -- Amplicon versus hybridization panel -- Library preparation -- Short-read technologies -- Long-read technologies -- Bioinformatic processing and interpretation of data -- Bioinformatics pipeline -- Interpretation of variants -- Utility -- Diagnostic -- Prognostic -- Therapeutic -- Measurable residual disease -- Germline predisposition -- Discovery -- Practical considerations -- Cost -- Turn-around-times -- Interpretation complexities. Ethical considerations -- The future -- Selected bibliography -- Chapter 9 The molecular basis of haematological malignancies -- Introduction -- The cancer genome -- Classes of DNA mutations -- Inherited predisposition to haematological cancers -- Acquired DNA mutations in haematological cancers -- Endogenous processes -- Exogenous processes -- From genotype to phenotype -- NOTCH-signalling and lymphoid malignancies -- Epigenetics and leukaemia -- Tyrosine kinases and myeloproliferation -- GM-CSF and RAS signalling in juvenile myelomonocytic leukaemia -- Other Ras pathway mutations in haematological malignancies -- The P53 network -- Splicing factors -- Multiple myeloma -- Clonal evolution and subclonal architecture of haematological cancers -- Clonal evolution of cancer -- Impact of clonal structure on treatment and relapse -- Selected bibliography -- Chapter 10 Laboratory diagnosis of haematological neoplasms -- Introduction -- Blood count and blood film -- Bone marrow aspirate -- Bone marrow trephine biopsy -- Cytochemistry -- Histology -- Flow cytometric immunophenotyping -- Immunohistochemistry -- Cytogenetic analysis -- Fluorescence in situ hybridisation -- Molecular genetic analysis -- Whole-genome scanning -- Microarray analysis of gene expression -- Next-generation sequencing -- Laboratory techniques and the WHO classification of tumours of haemopoietic and lymphoid tissues -- Conclusions -- Selected bibliography -- Part II Red blood cell disorders and blood transfusion -- Chapter 11 Iron metabolism, iron deficiency and disorders of haem synthesis -- Introduction -- Distribution of body iron -- Proteins important in iron metabolism -- Haem proteins and iron-containing enzymes -- Ferritin and haemosiderin -- Divalent metal transporter 1 -- Ferroportin -- Other proteins -- Hepcidin -- Erythroferrone -- Matriptase-2. Intracellular iron homeostasis -- Normal iron balance -- Iron absorption -- Iron uptake by erythroid cells -- Haem synthesis and mitochondrial iron metabolism -- Intracellular transit iron and plasma non-transferrin-bound iron -- Breakdown of haemoglobin and iron recycling -- Diagnostic methods for investigating iron metabolism -- Serum ferritin -- Bone marrow aspiration -- Serum iron and iron-binding capacity -- Serum transferrin receptors -- Red cell protoporphyrin -- Percentage of hypochromic red cells -- Reticulocyte haemoglobin content -- Iron deficiency -- Absolute iron deficiency -- Iron deficiency anaemia -- Functional iron deficiency -- Anaemia of inflammation -- Tissue effects of iron deficiency -- Causes of absolute iron deficiency -- Causes of anaemia of inflammation -- Features of the anaemia of inflammation -- Management of iron deficiency -- Oral iron therapy -- Parenteral iron therapy -- Pathological alterations in haem synthesis -- Porphyrias -- Congenital erythropoietic porphyria -- Erythropoietic protoporphyria -- Porphyria cutanea tarda -- Lead poisoning -- Sideroblastic anaemia -- Inherited sideroblastic anaemias -- Defective haem synthesis -- Mutations of proteins of the iron-sulfur cluster biogenesis -- Syndromic forms of sideroblastic anaemia -- Defective mitochondria respiratory chain -- Acquired sideroblastic anaemia -- Selected bibliography -- Chapter 12 Iron overload -- Introduction -- Hereditary haemochromatosis -- HFE haemochromatosis -- Body iron quantitation -- Non-HFE haemochromatosis -- Rare genetic causes of iron overload associated with anaemia -- Atransferrinaemia -- DMT1 deficiency -- Acaeruloplasminaemia -- Other causes of iron overload -- Hereditary hyperferritinaemia-cataract syndrome -- Iron-loading anaemias -- Tests of body iron burden -- Serum ferritin -- Liver iron -- Cardiac iron -- Urine iron excretion. Non-transferrin-bound iron.
Record Nr.	UNINA-9911019565303321