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Advances in HIV-1 assembly and release / / Eric O. Freed, editor
Advances in HIV-1 assembly and release / / Eric O. Freed, editor
Edizione [1st ed. 2013.]
Pubbl/distr/stampa New York, : Springer, 2013
Descrizione fisica 1 online resource (229 p.)
Disciplina 616.979201
Altri autori (Persone) FreedEric O
Soggetto topico HIV (Viruses)
Medical virology
ISBN 1-4614-7729-8
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Structural Biology of HIV Assembly -- Cellular Trafficking Mechanisms in the Assembly and Release of HIV -- Packaging of the HIV-1 RNA Genome -- Synthesis of Functional and Variable HIV-1 Envelope Glycoproteins -- HIV-1 Budding -- HIV-1 Maturation -- Cell-to-Cell Transmission of HIV -- Virus Assembly as a Target for Antiretroviral Therapy.
Record Nr. UNINA-9910437616503321
New York, : Springer, 2013
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Human immunodeficiency virus reverse transcriptase : a bench-to-bedside success / / Stuart LeGrice, Matthias Gotte, editors
Human immunodeficiency virus reverse transcriptase : a bench-to-bedside success / / Stuart LeGrice, Matthias Gotte, editors
Edizione [1st ed. 2013.]
Pubbl/distr/stampa New York, : Springer, 2013
Descrizione fisica 1 online resource (358 p.)
Disciplina 616.979201
Altri autori (Persone) LeGriceStuart
GotteMatthias
Soggetto topico Immunology
HIV infections - Research - Methodology
ISBN 1-4614-7291-1
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto 1.7.1 Highly Active Antiretroviral Therapy (HAART)1.8 Prevention of HIV Transmission; 1.9 Conclusions; References; Part I Structure and Function of HIV RT; Chapter 2: Proviral DNA Synthesis in HIV: Background; 2.1 Introduction; 2.2 The Viral RNA Genome and DNA Provirus; 2.3 Location of the Reverse Transcription Process; 2.4 HIV-1 Reverse Transcriptase; 2.5 Selection of the tRNA Primer for HIV-1; 2.6 Placement of tRNA3Lys onto the Viral Genome; 2.7 Initiation of Reverse Transcription; 2.8 First (Minus)-Strand DNA Transfer; 2.9 Recombination Between the Two Copies of the RNA Genome
2.10 Plus-Strand DNA Synthesis2.11 tRNA Primer Removal from the (+)PBS; 2.12 Plus (Second)-Strand DNA Transfer; 2.13 Priming and Termination of DNA Synthesis Within the cPPT Region; 2.14 Completion of the Viral DNA Genome; 2.15 Integration of the HIV-1 Genome into the Host Genome; 2.16 Unintegrated Viral DNA; 2.17 Conclusion; References; Chapter 3: The RNase H Domain: Structure, Function and Mechanism; 3.1 Overview; 3.2 Structures of RNases H1; 3.3 Substrate Binding; 3.4 Catalysis; 3.5 Catalytic Mechanism of HIV-1 RNase H; 3.6 The Role of RNase H Activity in Reverse Transcription
5.2.1 Interaction Between HIV-1 RT and Nucleoside Triphosphates5.2.2 Crystallographic Structural Studies; 5.3 Mechanisms of Drug Resistance; 5.3.1 Resistance Through Increased Discrimination Against the Active Form of the Drug; 5.3.2 Resistance Through ATP-Mediated Excision of Chain-Terminating Nucleotides; 5.3.3 Mutations in RT that Antagonize the Effect of TAMs; 5.4 Structural Dissection of Drug-Resistant RT; 5.4.1 TAMs and Excision of AZTMP; 5.4.2 The K65R Mutation: Resistance to Tenofovir Disoproxil Fumarate (TDF) and Suppression of TAMs; 5.5 Uptake and Phosphorylation of NRTIs and NtRTIs
5.6 Intracellular dNTP Concentrations
Record Nr. UNINA-9910739405103321
New York, : Springer, 2013
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui