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Ambivalence of scarcity and other essays / / Paul Dumouchel
| Ambivalence of scarcity and other essays / / Paul Dumouchel |
| Autore | Dumouchel Paul |
| Pubbl/distr/stampa | East Lansing, Michigan : , : Michigan State University Press, , 2014 |
| Descrizione fisica | 1 online resource (406 p.) |
| Disciplina | 616.9362 |
| Collana | Studies in Violence, Mimesis, and Culture |
| Soggetto topico | Mimesis in literature |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-60917-417-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | ""Contents""; ""Acknowledgments""; ""Introduction""; ""Part 1. On Economy and Economics""; ""The Ambivalence of Scarcity""; ""Indifference and Envy: Girard and the Anthropological Analysis of Modern Economy""; ""A Mimetic Rereading of Helmut Schoeck�s Envy: A Theory of Social Behaviour""; ""Homo mimeticus as an Economic Agent""; ""Part 2. On Mimetic Theory""; ""Mimetism and Autonomy""; ""Violence and Nonviolence""; ""Differences and Paradoxes: Reflections on Love and Violence in Girard�s Work""; ""Creation and Conversion in Girard""; ""Mimetic Theory: Concepts and Models"" |
| Record Nr. | UNINA-9910465480103321 |
Dumouchel Paul
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| East Lansing, Michigan : , : Michigan State University Press, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Ambivalence of scarcity and other essays / / Paul Dumouchel
| Ambivalence of scarcity and other essays / / Paul Dumouchel |
| Autore | Dumouchel Paul |
| Pubbl/distr/stampa | East Lansing, Michigan : , : Michigan State University Press, , 2014 |
| Descrizione fisica | 1 online resource (406 p.) |
| Disciplina | 616.9362 |
| Collana | Studies in Violence, Mimesis, and Culture |
| Soggetto topico | Mimesis in literature |
| ISBN | 1-60917-417-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | ""Contents""; ""Acknowledgments""; ""Introduction""; ""Part 1. On Economy and Economics""; ""The Ambivalence of Scarcity""; ""Indifference and Envy: Girard and the Anthropological Analysis of Modern Economy""; ""A Mimetic Rereading of Helmut Schoeck�s Envy: A Theory of Social Behaviour""; ""Homo mimeticus as an Economic Agent""; ""Part 2. On Mimetic Theory""; ""Mimetism and Autonomy""; ""Violence and Nonviolence""; ""Differences and Paradoxes: Reflections on Love and Violence in Girard�s Work""; ""Creation and Conversion in Girard""; ""Mimetic Theory: Concepts and Models"" |
| Record Nr. | UNINA-9910786603903321 |
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Dumouchel Paul
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||
| East Lansing, Michigan : , : Michigan State University Press, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Ambivalence of scarcity and other essays / / Paul Dumouchel
| Ambivalence of scarcity and other essays / / Paul Dumouchel |
| Autore | Dumouchel Paul |
| Pubbl/distr/stampa | East Lansing, Michigan : , : Michigan State University Press, , 2014 |
| Descrizione fisica | 1 online resource (406 p.) |
| Disciplina | 616.9362 |
| Collana | Studies in Violence, Mimesis, and Culture |
| Soggetto topico | Mimesis in literature |
| ISBN | 1-60917-417-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | ""Contents""; ""Acknowledgments""; ""Introduction""; ""Part 1. On Economy and Economics""; ""The Ambivalence of Scarcity""; ""Indifference and Envy: Girard and the Anthropological Analysis of Modern Economy""; ""A Mimetic Rereading of Helmut Schoeck�s Envy: A Theory of Social Behaviour""; ""Homo mimeticus as an Economic Agent""; ""Part 2. On Mimetic Theory""; ""Mimetism and Autonomy""; ""Violence and Nonviolence""; ""Differences and Paradoxes: Reflections on Love and Violence in Girard�s Work""; ""Creation and Conversion in Girard""; ""Mimetic Theory: Concepts and Models"" |
| Record Nr. | UNINA-9910807233803321 |
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Dumouchel Paul
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||
| East Lansing, Michigan : , : Michigan State University Press, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Basic malaria microscopy . Volume 2 Tutor's guide [[electronic resource] /] / World Health Organization
| Basic malaria microscopy . Volume 2 Tutor's guide [[electronic resource] /] / World Health Organization |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Geneva, : WHO, 2010 |
| Descrizione fisica | 1 online resource (57 p.) |
| Disciplina | 616.9362 |
| Soggetto topico |
Medical microscopy
Malaria - Diagnosis Malaria - Prevention |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-76085-8
9786612760853 92-4-068539-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
COVER; COPYRIGHT; Contents; Preface to the second edition; Introduction; Learning unit 1: Malaria, the disease; Learning unit 2: Cleaning and storing microscope slides; Learning unit 3: Keeping accurate records; Learning unit 4: Preparing blood films; Learning unit 5: Staining blood films with Giemsa stain; Learning unit 6: The microscope; Learning unit 7: Examining blood films; Learning unit 8: Examining blood films for malaria parasites; 39 Learning unit 9: Routine examination of blood films for malaria parasites; Learning unit 10: Supervision in malaria microscopy
Annex 1: Equipment and reagents required for the training course Annex 2: Questionnaire for evaluating training |
| Record Nr. | UNINA-9910459874303321 |
| Geneva, : WHO, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Basic malaria microscopy . Volume 2 Tutor's guide [[electronic resource] /] / World Health Organization
| Basic malaria microscopy . Volume 2 Tutor's guide [[electronic resource] /] / World Health Organization |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | Geneva, : WHO, 2010 |
| Descrizione fisica | 1 online resource (57 p.) |
| Disciplina | 616.9362 |
| Soggetto topico |
Medical microscopy
Malaria - Diagnosis Malaria - Prevention |
| ISBN |
1-282-76085-8
9786612760853 92-4-068539-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
COVER; COPYRIGHT; Contents; Preface to the second edition; Introduction; Learning unit 1: Malaria, the disease; Learning unit 2: Cleaning and storing microscope slides; Learning unit 3: Keeping accurate records; Learning unit 4: Preparing blood films; Learning unit 5: Staining blood films with Giemsa stain; Learning unit 6: The microscope; Learning unit 7: Examining blood films; Learning unit 8: Examining blood films for malaria parasites; 39 Learning unit 9: Routine examination of blood films for malaria parasites; Learning unit 10: Supervision in malaria microscopy
Annex 1: Equipment and reagents required for the training course Annex 2: Questionnaire for evaluating training |
| Record Nr. | UNINA-9910785006303321 |
| Geneva, : WHO, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Coming to grips with malaria in the new millennium / / UN Millennium Project 2005, Task Force on HIV/AIDS, Malaria, TB, and Access to Essential Medicines, Working Group on Malaria ; Lead authors: Awash Teklehaimanot (Coordinator). [et. al.]
| Coming to grips with malaria in the new millennium / / UN Millennium Project 2005, Task Force on HIV/AIDS, Malaria, TB, and Access to Essential Medicines, Working Group on Malaria ; Lead authors: Awash Teklehaimanot (Coordinator). [et. al.] |
| Autore | Teklehaimanot Awash |
| Pubbl/distr/stampa | London ; ; Sterling, Va. : , : Earthscan, , 2005 |
| Descrizione fisica | 1 online resource (147 p.) |
| Disciplina |
362.196/93620091724
614.5320091724 616.9362 |
| Soggetto topico |
Malaria - Developing countries - Prevention
Malaria - Prevention - International cooperation |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-136-55063-1
1-280-47541-2 9786610475414 1-4619-0573-7 600-00-0100-2 1-84977-349-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Coming to grips with malaria inthe new millennium; Copyright; Foreword; Contents; Working group members; Preface; Acknowledgements; Abbreviations; Millennium Development Goals; Executive summary; Chapter 1 Introduction; The Millennium Development Goal and target for malaria; Organization of this report; Chapter 2 The resurgence and burden of malaria; Health burden; Economic and social burden; Chapter 3 Review of major initiatives and institutional policies for malaria control; Global Malaria Eradication Program; Global Malaria Control Strategy
Harare Declaration on Malaria Prevention and ControlMultilateral Initiative on Malaria; Roll Back Malaria Initiative; Abuja Declaration on Roll Back Malaria; Medicines for Malaria Venture; Global Fund to fight AIDS, Tuberculosis, and Malaria; Chapter 4 Malaria control strategies; Disease prevention strategies; Disease management strategies; Epidemic prevention and control strategies; Information, education, and communication strategies; Monitoring and evaluation; Chapter 5 Examples of successful scale-up of malaria control programs; Tigray region of Ethiopia; Highlands of Madagascar; Viet Nam South AfricaTanzania; Lessons learned; Chapter 6 Priority challenges for scaling up malaria control programs; Strengthening health systems; Human resources capacity; Social mobilization of communities; Partnerships; Programmatic challenges; Chapter 7 Developing a global plan to achieve the Millennium Development Goal target for malaria; Conditions for achieving a sustained impact; Developing a global plan for reducing the burden of malaria; Components of a global plan; Needs assessment: costing and financing; Resource mobilization: needs assessment at the global level Resource mobilization: needs assessment at the country level - EthiopiaChapter 8 Monitoring and evaluation; Monitoring and evaluation of health programs; Malaria-related Millennium Development Goal, targets, and indicators; Coverage measures; Main approaches to data collection for monitoring malaria control; Monitoring the effectiveness of antimalarials and insecticides; Developing geographic information systems and remote sensing; Cost-effectiveness of service provision; Linkage of malaria monitoring with poverty alleviation Chapter 9 Research and development to meet current and future needsAntimalarial medicine development; Malaria diagnostics; Malaria management in young children; Malaria vector; Malaria vaccines; Chapter 10 Recommendations; 1. Establish a realistic and measurable target on malaria; 2. Enhance political commitment at country and global levels; 3. Strengthen health systems at national and district levels; 4. Develop human resources for program implementation; 5. Promote social mobilization and community participation; 6. Provide effective antimalarial supplies and commodities 7. Apply an integrated package of interventions |
| Record Nr. | UNINA-9910450653703321 |
|
Teklehaimanot Awash
|
||
| London ; ; Sterling, Va. : , : Earthscan, , 2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Coming to grips with malaria in the new millennium / / UN Millennium Project 2005, Task Force on HIV/AIDS, Malaria, TB, and Access to Essential Medicines, Working Group on Malaria ; Lead authors: Awash Teklehaimanot (Coordinator). [et. al.]
| Coming to grips with malaria in the new millennium / / UN Millennium Project 2005, Task Force on HIV/AIDS, Malaria, TB, and Access to Essential Medicines, Working Group on Malaria ; Lead authors: Awash Teklehaimanot (Coordinator). [et. al.] |
| Autore | Teklehaimanot Awash |
| Pubbl/distr/stampa | London ; ; Sterling, Va. : , : Earthscan, , 2005 |
| Descrizione fisica | 1 online resource (147 p.) |
| Disciplina |
362.196/93620091724
614.5320091724 616.9362 |
| Altri autori (Persone) | Awash Teklehaimanot |
| Soggetto topico |
Malaria - Developing countries - Prevention
Malaria - Prevention - International cooperation |
| ISBN |
1-136-55063-1
1-280-47541-2 9786610475414 1-4619-0573-7 600-00-0100-2 1-84977-349-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Coming to grips with malaria inthe new millennium; Copyright; Foreword; Contents; Working group members; Preface; Acknowledgements; Abbreviations; Millennium Development Goals; Executive summary; Chapter 1 Introduction; The Millennium Development Goal and target for malaria; Organization of this report; Chapter 2 The resurgence and burden of malaria; Health burden; Economic and social burden; Chapter 3 Review of major initiatives and institutional policies for malaria control; Global Malaria Eradication Program; Global Malaria Control Strategy
Harare Declaration on Malaria Prevention and ControlMultilateral Initiative on Malaria; Roll Back Malaria Initiative; Abuja Declaration on Roll Back Malaria; Medicines for Malaria Venture; Global Fund to fight AIDS, Tuberculosis, and Malaria; Chapter 4 Malaria control strategies; Disease prevention strategies; Disease management strategies; Epidemic prevention and control strategies; Information, education, and communication strategies; Monitoring and evaluation; Chapter 5 Examples of successful scale-up of malaria control programs; Tigray region of Ethiopia; Highlands of Madagascar; Viet Nam South AfricaTanzania; Lessons learned; Chapter 6 Priority challenges for scaling up malaria control programs; Strengthening health systems; Human resources capacity; Social mobilization of communities; Partnerships; Programmatic challenges; Chapter 7 Developing a global plan to achieve the Millennium Development Goal target for malaria; Conditions for achieving a sustained impact; Developing a global plan for reducing the burden of malaria; Components of a global plan; Needs assessment: costing and financing; Resource mobilization: needs assessment at the global level Resource mobilization: needs assessment at the country level - EthiopiaChapter 8 Monitoring and evaluation; Monitoring and evaluation of health programs; Malaria-related Millennium Development Goal, targets, and indicators; Coverage measures; Main approaches to data collection for monitoring malaria control; Monitoring the effectiveness of antimalarials and insecticides; Developing geographic information systems and remote sensing; Cost-effectiveness of service provision; Linkage of malaria monitoring with poverty alleviation Chapter 9 Research and development to meet current and future needsAntimalarial medicine development; Malaria diagnostics; Malaria management in young children; Malaria vector; Malaria vaccines; Chapter 10 Recommendations; 1. Establish a realistic and measurable target on malaria; 2. Enhance political commitment at country and global levels; 3. Strengthen health systems at national and district levels; 4. Develop human resources for program implementation; 5. Promote social mobilization and community participation; 6. Provide effective antimalarial supplies and commodities 7. Apply an integrated package of interventions |
| Record Nr. | UNINA-9910783533203321 |
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Teklehaimanot Awash
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||
| London ; ; Sterling, Va. : , : Earthscan, , 2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Current Topics and Emerging Issues in Malaria Elimination / / Alfonso J. Rodriguez-Morales
| Current Topics and Emerging Issues in Malaria Elimination / / Alfonso J. Rodriguez-Morales |
| Autore | Rodriguez-Morales Alfonso J. |
| Pubbl/distr/stampa | London : , : IntechOpen, , 2021 |
| Descrizione fisica | 1 online resource (334 pages) |
| Disciplina | 616.9362 |
| Soggetto topico |
Malaria
Malaria - Prevention |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910688226103321 |
|
Rodriguez-Morales Alfonso J.
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| London : , : IntechOpen, , 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Current Topics and Emerging Issues in Malaria Elimination / / edited by Alfonso J. Rodriguez-Morales
| Current Topics and Emerging Issues in Malaria Elimination / / edited by Alfonso J. Rodriguez-Morales |
| Pubbl/distr/stampa | London : , : IntechOpen, , 2021 |
| Descrizione fisica | 1 online resource (334 pages) : illustrations |
| Disciplina | 616.9362 |
| Collana | Infectious diseases |
| Soggetto topico |
Malaria
Malaria - Prevention |
| ISBN | 1-83968-484-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910586689903321 |
| London : , : IntechOpen, , 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Drug development for malaria : novel approaches for prevention and treatment / / edited by Pravin Kendrekar
| Drug development for malaria : novel approaches for prevention and treatment / / edited by Pravin Kendrekar |
| Pubbl/distr/stampa | Weinheim, Germany : , : Wiley-VCH, , [2023] |
| Descrizione fisica | 1 online resource (395 pages) |
| Disciplina | 616.9362 |
| Soggetto topico |
Malaria - Treatment
Drug development |
| ISBN |
3-527-83058-8
3-527-83060-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover -- Title Page -- Copyright -- Contents -- Part I Introduction -- Chapter 1 Chronology of Drug Development for Malaria -- 1.1 Introduction -- 1.1.1 Life Cycle of Malaria (Adapted from CDC) -- 1.2 Malaria - Erstwhile Memories -- 1.2.1 Progress Fighting Malaria -- 1.3 Current Chemotherapy Used to Treat Malaria -- 1.3.1 Current Combination Therapy -- 1.4 Drug Resistance of Antimalarial Drugs -- 1.4.1 Detection of Drug Resistance -- 1.5 Newer Drugs Approved for Malaria Treatment -- 1.6 Current Approaches to Developing a Malaria Vaccine -- 1.6.1 Hope for Vaccine Lies in the Parasite Itself -- 1.7 Conclusion: The Path Forward -- 1.7.1 RTS, ‐S Vaccine: A New Tool with Potential for Africa -- References -- Part II Challenges and Opportunities in Malaria Therapy -- Chapter 2 Scientific Challenges and Treatment Opportunities in the Face of Shifting Malaria Epidemiology -- 2.1 Introduction -- 2.2 The Scientific Challenges Against Malarial Drug -- 2.3 Advances in Understanding and Managing Drug Resistance -- 2.3.1 Vector and Its Control -- 2.3.2 Parasite and Its Control -- 2.3.2.1 Malaria Vaccine -- 2.3.2.2 Antimalarial Drugs -- 2.4 Methods to Assess the Presence and Level of Drug Resistance -- 2.4.1 Therapeutic Efficacy of Antimalarial Drugs -- 2.4.2 Molecular Markers Associated with P. falciparum -- 2.5 Antimalarial Drugs Currently in Use and in the Pipeline -- 2.6 Future -- References -- Chapter 3 Emerging Formulation Technologies Against Malaria Resurgence -- List of Abbreviations -- 3.1 Introduction -- 3.1.1 Major Pathological Hallmarks of Malaria -- 3.1.2 Current Treatment Strategies -- 3.2 Pitfalls of the Current Treatment Regimen -- 3.2.1 Drug Resistance -- 3.2.2 High Drug Dose -- 3.2.3 Long‐Term Treatment -- 3.2.4 Recurrence and Reversion of Diseases -- 3.3 Nanotechnology‐Based Strategies for Targeting in Antimalarial Therapy.
3.3.1 Passive Targeting -- 3.3.2 Active Targeting -- 3.3.2.1 Hepatocyte Targeting -- 3.3.2.2 Erythrocyte Targeting -- 3.3.2.3 Brain Targeting -- 3.3.3 Rapid Diagnosis and Vector Control -- 3.4 Nano Formulations for Malarial Treatment -- 3.4.1 Lipid‐Based Nanoplatforms -- 3.4.1.1 Nanoemulsion -- 3.4.1.2 Self‐Emulsifying Drug Delivery System (SEDDS) -- 3.4.1.3 Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) -- 3.4.1.4 Liposome -- 3.4.2 Polymer‐Based Nanoplatforms for Malaria -- 3.4.2.1 Nanoparticles -- 3.4.2.2 Nanocapsules -- 3.4.2.3 Dendrimers -- 3.4.2.4 Micelles -- 3.4.2.5 Polymeric Hydrogel Nanoparticles -- 3.4.2.6 Nanosuspension -- 3.4.3 Organized Layer‐by‐Layer Assembly -- 3.4.4 Inorganic Nano‐architectonics -- 3.4.4.1 Metallic Platforms -- 3.4.4.2 Quantum Dots -- 3.4.4.3 Carbon Nanostructures -- 3.4.4.4 Bio‐ceramics -- 3.4.5 Bio‐inspired Nanocarriers -- 3.4.5.1 Vaccines Based on Bio‐inspired Nanocarriers -- 3.4.5.2 Bio‐engineered Strategy Based on Erythrocytes -- 3.4.6 Protein-Peptide‐Based Drug Delivery System -- 3.4.7 Stimuli‐Responsive Platforms for Malaria -- 3.4.7.1 pH‐Responsive Formulations -- 3.4.7.2 Thermo‐Responsive Formulations -- 3.4.7.3 Redox State Responsive Substances -- 3.4.7.4 Stimuli‐Responsive Liquid Crystalline Materials -- 3.5 Diagnostics -- 3.5.1 Stimuli‐Responsive Iron Oxide and Gold Nanoparticle Reagent System -- 3.5.2 Immunological Adjuvants -- 3.5.3 Nanofibers -- 3.6 Challenges in Clinical Translation of Nanomedicine -- 3.6.1 Biological Challenges -- 3.6.2 Biocompatibility and Safety -- 3.6.3 Challenges in Manufacturing Scale‐Up and Reproducibility -- 3.6.4 Analytical Characterization and Quality Control Challenges of Nano‐Formulations -- 3.6.5 Regulatory Challenges -- 3.6.6 Other Challenges -- 3.7 Summary and Future Perspective -- 3.8 Conclusion -- Acknowledgments -- References. Chapter 4 Targeted Drug Delivery for Antimalarial Therapy -- 4.1 Introduction -- 4.2 Remodelling of Parasite‐Infected Red Blood Cell (pRBC) -- 4.2.1 The Red Blood Cell Membrane (RBCM) -- 4.2.2 The Parasitophorous Vacuole Membrane (PVM) -- 4.2.3 The Parasite Plasma Membrane (PPM) -- 4.3 The Emergence of Resistance and Antimalarial Therapy Approach -- 4.4 Nanocarriers for Antimalarial Drug Delivery -- 4.4.1 Liposomes -- 4.4.2 Solid Lipid Nanoparticles (SLNs) -- 4.4.3 Nanostructured Lipid Carriers (NLCs) -- 4.4.4 Nano‐emulsions (NEs) -- 4.4.5 Polymeric Nanoparticles -- 4.5 Targeted Antimalarial Drug Delivery Systems -- 4.5.1 Passive Drug Targeting with Conventional Nanocarriers -- 4.5.2 Active Drug Targeting with Surface‐Modified Nanocarrier -- 4.6 Conclusion: Moving Towards the Future -- Acknowledgements -- References -- Chapter 5 The Imminent Threat of Antimalarial Drug Resistance -- 5.1 Introduction -- 5.2 Antimalarial Drugs: An Overview -- 5.3 The Evolution of CQ Resistance -- 5.3.1 Mechanism of Action of CQ -- 5.3.2 Basis of CQ Resistance -- 5.3.3 Prevalence of CQ Resistance -- 5.3.4 WHO Guidelines to Use CQ -- 5.4 Impact of Sulfadoxine-Pyrimethamine Resistance -- 5.4.1 Mechanism of Action of SP -- 5.4.2 SP Resistance -- 5.4.3 Distribution of DHPS and DHFR Mutation Across Globe -- 5.4.3.1 dhfr -- 5.4.3.2 dhps -- 5.4.4 WHO Guidelines to Use SP -- 5.4.4.1 IPTp Guidelines -- 5.4.4.2 IPTi Guidelines -- 5.5 ACT Resistance -- 5.5.1 Mechanism of Action of ART -- 5.5.2 ART Resistance and ACT Failure -- 5.5.3 WHO Guidelines -- 5.6 Conclusion: The Road Ahead -- References -- Chapter 6 Current Therapies and New Drug Targets for the Future Drug Development of Drug Resistant Malaria -- 6.1 Introduction -- 6.2 Life Cycle of Plasmodium falciparum -- 6.3 Current Antimalarial Therapy and Their Shortcomings -- 6.4 Drug Targets for Current Antimalarial Therapy. 6.4.1 Drug‐Resistant Malaria and Identification of New Targets -- 6.4.1.1 Food Vacuole as Drug Targets -- 6.4.1.2 Shikimic Acid Pathway Targeting -- 6.4.1.3 Targeting Folate Pathway and Methionine Synthesis Pathway -- 6.4.1.4 Glycolytic Pathway Inhibition -- 6.4.2 Mitochondria as Drug Targets -- 6.4.2.1 Targeting Electron Transport Chain -- 6.4.2.2 Inhibition of Dihydroorate Dehydrogenase -- 6.5 Future Drug Development for the Treatment of Malaria -- 6.5.1 Benefits of Nanocarriers -- 6.5.2 Lipid‐Based Drug Delivery -- 6.5.3 Liposomes (as Nanocarriers) -- 6.5.4 Nanostructured Lipid Carriers -- 6.5.5 Solid Lipid Nanocarriers -- 6.6 Conclusion -- References -- Part III Drug Development -- Chapter 7 Assays for Antimalarial Drug Discovery -- 7.1 Introduction -- 7.2 In Vitro Assays for Antimalarial Drug Discovery -- 7.2.1 Schizont Maturation Inhibition Assay (Microscopic Test) -- 7.2.2 In Vitro Micro Test Technique -- 7.2.3 Radioisotope Assay -- 7.2.4 Colorimetric Assay (Plasmodium Lactate Dehydrogenase Assay [pLDH]) -- 7.2.5 ELISA‐Based Methods -- 7.2.5.1 DELI Assay -- 7.2.5.2 Assay Based on Histidine‐Rich Protein II (HRP II) of P. falciparum -- 7.2.6 Flow Cytometry -- 7.2.7 Fluorometric Assay -- 7.2.8 β‐Hematin Formation (Haemozoin Test) -- 7.2.9 Drug Interaction Assay and Isobologram Analysis -- 7.2.10 PCR‐Based Methods -- 7.2.11 In Vitro Assays Targeting Exo‐erythrocytic and Sexual Stages of the Parasite -- 7.2.11.1 Exo‐erythrocytic Schizontocidal Assay -- 7.2.11.2 Ex‐flagellation Assay -- 7.3 In Vivo Assays for Antimalarial Drug Discovery -- 7.3.1 Peters' 4‐Day Test -- 7.3.2 Dose Ranging Full 4‐Day Test -- 7.3.3 Onset/Recrudescence Test -- 7.3.4 Preventive Test -- 7.3.5 Curative Test -- 7.3.6 Hill's Test for Causal Prophylaxis and Residual Activity -- 7.3.7 Assays with P. berghei Green Fluorescent Protein (PbGFP). 7.3.8 Assays Employing Immunocompromised Mice -- 7.3.9 Primate Models for In Vivo Studies -- 7.3.10 Sporontocidal Assays -- 7.3.11 Anti‐sporozoite Assay -- 7.4 Ex Vivo Assays for Antimalarial Drug Discovery -- 7.5 Assays for Assessment of In Vitro Toxicity -- 7.5.1 MTT Assay -- 7.5.2 XTT Assay -- 7.5.3 LDH (Lactate Dehydrogenase) Assay -- 7.5.4 Protein Content Assay -- 7.5.5 Neutral Red Uptake Assay (NRU) -- 7.6 Assays for Assessment of In Vivo Toxicity -- 7.6.1 Acute Toxicity -- 7.6.1.1 Limit Test of Lorke -- 7.6.1.2 Up and Down Procedure -- 7.6.2 Chronic Toxicity -- 7.7 Conclusion -- References -- Chapter 8 Aminoacyl‐tRNA Synthetases as Malarial Drug Targets: A Structural Biology Perspective -- 8.1 Introduction -- 8.2 Pf/Pv‐aaRSs -- 8.2.1 Pf/Pv Genome -- 8.2.2 Aminoacyl‐tRNA Synthetases (aaRSs) -- 8.3 Aminoacyl‐tRNA Synthetases as Druggable Targets -- 8.4 Biochemical Screening of Drug Libraries -- 8.4.1 Colorimetric Assays -- 8.4.2 Enzyme‐Coupled Assays -- 8.4.3 Luciferase Assay -- 8.4.4 Assay to Test Synthetic as Well as Proofreading Activity -- 8.5 Structurally Validated Pf/Pv‐aaRSs as Drug Targets -- 8.5.1 Lysyl‐tRNA Synthetase (KRS) -- 8.5.2 Prolyl‐tRNA Synthetase -- 8.6 Potential Drug Targets Pf/Pv‐aaRSs -- 8.6.1 Leucyl‐tRNA Synthetase (LRS) -- 8.7 Arginyl‐tRNA Synthetase (RRS) -- 8.7.1 Tryptophanyl‐tRNA Synthetase (WRS) -- 8.7.2 Tyrosyl‐tRNA Synthetase -- 8.8 Others -- 8.9 Conclusion: The Road Ahead -- References -- Chapter 9 Natural Products as a Source for Antimalarial Drug Development Process - An Overview -- 9.1 Introduction -- 9.2 Phytochemicals as Antimalarial Agents: Recent Developments -- 9.2.1 Alkaloids -- 9.2.2 Terpenes -- 9.2.2.1 Sesquiterpene Lactones -- 9.2.2.2 Diterpenes -- 9.2.2.3 Triterpenes -- 9.2.2.4 Steroids and Others -- 9.2.3 Polyphenols -- 9.2.3.1 Biflavonoids -- 9.2.3.2 Prenylated Flavonoids -- 9.2.3.3 Other Flavonoids. 9.3 Traditional System of Medicine and Malaria. |
| Record Nr. | UNINA-9910830804403321 |
| Weinheim, Germany : , : Wiley-VCH, , [2023] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
