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Deep Brain Stimulation for Neurological Disorders : Theoretical Background and Clinical Application / / edited by Toru Itakura
| Deep Brain Stimulation for Neurological Disorders : Theoretical Background and Clinical Application / / edited by Toru Itakura |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (212 p.) |
| Disciplina |
616.8/0471
616.89 |
| Soggetto topico |
Neurosurgery
Neurology Neurology |
| ISBN | 3-319-08476-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Basic Background of Brain Stimulation: Anatomy and Physiology -- Basal Ganglia and Neuron Network -- Mechanism of Brain Stimulation -- Symptoms and Signs -- Parkinson disease -- Other movement disorders -- Epilepsy. Clinical Studies on Deep Brain Stimulation: Intraoperative Microrecording -- Instrument of Brain Stimulation -- Surgical Technique -- Instrument -- Parkinson disease -- Stimulation of Subthalamic Nucleus -- Stimulation of Globus Pallidus -- Stimulation of Thalamus -- Dystonia -- Essential Tremor -- Intractable pain -- Motor Cortex Stimulation -- Spinal Cord Stimulation -- Psychiatric Disorders -- Epilepsy -- Complications. |
| Record Nr. | UNINA-9910300182103321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Developmental neurotoxicology research [[electronic resource] ] : principles, models, techniques, strategies, and mechanisms / / [edited by] Cheng Wang, William Slikker Jr
| Developmental neurotoxicology research [[electronic resource] ] : principles, models, techniques, strategies, and mechanisms / / [edited by] Cheng Wang, William Slikker Jr |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2011 |
| Descrizione fisica | 1 online resource (666 p.) |
| Disciplina |
616.8/0471
616.80471 |
| Altri autori (Persone) |
WangCheng <1954->
SlikkerWilliam |
| Soggetto topico |
Neurotoxicology
Developmental toxicology |
| ISBN |
0-470-92274-5
1-282-90483-3 9786612904837 0-470-91705-9 0-470-91706-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DEVELOPMENTALNEUROTOXICOLOGYRESEARCH; CONTENTS; PREFACE; CONTRIBUTORS; I MODELS, APPROACHES, AND CHALLENGES IN NEUROTOXICITY RESEARCH DURING DEVELOPMENT; 1 APPROACHES AND MODELS FOR EVALUATING THE TOXIC EFFECTS OF ANESTHETICS IN THE DEVELOPING NERVOUS SYSTEM; 2 SYSTEMS BIOLOGY APPROACHES TO NEUROTOXICITY STUDIES DURING DEVELOPMENT; 3 BEHAVIORAL APPROACHES FOR ASSESSING NERVOUS SYSTEM FUNCTION DURING DEVELOPMENT IN ANIMAL MODELS; 4 APPLICATIONS OF UNBIASED STEREOLOGY TO NEURODEVELOPMENTAL TOXICOLOGY; II EFFECTS OF ANESTHETICS AND THEIR POTENTIAL NEUROTOXICITY DURING DEVELOPMENT
5 NEUROTOXIC EFFECTS OF ANESTHETICS AND POTENTIAL PROTECTIVE AGENTS6 PERINATAL RHESUS MONKEY MODELS AND ANESTHETIC-INDUCED NEURONAL CELL DEATH; 7 EFFECTS OF GASEOUS ANESTHETIC COMBINATIONS DURING DEVELOPMENT; 8 PERINATAL ANESTHETIC ADMINISTRATION AND SHORT LONG-TERM BEHAVIORAL DEFICITS; III THE DEVELOPMENTAL BASIS OF ADOLESCENT OR ADULT DISEASE; 9 DEVELOPMENTAL LEAD EXPOSURE, EPIGENTICS AND LATE ONSET ALZHEIMER'S DISEASE; 10 DEVELOPMENTAL TRAJECTORIES OF AUTISM AND ENVIRONMENTAL EXPOSURES-WHAT WE KNOW AND WHERE WE NEED TO GO; 11 ACTIONS OF MANGANESE ON PUBERTAL DEVELOPMENT 12 EXPOSURE OF THE DEVELOPING BRAIN TO POLYCHLORINATED BIPHENYLS INFLUENCES THE SUSCEPTIBILITY OF THE ADULT BRAIN TO STRESS13 A NEURODEVELOPMENTAL ORIGIN FOR PAKINSON'S DISEASE: A LINK TO THE FETAL BASIS FOR ADULT DISEASE HYPOTHESIS; 14 GENETIC AND ENVIRONMENTAL FACTORS IN ATTENTION-DEFICIT HYPERACTIVITY DISORDER; IV RISK ASSESSMENT OF METHYL MERCURY AND ITS EFFECTS ON NEURODEVELOPMENT; 15 FISH NUTRIENTS AND METHYLMERCURY: A VIEW FROM THE LABORATORY 16 NEURODEVELOPMENTAL EFFECTS OF MATERNAL NUTRITION STATUS AND EXPOSURE TO METHYL MERCURY FROM EATING FISH DURING PREGNANCY: EVIDENCE FROM THE SEYCHELLES CHILD DEVELOPMENT STUDY17 METHYLMERCURY NEUROTOXICOLOGY: FROM RARE POISONINGS TO SILENT PANDEMIC; 18 OXIDATIVE STRESS AND METHYLMERCURY-INDUCED NEUROTOXICITY; 19 LEARNING DEFICITS AND DEPRESSION-LIKE BEHAVIORS ASSOCIATED WITH DEVELOPMENTAL METHYLMERCURY EXPOSURES; 20 METHYLMERCURY EFFECTS ON NEURAL DEVELOPMENTAL SIGNALING PATHWAYS; V AUTISM SPECTRUM DISORDERS; 21 NEURODEVELOPMENTAL TOXICOLOGY AND AUTISM SPECTRUM DISORDERS 22 REDOX IMBALANCE AND THE METABOLIC PATHOLOGY OF AUTISM23 NEUROINFLAMMATION AND AUTISM; 24 AUTISM, PERIPHERAL IMMUNITY, AND POLYBROMINATED DIPHENYL ETHERS; 25 AN EMERGING GENE-ENVIRONMENT INTERACTION MODEL: AUTISM SPECTRUM DISORDER PHENOTYPES RESULTING FROM EXPOSURE TO ENVIRONMENTAL CONTAMINANTS DURING GESTATION; VI STRATEGIES AND PROGRESS IN EPILEPSY RESEARCH; 26 NEONATAL SEIZURES; 27 EXPERIMENTAL MODELS OF EPILEPTOGENESIS; 28 EFFECT OF SEIZURES ON THE DEVELOPING BRAIN: LESSONS FROM THE LABORATORY; INDEX |
| Record Nr. | UNINA-9910133587803321 |
| Hoboken, N.J., : Wiley, c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Developmental neurotoxicology research [[electronic resource] ] : principles, models, techniques, strategies, and mechanisms / / [edited by] Cheng Wang, William Slikker Jr
| Developmental neurotoxicology research [[electronic resource] ] : principles, models, techniques, strategies, and mechanisms / / [edited by] Cheng Wang, William Slikker Jr |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2011 |
| Descrizione fisica | 1 online resource (666 p.) |
| Disciplina |
616.8/0471
616.80471 |
| Altri autori (Persone) |
WangCheng <1954->
SlikkerWilliam |
| Soggetto topico |
Neurotoxicology
Developmental toxicology |
| ISBN |
0-470-92274-5
1-282-90483-3 9786612904837 0-470-91705-9 0-470-91706-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
DEVELOPMENTALNEUROTOXICOLOGYRESEARCH; CONTENTS; PREFACE; CONTRIBUTORS; I MODELS, APPROACHES, AND CHALLENGES IN NEUROTOXICITY RESEARCH DURING DEVELOPMENT; 1 APPROACHES AND MODELS FOR EVALUATING THE TOXIC EFFECTS OF ANESTHETICS IN THE DEVELOPING NERVOUS SYSTEM; 2 SYSTEMS BIOLOGY APPROACHES TO NEUROTOXICITY STUDIES DURING DEVELOPMENT; 3 BEHAVIORAL APPROACHES FOR ASSESSING NERVOUS SYSTEM FUNCTION DURING DEVELOPMENT IN ANIMAL MODELS; 4 APPLICATIONS OF UNBIASED STEREOLOGY TO NEURODEVELOPMENTAL TOXICOLOGY; II EFFECTS OF ANESTHETICS AND THEIR POTENTIAL NEUROTOXICITY DURING DEVELOPMENT
5 NEUROTOXIC EFFECTS OF ANESTHETICS AND POTENTIAL PROTECTIVE AGENTS6 PERINATAL RHESUS MONKEY MODELS AND ANESTHETIC-INDUCED NEURONAL CELL DEATH; 7 EFFECTS OF GASEOUS ANESTHETIC COMBINATIONS DURING DEVELOPMENT; 8 PERINATAL ANESTHETIC ADMINISTRATION AND SHORT LONG-TERM BEHAVIORAL DEFICITS; III THE DEVELOPMENTAL BASIS OF ADOLESCENT OR ADULT DISEASE; 9 DEVELOPMENTAL LEAD EXPOSURE, EPIGENTICS AND LATE ONSET ALZHEIMER'S DISEASE; 10 DEVELOPMENTAL TRAJECTORIES OF AUTISM AND ENVIRONMENTAL EXPOSURES-WHAT WE KNOW AND WHERE WE NEED TO GO; 11 ACTIONS OF MANGANESE ON PUBERTAL DEVELOPMENT 12 EXPOSURE OF THE DEVELOPING BRAIN TO POLYCHLORINATED BIPHENYLS INFLUENCES THE SUSCEPTIBILITY OF THE ADULT BRAIN TO STRESS13 A NEURODEVELOPMENTAL ORIGIN FOR PAKINSON'S DISEASE: A LINK TO THE FETAL BASIS FOR ADULT DISEASE HYPOTHESIS; 14 GENETIC AND ENVIRONMENTAL FACTORS IN ATTENTION-DEFICIT HYPERACTIVITY DISORDER; IV RISK ASSESSMENT OF METHYL MERCURY AND ITS EFFECTS ON NEURODEVELOPMENT; 15 FISH NUTRIENTS AND METHYLMERCURY: A VIEW FROM THE LABORATORY 16 NEURODEVELOPMENTAL EFFECTS OF MATERNAL NUTRITION STATUS AND EXPOSURE TO METHYL MERCURY FROM EATING FISH DURING PREGNANCY: EVIDENCE FROM THE SEYCHELLES CHILD DEVELOPMENT STUDY17 METHYLMERCURY NEUROTOXICOLOGY: FROM RARE POISONINGS TO SILENT PANDEMIC; 18 OXIDATIVE STRESS AND METHYLMERCURY-INDUCED NEUROTOXICITY; 19 LEARNING DEFICITS AND DEPRESSION-LIKE BEHAVIORS ASSOCIATED WITH DEVELOPMENTAL METHYLMERCURY EXPOSURES; 20 METHYLMERCURY EFFECTS ON NEURAL DEVELOPMENTAL SIGNALING PATHWAYS; V AUTISM SPECTRUM DISORDERS; 21 NEURODEVELOPMENTAL TOXICOLOGY AND AUTISM SPECTRUM DISORDERS 22 REDOX IMBALANCE AND THE METABOLIC PATHOLOGY OF AUTISM23 NEUROINFLAMMATION AND AUTISM; 24 AUTISM, PERIPHERAL IMMUNITY, AND POLYBROMINATED DIPHENYL ETHERS; 25 AN EMERGING GENE-ENVIRONMENT INTERACTION MODEL: AUTISM SPECTRUM DISORDER PHENOTYPES RESULTING FROM EXPOSURE TO ENVIRONMENTAL CONTAMINANTS DURING GESTATION; VI STRATEGIES AND PROGRESS IN EPILEPSY RESEARCH; 26 NEONATAL SEIZURES; 27 EXPERIMENTAL MODELS OF EPILEPTOGENESIS; 28 EFFECT OF SEIZURES ON THE DEVELOPING BRAIN: LESSONS FROM THE LABORATORY; INDEX |
| Record Nr. | UNINA-9910830131203321 |
| Hoboken, N.J., : Wiley, c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Metal-based neurodegeneration : from molecular mechanisms to therapeutic strategies / / Robert Crichton and Roberta Ward
| Metal-based neurodegeneration : from molecular mechanisms to therapeutic strategies / / Robert Crichton and Roberta Ward |
| Autore | Crichton Robert R |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Chichester, West Sussex, U.K. : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (439 p.) |
| Disciplina | 616.8/0471 |
| Altri autori (Persone) | WardRoberta J |
| Soggetto topico |
Brain - Pathophysiology
Metals - Health aspects Nervous system - Degeneration - Etiology Oxidative stress |
| ISBN |
1-118-55351-9
1-118-55348-9 1-118-55349-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Brain function, physiology, and the blood-brain barrier -- Role of metal ions in brain function, metal transport, storage, and homeostasis -- Immune system and neuroinflammation -- Oxidative stress in neurodegenerative diseases -- Aging and mild cognitive impairment, MCI -- Parkinson's disease -- Alzheimer's disease -- Huntington's disease and polyglutamine expansion neurodegenerative diseases -- Friedreich's ataxia and diseases associated with expansion of non-coding triplets -- Creutzfeldt-Jakob and other prion diseases -- Amyotropic lateral sclerosis -- Alcoholic brain damage -- Other neurological diseases -- Therapeutic strategies to combat the onset and progression of neurological diseases. |
| Record Nr. | UNINA-9910139014103321 |
Crichton Robert R
|
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| Chichester, West Sussex, U.K. : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Metal-based neurodegeneration : from molecular mechanisms to therapeutic strategies / / Robert Crichton and Roberta Ward
| Metal-based neurodegeneration : from molecular mechanisms to therapeutic strategies / / Robert Crichton and Roberta Ward |
| Autore | Crichton Robert R |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Chichester, West Sussex, U.K. : , : Wiley, , 2014 |
| Descrizione fisica | 1 online resource (439 p.) |
| Disciplina | 616.8/0471 |
| Altri autori (Persone) | WardRoberta J |
| Soggetto topico |
Brain - Pathophysiology
Metals - Health aspects Nervous system - Degeneration - Etiology Oxidative stress |
| ISBN |
1-118-55351-9
1-118-55348-9 1-118-55349-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Brain function, physiology, and the blood-brain barrier -- Role of metal ions in brain function, metal transport, storage, and homeostasis -- Immune system and neuroinflammation -- Oxidative stress in neurodegenerative diseases -- Aging and mild cognitive impairment, MCI -- Parkinson's disease -- Alzheimer's disease -- Huntington's disease and polyglutamine expansion neurodegenerative diseases -- Friedreich's ataxia and diseases associated with expansion of non-coding triplets -- Creutzfeldt-Jakob and other prion diseases -- Amyotropic lateral sclerosis -- Alcoholic brain damage -- Other neurological diseases -- Therapeutic strategies to combat the onset and progression of neurological diseases. |
| Record Nr. | UNINA-9910822397703321 |
|
Crichton Robert R
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||
| Chichester, West Sussex, U.K. : , : Wiley, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Microglia [[electronic resource] ] : biology, functions and roles in disease / / Charanjit Kaur and Ling Eng-Ang, editors
| Microglia [[electronic resource] ] : biology, functions and roles in disease / / Charanjit Kaur and Ling Eng-Ang, editors |
| Pubbl/distr/stampa | New York, : Nova Science Publishers, Inc., c2012 |
| Descrizione fisica | 1 online resource (331 p.) |
| Disciplina | 616.8/0471 |
| Altri autori (Persone) |
KaurCharanjit
Eng-AngLing |
| Collana | Cell biology research progress |
| Soggetto topico |
Nervous system - Degeneration
Microglia |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-61942-252-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910452913003321 |
| New York, : Nova Science Publishers, Inc., c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Microglia [[electronic resource] ] : biology, functions and roles in disease / / Charanjit Kaur and Ling Eng-Ang, editors
| Microglia [[electronic resource] ] : biology, functions and roles in disease / / Charanjit Kaur and Ling Eng-Ang, editors |
| Pubbl/distr/stampa | New York, : Nova Science Publishers, Inc., c2012 |
| Descrizione fisica | 1 online resource (331 p.) |
| Disciplina | 616.8/0471 |
| Altri autori (Persone) |
KaurCharanjit
Eng-AngLing |
| Collana | Cell biology research progress |
| Soggetto topico |
Nervous system - Degeneration
Microglia |
| ISBN | 1-61942-252-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910779628503321 |
| New York, : Nova Science Publishers, Inc., c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Microglia [[electronic resource] ] : biology, functions and roles in disease / / Charanjit Kaur and Ling Eng-Ang, editors
| Microglia [[electronic resource] ] : biology, functions and roles in disease / / Charanjit Kaur and Ling Eng-Ang, editors |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | New York, : Nova Science Publishers, Inc., c2012 |
| Descrizione fisica | 1 online resource (331 p.) |
| Disciplina | 616.8/0471 |
| Altri autori (Persone) |
KaurCharanjit
Eng-AngLing |
| Collana | Cell biology research progress |
| Soggetto topico |
Nervous system - Degeneration
Microglia |
| ISBN | 1-61942-252-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- MICROGLIA: BIOLOGY, FUNCTIONS AND ROLES IN DISEASE -- MICROGLIA: BIOLOGY, FUNCTIONS AND ROLES IN DISEASE -- LIBRARY OF CONGRESS CATALOGING-IN-PUBLICATION DATA -- CONTENTS -- PREFACE -- REFERENCE -- Chapter 1: MICROGLIA IN THE DEVELOPING BRAIN -- ABSTRACT -- ABBREVATIONS -- I. INTRODUCTION -- II. MICROGLIAL PHENOTYPES -- 1. Amoeboid Microglia -- 2. Ramified Microglia -- III. LOCALISATION OF MICROGLIAL CELLS IN THE DEVELOPING BRAIN -- 1. Developing Cerebrum -- 2. Developing Cerebellum -- IV. ULTRASTRUCTURAL FEATURES OF AMCS -- V. FUNCTIONS OF MICROGLIA IN THE DEVELOPING BRAIN -- 1. Phagocytosis -- 2. Immune Functions of Microglia -- 3. Iron Acquisition -- 4. Nitric Oxide Production -- 5. Growth Factors -- 6. Microglia in Myelination -- 7. Microglia in Neurogenesis and Astrogenesis -- 8. Microglia and Synapses -- 9. Microglia and Vascularisation -- XIII. MICROGLIA IN DISORDERS OF THE DEVELOPING BRAIN -- 1. Infections -- 2. Periventricular White Matter Damage -- 3. Epilepsy -- 4. Autism -- CONCLUSION -- REFERENCES -- Chapter 2: THE MYSTIC EMBRYONIC MICROGLIA: ITS ORIGIN, FUNCTION AND SEEDING -- ABSTRACT -- INTRODUCTION -- NEUROECTODERMAL ORIGIN OF MICROGLIA -- MONOCYTIC ORIGIN OF MICROGLIA -- MESODERMAL ORIGIN OF MICROGLIA -- TROUBLESHOOTING -- MIGRATION CHARACTERISTICS OF MICROGLIA -- If Microglia Use the Blood Vessels -- If Microglia Are Derived from Meningeal Sources -- DEVELOPMENTAL ROLES OF MICROGLIA -- Angiogenesis -- Scavengers of Cell Debris -- Synaptics Pruning -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 3: SOLDIERS OF THE NERVOUS SYSTEM: MICROGLIA IN SURVEILLANCE, OFFENSE AND DEFENSE -- ABSTRACT -- SOLDIERS OF THE NERVOUS SYSTEM: MICROGLIA IN SURVEILLANCE, OFFENSE AND DEFENSE -- MARKERS OF MICROGLIA -- MICROGLIA AS SURVEILLANCE CELLS -- MICROGLIA AND DEVELOPMENT -- MICROGLIA AND DISEASE -- Neuron-Glia Interactions.
Microglia and Pathogens -- Microglia and Neuropathogenesis -- MICROGLIA AND REGENERATION -- THERAPEUTIC APPROACHES AND CHALLENGES -- CONCLUSIONS -- REFERENCES -- Chapter 4: MICROGLIA SECRETOME: FROM NEUROTOXINS TO NEUROTROPHINS -- ABSTRACT -- 1. INTRODUCTION -- 2. MICROGLIA SECRETOME -- 3. IDENTIFICATION OF SECRETOME COMPONENTS -- 4. NEUROTROPHIC FACTORS -- 4.1. Neuroprotective Cytokines -- 4.2. Growth Factors -- 4.3. Neuroprotective Enzymes -- 4.4. Other Potential Neuroprotective Substances -- 5. NEUROTOXIC FACTORS -- 5.1. Reactive Molecules -- 5.2. Neurotoxic Enzymes -- 5.3. Other Potential Neurotoxic Substances -- 6. FACTORS WITH MULTIPLE EFFECTS -- 6.1. Cytokines -- 6.2. Cathepsins and Cystatins -- 6.3. Other Substances with Multiple Effects -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 5: THE ROLE OF MICROGLIA IN NEURODEGENERATIVE DISEASE -- ABSTRACT -- 1. INTRODUCTION -- 2. NORMAL IMMUNE FUNCTIONS OF MICROGLIA -- 2.1. Microglia as Mediators of CNS Inflammation -- 2.2. The In Vivo Visualization of Activated Microglia -- 3. MICROGLIA IN NEURODEGENERATIVE DISEASE -- 3.1. Alzheimer's Disease and other Dementias -- 3.2. Parkinson's Disease and Related Disorders -- 3.3. Huntington's Disease -- 3.4. Multiple Sclerosis -- 3.5. Amyotrophic Lateral Sclerosis -- CONCLUSIONS -- REFERENCES -- Chapter 6: MICROGLIA FUNCTION IN ALZHEIMER'S DISEASE -- ABSTRACT -- INTRODUCTION -- MICROGLIA FUNCTION IN AD -- Microglia -- Microglia in AD -- Microglia as Target for AD Therapy -- CONCLUSION -- REFERENCES -- Chapter 7: BLOOD DERIVED MICROGLIA-LIKE CELLS IN ALZHEIMER'S DISEASE -- ABSTRACT -- 1. NEUROPATHOLOGY OF AD AND ACTIVATION OF MICROGLIA -- 1.1. Basic Neuropathological Features of AD -- 1.2. Dual and Opposing Effects of Microglia on Brain Pathology of AD -- 2. BLOOD-DERIVED MONOCYTIC CELLS IN THE AD BRAIN: OPENING OF NOVEL THERAPEUTIC AVENUES?. 3. MECHANISMS OF THE ENGRAFTMENT OF BLOOD-DERIVED MONOCYTIC CELLS INTO THE AD BRAIN -- 3.1. Engraftment of Monocytic Cells without Preconditioning -- 3.2. Studies on Animal Models with Preconditioning -- 3.3. Phenotype of the Monocytic Cells that Enter the Brain and the Role of Chemokines and Adhesion Proteins -- 3.4. Macrophage Colony-Stimulating Factor and Engraftment of Monocytic Cells to the Brain -- 3.5. Potential Role of Prostaglandins in Engraftment of Monocytic Cells tothe Brain -- 3.6. Involvement of Toll Like Receptors and Myd88 in Engraftment ofMonocytic Cells to the Brain -- 4. MECHANISM OF CLEARANCE BY BONE-MARROW DERIVEDMONOCYTIC CELLS -- 4.1. Involvement of Phagocytosis and Lysosomal Pathway -- 4.2 A Special Role of Β-1,4-Mannosyl-Glycoprotein 4-Β-NAcetylglucosaminyltransferase -- 4.3. Other Molecules of Inflammatory Signaling in Ab Clearance by BMDerivedMonocytic Cells -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 8: MICROGLIAL FUNCTIONS AGAINST AMYLOID-β ACCUMULATION IN BRAINS OF ALZHEIMER'S DISEASE -- ABSTRACT -- INTRODUCTION -- Aβ AND HYPOTHESIS IN AD PATHOGENESIS -- MICROGLIAL Aβ PHAGOCYTOSIS IN AD BRAIN -- REGULATION OF MICROGLIAL Aβ PHAGOCYTOSIS -- CELL THERAPEUTIC APPROACHES IN AD -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 9: MODULATION OF MICROGLIAL REACTION IN BRAIN INJURY BY NOVEL THERAPEUTIC TOOLS BASED ONGENE THERAPY APPROACHES -- ABSTRACT -- 1. INTRODUCTION -- 2. ROLE OF NEUROINFLAMMATION IN HIV-1 ASSOCIATED COGNITIVE DISORDER -- 3. EXPERIMENTAL MODELS -- 4. HIV-1 GP120 ELICITS INCREASES IN DIFFERENT POPULATIONS OF MICROGLIAL CELLS -- 5. THE INCREASE OF CD68-POSITIVE CELLS WAS DOSE- AND TIME-DEPENDENT -- 6. ASTROCYTE PROLIFERATION IN RESPONSE TO GP120 ADMINISTRATION -- 7. NEUROINFLAMMATION CORRELATES WITH NEURON LOSS AFTER GP120 INJECTION. 8. RSV40-DELIVERED ANTIOXIDANT ENZYMES REDUCE INFLAMMATION CAUSED BY GP120 -- 9. ACTIVATION OF MICROGLIAL CELLS AND ASTROCYTES PROLIFERATION AFTER INJECTION OF SV(GP120) INTO THE CP AND PROTECTION BY RSV40-DELIVERED ANTIOXIDANT ENZYMES -- DISCUSSION -- REFERENCES -- Chapter 10: THE APPLICATION OF INHIBITORS OF MICROGLIAL ACTIVATION IN BRAIN DISEASES -- ABSTRACT -- INTRODUCTION -- 1. GLUCOCORTICOIDS -- 2. MINOCYCLINE -- 2.1. Parkinson's Disease -- 2.2. Amyotrophic Lateral Sclerosis (ALS) -- 2.3. Alzheimer's Disease (AD) -- 3. ENDOCANNABINOIDS -- 3.1. Alzheimer's Disease (AD) -- 3.2. Multiple Sclerosis -- 3.3. Parkinson's Disease -- 4. ACTIVIN -- 5. CHEMOKINES -- REFERENCES -- Chapter 11: MICROGLIAL ACTIVATION IS REDUCED BY PROSTAGLANDIN E2 -- ABSTRACT -- INTRODUCTION -- PROSTAGLANDIN E2 IS A REDUCTION FACTOR OF MICROGLIAL ACTIVATION -- PROSTAGLANDIN E2 REDUCES MICROGLIAL ACTIVATION THROUGH EP2 -- OTHER PROSTAGLANDIN E2 RECEPTORS MAY BE INVOLVED IN MICROGLIAL ACTIVATION -- MIROGLIAL ACTIVATION IS AUTO-REGULATED BY PROSTAGLANDIN E2 -- PROSTAGLANDIN D2 MIGHT AFFECT MICROGLIAL ACTIVATION -- PROSTAGLANDIN E2 PRODUCTION IS UP-REGULATED IN CENTRAL NERVOUS SYSTEM DISEASES -- EFFECT OF PROSTAGLANDIN E2 ON MICROGLIAL ACTIVATION HAS A NEUROPROTECTIVE ASPECT AGAINST CENTRAL NERVOUS SYSTEM DISEASES -- CONCLUSION -- REFERENCES -- Chapter 12: SYNAPTIC STRIPPING AND BEYOND: MICROGLIA OR ASTROCYTES? -- ABSTRACT -- INTRODUCTION -- MICROGLIAL ACTIVATION AND SYNAPTIC STRIPPING AFTER NERVE INJURY OF MOTOR NEURON -- REDUCED SYNAPTIC ACTIVITIES PRECEDS SYNAPTIC STRIPPING -- POSSIBLE SOURCES OF EXTRACELLULAR NUCLEOTIDES AFTER NERVE INJURY -- DIFFERENTIAL REACTIONS OF PERINEURONAL ASTROCYTES AND MICROGLIA AFTER HYPOGLOSSAL NERVE AXOTOMY -- ASTROCYTE AND MICROGLIA PLAY DISTINCT ROLES IN SYNAPTIC STRIPPING AND CELL FATE DECISION -- CONCLUDING REMARKS -- ACKNOWLEGEMENTS. REFERENCES -- Chapter 13: MICROGLIA-TO-NEURON COMMUNICATION INSPINAL NOCICEPTIVE PATHWAYS -- ABSTRACT -- 1. INTRODUCTION -- 2. NEURON-TO-MICROGLIA AND MICROGLIA-TO-NEURON COMMUNICATION IN NEUROPATHIC PAIN: THE NERVE INJURY MODEL -- 2.1. From Injured Primary Afferent Fibres to Spinal Microglia -- 2.2. Molecular Changes in Activated Spinal Microglia -- 2.3. From Spinal Microglia to DH Neurons -- 3. OTHER MODELS OF MICROGLIA-TO-NEURON COMMUNICATION IN NOCICEPTION -- 3.1. Diabetes-Induced Neuropathic Pain -- 3.2. Morphine and Microglia -- 4. CLINICAL APPLICATIONS -- CONCLUSION -- REFERENCES -- Chapter 14: MICROGLIA IN HUNTINGTON DISEASE -- INTRODUCTION -- HUNTINGTON DISEASE HISTORY -- HD CLINICAL FEATURES -- HD NEUROPATHOLOGY -- HD GENETICS -- HUNTINGTIN FUNCTION -- PUTATIVE MECHANISMS OF MUTANT HTT TOXICITY -- INTRODUCTION TO MICROGLIA -- INFLAMMATION IN HD -- COMPLEMENT SYSTEM AND HD -- NEUROINFLAMMATION IN HD -- PERIPHERAL VS. CENTRAL INFLAMMATION IN HD -- CASPASE INVOLVEMNT IN MICROGLIA ACTIVATION -- CASPASES AND HD -- THE KYNURENINE PATHWAY -- ALTERATIONS IN THE KYNURENINE PATHWAY IN HD -- TARGETING THE KYNURENINE PATHWAY IN HD -- MICROGLIA SIGNALING PATHWAYS IN HD -- IRON REGULATION IN THE BRAIN -- IRON IN HUNTINGTON DISEASE -- THE CANNABINOID SYSTEM -- CANNABINOIDS IN HD -- PERSPECTIVES AND CONCLUSION -- REFERENCES -- Chapter 15: THE NEUROINFLAMMATORY ROLE OF SCHWANN CELLS IN HEALTH AND DISEASE -- ABSTRACT -- ABBREVIATIONS -- 1. INTRODUCTION -- 2. SCHWANN CELLS ARE IMMUNE COMPETENT CELLS -- 2.1. Schwann Cells as Sensors of Danger within the PNS -- 2.2. Schwann Cells as Immune Effector Cells within the PNS -- 2.3. Schwann Cells as Antigen Presenting Cells? -- 3. THE NEUROINFLAMMATORY ROLE OF SCHWANN CELLS IN DISEASE -- 3.1. A Dysregulated Immune Response is the Driving Force of Inflammatory Neuropathies. 3.2. A Secondary Immune Response in Hereditary Neuropathies Contributesto Disease Manifestation. |
| Record Nr. | UNINA-9910826543603321 |
| New York, : Nova Science Publishers, Inc., c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Neuroinflammation and Neurodegeneration / / edited by Phillip K. Peterson, Michal Toborek
| Neuroinflammation and Neurodegeneration / / edited by Phillip K. Peterson, Michal Toborek |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (606 p.) |
| Disciplina |
616.8
616.8/0471 |
| Soggetto topico |
Neurosciences
Neurochemistry Neurobiology |
| ISBN | 1-4939-1071-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | The Blood Brain Barrier -- Immune Cell Trafficking in the Central Nervous System -- General Physiology and Pathophysiology of Microglia Inflammation and the Pathophysiology of Astrocytes in Neurodegenerative Diseases -- Oxidative stress, neuroinflammation, and neurodegeneration -- Peripheral Neuroimmune Interactions and Neuropathic Pain -- Innate and Adaptive Immune-Mediated Neuroinflammation and Neurodegeneration in Parkinson’s Disease -- Multiple sclerosis: impact on functioning of the blood-brain barrier -- Neuroinflammation in Alzheimer’s disease -- Neuroinflammation in Huntington’s Disease -- Neuroinflammation and immune regulation in ischemic stroke: identification of new pharmacological targets -- HIV/NeuroAIDS -- Herpes Simplex Virus Infections Of The Central Nervous System -- Congenital Cytomegalovirus Disease -- Japanese Encephalitis: A Tale of Inflammation and Degeneration in the Central Nervous System -- The biology and clinical consequence of infection with the human polyomavirus JCV -- Role of Retrovirus-Induced Transactivator Proteins in Neuroinflammatory Disease -- Immunopathogenesis of bacterial meningitis -- Cerebral Malaria -- HIV and Cocaine Interplay in HIV-associated Neurocognitive Disorders -- Methamphetamine Neurotoxicity and Neuroinflammatory Processes -- Drugs of Abuse and NeuroAIDS: Opiates -- Cannabinoids -- Alcohol and Neurodegeneration -- Cell-Based Drug Delivery for Improving Antiretroviral Therapeutic Outcomes -- Immunomodulatory Therapeutics for Neurodegenerative Diseases -- Therapeutic Potential Of Cannabinoids. |
| Record Nr. | UNINA-9910298348603321 |
| New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Prenatal alcohol use and fetal alcohol spectrum disorders [[electronic resource] ] : diagnosis, assessment and new directions in research and multimodal treatment / / editor, Susan A. Adubato and Deborah E. Cohen
| Prenatal alcohol use and fetal alcohol spectrum disorders [[electronic resource] ] : diagnosis, assessment and new directions in research and multimodal treatment / / editor, Susan A. Adubato and Deborah E. Cohen |
| Pubbl/distr/stampa | [United Arab Emirates, : Bentham eBooks, 2011] |
| Descrizione fisica | 1 online resource (216 p.) |
| Disciplina | 616.8/0471 |
| Altri autori (Persone) |
AdubatoSusan A
CohenDeborah E |
| Soggetto topico |
Fetal alcohol syndrome
Alcoholism in pregnancy - Complications Children of prenatal alcohol abuse |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-60805-031-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 01 Title.pdf; 02 Cover Page; 03 REVISED eBooks End User License Agreement-Website; 04 Dedication; 05 Contents; 06 Foreword; 07 PREFACE; 08 Contributors; 09 Chapter 1; 10 Chapter 2; 11 Chapter 3; 12 Chapter 4; 13 Chapter 5; 14 Chapter 6; 15 Chapter 7; 16 Chapter 8; 17 Chapter 9; 18 Afterword; 19 Index |
| Record Nr. | UNINA-9910457370103321 |
| [United Arab Emirates, : Bentham eBooks, 2011] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
