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Clinical diabetes research [[electronic resource] ] : methods and techniques / / edited by Michael Roden
| Clinical diabetes research [[electronic resource] ] : methods and techniques / / edited by Michael Roden |
| Pubbl/distr/stampa | Chichester, West Sussex, England ; ; Hoboken, N.J., : John Wiley and Sons, c2007 |
| Descrizione fisica | 1 online resource (424 p.) |
| Disciplina | 616.4620072 |
| Altri autori (Persone) | RodenMichael, Dr. |
| Soggetto topico |
Diabetes
Diabetes - Research |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-03198-4
9786611031985 0-470-51309-8 0-470-51308-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Clinical Diabetes Research; Contents; List of Contributors; 1 Basics of Clinical Metabolic Research; 2 Methods for the Assessment of β-Cell Function In Vivo; Introduction; Methods for insulin secretion in vivo; β-cell response characteristics; β-cell function tests; Modelling methods; β-cell function and insulin sensitivity; Comparative evaluation of methods; Conclusion; 3 Assessment of Insulin Sensitivity from Steady-State and Dynamic Tests; Introduction; Insulin sensitivity from steady-state tests; Insulin sensitivity from dynamic tests; Conclusion; 4 Glucose Clamp Techniques; Introduction
Basic principles of the euglycaemic hyperinsulinaemic clamp techniqueMethodology; Reproducibility of insulin sensitivity obtained from clamp tests; Safety considerations for hyperinsulinaemiac euglycaemic clamp test; Modifications of the euglycaemic hyperinsulinaemic clamp test protocol; Conclusion; 5 Methods of Assessment of Counterregulation to Hypoglycaemia; Introduction; Definitions; Pathophysiology; Documentation of hypoglycaemia experience; Investigating the pathogenesis of problematic hypoglycaemia; Hypoglycaemic stimuli for research; Measurement of physiological responses; Conclusion 6 Glucose Kinetics: Measurement of Flux RatesIntroduction; Measurement of glucose production and uptake by the liver - tissue balance techniques; Properties of glucose tracers; Measurement of glucose production and uptake by the liver - systemic techniques; Conclusion; Acknowledgements; 7 Xenobiotics as Probes of Carbohydrate Metabolism; Introduction; Glucuronidation; Glutamination; Ribosylation; Acetylation; Glycination; 8 Tracing Hepatic Glucose and Glycogen Fluxes with 2H2O; Introduction; Methodology; Theoretical considerations; Quantifying hepatic glucose and glycogen metabolism Conclusion9 Lipid Kinetics; Introduction; Tracers for the study of adipose tissue lipolysis; Tracers for the study of triglyceride-rich lipoprotein kinetics; Conclusion; Acknowledgements; 10 Protein and Amino Acid Kinetics; Introduction; Measuring amino acid turnover; Measuring protein turnover; Proteome dynamics; Urea kinetics; Determining the molecular control of protein dynamics; Conclusion; Acknowledgements; 11 Assessment of Metabolic Fluxes by In Vivo MR Spectroscopy; Phenomena of nuclear magnetic resonance - imaging and spectroscopy; Skeletal muscle; Liver; Brain; Conclusion 12 Positron Emission Tomography in Metabolic ResearchIntroduction; Tracers for metabolic imaging; Principles of modeling; Future perspectives; 13 Assessment of Body Fat Content and Distribution; Introduction; Measurement techniques; Body fat distribution and insulin resistance; 14 Tissue Biopsies in Diabetes Research; Introduction; Percutaneous needle biopsy of skeletal muscle; Biopsy procedure and sample handling; Discomfort and complications of needle biopsy; Advantages and limitations of needle biopsy; Application of muscle biopsy in diabetes; Morphology of skeletal muscle Application of muscle morphology in type 2 diabetes |
| Record Nr. | UNINA-9910144740503321 |
| Chichester, West Sussex, England ; ; Hoboken, N.J., : John Wiley and Sons, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical diabetes research [[electronic resource] ] : methods and techniques / / edited by Michael Roden
| Clinical diabetes research [[electronic resource] ] : methods and techniques / / edited by Michael Roden |
| Pubbl/distr/stampa | Chichester, West Sussex, England ; ; Hoboken, N.J., : John Wiley and Sons, c2007 |
| Descrizione fisica | 1 online resource (424 p.) |
| Disciplina | 616.4620072 |
| Altri autori (Persone) | RodenMichael, Dr. |
| Soggetto topico |
Diabetes
Diabetes - Research |
| ISBN |
1-281-03198-4
9786611031985 0-470-51309-8 0-470-51308-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Clinical Diabetes Research; Contents; List of Contributors; 1 Basics of Clinical Metabolic Research; 2 Methods for the Assessment of β-Cell Function In Vivo; Introduction; Methods for insulin secretion in vivo; β-cell response characteristics; β-cell function tests; Modelling methods; β-cell function and insulin sensitivity; Comparative evaluation of methods; Conclusion; 3 Assessment of Insulin Sensitivity from Steady-State and Dynamic Tests; Introduction; Insulin sensitivity from steady-state tests; Insulin sensitivity from dynamic tests; Conclusion; 4 Glucose Clamp Techniques; Introduction
Basic principles of the euglycaemic hyperinsulinaemic clamp techniqueMethodology; Reproducibility of insulin sensitivity obtained from clamp tests; Safety considerations for hyperinsulinaemiac euglycaemic clamp test; Modifications of the euglycaemic hyperinsulinaemic clamp test protocol; Conclusion; 5 Methods of Assessment of Counterregulation to Hypoglycaemia; Introduction; Definitions; Pathophysiology; Documentation of hypoglycaemia experience; Investigating the pathogenesis of problematic hypoglycaemia; Hypoglycaemic stimuli for research; Measurement of physiological responses; Conclusion 6 Glucose Kinetics: Measurement of Flux RatesIntroduction; Measurement of glucose production and uptake by the liver - tissue balance techniques; Properties of glucose tracers; Measurement of glucose production and uptake by the liver - systemic techniques; Conclusion; Acknowledgements; 7 Xenobiotics as Probes of Carbohydrate Metabolism; Introduction; Glucuronidation; Glutamination; Ribosylation; Acetylation; Glycination; 8 Tracing Hepatic Glucose and Glycogen Fluxes with 2H2O; Introduction; Methodology; Theoretical considerations; Quantifying hepatic glucose and glycogen metabolism Conclusion9 Lipid Kinetics; Introduction; Tracers for the study of adipose tissue lipolysis; Tracers for the study of triglyceride-rich lipoprotein kinetics; Conclusion; Acknowledgements; 10 Protein and Amino Acid Kinetics; Introduction; Measuring amino acid turnover; Measuring protein turnover; Proteome dynamics; Urea kinetics; Determining the molecular control of protein dynamics; Conclusion; Acknowledgements; 11 Assessment of Metabolic Fluxes by In Vivo MR Spectroscopy; Phenomena of nuclear magnetic resonance - imaging and spectroscopy; Skeletal muscle; Liver; Brain; Conclusion 12 Positron Emission Tomography in Metabolic ResearchIntroduction; Tracers for metabolic imaging; Principles of modeling; Future perspectives; 13 Assessment of Body Fat Content and Distribution; Introduction; Measurement techniques; Body fat distribution and insulin resistance; 14 Tissue Biopsies in Diabetes Research; Introduction; Percutaneous needle biopsy of skeletal muscle; Biopsy procedure and sample handling; Discomfort and complications of needle biopsy; Advantages and limitations of needle biopsy; Application of muscle biopsy in diabetes; Morphology of skeletal muscle Application of muscle morphology in type 2 diabetes |
| Record Nr. | UNINA-9910830885803321 |
| Chichester, West Sussex, England ; ; Hoboken, N.J., : John Wiley and Sons, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease : A Focus on Early Phase Clinical Drug Development / / edited by Andrew J. Krentz, Christian Weyer, Marcus Hompesch
| Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease : A Focus on Early Phase Clinical Drug Development / / edited by Andrew J. Krentz, Christian Weyer, Marcus Hompesch |
| Edizione | [2nd ed. 2019.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
| Descrizione fisica | 1 online resource (557 pages) |
| Disciplina | 616.4620072 |
| Soggetto topico |
Diabetes
Metabolic diseases Pharmacology Metabolic Diseases Pharmacology/Toxicology |
| ISBN | 3-030-11748-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part 1: Review of Clinical Investigative Methods -- Chapter 1: Quantifying Insulin Action in Humans -- Chapter 2: Assessment of Islet Alpha- and Beta-Cell Function -- Chapter 3: Pharmacokinetic and Pharmacodynamic Assessment of Novel and Biosimilar Insulins -- Chapter 4: Measurement of Energy Expenditure -- Chapter 5: QUANTIFYING APPETITE AND SATIETY -- Chapter 6: Non-invasive quantitative magnetic resonance imaging and spectroscopic biomarkers in nonalcoholic fatty liver disease and other cardiometabolic diseases associated with ectopic fat deposition -- Chapter 7: Structural and Functional Imaging of Muscle, Heart, Endocrine Pancreas and Kidneys in Cardiometabolic Drug Development -- Chapter 8: Positron emission tomography and computed tomography measurement of brown fat thermal activation: key tool for developing novel pharmacotherapeutics for obesity and diabetes -- Chapter 9: Isotopic Tracers for the Measurement of Metabolic Flux Rates -- Chapter 10: Role of Tissue Biopsy in Drug Development for NonAlcoholic Fatty Liver Disease and Other Metabolic Disorders -- Chapter 11: Utility of Invasive and Non-invasive Cardiovascular Research Methodologies in Drug Development for Diabetes, Obesity and NAFLD/NASH -- Chapter 12: Omics: Potential role in early phase drug development -- Part 2: Preclinical Drug Development and Transitioning to Clinical Studies -- Chapter 13: Peptide Drug Design for Diabetes & Related Metabolic Diseases -- Chapter 14: ANIMAL MODELS OF TYPE 2 DIABETES, OBESITY AND NONALCOHOLIC STEATOHEPATITIS – CLINICAL TRANSLATABILITY AND APPLICABILITY IN PRECLINICAL DRUG DEVELOPMENT -- Chapter 15: Drug Development for Diabetes Mellitus: Beyond Hemoglobin A1c -- Chapter 16: Emerging Circulating Biomarkers For The Diagnosis And Assessment Of Treatment Responses In Patients With Hepatic Fat Accumulation, Nash And Liver Fibrosis -- Chapter 17: Quantitative Approaches in Translational Cardiometabolic Research: An Overview -- Chapter 18: Transitioning from Preclinical to Clinical Drug Development -- Chapter 19: Regulatory Considerations for Early Study and Clinical Development of Drugs for Diabetes, Obesity, NonAlcoholic Steatohepatitis (NASH) and other Cardiometabolic Disorders -- Chapter 20: Early Phase Metabolic Research with Reference to Special Populations. |
| Record Nr. | UNINA-9910337481203321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||