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Clinical Relevance of Genetic Factors in Pulmonary Diseases / / edited by Takeshi Kaneko

Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018

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Meshless Methods in Biomechanics : Bone Tissue Remodelling Analysis / / by Jorge Belinha

Belinha Jorge

Cham : , : Springer International Publishing : , : Imprint : Springer, , 2014

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Practical Lung Pathology : Frequently Asked Questions / / edited by Haodong Xu, Robert W. Ricciotti, Jose G. Mantilla

Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022

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Prove di funzionalit respiratoria : Realizzazione, interpretazione, referti / / Dennis Bosch, Carl-Peter Criee ; Edizione italiana a cura di Andrea Rossi

Bosch Dennis

Milan, : Springer, 2009

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Pulmonary pathology / / Nagarjun Rao, Cesar A. Moran

Rao Nagarjun

New York, New York : , : Demos Medical Publishing, , 2014

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Pulmonary pathology / / Nagarjun Rao, Cesar A. Moran

Rao Nagarjun

New York, New York : , : Demos Medical Publishing, , 2014

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Pulmonary pathology / / Nagarjun Rao, Cesar A. Moran

Rao Nagarjun

New York, New York : , : Demos Medical Publishing, , 2014

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Targeting cellular signalling pathways in lung diseases / / Kamal Dua [and four others], editors

Gateway East, Singapore : , : Springer, , [2021]

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Edizione	[1st ed. 2018.]
Pubbl/distr/stampa	Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018
Descrizione fisica	1 online resource (IX, 344 p. 55 illus., 36 illus. in color.)
Disciplina	616.2407
Collana	Respiratory Disease Series: Diagnostic Tools and Disease Managements
Soggetto topico	Respiratory organs—Diseases Human genetics Pneumology/Respiratory System Human Genetics
ISBN	981-10-8144-1
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Part I　Introduction -- 1. Clinical development of genomic medicine in pulmonary diseases: Are genetic factors enough to determine the phenotype and inheritance of pulmonary diseases? -- 2. Statistical approaches and strategies for complex diseases - Overview - : What is the rationale for the genome-wide approach to understand complex diseases - its application and limitations -- Part II　Genetic Disorders in Pulmonary Disease -- 3 (旧4)Bronchial asthma: Is asthma inherited? -- 4 (旧5)COPD - Hereditary (A1-AT) and Non-hereditary: What are the roles of genetic factors in the pathogenesis of COPD? -- 5 (旧3)Smoking behavior and cessation (nicotine addiction): Are genetic factors involved in smoking behavior? -- 6. Cystic fibrosis, Primary ciliary dyskinesia and Diffuse panbronchiolitis - Hereditary and Non-Hereditary: What are the roles of genetic factors in the pathogenesis of these diseases? -- 7. Pulmonary Fibrosis -Hereditary and Nonhereditary: What are the role of genetic factors in the pathogenesis of pulmonary fibrosis? -- 8. Other diffuse lung diseases - Diffuse cystic lung diseases (LAM, TSC, BHD), Sarcoidosis, Pulmonary alveolar proteinosis, and Pulmonary alveolar microlithiasis: What are the roles of genetic factors in the pathogenesis of these diseases? -- 9. Pulmonary vascular diseases - Pulmonary hypertension and HHT: What are the roles of genetic factors in the pathogenesis of pulmonary vascular diseases? -- 10. Mycobacterial infection – TB and NTM: What are the roles of genetic factors in the pathogenesis of mycobacterial infection? -- 11. Pulmonary malignancies (1): Lung cancer: What are the roles of genetic factors in lung cancer pathogenesis? -- 12. Pulmonary malignancies (2): Mesothelioma: What are the Roles of Genetic Factors in the Pathogenesis of Mesothelioma? -- 13. Genetic Factors in Sleep Disorders: What are the roles of genetic factors in the pathogenesis of sleep disorders? -- 14. Pharmacokinetics, pharmacodynamics, and toxicities: What should we know about genetic factors that affect the pharmacotherapy of pulmonary diseases? -- Part III　Oncogenic Driver Mutation (Somatic Mutations) in Lung Cancer -- 15. EGFR: How important is EGFR mutation status in the management of lung cancer? -- 16. ALK, and others: How important are ALK, and other mutations in the management of lung cancer? -- Part IV　Current Topics -- 17.Application of high-throughput technologies in personal genomics: How is the progress in personal genome service? -- 18. Nucleic acid amplification-based diagnostics for pulmonary diseases : What is the current state and perspectives of nucleic acid amplification technologies used in diagnostics associated with pulmonary diseases?.
Record Nr.	UNINA-9910300443303321

Autore	Belinha Jorge
Edizione	[1st ed. 2014.]
Pubbl/distr/stampa	Cham : , : Springer International Publishing : , : Imprint : Springer, , 2014
Descrizione fisica	1 online resource (328 p.)
Disciplina	616.2407
Collana	Lecture Notes in Computational Vision and Biomechanics
Soggetto topico	Biomedical engineering Mechanics Mechanics, Applied Numerical analysis Computer science - Mathematics Mechanical engineering Biomedical Engineering and Bioengineering Solid Mechanics Numerical Analysis Computational Science and Engineering Mechanical Engineering
ISBN	3-319-06400-2
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	1. Introduction -- 1.1 Meshless Methods -- 1.2 Natural Neighbour Radial Point Interpolation Method -- 1.3 Bone tissue remodelling analysis -- 1.4 Book Purpose -- 1.5 Meshless method software -- 1.6 Book arrangement -- 2. Solid Mechanics Fundamentals -- 2.1 Continuum formulation -- 2.2 Weak form -- 2.3 Discrete system of equations -- 3. Meshless Methods Introduction -- 3.1 Meshless generic procedure -- 3.2 Nodal connectivity -- 3.3 Numerical integration -- 3.4 Numerical implementation -- 4. Shape Functions -- 4.1 Introduction -- 4.2 Support-Domain -- 4.3 Moving Least Squares -- 4.4 Radial Point Interpolators -- 5. Solid Mechanics Problems -- 5.1 Solid Mechanics NNRPIM flow chart -- 5.2 RPI shape function patch test -- 5.3 Elastostatic numerical examples -- 5.4 Elastodynamic numerical examples -- 6. Bone Tissue -- 6.1 Bone biology: Basic concepts -- 6.2 Bone tissue mechanical properties -- 6.3 Bone remodelling algorithms -- 7. Bone Tissue Remodelling Analysis -- 7.1 Bone Patch Analysis -- 7.2 Bone Structures -- 7.3 Implants -- 8. References -- 9. Subject Index.
Record Nr.	UNINA-9910299744403321

Edizione	[1st ed. 2022.]
Pubbl/distr/stampa	Cham : , : Springer International Publishing : , : Imprint : Springer, , 2022
Descrizione fisica	1 online resource (354 pages)
Disciplina	262 616.2407
Collana	Practical Anatomic Pathology
Soggetto topico	Pathology Internal medicine Internal Medicine
ISBN	3-031-14402-3
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Part I. Neoplastic Lung Pathology -- Bronchial Squamous Cell Papilloma versus Squamous Cell Carcinoma -- Pulmonary Hamartoma versus Chondroid Neoplasms -- Reactive Type II Pneumocyte Hyperplasia versus Adenocarcinoma -- Atypical Adenomatous Hyperplasia versus Peribronchiolar Metaplasia -- Adenocarcinoma In-Situ versus Atypical Adenomatous Hyperplasia -- Invasive Adenocarcinoma versus Adenocarcinoma In-Situ -- Solid Pulmonary Adenocarcinoma versus Large Cell Undifferentiated Carcinoma -- Large Cell Neuroendocrine Carcinoma versus Solid-Predominant Lung Adenocarcinoma -- Poorly Differentiated Squamous Cell Carcinoma versus Solid Pattern Adenocarcinoma -- Invasive Mucinous Adenocarcinoma versus Ciliated Muconodular Papillary Tumor -- Mucoepidermoid Carcinoma versus Adenosquamous Carcinoma -- Large Cell (Undifferentiated) Carcinoma (LCC) versus Large Cell Neuroendocrine Carcinoma (LCNEC) -- Large Cell Neuroendocrine Carcinoma versus Small Cell Carcinoma of the Lung -- Atypical Carcinoid Tumor versus Large Cell Neuroendocrine Carcinoma -- Small Cell Carcinoma versus Atypical Carcinoid Tumor -- Typical versus Atypical Carcinoid and Diffuse Idiopathic Neuroendocrine Cell Hyperplasia versus Carcinoid Tumorlets -- Minute Meningothelial-Like Nodules versus Tumorlet -- Primary Lung versus Metastatic Adenocarcinoma -- Metastatic Urothelial Carcinoma versus Squamous Cell Carcinoma -- Thymic Carcinoma versus Lung Squamous Cell Carcinoma -- Pulmonary Epithelioid Hemangioendothelioma versus Carcinoma and Other Epithelioid Neoplasms -- Epithelioid Malignant Mesothelioma versus Adenocarcinoma -- Sarcomatoid Carcinoma versus Sarcomatoid Malignant Mesothelioma -- Primary Sarcoma (Unclassified) versus Sarcomatoid Mesothelioma/Carcinoma -- Synovial Sarcoma versus Solitary Fibrous Tumor -- Inflammatory Myofibroblastic Tumor versus Organizing Pneumonia -- Metastatic Malignant Epithelioid Melanoma versus Poorly Differentiated Carcinoma -- Pulmonary Epithelioid Angiosarcoma versus Carcinoma -- Epithelioid Sarcoma versusLarge Cell (Undifferentiated) Carcinoma -- Intimal Sarcoma versus Other Spindle Cell Neoplasms -- Sclerosing Pneumocytoma versus Lung Adenocarcinoma -- Erdheim-Chester Disease versus Reactive Inflammatory Infiltrates -- Mucosal Marginal Zone Lymphoma versus Follicular Bronchiolitis -- Primary Pulmonary Diffuse Large B Cell Lymphoma versus Poorly Differentiated Carcinomas -- Lymphomatoid Granulomatosis versus Granulomatosis with Polyangiitis -- Primary Pulmonary Classic Hodgkin Lymphoma versus Other Non-Hodgkin Lymphomas -- Post-Transplant Lymphoproliferative Disorders in Lung after Lung Transplantation versus Infection and Inflammation -- Part II. Non-Neoplastic Lung Pathology -- Usual Interstitial Pneumonia versus Non-Specific Interstitial Pneumonia -- Hypersensitivity Pneumonitis versus Usual Interstitial Pneumonia -- Organizing Pneumonia versus Usual Interstitial Pneumonia -- Diffuse Alveolar Damage (Organizing Phase) versus Nonspecific Interstitial Pneumonia -- Chronic Eosinophilic Pneumonia versus Organizing Pneumonia -- Pulmonary Langerhans Cell Histiocytosis with Fibrosis versus Organizing Pneumonia -- IgG4-Related Lung Disease versus Other Fibroinflammatory Processes -- Pulmonary Alveolar Proteinosis versus Pulmonary Edema -- Non-Specific Interstitial Pneumonia versus Lymphoid Interstitial Pneumonia versus Follicular Bronchiolitis -- Respiratory Bronchiolitis versus Desquamative Interstitial Pneumonia -- Constrictive Bronchiolitis -- Granulomatosis with Polyangiitis versus Mycobacterial/Fungal Infection -- Eosinophilic Granulomatosis with Polyangiitis versus Eosinophilic Pneumonia -- Pulmonary Sarcoidosis versus Mycobacterial/Fungal Disease in the Lung -- Histoplasmosis, Blastomycosis, Coccidioidomycosis, and Cryptococcosis in the Lung -- Pneumocystis jirovecii Pneumonia versus Histoplasmosis -- The Differential Diagnosis of Invasive Mold Infections in the Lung -- Primary Pulmonary Arterial Hypertension versus Secondary Pulmonary Hypertension -- Pulmonary Capillary Hemangiomatosis versus Congestion -- Pulmonary Veno-Occlusive Disease versus Pulmonary Arterial Hypertension -- Lymphangioleiomyomatosis versus Benign Metastasizing Leiomyoma -- Diffuse Pulmonary Lymphangiomatosis versus Lympangioleiomyomatosis -- Intralobar versus Extralobar Pulmonary Sequestration.
Record Nr.	UNINA-9910631077703321

Autore	Bosch Dennis
Edizione	[1st ed. 2009.]
Pubbl/distr/stampa	Milan, : Springer, 2009
Descrizione fisica	1 online resource (164 p.)
Disciplina	616.2 616.2407
Altri autori (Persone)	CrieeCarl-Peter RossiAndrea
Soggetto topico	Pulmonary function tests
ISBN	1-283-07272-6 9786613072726 88-470-0799-2
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	ita
Nota di contenuto	Veduta d’insieme delle prove di funzionalitä respiratoria -- Parametri inerenti alla funzione polmonare -- Spirometria -- Pletismografia corporea -- Test di broncodilatazione e di broncoprovocazione -- Test di diffusione -- Misura della pressione d’occlusione alla bocca -- Misura del picco di flusso -- Emogasanalisi -- Strategie interpretative delle prove di funzionalità respiratoria -- Esercizi pratici.
Record Nr.	UNINA-9910141018103321

Autore	Rao Nagarjun
Pubbl/distr/stampa	New York, New York : , : Demos Medical Publishing, , 2014
Descrizione fisica	1 online resource : color illustrations
Disciplina	616.2407
Collana	Demos Surgical Pathology Guides
Soggetto topico	Lungs - Pathophysiology Lungs - Histopathology Lungs - Diseases
ISBN	1-61705-068-7
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Cover; Title; Copyright; Contents; Series Foreword; Preface; Part I: Nonneoplastic Conditions; Chapter 1: Infections; Bacterial; Viral; Fungal; Mycobacterial; Chapter 2: Granulomatous Diseases; Sarcoidosis; Hypersensitivity Pneumonitis; Bronchocentric Granulomatosis; Chapter 3: Acute Lung Injury; Diffuse Alveolar Damage; Organizing Pneumonia; Acute Eosinophilic Pneumonia; Chapter 4: Idiopathic Interstitial Pneumonias; Usual Interstitial Pneumonia; Nonspecific Interstitial Pneumonia; Desquamative Interstitial Pneumonia; Cryptogenic Organizing Pneumonia; Chapter 5: Vasculitis Wegener's Granulomatosis (Granulomatosis and Polyangiitis)Microscopic Polyangiitis; Chapter 6: Histiocytoses; Pulmonary Langerhans' Cell Histiocytosis; Erdheim-Chester Disease; Rosai-Dorfman Disease; Chapter 7: Lung Pathology in Systemic Diseases; Collagen Vascular Disease and Inflammatory Bowel Disease; Chapter 8: Transplant-Related Lung Pathology; Rejection and Infections; Chapter 9: Miscellaneous Nonneoplastic Conditions; Lymphangioleiomyomatosis; Pneumoconioses; Part II: Neoplasia; Chapter 10: Benign Epithelial Neoplasia; Adenoma, Papillary, and Alveolar; Chapter 11: Preinvasive Neoplasia Squamous Cell Carcinoma In-SituAtypical Adenomatous Hyperplasia; Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia and Carcinoid Tumorlets; Chapter 12: Squamous Cell Carcinoma; Chapter 13: Adenocarcinoma; Chapter 14: Neuroendocrine Neoplasia; Low Grade Neuroendocrine Carcinoma; Intermediate Grade Neuroendocrine Carcinoma; High Grade Neuroendocrine Neoplasia; Large Cell Neuroendocrine Carcinoma; Small Cell Neuroendocrine Carcinoma; Chapter 15: Other Epithelial Neoplasia; Sclerosing Hemangioma; Chapter 16: Mesenchymal Neoplasia; Hamartoma; Solitary Fibrous Tumor; Synovial Sarcoma LeiomyomaLeiomyosarcoma; Epithelioid Hemangioendothelioma; Angiosarcoma; Chapter 17: Lymphoproliferative Disorders; Nodular Lymphoid Hyperplasia; Mucosa Associated Lymphoid Tissue Lymphoma; Lymphomatoid Granulomatosis; Large Cell Lymphoma; Chapter 18: Pleural Tumors; Solitary Fibrous Tumor; Mesothelioma; Chapter 19: Metastatic Tumors; Chapter 20: Tumor-Like Conditions; Amyloidosis; Pulmonary Hyalinizing Granuloma; Bibliography; Index
Record Nr.	UNINA-9910787609603321

Pubbl/distr/stampa	Gateway East, Singapore : , : Springer, , [2021]
Descrizione fisica	1 online resource (921 pages)
Disciplina	616.2407
Soggetto topico	Lungs - Diseases - Molecular aspects
ISBN	981-336-827-6
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Intro -- Preface -- Acknowledgment -- Contents -- About the Editors -- 1: Introduction to Lung Diseases -- 1.1 Chronic Obstructive Pulmonary Disorder (COPD) -- 1.1.1 Definition -- 1.1.2 Epidemiology -- 1.1.3 Causes -- 1.1.4 Symptoms (Fig. 1.2) -- 1.1.5 Pathophysiology -- 1.1.6 Treatment -- 1.2 Asthma -- 1.2.1 Definition -- 1.2.2 Epidemiology -- 1.2.3 Causes (Fig. 1.3) -- 1.2.4 Symptoms (Fig. 1.4) -- 1.2.5 Pathophysiology -- 1.2.6 Types of Asthma [40] -- 1.2.7 Treatment -- 1.3 Lung Cancer -- 1.3.1 Classification -- 1.3.2 Epidemiology -- 1.3.3 Etiology and Risk Factors [45] (Fig. 1.6) -- 1.3.4 Sign and Symptoms -- 1.3.5 Diagnosis -- 1.3.6 Staging of Lung Cancer -- 1.3.7 Treatment [54] -- 1.4 Acute Respiratory Tract Infections -- 1.4.1 Upper Respiratory Tract Infections -- 1.4.1.1 Acute Pharyngitis -- 1.4.1.2 Acute Sinusitis -- 1.4.1.3 Acute Viral Laryngitis -- 1.4.2 Lower Respiratory Tract Infection -- 1.4.2.1 Pneumonia -- 1.4.2.2 Influenza -- 1.5 Idiopathic Pulmonary Fibrosis (IPF) -- 1.5.1 Epidemiology -- 1.5.2 Causes -- 1.5.3 Pathophysiology -- 1.5.4 Symptoms -- 1.5.5 Diagnosis -- 1.5.6 Treatment -- References -- 2: Targeting Molecular and Cellular Mechanisms in Asthma -- 2.1 Introduction -- 2.1.1 Rationale to the Study -- 2.1.2 Asthma: A Global Health Burden -- 2.1.3 Asthma: GINA Definition -- 2.2 Traditional Understanding and Parallel Non-specific Therapy -- 2.2.1 Major Types of Asthma -- 2.2.2 Allergens Are Major Inducers for Atopic Asthma -- 2.2.3 Pathophysiology -- 2.2.4 Symptomatic Therapy -- 2.3 Current Understanding and Steps Towards Pathway-Specific Therapy(Fig. 2.1) -- 2.3.1 Cells Involved in Asthma Pathogenesis and Respective Targets -- 2.3.1.1 Airway Epithelium -- 2.3.1.2 Dendritic Cells -- Dendritic Cell Modulator as a Target -- 2.3.1.3 Lymphocytes -- 2.3.1.4 T Helper Type 2 (Th2) Cells -- Th2 Cytokines as Target. 2.3.1.5 B Lymphocytes and IgE -- 2.3.1.6 Mast Cells -- 2.3.2 Th2-High Eosinophilic Asthma Versus Th2-Low Neutrophilic Asthma -- 2.3.2.1 Eosinophilic Asthma/Th2-High Asthma -- 2.3.2.2 Neutrophilic Asthma -- 2.3.3 Asthma: A Complex Syndrome with Multiple Endotypes -- 2.4 Nitro-Oxidative Stress in Asthma Pathogenesis -- 2.4.1 Oxidative Stress -- 2.4.2 Mitochondrial Dysfunction in Asthma -- 2.4.3 Nitric Oxide (NO) -- 2.5 Airway Remodelling in Asthma: The Knowledge that Will Shape the Future Treatment -- 2.6 Non-pharmacological Intervention for Asthma: Bronchial Thermoplasty -- 2.7 Tailoring the Patient Needs Via `Personalised Approach´ in Asthma -- 2.8 Conclusions and Future Perspectives -- References -- 3: Various Cellular and Molecular Axis Involved in the Pathogenesis of Asthma -- 3.1 Introduction -- 3.2 Epidemiology and Risk Factors -- 3.3 Granulocytes: As Predictors of Asthma -- 3.3.1 Basophils and Allergic Inflammation -- 3.3.1.1 Stimuli for Basophil Activation -- 3.3.1.2 Inflammatory Mediators of Basophils -- 3.3.1.3 Basophil Adhesion Molecules -- 3.3.2 Neutrophil Granule Contents -- 3.3.2.1 Mechanisms in Neutrophil Activation -- 3.3.2.2 Neutrophil in Airway Inflammation and its Signal Transduction Pathways -- 3.3.2.3 Neutrophil Apoptosis: The Resolution of Inflammation -- 3.3.3 Eosinophilic Asthma -- 3.3.3.1 Eosinophil-Derived Cytokines and Associated Bronchial Hyperresponsiveness -- 3.4 Fibroblasts and Myofibroblasts -- 3.4.1 Extracellular Matrix Production in the Airways -- 3.4.2 Fibroblast to Myofibroblast Transition -- 3.5 Pathological Signaling Pathways Involved in the Activation of Lung-Resident Macrophages and Dendritic Cells (DCs) -- 3.5.1 Macrophage Activation Pathways -- 3.5.1.1 IL-4/IL-13 Signaling Pathway -- 3.5.1.2 TNF-α Signaling Pathway -- 3.5.1.3 TGF-β Signaling Pathway -- 3.5.2 Reactive Oxygen and Nitrogen Species. 3.5.3 Antigen Presentation by Dendritic Cells and their Role in the Pathology of Asthma -- 3.6 Bronchial Epithelial Cells -- 3.6.1 Mechanisms of Endothelial Cell Activation -- 3.6.1.1 Cytokine Activation -- 3.6.1.2 Role of Epithelial Cells in Type 2-Driven and Non-type 2 Allergic Asthma -- 3.7 Airway Epithelial and Smooth Muscle Cells -- 3.7.1 Physiological Barrier -- 3.7.2 Airway Epithelial Cell-Derived Mediators -- 3.7.2.1 Nitric Oxide (NO) -- 3.7.2.2 Endothelin -- 3.7.2.3 Arachidonic Acid Metabolites -- 3.7.2.4 Inflammatory Cytokines -- 3.7.2.5 Cell Adhesion Molecules -- 3.7.2.6 Platelet-Activating Factor (PAF) -- 3.7.2.7 Tachykinin -- 3.7.2.8 Histamine -- 3.7.2.9 Adenosine -- 3.8 Role of Innate Immunity in Asthma -- 3.8.1 CD4+ and CD8+ T Cells in Asthma -- 3.8.2 Cellular Receptors of Innate Immunity in Asthma -- 3.8.3 Innate-like T Cells and Asthma -- 3.9 Conclusion -- References -- 4: Targeting Molecular and Cellular Mechanisms in Steroid-Resistant Asthma -- 4.1 Introduction -- 4.2 Inducers of Steroid Resistance in Asthma -- 4.3 Shedding Light on the Cellular Mechanisms Underlying the Glucocorticoid Receptor Signalling Pathway-Mediated Steroid Resis... -- 4.3.1 Neutrophils -- 4.3.2 Factors Inducing Airway Neutrophilia -- 4.3.3 Eosinophils -- 4.3.4 Group 2 Innate Lymphoid Cells (ILC-2) -- 4.3.5 T Helper Type 9 Cells (Th9 Cells) -- 4.3.6 CD8+ T Cells -- 4.4 Possible Molecular Mechanisms behind Steroid-Resistant (SR) Asthma (Fig. 4.1) -- 4.4.1 Bioavailability of Glucocorticoid Receptor (GR) and the Underlying Molecular Mechanism -- 4.4.2 IL-17A High and IFN-γ High Phenotypes -- 4.4.3 PI3K/HDAC Signalling Pathway -- 4.4.4 p38 MAPK -- 4.4.5 NLPR3 Inflammasome -- 4.4.6 Lack of Autophagy -- 4.4.7 Other Key Mechanisms -- 4.5 Tailoring Steroid-Refractory Asthma: The Possible Diagnosis and Therapeutics -- 4.5.1 Immunosuppressive Drugs. 4.5.2 Biologic Therapies -- 4.5.3 Highly Potent Glucocorticoids -- 4.5.4 Vitamin D -- 4.5.5 Sulforaphane -- 4.6 Conclusions and Future Outlook -- References -- 5: Targeting Molecular and Cellular Mechanisms in Chronic Obstructive Pulmonary Disease -- 5.1 Introduction -- 5.2 Pathophysiology of COPD -- 5.2.1 Inflammatory Mediators and Cells -- 5.2.1.1 Neutrophils (NPHs) -- 5.2.1.2 Macrophages (MPs) -- 5.2.1.3 T-Lymphocyte -- Eosinophils (Eos) -- 5.2.1.4 Dendritic Cells (DCs) -- 5.2.1.5 Epithelial Cells (EP) -- 5.2.2 Protease and Antiprotease Imbalance -- 5.2.3 Oxidative Stress (OS) -- 5.3 Mediators Involved in COPD -- 5.3.1 Lipid Mediators -- 5.3.1.1 Prostaglandin -- 5.3.1.2 Thromboxane -- 5.3.1.3 Leukotrienes (LT) -- 5.3.1.4 Platelet-Activating Factor (PAF) -- 5.3.2 Peptide Mediators -- 5.3.2.1 Endothelins (ET) -- 5.3.2.2 Bradykinin (BK) -- 5.3.2.3 Tachykinins (TK) -- 5.3.2.4 Chemokines -- 5.3.2.5 Interleukin-8 (IL-8) -- 5.4 Potential Targets and Therapies for COPD -- 5.4.1 PDE (Phosphodiesterase) Inhibitors -- 5.4.2 Hypersecretion of Mucus -- 5.4.3 Bronchodilators -- 5.4.4 Glucocorticoids (Inhaled Corticosteroids) -- 5.4.5 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) -- 5.4.5.1 CXCR2 Inhibitors -- 5.4.6 Phosphoinositide-3 Kinase Delta (PI3K) Inhibitor -- 5.4.7 Targeting Inflammatory Markers -- 5.4.8 Other COPD Treatments -- 5.5 Conclusion -- References -- 6: Probing the Cellular and Molecular Mechanisms Underlying in the Pathogenesis of Chronic Obstructive Pulmonary Disease -- 6.1 Introduction -- 6.2 Subtypes of COPD -- 6.2.1 Chronic Bronchitis -- 6.2.2 Emphysema -- 6.2.3 Small Airway Disease -- 6.3 Inflammatory Cells Involved in COPD -- 6.3.1 Epithelial Cells -- 6.3.2 Macrophages -- 6.3.3 Neutrophils -- 6.3.4 Eosinophil -- 6.3.5 Dendritic Cells -- 6.3.6 T-Lymphocytes -- 6.4 Inflammatory Mediators Involved in COPD. 6.4.1 Lipid Mediators -- 6.4.2 Pro-inflammatory Cytokines -- 6.4.3 Inflammasomes -- 6.4.4 Role of Reactive Oxygen Species (ROS) and Oxidative Stress in COPD -- 6.5 Conclusion -- References -- 7: Chronic Obstructive Pulmonary Disease: Molecular Basis of Pathogenesis and Targeted Therapeutic Approaches -- 7.1 Introduction -- 7.2 Epidemiology -- 7.3 Aetiology of Disease Progression -- 7.3.1 Inflammation -- 7.3.1.1 Neutrophils -- 7.3.1.2 Macrophages -- 7.3.1.3 T Lymphocytes -- 7.3.1.4 Eosinophils -- 7.3.1.5 Dendritic Cells -- 7.3.1.6 Epithelial Cells -- 7.3.2 Oxidative Stress -- 7.3.3 Genetic Predisposition -- 7.3.4 Epigenetics -- 7.3.5 Activity of Proteases -- 7.3.5.1 Neutrophil Wlastase -- 7.3.5.2 Cysteine Proteases -- 7.3.5.3 Matrix Metalloproteinases -- 7.4 Current Treatments and Their Drawbacks -- 7.4.1 Quit Smoking -- 7.4.2 Vaccination -- 7.4.3 Physical Activity -- 7.4.4 Pharmacological Treatment -- 7.4.5 Emerging Antioxidants for an Alternative Therapeutic Approach -- 7.4.6 Interventional Treatments -- 7.4.7 Oxygen and Ventilator Support -- 7.4.8 Comorbidity Treatment -- 7.5 Conclusion -- References -- 8: Exploring the `Dormancy Activation Switch´ in the Tumour Microenvironment for Metastatic Lung Cancer: The Possible Role of ... -- 8.1 Lung Cancer -- 8.2 Metastatic Niche in Different Sites -- 8.3 Lymph Node Metastasis -- 8.3.1 MAPK Signalling in Lymph Node Metastasis of Lung Cancer -- 8.4 Pleura Metastasis -- 8.4.1 CXCR4/CXCL12 Signalling and Pleura Metastasis in Lung Cancer -- 8.5 Liver Metastasis -- 8.5.1 ALK and Liver Metastasis in Lung Cancer -- 8.6 Brain Metastasis -- 8.6.1 Rho/ROCK Signalling and Brain Metastasis in Lung Cancer -- 8.6.2 PI3K/AKT Signalling and Brain Metastasis in Lung Cancer -- 8.7 Bone Metastasis -- 8.7.1 RANK/RANKL Signalling and Bone Metastasis in Lung Cancer -- 8.8 Controversial Role miRNA in Lung Cancer Metastasis. 8.9 Concluding Remarks.
Record Nr.	UNINA-9910488713203321