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Analytical techniques for clinical chemistry [[electronic resource] ] : methods and applications / / edited by Sergio Caroli, Gyula Záray
| Analytical techniques for clinical chemistry [[electronic resource] ] : methods and applications / / edited by Sergio Caroli, Gyula Záray |
| Pubbl/distr/stampa | Hoboken, : Wiley, c2012 |
| Descrizione fisica | 1 online resource (840 p.) |
| Disciplina | 616.07/9 |
| Altri autori (Persone) |
CaroliSergio <1943->
ZárayGyula |
| Soggetto topico |
Clinical chemistry - Analysis
Biochemistry |
| ISBN |
1-280-77257-3
9786613683342 1-118-27184-X 1-118-27185-8 1-118-27183-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Analytical Techniques for Clinical Chemistry: Methods and Applications; CONTENTS; FOREWORD; PREFACE; CONTRIBUTORS; PART I: Exploring Fundamentals; 1. Good Clinical Practice Principles: Legal Background and Applicability; Summary; 1.1. Introduction; 1.2. Good Clinical Practice; 1.2.1. ICH E6: Guidelines for Good Clinical Practice; 1.2.2. WHO Guidelines for Good Clinical Practice for Trials on Pharmaceutical Products; 1.2.3. WHO Handbook for Good Clinical Research Practice Guidance for Implementation; 1.2.4. WHO Good Clinical Laboratory Practice
1.3. Good Clinical Practice: Legal Background in the European Union1.4. Good Clinical Practice: Applicability in the European Union; 1.4.1. EU 2007 Conference on the Implementation and Applicability in the European Union of Legislation on Clinical Trials of Medical Products; 1.4.2. Directives 2001/20/EC, 2005/28/EC, and Good Clinical Practice in Case of Noncommercial Clinical Trials; 1.5. Good Clinical Practice and Bioequivalence Trials: GCP Inspections and Laboratories; 1.5.1. General Aspects; 1.5.2. EMA Guidelines on Bioequivalence Studies 1.5.3. EMA Reflection Paper for Applicants Who Want to Submit Bioequivalence Performed Outside the European Union1.5.4. Good Clinical Practice Bioequivalence Inspections; 1.5.5. Good Clinical Practice Clinical Laboratory Inspections; 1.5.6. Good Clinical Practice Inspections on Phase I Units; 1.6. Good Clinical Practice for Clinical Trials with Advanced Therapy Medicinal Product; 1.7. Good Clinical Practice and Clinical Trials in Developing Countries; 1.7.1. The Increase of Clinical Trials in Developing Countries; 1.7.2. European Union Legislation and Clinical Trials in Developing Countries References2. Clinical Chemistry and the Quest for Quality; Summary; 2.1. Introduction; 2.2. Quality Today; 2.2.1. General Aspects; 2.2.2. Major Quality Systems and Their Scope; 2.3. Conclusions; References; 3. Uncertainty in Clinical Chemistry Measurements Including Preanalytical Variables; Summary; 3.1. Introduction; 3.2. Analytical Uncertainty in Laboratory Results; 3.2.1. General Aspects; 3.2.2. Control Materials; 3.2.3. Estimating Analytical Precision; 3.2.4. Within-Run Precision (Repeatability); 3.2.5. Total Analytical Precision (Reproducibility) 3.2.6. Estimating Precision Using Duplicates3.3. Trueness and Traceability; 3.3.1. Basic Concepts; 3.3.2. Reference Methods and Materials; 3.3.3. Estimating the Trueness; 3.3.4. Factorizing the Patients' Results; 3.3.5. Changing Reagent Lot; 3.3.6. Analytical Specificity; 3.3.7. Method Validation; 3.4. Proficiency Testing; 3.4.1. Background Information; 3.4.2. Choice of EQA Schemes; 3.4.3. Interpretation and Actions; 3.5. Biological Variations and Quality Goals; 3.6. Reference Intervals; 3.6.1. Establishing Reference Intervals; 3.6.2. Transferring Reference Intervals 3.7. Estimating Preanalytical Uncertainty |
| Record Nr. | UNINA-9910141258903321 |
| Hoboken, : Wiley, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Analytical techniques for clinical chemistry [[electronic resource] ] : methods and applications / / edited by Sergio Caroli, Gyula Záray
| Analytical techniques for clinical chemistry [[electronic resource] ] : methods and applications / / edited by Sergio Caroli, Gyula Záray |
| Pubbl/distr/stampa | Hoboken, : Wiley, c2012 |
| Descrizione fisica | 1 online resource (840 p.) |
| Disciplina | 616.07/9 |
| Altri autori (Persone) |
CaroliSergio <1943->
ZárayGyula |
| Soggetto topico |
Clinical chemistry - Analysis
Biochemistry |
| ISBN |
1-280-77257-3
9786613683342 1-118-27184-X 1-118-27185-8 1-118-27183-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Analytical Techniques for Clinical Chemistry: Methods and Applications; CONTENTS; FOREWORD; PREFACE; CONTRIBUTORS; PART I: Exploring Fundamentals; 1. Good Clinical Practice Principles: Legal Background and Applicability; Summary; 1.1. Introduction; 1.2. Good Clinical Practice; 1.2.1. ICH E6: Guidelines for Good Clinical Practice; 1.2.2. WHO Guidelines for Good Clinical Practice for Trials on Pharmaceutical Products; 1.2.3. WHO Handbook for Good Clinical Research Practice Guidance for Implementation; 1.2.4. WHO Good Clinical Laboratory Practice
1.3. Good Clinical Practice: Legal Background in the European Union1.4. Good Clinical Practice: Applicability in the European Union; 1.4.1. EU 2007 Conference on the Implementation and Applicability in the European Union of Legislation on Clinical Trials of Medical Products; 1.4.2. Directives 2001/20/EC, 2005/28/EC, and Good Clinical Practice in Case of Noncommercial Clinical Trials; 1.5. Good Clinical Practice and Bioequivalence Trials: GCP Inspections and Laboratories; 1.5.1. General Aspects; 1.5.2. EMA Guidelines on Bioequivalence Studies 1.5.3. EMA Reflection Paper for Applicants Who Want to Submit Bioequivalence Performed Outside the European Union1.5.4. Good Clinical Practice Bioequivalence Inspections; 1.5.5. Good Clinical Practice Clinical Laboratory Inspections; 1.5.6. Good Clinical Practice Inspections on Phase I Units; 1.6. Good Clinical Practice for Clinical Trials with Advanced Therapy Medicinal Product; 1.7. Good Clinical Practice and Clinical Trials in Developing Countries; 1.7.1. The Increase of Clinical Trials in Developing Countries; 1.7.2. European Union Legislation and Clinical Trials in Developing Countries References2. Clinical Chemistry and the Quest for Quality; Summary; 2.1. Introduction; 2.2. Quality Today; 2.2.1. General Aspects; 2.2.2. Major Quality Systems and Their Scope; 2.3. Conclusions; References; 3. Uncertainty in Clinical Chemistry Measurements Including Preanalytical Variables; Summary; 3.1. Introduction; 3.2. Analytical Uncertainty in Laboratory Results; 3.2.1. General Aspects; 3.2.2. Control Materials; 3.2.3. Estimating Analytical Precision; 3.2.4. Within-Run Precision (Repeatability); 3.2.5. Total Analytical Precision (Reproducibility) 3.2.6. Estimating Precision Using Duplicates3.3. Trueness and Traceability; 3.3.1. Basic Concepts; 3.3.2. Reference Methods and Materials; 3.3.3. Estimating the Trueness; 3.3.4. Factorizing the Patients' Results; 3.3.5. Changing Reagent Lot; 3.3.6. Analytical Specificity; 3.3.7. Method Validation; 3.4. Proficiency Testing; 3.4.1. Background Information; 3.4.2. Choice of EQA Schemes; 3.4.3. Interpretation and Actions; 3.5. Biological Variations and Quality Goals; 3.6. Reference Intervals; 3.6.1. Establishing Reference Intervals; 3.6.2. Transferring Reference Intervals 3.7. Estimating Preanalytical Uncertainty |
| Record Nr. | UNINA-9910820480403321 |
| Hoboken, : Wiley, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Antiphospholipid syndrome : recent advances in clinical and basic aspects / / edited by Polona Žigon
| Antiphospholipid syndrome : recent advances in clinical and basic aspects / / edited by Polona Žigon |
| Pubbl/distr/stampa | London, England : , : IntechOpen, , 2022 |
| Descrizione fisica | 1 online resource (142 pages) |
| Disciplina | 616.07/9 |
| Soggetto topico |
Autoimmune diseases
Antiphospholipid syndrome |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Antiphospholipid Syndrome |
| Record Nr. | UNINA-9910688182403321 |
| London, England : , : IntechOpen, , 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Autophagy, infection, and the immune response / / edited by William T. Jackson and Michele Swanson
| Autophagy, infection, and the immune response / / edited by William T. Jackson and Michele Swanson |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley Blackwell, , 2015 |
| Descrizione fisica | 1 online resource (364 p.) |
| Disciplina | 616.07/9 |
| Soggetto topico |
Autophagic vacuoles
Immune response |
| ISBN |
1-118-67773-0
1-118-67755-2 1-118-67771-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Autophagy and immunity / Xu Liu and Daniel J. Klionsky -- Techniques for studying autophagy / Isei Tanida and Masato Koike -- Role of autophagy in DNA virus infections in vivo / Xionan Dong and Beth Levine -- Studying RNA viruses and autophagy in vivo / Mehrdad Alirezaei and J. Lindsay Whitton -- Autophagy and picornavirus infection / Tom Wileman, Zhigang Zhou, Matthew Whelband, Eleanor Cottam, Stephen Berryman, Terry Jackson, and Rebecca Roberts -- Flaviviruses and autophagy / Tristan X. Jordan and Glenn Randall -- Autophagy : a home remodeler for Hepatitis C virus / Marine L.B. Hillaire, Elodie Decembre, and Marlene Dreux -- Modulating autophagy to cure Human Immunodeficiency Virus type-1 / Stephen A. Spector and Grant R. Campbell -- Autophagy in the infected cell : insights from pathogenic bacteria / Andrea Sirianni and Serge Mostowy -- Rab proteins in autophagy: streptococcus model / Ichiro Nakagawa -- Helicobacter pylori infection control by autophagy / Laura K. Greenfield, Frances Dang, and Nicola L. Jones -- Interactions between salmonella and the autophagy system / Teresa L.M. Thurston and David W. Holden -- Host factors that recruit autophagy as defense against toxoplasma gondii / Carlos S. Subauste -- Mycobacterium tuberculosis and the autophagic pathway / Gabriela María Recalde and María Isabel Colombo -- Autophagy enhances the efficacy of BCG vaccine / Arshad Khan, Christopher R. Singh, Emily Soudani, Pearl Bakhru, Sankaralingam Saikolappan, Jeffrey D. Cirillo, N. Tony Eissa, Subramanian Dhandayuthapani, and Chinnaswamy Jagannath -- Autophagy's contribution to innate and adaptive immunity : an overview / Christina Bell, Michel Desjardins, Pierre Thibault, and Kerstin Radtke -- Autophagy in immune responses to viruses / Christophe Viret and Mathias Faure -- Processing and MHC presentation of antigens after autophagy-assisted endocytosis, exocytosis and cytoplasm degradation / Christian Münz. |
| Record Nr. | UNINA-9910140485703321 |
| Hoboken, New Jersey : , : Wiley Blackwell, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Autophagy, infection, and the immune response / / edited by William T. Jackson and Michele Swanson
| Autophagy, infection, and the immune response / / edited by William T. Jackson and Michele Swanson |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, New Jersey : , : Wiley Blackwell, , 2015 |
| Descrizione fisica | 1 online resource (364 p.) |
| Disciplina | 616.07/9 |
| Soggetto topico |
Autophagic vacuoles
Immune response |
| ISBN |
1-118-67773-0
1-118-67755-2 1-118-67771-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Autophagy and immunity / Xu Liu and Daniel J. Klionsky -- Techniques for studying autophagy / Isei Tanida and Masato Koike -- Role of autophagy in DNA virus infections in vivo / Xionan Dong and Beth Levine -- Studying RNA viruses and autophagy in vivo / Mehrdad Alirezaei and J. Lindsay Whitton -- Autophagy and picornavirus infection / Tom Wileman, Zhigang Zhou, Matthew Whelband, Eleanor Cottam, Stephen Berryman, Terry Jackson, and Rebecca Roberts -- Flaviviruses and autophagy / Tristan X. Jordan and Glenn Randall -- Autophagy : a home remodeler for Hepatitis C virus / Marine L.B. Hillaire, Elodie Decembre, and Marlene Dreux -- Modulating autophagy to cure Human Immunodeficiency Virus type-1 / Stephen A. Spector and Grant R. Campbell -- Autophagy in the infected cell : insights from pathogenic bacteria / Andrea Sirianni and Serge Mostowy -- Rab proteins in autophagy: streptococcus model / Ichiro Nakagawa -- Helicobacter pylori infection control by autophagy / Laura K. Greenfield, Frances Dang, and Nicola L. Jones -- Interactions between salmonella and the autophagy system / Teresa L.M. Thurston and David W. Holden -- Host factors that recruit autophagy as defense against toxoplasma gondii / Carlos S. Subauste -- Mycobacterium tuberculosis and the autophagic pathway / Gabriela María Recalde and María Isabel Colombo -- Autophagy enhances the efficacy of BCG vaccine / Arshad Khan, Christopher R. Singh, Emily Soudani, Pearl Bakhru, Sankaralingam Saikolappan, Jeffrey D. Cirillo, N. Tony Eissa, Subramanian Dhandayuthapani, and Chinnaswamy Jagannath -- Autophagy's contribution to innate and adaptive immunity : an overview / Christina Bell, Michel Desjardins, Pierre Thibault, and Kerstin Radtke -- Autophagy in immune responses to viruses / Christophe Viret and Mathias Faure -- Processing and MHC presentation of antigens after autophagy-assisted endocytosis, exocytosis and cytoplasm degradation / Christian Münz. |
| Record Nr. | UNINA-9910819421303321 |
| Hoboken, New Jersey : , : Wiley Blackwell, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Bacterial evasion of host immune responses / / edited by Brian Henderson, Petra C.F. Oyston [[electronic resource]]
| Bacterial evasion of host immune responses / / edited by Brian Henderson, Petra C.F. Oyston [[electronic resource]] |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2003 |
| Descrizione fisica | 1 online resource (xvi, 304 pages) : digital, PDF file(s) |
| Disciplina | 616.07/9 |
| Collana | Advances in molecular and cellular microbiology |
| Soggetto topico |
Virulence (Microbiology) - Molecular aspects
Immunity Bacteria |
| ISBN |
1-107-13042-5
1-280-16049-7 9786610160495 1-139-14708-0 0-511-11939-9 0-511-05705-9 0-511-54626-2 0-511-30741-1 0-511-07184-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part I. Recognition of bacteria: [Ch.] 1. The dendritic cell in bacterial infection : sentinel or Trojan horse? / Benjamin M. Chain and Janusz Marcinkiewicz -- [ch.] 2. CD1 and nonpeptide antigen recognition systems in microbial immunity / Kayvan R. Niazi, Steven A. Pocelli, and Robert L. Modlin -- [ch.] 3. The NRAMP family : co-evolution of a host/pathogen defence system -- Part II. Evasion of humoral immunity: [ch.] 4. Evasion of complement system pathwas by bacteria / Michael A. Kerr and Brian Henderson -- [ch.] 5. Bacterial immunoglobulin-evading mechanisms : lg-dregrading and lg-binding proteins / Mogen Kilian -- [ch.] 6. Evasion of antibody responses : bacterial phase variation / Nigel J. Saunders -- Part III. Evasion of cellular immunity: [ch.] 7. Type III protein secretion and resistance to phagocytosis / Ake Forsberg, Roland Rosqvist and Maria Fallman -- [ch.] 8. Bacterial superantigens and immune evasion / John Fraser, Thomas Proft, Vickery Arcus and Edward Baker -- [ch.] 9. Bacterial quorum sensing signalling molecules as immune modulators / David Pritchard, Doreen Hooi, Eleanor Watson, Sek Chow, Gary Telford, Barrie Bycroft, Siri Ram Chhabra, Christopher Harty, Miguel Camara, Stephen Diggle and Paul Williams -- [ch.] 10. Microbial modulation of cytokine networks / B. Henderson and Rob M. Seymour -- [ch.] 11. Enterotoxins : adjuvants and immune inhibitors / Jan-Michael Klapproth and Michael S. Donnenberg -- [ch.]. 12. Type III protein secretion and inhibition of NF-kB / Klaus Ruckdeschel, Bruno Rouot and Jü̈rgen Heesemann. |
| Record Nr. | UNINA-9910450509803321 |
| Cambridge : , : Cambridge University Press, , 2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Bacterial evasion of host immune responses / / edited by Brian Henderson, Petra C.F. Oyston [[electronic resource]]
| Bacterial evasion of host immune responses / / edited by Brian Henderson, Petra C.F. Oyston [[electronic resource]] |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2003 |
| Descrizione fisica | 1 online resource (xvi, 304 pages) : digital, PDF file(s) |
| Disciplina | 616.07/9 |
| Collana | Advances in molecular and cellular microbiology |
| Soggetto topico |
Virulence (Microbiology) - Molecular aspects
Immunity Bacteria |
| ISBN |
1-107-13042-5
1-280-16049-7 9786610160495 1-139-14708-0 0-511-11939-9 0-511-05705-9 0-511-54626-2 0-511-30741-1 0-511-07184-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part I. Recognition of bacteria: [Ch.] 1. The dendritic cell in bacterial infection : sentinel or Trojan horse? / Benjamin M. Chain and Janusz Marcinkiewicz -- [ch.] 2. CD1 and nonpeptide antigen recognition systems in microbial immunity / Kayvan R. Niazi, Steven A. Pocelli, and Robert L. Modlin -- [ch.] 3. The NRAMP family : co-evolution of a host/pathogen defence system -- Part II. Evasion of humoral immunity: [ch.] 4. Evasion of complement system pathwas by bacteria / Michael A. Kerr and Brian Henderson -- [ch.] 5. Bacterial immunoglobulin-evading mechanisms : lg-dregrading and lg-binding proteins / Mogen Kilian -- [ch.] 6. Evasion of antibody responses : bacterial phase variation / Nigel J. Saunders -- Part III. Evasion of cellular immunity: [ch.] 7. Type III protein secretion and resistance to phagocytosis / Ake Forsberg, Roland Rosqvist and Maria Fallman -- [ch.] 8. Bacterial superantigens and immune evasion / John Fraser, Thomas Proft, Vickery Arcus and Edward Baker -- [ch.] 9. Bacterial quorum sensing signalling molecules as immune modulators / David Pritchard, Doreen Hooi, Eleanor Watson, Sek Chow, Gary Telford, Barrie Bycroft, Siri Ram Chhabra, Christopher Harty, Miguel Camara, Stephen Diggle and Paul Williams -- [ch.] 10. Microbial modulation of cytokine networks / B. Henderson and Rob M. Seymour -- [ch.] 11. Enterotoxins : adjuvants and immune inhibitors / Jan-Michael Klapproth and Michael S. Donnenberg -- [ch.]. 12. Type III protein secretion and inhibition of NF-kB / Klaus Ruckdeschel, Bruno Rouot and Jü̈rgen Heesemann. |
| Record Nr. | UNINA-9910783115203321 |
| Cambridge : , : Cambridge University Press, , 2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Bacterial evasion of host immune responses / / edited by Brian Henderson, Petra C.F. Oyston [[electronic resource]]
| Bacterial evasion of host immune responses / / edited by Brian Henderson, Petra C.F. Oyston [[electronic resource]] |
| Pubbl/distr/stampa | Cambridge : , : Cambridge University Press, , 2003 |
| Descrizione fisica | 1 online resource (xvi, 304 pages) : digital, PDF file(s) |
| Disciplina | 616.07/9 |
| Collana | Advances in molecular and cellular microbiology |
| Soggetto topico |
Virulence (Microbiology) - Molecular aspects
Immunity Bacteria |
| ISBN |
1-107-13042-5
1-280-16049-7 9786610160495 1-139-14708-0 0-511-11939-9 0-511-05705-9 0-511-54626-2 0-511-30741-1 0-511-07184-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Part I. Recognition of bacteria: [Ch.] 1. The dendritic cell in bacterial infection : sentinel or Trojan horse? / Benjamin M. Chain and Janusz Marcinkiewicz -- [ch.] 2. CD1 and nonpeptide antigen recognition systems in microbial immunity / Kayvan R. Niazi, Steven A. Pocelli, and Robert L. Modlin -- [ch.] 3. The NRAMP family : co-evolution of a host/pathogen defence system -- Part II. Evasion of humoral immunity: [ch.] 4. Evasion of complement system pathwas by bacteria / Michael A. Kerr and Brian Henderson -- [ch.] 5. Bacterial immunoglobulin-evading mechanisms : lg-dregrading and lg-binding proteins / Mogen Kilian -- [ch.] 6. Evasion of antibody responses : bacterial phase variation / Nigel J. Saunders -- Part III. Evasion of cellular immunity: [ch.] 7. Type III protein secretion and resistance to phagocytosis / Ake Forsberg, Roland Rosqvist and Maria Fallman -- [ch.] 8. Bacterial superantigens and immune evasion / John Fraser, Thomas Proft, Vickery Arcus and Edward Baker -- [ch.] 9. Bacterial quorum sensing signalling molecules as immune modulators / David Pritchard, Doreen Hooi, Eleanor Watson, Sek Chow, Gary Telford, Barrie Bycroft, Siri Ram Chhabra, Christopher Harty, Miguel Camara, Stephen Diggle and Paul Williams -- [ch.] 10. Microbial modulation of cytokine networks / B. Henderson and Rob M. Seymour -- [ch.] 11. Enterotoxins : adjuvants and immune inhibitors / Jan-Michael Klapproth and Michael S. Donnenberg -- [ch.]. 12. Type III protein secretion and inhibition of NF-kB / Klaus Ruckdeschel, Bruno Rouot and Jü̈rgen Heesemann. |
| Record Nr. | UNINA-9910817260903321 |
| Cambridge : , : Cambridge University Press, , 2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Carbohydrate-based vaccines and immunotherapies [[electronic resource] /] / edited by Zhongwu Guo, Geert-Jan Boons
| Carbohydrate-based vaccines and immunotherapies [[electronic resource] /] / edited by Zhongwu Guo, Geert-Jan Boons |
| Pubbl/distr/stampa | Hoboken, N.J. ; ; Oxford, [UK], : Wiley, c2009 |
| Descrizione fisica | 1 online resource (436 p.) |
| Disciplina |
616.07/9
616.079 |
| Altri autori (Persone) |
GuoZhongwu
BoonsGeert-Jan |
| Collana | Wiley series in drug discovery and development |
| Soggetto topico |
Carbohydrates - Immunology
Vaccines Glycoconjugates - Immunology |
| ISBN |
1-282-36851-6
9786612368516 0-470-47328-2 0-470-47327-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CARBOHYDRATE-BASED VACCINES AND IMMUNOTHERAPIES; CONTENTS; Preface; Contributors; 1 Glycobiology and Immunology; 1.1 Introduction; 1.2 Glycobiology; 1.2.1 Glycosylation-Is It Worth the Cost?; 1.2.2 Glycan Biosynthesis-A Dauntingly Complex Process; 1.2.3 Glycoproteins; 1.2.4 Lipid-Based Glycans; 1.2.5 Polysaccharides: Glycosaminoglycans and Bacterial Capsular Components; 1.3 The Immune System; 1.3.1 Introductory Comments; 1.3.2 Overview of the Immune System; 1.3.3 Glycoimmunobiology; 1.3.4 Interplay between Glycosylation and Sugars: a Two-Way Street; 1.4 Carbohydrate Antigens
1.4.1 Carbohydrate Antigens in Humans1.4.2 Carbohydrates and Pathogens; 1.4.3 Carbohydrate-Based Vaccines; 1.4.4 Concluding Comments: Building on Success; Acknowledgment; References; 2 Preparation of Glycoconjugate Vaccines; 2.1 Introduction; 2.2 Capsular Polysaccharide-Protein Conjugates; 2.2.1 Haemophilus influenzae Type b; 2.2.2 Streptococcus pneumoniae; 2.2.3 Neisseria meningitidis; 2.2.4 Salmonella typhi Vi; 2.2.5 Group B Streptococcus; 2.2.6 Staphylococcus aureus Types 5 and 8; 2.3 Lipopolysaccharide (LPS) and Lipooligosaccharide (LOS) Conjugates; 2.3.1 Escherichia coli O157 2.3.2 Vibrio cholerae O1 and O1392.3.3 Shigella dysenteriae Type 1, sonnei and flexneri 2a; 2.3.4 Neisseria meningitidis and Nontypeable Haemophilus influenzae; 2.4 Total Synthetic Glycoconjugate Vaccines; References; 3 Adjuvants for Protein- and Carbohydrate-Based Vaccines; 3.1 Introduction; 3.2 Initiation and Stimulation of Adaptive Responses; 3.3 "Old" Adjuvants and Formulations; 3.3.1 Aluminum; 3.3.2 Emulsions; 3.3.3 Saponins, QS21, and ISCOMS; 3.3.4 Liposomes and Microparticles; 3.3.5 Antigen/Formulation Targeting; 3.3.6 Induction of CD8 CTLs with Soluble Antigens 3.4 Renaissance of Innate Immunity3.4.1 Toll-Like Receptors: Agonists and Roles; 3.4.2 Non-TLRs Innate Receptors; 3.4.3 Other Receptors Involved in Antigen Capture and Recognition; 3.5 From Basic Research to Practical Applications: Identification of New Adjuvants; 3.5.1 TLR Synthetic Agonists; 3.5.2 Combination of PRR Agonists; 3.6 Adjuvants for Carbohydrate-Based Vaccines; 3.6.1 Td and Ti B-Cell Responses; 3.6.2 Adjuvants for "Free" Polysaccharides (Ti Antigens); 3.6.3 Adjuvants for Glycoconjugate Vaccines (T-Dependent Antigens) 3.7 Combinations of Adjuvants: Preclinical and Clinical Developments3.8 Immunomodulation of Existing Responses: Adjuvants for Therapeutic Vaccines; 3.9 Take Another Route; 3.9.1 Adjuvants for Mucosal Immunization; 3.9.2 Epidermal or Intradermal Routes; 3.10 Practical Aspects of Adjuvant Development; 3.10.1 Regulatory Aspects; 3.10.2 Safety versus Efficacy: Risk-Benefit Ratio; 3.11 Preclinical Models Used in Adjuvant Development; 3.11.1 Animal Models; 3.11.2 In vitro Models; 3.12 Conclusions and Perspectives; Acknowledgment; References; 4 Carbohydrate-Based Antibacterial Vaccines 4.1 Introduction |
| Record Nr. | UNINA-9910139986703321 |
| Hoboken, N.J. ; ; Oxford, [UK], : Wiley, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Carbohydrate-based vaccines and immunotherapies [[electronic resource] /] / edited by Zhongwu Guo, Geert-Jan Boons
| Carbohydrate-based vaccines and immunotherapies [[electronic resource] /] / edited by Zhongwu Guo, Geert-Jan Boons |
| Pubbl/distr/stampa | Hoboken, N.J. ; ; Oxford, [UK], : Wiley, c2009 |
| Descrizione fisica | 1 online resource (436 p.) |
| Disciplina |
616.07/9
616.079 |
| Altri autori (Persone) |
GuoZhongwu
BoonsGeert-Jan |
| Collana | Wiley series in drug discovery and development |
| Soggetto topico |
Carbohydrates - Immunology
Vaccines Glycoconjugates - Immunology |
| ISBN |
1-282-36851-6
9786612368516 0-470-47328-2 0-470-47327-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CARBOHYDRATE-BASED VACCINES AND IMMUNOTHERAPIES; CONTENTS; Preface; Contributors; 1 Glycobiology and Immunology; 1.1 Introduction; 1.2 Glycobiology; 1.2.1 Glycosylation-Is It Worth the Cost?; 1.2.2 Glycan Biosynthesis-A Dauntingly Complex Process; 1.2.3 Glycoproteins; 1.2.4 Lipid-Based Glycans; 1.2.5 Polysaccharides: Glycosaminoglycans and Bacterial Capsular Components; 1.3 The Immune System; 1.3.1 Introductory Comments; 1.3.2 Overview of the Immune System; 1.3.3 Glycoimmunobiology; 1.3.4 Interplay between Glycosylation and Sugars: a Two-Way Street; 1.4 Carbohydrate Antigens
1.4.1 Carbohydrate Antigens in Humans1.4.2 Carbohydrates and Pathogens; 1.4.3 Carbohydrate-Based Vaccines; 1.4.4 Concluding Comments: Building on Success; Acknowledgment; References; 2 Preparation of Glycoconjugate Vaccines; 2.1 Introduction; 2.2 Capsular Polysaccharide-Protein Conjugates; 2.2.1 Haemophilus influenzae Type b; 2.2.2 Streptococcus pneumoniae; 2.2.3 Neisseria meningitidis; 2.2.4 Salmonella typhi Vi; 2.2.5 Group B Streptococcus; 2.2.6 Staphylococcus aureus Types 5 and 8; 2.3 Lipopolysaccharide (LPS) and Lipooligosaccharide (LOS) Conjugates; 2.3.1 Escherichia coli O157 2.3.2 Vibrio cholerae O1 and O1392.3.3 Shigella dysenteriae Type 1, sonnei and flexneri 2a; 2.3.4 Neisseria meningitidis and Nontypeable Haemophilus influenzae; 2.4 Total Synthetic Glycoconjugate Vaccines; References; 3 Adjuvants for Protein- and Carbohydrate-Based Vaccines; 3.1 Introduction; 3.2 Initiation and Stimulation of Adaptive Responses; 3.3 "Old" Adjuvants and Formulations; 3.3.1 Aluminum; 3.3.2 Emulsions; 3.3.3 Saponins, QS21, and ISCOMS; 3.3.4 Liposomes and Microparticles; 3.3.5 Antigen/Formulation Targeting; 3.3.6 Induction of CD8 CTLs with Soluble Antigens 3.4 Renaissance of Innate Immunity3.4.1 Toll-Like Receptors: Agonists and Roles; 3.4.2 Non-TLRs Innate Receptors; 3.4.3 Other Receptors Involved in Antigen Capture and Recognition; 3.5 From Basic Research to Practical Applications: Identification of New Adjuvants; 3.5.1 TLR Synthetic Agonists; 3.5.2 Combination of PRR Agonists; 3.6 Adjuvants for Carbohydrate-Based Vaccines; 3.6.1 Td and Ti B-Cell Responses; 3.6.2 Adjuvants for "Free" Polysaccharides (Ti Antigens); 3.6.3 Adjuvants for Glycoconjugate Vaccines (T-Dependent Antigens) 3.7 Combinations of Adjuvants: Preclinical and Clinical Developments3.8 Immunomodulation of Existing Responses: Adjuvants for Therapeutic Vaccines; 3.9 Take Another Route; 3.9.1 Adjuvants for Mucosal Immunization; 3.9.2 Epidermal or Intradermal Routes; 3.10 Practical Aspects of Adjuvant Development; 3.10.1 Regulatory Aspects; 3.10.2 Safety versus Efficacy: Risk-Benefit Ratio; 3.11 Preclinical Models Used in Adjuvant Development; 3.11.1 Animal Models; 3.11.2 In vitro Models; 3.12 Conclusions and Perspectives; Acknowledgment; References; 4 Carbohydrate-Based Antibacterial Vaccines 4.1 Introduction |
| Record Nr. | UNINA-9910825792303321 |
| Hoboken, N.J. ; ; Oxford, [UK], : Wiley, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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