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Annual review of clinical biochemistry
| Annual review of clinical biochemistry |
| Pubbl/distr/stampa | New York - Toronto, : Wiley |
| Disciplina | 616.07/56 |
| ISSN | 0195-8488 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Note periodicità | Annuale |
| Record Nr. | UNINA-990008902220403321 |
| New York - Toronto, : Wiley | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Antigen retrieval immunohistochemistry based research and diagnostics [[electronic resource] /] / edited by Shan-Rong Shi, Clive R. Taylor
| Antigen retrieval immunohistochemistry based research and diagnostics [[electronic resource] /] / edited by Shan-Rong Shi, Clive R. Taylor |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley, 2010 |
| Descrizione fisica | 1 online resource (470 p.) |
| Disciplina | 616.07/56 |
| Altri autori (Persone) |
ShiShan-Rong <1936->
TaylorC. R (Clive Roy) |
| Collana | Wiley series in biomedical engineering and multi-disciplinary integrated systems. |
| Soggetto topico |
Immunohistochemistry
Antigens |
| ISBN |
1-118-06030-X
1-282-75617-6 9786612756177 0-470-87561-5 0-470-87560-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ANTIGEN RETRIEVAL IMMUNOHISTOCHEMISTRY BASED RESEARCH AND DIAGNOSTICS; CONTENTS; PREFACE; CONTRIBUTORS; PART I: RECENT ADVANCES IN ANTIGEN RETRIEVAL TECHNIQUES AND ITS APPLICATION; CHAPTER 1: STANDARDIZATION OF ANTIGEN RETRIEVAL TECHNIQUES BASED ON THE TEST BATTERY APPROACH; CHAPTER 2: EXTENDED APPLICATION OF ANTIGEN RETRIEVAL TECHNIQUE IN IMMUNOHISTOCHEMISTRY AND IN SITU HYBRIDIZATION; CHAPTER 3: EXTRACTION OF DNA/RNA FROM FORMALIN-FIXED, PARAFFIN-EMBEDDED TISSUE BASED ON THE ANTIGEN RETRIEVAL PRINCIPLE; PART II: STANDARDIZATION OF IMMUNOHISTOCHEMISTRY
CHAPTER 4: KEY ISSUES AND STRATEGIES OF STANDARDIZATION FOR QUANTIFIABLE IMMUNOHISTOCHEMISTRYCHAPTER 5: STANDARDIZATION OF IMMUNOHISTOCHEMISTRY BASED ON ANTIGEN RETRIEVAL TECHNIQUE; CHAPTER 6: STANDARD REFERENCE MATERIAL: CELL LINE DEVELOPMENT AND USE OF REFERENCE CELL LINES AS STANDARDS FOR EXTERNAL QUALITY ASSURANCE OF HER2 IHC AND ISH TESTING; CHAPTER 7: PEPTIDES AS IMMUNOHISTOCHEMISTRY CONTROLS; CHAPTER 8: STANDARD REFERENCE MATERIAL: PROTEIN-EMBEDDING TECHNIQUE AND DESIGN OF BAR CODE CHAPTER 9: THE PROS AND CONS OF AUTOMATION FOR IMMUNOHISTOCHEMISTRY FROM THE PROSPECTIVE OF THE PATHOLOGY LABORATORYCHAPTER 10: IMAGE ANALYSIS IN IMMUNOHISTOCHEMISTRY; PART III: TISSUE/CELL SAMPLE PREPARATION; CHAPTER 11: TISSUE CELL SAMPLE PREPARATION: LESSONS FROM THE ANTIGEN RETRIEVAL TECHNIQUE; CHAPTER 12: MECHANISMS OF ACTION AND PROPER USE OF COMMON FIXATIVES; CHAPTER 13: CELL SAMPLE PREPARATION FOR CLINICAL CYTOPATHOLOGY: CURRENT STATUS AND FUTURE DEVELOPMENT; CHAPTER 14: DESIGN OF A TISSUE SURROGATE TO EXAMINE ACCURACY OF PROTEOMIC ANALYSIS PART IV: MOLECULAR MECHANISM OF ANTIGEN RETRIEVAL TECHNIQUECHAPTER 15: STUDY OF FORMALIN FIXATION AND HEAT-INDUCED ANTIGEN RETRIEVAL; CHAPTER 16: A LINEAR EPITOPES MODEL OF ANTIGEN RETRIEVAL; CHAPTER 17: pH OR IONIC STRENGTH OF ANTIGEN RETRIEVAL SOLUTION: A POTENTIAL ROLE FOR REFOLDING DURING HEAT TREATMENT; CHAPTER 18: COMMENTARY: FUTURE DIRECTIONS; PART V: PROTEOMIC ANALYSIS OF PROTEIN EXTRACTED FROM TISSUE/CELLS; CHAPTER 19: TECHNIQUES OF PROTEIN EXTRACTION FROM FFPE TISSUE/ CELLS FOR MASS SPECTROMETRY CHAPTER 20: APPLICATION OF SHOTGUN PROTEOMICS TO FORMALIN-FIXED AND PARAFFIN-EMBEDDED TISSUESCHAPTER 21: VISUALIZING PROTEIN MAPS IN TISSUE; CHAPTER 22: SYMBIOSIS OF IMMUNOHISTOCHEMISTRY AND PROTEOMICS: MARCHING TO A NEW ERA; APPENDIX: RELATED LABORATORY PROTOCOLS; INDEX; Color plates |
| Record Nr. | UNINA-9910140778003321 |
| Hoboken, NJ, : Wiley, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Antigen retrieval immunohistochemistry based research and diagnostics / / edited by Shan-Rong Shi, Clive R. Taylor
| Antigen retrieval immunohistochemistry based research and diagnostics / / edited by Shan-Rong Shi, Clive R. Taylor |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley, 2010 |
| Descrizione fisica | 1 online resource (470 p.) |
| Disciplina | 616.07/56 |
| Altri autori (Persone) |
ShiShan-Rong <1936->
TaylorC. R (Clive Roy) |
| Collana | Wiley series in biomedical engineering and multi-disciplinary integrated systems. |
| Soggetto topico |
Immunohistochemistry
Antigens |
| ISBN |
9786612756177
9781118060308 111806030X 9781282756175 1282756176 9780470875612 0470875615 9780470875605 0470875607 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ANTIGEN RETRIEVAL IMMUNOHISTOCHEMISTRY BASED RESEARCH AND DIAGNOSTICS; CONTENTS; PREFACE; CONTRIBUTORS; PART I: RECENT ADVANCES IN ANTIGEN RETRIEVAL TECHNIQUES AND ITS APPLICATION; CHAPTER 1: STANDARDIZATION OF ANTIGEN RETRIEVAL TECHNIQUES BASED ON THE TEST BATTERY APPROACH; CHAPTER 2: EXTENDED APPLICATION OF ANTIGEN RETRIEVAL TECHNIQUE IN IMMUNOHISTOCHEMISTRY AND IN SITU HYBRIDIZATION; CHAPTER 3: EXTRACTION OF DNA/RNA FROM FORMALIN-FIXED, PARAFFIN-EMBEDDED TISSUE BASED ON THE ANTIGEN RETRIEVAL PRINCIPLE; PART II: STANDARDIZATION OF IMMUNOHISTOCHEMISTRY
CHAPTER 4: KEY ISSUES AND STRATEGIES OF STANDARDIZATION FOR QUANTIFIABLE IMMUNOHISTOCHEMISTRYCHAPTER 5: STANDARDIZATION OF IMMUNOHISTOCHEMISTRY BASED ON ANTIGEN RETRIEVAL TECHNIQUE; CHAPTER 6: STANDARD REFERENCE MATERIAL: CELL LINE DEVELOPMENT AND USE OF REFERENCE CELL LINES AS STANDARDS FOR EXTERNAL QUALITY ASSURANCE OF HER2 IHC AND ISH TESTING; CHAPTER 7: PEPTIDES AS IMMUNOHISTOCHEMISTRY CONTROLS; CHAPTER 8: STANDARD REFERENCE MATERIAL: PROTEIN-EMBEDDING TECHNIQUE AND DESIGN OF BAR CODE CHAPTER 9: THE PROS AND CONS OF AUTOMATION FOR IMMUNOHISTOCHEMISTRY FROM THE PROSPECTIVE OF THE PATHOLOGY LABORATORYCHAPTER 10: IMAGE ANALYSIS IN IMMUNOHISTOCHEMISTRY; PART III: TISSUE/CELL SAMPLE PREPARATION; CHAPTER 11: TISSUE CELL SAMPLE PREPARATION: LESSONS FROM THE ANTIGEN RETRIEVAL TECHNIQUE; CHAPTER 12: MECHANISMS OF ACTION AND PROPER USE OF COMMON FIXATIVES; CHAPTER 13: CELL SAMPLE PREPARATION FOR CLINICAL CYTOPATHOLOGY: CURRENT STATUS AND FUTURE DEVELOPMENT; CHAPTER 14: DESIGN OF A TISSUE SURROGATE TO EXAMINE ACCURACY OF PROTEOMIC ANALYSIS PART IV: MOLECULAR MECHANISM OF ANTIGEN RETRIEVAL TECHNIQUECHAPTER 15: STUDY OF FORMALIN FIXATION AND HEAT-INDUCED ANTIGEN RETRIEVAL; CHAPTER 16: A LINEAR EPITOPES MODEL OF ANTIGEN RETRIEVAL; CHAPTER 17: pH OR IONIC STRENGTH OF ANTIGEN RETRIEVAL SOLUTION: A POTENTIAL ROLE FOR REFOLDING DURING HEAT TREATMENT; CHAPTER 18: COMMENTARY: FUTURE DIRECTIONS; PART V: PROTEOMIC ANALYSIS OF PROTEIN EXTRACTED FROM TISSUE/CELLS; CHAPTER 19: TECHNIQUES OF PROTEIN EXTRACTION FROM FFPE TISSUE/ CELLS FOR MASS SPECTROMETRY CHAPTER 20: APPLICATION OF SHOTGUN PROTEOMICS TO FORMALIN-FIXED AND PARAFFIN-EMBEDDED TISSUESCHAPTER 21: VISUALIZING PROTEIN MAPS IN TISSUE; CHAPTER 22: SYMBIOSIS OF IMMUNOHISTOCHEMISTRY AND PROTEOMICS: MARCHING TO A NEW ERA; APPENDIX: RELATED LABORATORY PROTOCOLS; INDEX; Color plates |
| Record Nr. | UNINA-9910823359103321 |
| Hoboken, NJ, : Wiley, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chromatographic methods in clinical chemistry and toxicology / / [edited by] Roger L. Bertholf, Ruth E. Winecker
| Chromatographic methods in clinical chemistry and toxicology / / [edited by] Roger L. Bertholf, Ruth E. Winecker |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2007 |
| Descrizione fisica | 1 online resource (310 p.) |
| Disciplina | 616.07/56 |
| Altri autori (Persone) |
BertholfRoger L
WineckerRuth E |
| Soggetto topico |
Chromatographic analysis
Clinical chemistry Toxicological chemistry |
| ISBN |
9786610739509
9781280739507 1280739509 9780470023129 0470023120 9780470023105 0470023104 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Quality assurance, quality control, and method validation in chromatographic applications / Michele Merves, Bruce A. Goldberger -- Liquid chromatographic-mass spectrometric measurement of anabolic steroids / Don H. Catlin ... [et al.] -- High performance liquid chromatography in analysis of active ingredients in herbal nutritional supplements / Amitava Dasgupta -- Measurement of plasma L-DOPA and L-tyrosine by High-performance liquid chromatography as a tumor marker in malignant melanoma / Thierry Le Bricon ... [et al.] -- Hypersensitive measurement of proteins by capillary isoelectric focusing and Liquid chromatography-mass spectrometry / Feng Zhou, Murray Johnston -- Chromatographic measurement of transferrin glycoforms for detecting alcohol abuse and congenital disorders of glycosylation / Anders Helander -- Chromatographic measurements of catecholamines and metanephrines / Eric C.Y. Chan, Paul C.L. Ho -- Chromatographic measurement of volatile organic compounds (VOCs) / Larry A. Broussard -- Chromatographic techniques for measuring organophosphorous pesticides / H. Wollersen, F. Musshoff -- Chromatographic analysis of nerve agents / Jeri D. Ropero-Miller -- History and pharmacology of [gamma]-hydroxybutyric acid / Laureen Marinetti -- Liquid chromatography with inductively coupled plasma mass spectrometric detection for element speciation : clinical and toxicological applications / Katarzyna Wrobel, Kazimierz Wrobel, Joseph A. Caruso -- Applications of gas chromatography-mass spectrometry for determination of toxic metals / Suresh K. Aggarwal, Robert L. Fitzgerald, David A. Herold. |
| Record Nr. | UNINA-9911019618803321 |
| Chichester, England ; ; Hoboken, NJ, : John Wiley & Sons, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical Biochemistry
| Clinical Biochemistry |
| Autore | Walker Simon W |
| Edizione | [9th ed.] |
| Pubbl/distr/stampa | New York : , : John Wiley & Sons, Incorporated, , 2013 |
| Descrizione fisica | 1 online resource (304 pages) |
| Disciplina | 616.07/56 |
| Altri autori (Persone) |
BeckettGeoffrey J
RaePeter AshbyPeter |
| Collana | Lecture Notes Ser. |
| Soggetto topico | Biochemical Phenomena |
| Soggetto genere / forma | Electronic books. |
| ISBN |
9781118272114
9781118272138 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Clinical Biochemistry: Lecture Notes -- Contents -- Preface -- List of abbreviations -- How to use your textbook -- About the companion website -- 1 Requesting and interpreting tests -- Introduction -- Collection of specimens -- The use of clinical biochemistry tests -- Point of care testing (POCT) (Table 1.5) -- Interpretation of clinical biochemistry tests -- Sources of variation intest results -- Analytical sources of variation -- Blunders -- Biological causes of variation -- How do results vary in health? -- How do results vary in disease? -- The assessment of diagnostic tests -- Audit in clinical biochemistry -- The audit process -- FURTHER READING -- Appendix 1.1: Screening for rare diseases -- 2 Disturbances of water, sodium and potassium balance -- Introduction -- Water and sodium balance -- Internal distribution of water and sodium -- Osmolality and tonicity -- Colloid osmotic pressure (oncotic pressure -- Regulation of external water balance -- Regulation of external sodium balance -- Disorders of water and sodium homeostasis -- Hyponatraemia -- Hypernatraemia -- Other chemical investigations influid balance disorders -- Blood specimens -- Urine specimens -- Potassium balance -- Abnormalities of plasma potassium concentration -- Hypokalaemia -- Hyperkalaemia -- Other investigations in disordered K+ metabolism -- Fluid and electrolyte balance in surgical patients -- Intravenous fluid administration -- FURTHER READING -- 3 Acid-base balance and oxygen transport -- Introduction -- Transport of carbondioxide -- Renal mechanisms for HCO3 reabsorption and H+ excretion -- Buffering of hydrogen ions -- Investigating acid-base balance -- Collection and transport of specimens -- Temperature effects -- Disturbances of acid-base status -- Respiratory acidosis -- Respiratory alkalosis -- Metabolic acidosis -- Metabolic alkalosis.
Interpretation of results of acid-base assessment -- Plasma [H+] is increased -- Plasma [H+] is decreased -- Plasma [H+] is normal -- Mixed acid-base disturbances -- Other investigations in acid-base assessment -- Total CO2 (reference range 24-30 mmol/L) -- Anion gap (reference range 10-20 mmol/L) -- Plasma chloride (reference range 95-107 mmol/L) -- Treatment of acid-base disturbances -- Oxygen transport -- Indications for full blood acid-base and oxygen measurements -- Respiratory insufficiency -- Type I: low PO2 with normal or low PCO2 -- Type II: low PO2 with high PCO2 -- Oxygen therapy -- FURTHER READING -- 4 Renal disease -- Introduction -- Impaired renal function -- Tests of glomerular function -- Measurement of creatinine clearance -- Estimation of creatinine clearance -- Plasma creatinine -- Creatinine clearance or plasma [creatinine]? -- Low plasma [creatinine] -- High plasma [creatinine] -- Plasma urea -- Tests of tubular function -- Urine osmolality and renal concentration tests -- Fluid deprivation test -- DDAVP test -- Urinary acidification tests -- Renal tubular acidosis -- Glycosuria -- The amino acidurias -- Fanconi syndrome -- Renal handling of sodium and potassium -- Sodium excretion -- Potassium excretion -- Acute kidney injury -- Chronic kidney disease -- Proteinuria -- Overflow proteinuria -- Glomerular proteinuria -- Nephrotic syndrome -- Glomerulonephritis -- Orthostatic proteinuria -- Tubular proteinuria -- Renal stones -- Hypercalciuria -- Oxalate, cystine and xanthine excretion -- Chemical investigations on patients with renal stones -- FURTHER READING -- 5 Disorders of calcium, phosphate and magnesium metabolism -- Calcium homeostasis -- Calcium balance -- Biological function of calcium -- Control of calcium metabolism -- Investigation of abnormal calcium metabolism -- Hypercalcaemia -- Primary hyperparathyroidism. Hypercalcaemia of malignancy -- Other causes of hypercalcaemia -- Hypocalcaemia -- Vitamin D deficiency -- Hypoparathyroidism -- Metabolic bone disease -- Markers of bone turnover -- Rickets and osteomalacia -- Osteoporosis -- Paget's disease -- Renal osteodystrophy -- Phosphate metabolism -- Hypo- and hyperphosphataemia -- Magnesium metabolism -- Hypomagnesaemia and magnesium deficiency -- Hypermagnesaemia -- 6 Diabetes mellitus and hypoglycaemia -- Glucose homeostasis -- Insulin secretion -- Diabetes mellitus -- Diagnosis -- Blood and plasma glucose -- Oral glucose tolerance test (OGTT) -- Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) -- Monitoring the treatment of diabetic patients -- Home blood glucose monitoring -- Glycated haemoglobin -- Glycated plasma proteins -- Microalbumin -- Metabolic complications of diabetes mellitus -- Diabetic ketoacidosis (DKA) -- Laboratory assessment and management of diabetic ketoacidosis -- Nonketotic, hyperglycaemic coma -- Hypoglycaemia -- Fasting hypoglycaemia -- Reactive or postprandial hypoglycaemia -- Insulinoma -- Other causes of fasting hypoglycaemia -- FURTHER READING -- 7 Disorders of the hypothalamus and pituitary -- Introduction -- The hypothalamus -- Anterior pituitary hormones -- Corticotrophin-releasing hormone and adrenocorticotrophic hormone -- Gonadotrophin-releasing hormone and the gonadotrophins luteinising hormone and follicle-stimulating hormone -- Thyrotrophin-releasing hormone and thyroid-stimulating hormone -- Growth hormone-releasing hormone and growth hormone -- Acromegaly and gigantism -- Prolactin -- Hyperprolactinaemia and its investigation -- Hyperprolactinaemia in psychiatric patients -- Endocrine changes in anorexia nervosa -- Anterior pituitary disease and its investigation -- Causes -- Investigation -- Treatment. Dynamic function tests - insulin stress test -- Monitoring treatment in hypopituitarism -- Monitoring hormone replacement therapy -- Posterior pituitary hormones -- Vasopressin -- 8 Abnormalities of thyroid function -- Introduction -- Thyroid hormone synthesis, action and metabolism -- Synthesis and metabolism -- Plasma transport and cellular action -- Regulation of thyroid function -- Investigations to determine thyroid status -- Selective use of thyroid function tests -- Interpreting results of thyroid function tests -- Hyperthyroidism -- Hypothyroidism -- T4 replacement therapy -- T4 replacement in subclinical hypothyroidism -- T4 therapy in central hypothyroidism (hypopituitarism) -- Situations in which thyroid function test results may be misleading -- Thyroid hormone resistance (THR) -- Causes of abnormal results for thyroid hormone measurements in euthyroid subjects -- Miscellaneous chemical tests and thyroid disease -- TRH test -- Anti-thyroid peroxidase antibodies (TPOAbs) -- Thyrotrophin receptor antibodies (TRAbs) -- Tests affected by thyroid dysfunction -- 9 Disorders of the adrenal cortex and medulla -- Introduction -- Regulation of adrenal steroid hormone synthesis and secretion -- Glucocorticoid secretion -- Aldosterone secretion -- Androgen secretion -- Investigation of suspected adrenocortical hyperfunction -- Cushing's syndrome -- Tests used to establish if a clinical diagnosis of Cushing's syndrome is likely -- Treatment -- Investigation of suspected adrenocortical hypofunction -- Diagnosis of primary adrenal hypofunction (Addison's disease) -- Diagnosis of secondary adrenocortical insufficiency -- Other pituitary function tests -- Biochemical tests in the investigation of hypertension -- Secondary hypertension -- Primary hyperaldosteronism (low-renin hyperaldosteronism) -- Investigation of suspected primary hyperaldosteronism. Secondary hyperaldosteronism (high-renin hyperaldosteronism) -- Mineralocorticoid deficiency -- Inherited adrenocortical enzyme defects -- Phaeochromocytoma -- Diagnosis -- Urine fractionated metadrenalines -- 10 Investigation of gonadal function infertility, menstrual irregularities and hirsutism -- Introduction -- Male gonadal function -- Spermatogenesis and its control -- Transport, metabolism and actions of testosterone -- Investigation of infertility and male hypogonadism -- Hypergonadotrophic and hypogonadotrophic hypogonadism -- Female gonadal function -- Menstrual disorders and infertility -- Ovarian dysfunction and its investigation -- Oligomenorrhoea and amenorrhoea -- Infertility -- Hirsutism and virilism -- Polycystic ovarian syndrome (PCOS) -- Ovarian failure -- Hormone replacement therapy -- Steroid contraceptives -- 11 Pregnancy and antenatal screening -- Introduction -- The foetoplacental unit -- Human chorionic gonadotrophin -- Steroids in pregnancy -- Effect of pregnancy on biochemical tests -- Reproductive hormones -- Cortisol -- Thyroid function tests -- Plasma volume and renal function -- Serum lipids and proteins -- Liver function tests -- Iron and ferritin -- Complications in pregnancy -- Ectopic pregnancy -- Diabetes mellitus -- Thyroid disorders -- Pre-eclampsia -- Obstetric cholestasis -- Pre-natal diagnosis of foetal abnormalities -- Screening for trisomy 21 -- Neural tube defects -- 12 Cardiovascular disorders -- The diagnosis of myocardial infarction -- Biochemical tests in myocardial infarction and ischaemia -- Time-course of changes -- Optimal times for blood sampling -- Creatine kinase -- The diagnosis of heart failure -- The diagnosis of thromboembolic disease -- Cardiovascular risk factors -- Lipids -- Enzymes involved in lipid transport -- Metabolism of plasma lipoproteins -- Chylomicron metabolism. VLDL and IDL metabolism. |
| Record Nr. | UNINA-9910795809503321 |
Walker Simon W
|
||
| New York : , : John Wiley & Sons, Incorporated, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical Biochemistry
| Clinical Biochemistry |
| Autore | Walker Simon W |
| Edizione | [9th ed.] |
| Pubbl/distr/stampa | New York : , : John Wiley & Sons, Incorporated, , 2013 |
| Descrizione fisica | 1 online resource (304 pages) |
| Disciplina | 616.07/56 |
| Altri autori (Persone) |
BeckettGeoffrey J
RaePeter AshbyPeter |
| Collana | Lecture Notes Ser. |
| Soggetto topico | Biochemical Phenomena |
| ISBN |
9781118272114
9781118272138 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Intro -- Clinical Biochemistry: Lecture Notes -- Contents -- Preface -- List of abbreviations -- How to use your textbook -- About the companion website -- 1 Requesting and interpreting tests -- Introduction -- Collection of specimens -- The use of clinical biochemistry tests -- Point of care testing (POCT) (Table 1.5) -- Interpretation of clinical biochemistry tests -- Sources of variation intest results -- Analytical sources of variation -- Blunders -- Biological causes of variation -- How do results vary in health? -- How do results vary in disease? -- The assessment of diagnostic tests -- Audit in clinical biochemistry -- The audit process -- FURTHER READING -- Appendix 1.1: Screening for rare diseases -- 2 Disturbances of water, sodium and potassium balance -- Introduction -- Water and sodium balance -- Internal distribution of water and sodium -- Osmolality and tonicity -- Colloid osmotic pressure (oncotic pressure -- Regulation of external water balance -- Regulation of external sodium balance -- Disorders of water and sodium homeostasis -- Hyponatraemia -- Hypernatraemia -- Other chemical investigations influid balance disorders -- Blood specimens -- Urine specimens -- Potassium balance -- Abnormalities of plasma potassium concentration -- Hypokalaemia -- Hyperkalaemia -- Other investigations in disordered K+ metabolism -- Fluid and electrolyte balance in surgical patients -- Intravenous fluid administration -- FURTHER READING -- 3 Acid-base balance and oxygen transport -- Introduction -- Transport of carbondioxide -- Renal mechanisms for HCO3 reabsorption and H+ excretion -- Buffering of hydrogen ions -- Investigating acid-base balance -- Collection and transport of specimens -- Temperature effects -- Disturbances of acid-base status -- Respiratory acidosis -- Respiratory alkalosis -- Metabolic acidosis -- Metabolic alkalosis.
Interpretation of results of acid-base assessment -- Plasma [H+] is increased -- Plasma [H+] is decreased -- Plasma [H+] is normal -- Mixed acid-base disturbances -- Other investigations in acid-base assessment -- Total CO2 (reference range 24-30 mmol/L) -- Anion gap (reference range 10-20 mmol/L) -- Plasma chloride (reference range 95-107 mmol/L) -- Treatment of acid-base disturbances -- Oxygen transport -- Indications for full blood acid-base and oxygen measurements -- Respiratory insufficiency -- Type I: low PO2 with normal or low PCO2 -- Type II: low PO2 with high PCO2 -- Oxygen therapy -- FURTHER READING -- 4 Renal disease -- Introduction -- Impaired renal function -- Tests of glomerular function -- Measurement of creatinine clearance -- Estimation of creatinine clearance -- Plasma creatinine -- Creatinine clearance or plasma [creatinine]? -- Low plasma [creatinine] -- High plasma [creatinine] -- Plasma urea -- Tests of tubular function -- Urine osmolality and renal concentration tests -- Fluid deprivation test -- DDAVP test -- Urinary acidification tests -- Renal tubular acidosis -- Glycosuria -- The amino acidurias -- Fanconi syndrome -- Renal handling of sodium and potassium -- Sodium excretion -- Potassium excretion -- Acute kidney injury -- Chronic kidney disease -- Proteinuria -- Overflow proteinuria -- Glomerular proteinuria -- Nephrotic syndrome -- Glomerulonephritis -- Orthostatic proteinuria -- Tubular proteinuria -- Renal stones -- Hypercalciuria -- Oxalate, cystine and xanthine excretion -- Chemical investigations on patients with renal stones -- FURTHER READING -- 5 Disorders of calcium, phosphate and magnesium metabolism -- Calcium homeostasis -- Calcium balance -- Biological function of calcium -- Control of calcium metabolism -- Investigation of abnormal calcium metabolism -- Hypercalcaemia -- Primary hyperparathyroidism. Hypercalcaemia of malignancy -- Other causes of hypercalcaemia -- Hypocalcaemia -- Vitamin D deficiency -- Hypoparathyroidism -- Metabolic bone disease -- Markers of bone turnover -- Rickets and osteomalacia -- Osteoporosis -- Paget's disease -- Renal osteodystrophy -- Phosphate metabolism -- Hypo- and hyperphosphataemia -- Magnesium metabolism -- Hypomagnesaemia and magnesium deficiency -- Hypermagnesaemia -- 6 Diabetes mellitus and hypoglycaemia -- Glucose homeostasis -- Insulin secretion -- Diabetes mellitus -- Diagnosis -- Blood and plasma glucose -- Oral glucose tolerance test (OGTT) -- Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) -- Monitoring the treatment of diabetic patients -- Home blood glucose monitoring -- Glycated haemoglobin -- Glycated plasma proteins -- Microalbumin -- Metabolic complications of diabetes mellitus -- Diabetic ketoacidosis (DKA) -- Laboratory assessment and management of diabetic ketoacidosis -- Nonketotic, hyperglycaemic coma -- Hypoglycaemia -- Fasting hypoglycaemia -- Reactive or postprandial hypoglycaemia -- Insulinoma -- Other causes of fasting hypoglycaemia -- FURTHER READING -- 7 Disorders of the hypothalamus and pituitary -- Introduction -- The hypothalamus -- Anterior pituitary hormones -- Corticotrophin-releasing hormone and adrenocorticotrophic hormone -- Gonadotrophin-releasing hormone and the gonadotrophins luteinising hormone and follicle-stimulating hormone -- Thyrotrophin-releasing hormone and thyroid-stimulating hormone -- Growth hormone-releasing hormone and growth hormone -- Acromegaly and gigantism -- Prolactin -- Hyperprolactinaemia and its investigation -- Hyperprolactinaemia in psychiatric patients -- Endocrine changes in anorexia nervosa -- Anterior pituitary disease and its investigation -- Causes -- Investigation -- Treatment. Dynamic function tests - insulin stress test -- Monitoring treatment in hypopituitarism -- Monitoring hormone replacement therapy -- Posterior pituitary hormones -- Vasopressin -- 8 Abnormalities of thyroid function -- Introduction -- Thyroid hormone synthesis, action and metabolism -- Synthesis and metabolism -- Plasma transport and cellular action -- Regulation of thyroid function -- Investigations to determine thyroid status -- Selective use of thyroid function tests -- Interpreting results of thyroid function tests -- Hyperthyroidism -- Hypothyroidism -- T4 replacement therapy -- T4 replacement in subclinical hypothyroidism -- T4 therapy in central hypothyroidism (hypopituitarism) -- Situations in which thyroid function test results may be misleading -- Thyroid hormone resistance (THR) -- Causes of abnormal results for thyroid hormone measurements in euthyroid subjects -- Miscellaneous chemical tests and thyroid disease -- TRH test -- Anti-thyroid peroxidase antibodies (TPOAbs) -- Thyrotrophin receptor antibodies (TRAbs) -- Tests affected by thyroid dysfunction -- 9 Disorders of the adrenal cortex and medulla -- Introduction -- Regulation of adrenal steroid hormone synthesis and secretion -- Glucocorticoid secretion -- Aldosterone secretion -- Androgen secretion -- Investigation of suspected adrenocortical hyperfunction -- Cushing's syndrome -- Tests used to establish if a clinical diagnosis of Cushing's syndrome is likely -- Treatment -- Investigation of suspected adrenocortical hypofunction -- Diagnosis of primary adrenal hypofunction (Addison's disease) -- Diagnosis of secondary adrenocortical insufficiency -- Other pituitary function tests -- Biochemical tests in the investigation of hypertension -- Secondary hypertension -- Primary hyperaldosteronism (low-renin hyperaldosteronism) -- Investigation of suspected primary hyperaldosteronism. Secondary hyperaldosteronism (high-renin hyperaldosteronism) -- Mineralocorticoid deficiency -- Inherited adrenocortical enzyme defects -- Phaeochromocytoma -- Diagnosis -- Urine fractionated metadrenalines -- 10 Investigation of gonadal function infertility, menstrual irregularities and hirsutism -- Introduction -- Male gonadal function -- Spermatogenesis and its control -- Transport, metabolism and actions of testosterone -- Investigation of infertility and male hypogonadism -- Hypergonadotrophic and hypogonadotrophic hypogonadism -- Female gonadal function -- Menstrual disorders and infertility -- Ovarian dysfunction and its investigation -- Oligomenorrhoea and amenorrhoea -- Infertility -- Hirsutism and virilism -- Polycystic ovarian syndrome (PCOS) -- Ovarian failure -- Hormone replacement therapy -- Steroid contraceptives -- 11 Pregnancy and antenatal screening -- Introduction -- The foetoplacental unit -- Human chorionic gonadotrophin -- Steroids in pregnancy -- Effect of pregnancy on biochemical tests -- Reproductive hormones -- Cortisol -- Thyroid function tests -- Plasma volume and renal function -- Serum lipids and proteins -- Liver function tests -- Iron and ferritin -- Complications in pregnancy -- Ectopic pregnancy -- Diabetes mellitus -- Thyroid disorders -- Pre-eclampsia -- Obstetric cholestasis -- Pre-natal diagnosis of foetal abnormalities -- Screening for trisomy 21 -- Neural tube defects -- 12 Cardiovascular disorders -- The diagnosis of myocardial infarction -- Biochemical tests in myocardial infarction and ischaemia -- Time-course of changes -- Optimal times for blood sampling -- Creatine kinase -- The diagnosis of heart failure -- The diagnosis of thromboembolic disease -- Cardiovascular risk factors -- Lipids -- Enzymes involved in lipid transport -- Metabolism of plasma lipoproteins -- Chylomicron metabolism. VLDL and IDL metabolism. |
| Record Nr. | UNINA-9910954386003321 |
|
Walker Simon W
|
||
| New York : , : John Wiley & Sons, Incorporated, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical chemistry : quality in laboratory diagnosis / / James H. Nichols, Carol A. Rauch
| Clinical chemistry : quality in laboratory diagnosis / / James H. Nichols, Carol A. Rauch |
| Autore | Nichols James H. <1961-> |
| Pubbl/distr/stampa | New York : , : Demos Medical Publishing, LLC, , [2014] |
| Descrizione fisica | 1 online resource (173 p.) |
| Disciplina | 616.07/56 |
| Altri autori (Persone) | RauchCarol A |
| Collana | Diagnostic standards of care |
| Soggetto topico |
Clinical chemistry
Diagnosis, Laboratory |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-4619-4825-8
1-61705-189-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Specimen receiving and processing -- Core chemistry -- Therapeutic drug monitoring/toxicology -- Point of care testing -- Endocrine/tumor markers/special chemistry -- Laboratory information systems/informatics -- Laboratory safety -- Outreach testing. |
| Record Nr. | UNINA-9910462975703321 |
|
Nichols James H. <1961->
|
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| New York : , : Demos Medical Publishing, LLC, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Clinical chemistry : quality in laboratory diagnosis / / James H. Nichols, Carol A. Rauch
| Clinical chemistry : quality in laboratory diagnosis / / James H. Nichols, Carol A. Rauch |
| Autore | Nichols James H. <1961-> |
| Pubbl/distr/stampa | New York : , : Demos Medical Publishing, LLC, , [2014] |
| Descrizione fisica | 1 online resource (173 p.) |
| Disciplina | 616.07/56 |
| Altri autori (Persone) | RauchCarol A |
| Collana | Diagnostic standards of care |
| Soggetto topico |
Clinical chemistry
Diagnosis, Laboratory |
| ISBN |
1-4619-4825-8
1-61705-189-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Specimen receiving and processing -- Core chemistry -- Therapeutic drug monitoring/toxicology -- Point of care testing -- Endocrine/tumor markers/special chemistry -- Laboratory information systems/informatics -- Laboratory safety -- Outreach testing. |
| Record Nr. | UNINA-9910787503003321 |
|
Nichols James H. <1961->
|
||
| New York : , : Demos Medical Publishing, LLC, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical chemistry : quality in laboratory diagnosis / / James H. Nichols, Carol A. Rauch
| Clinical chemistry : quality in laboratory diagnosis / / James H. Nichols, Carol A. Rauch |
| Autore | Nichols James H. <1961-> |
| Pubbl/distr/stampa | New York : , : Demos Medical Publishing, LLC, , [2014] |
| Descrizione fisica | 1 online resource (173 p.) |
| Disciplina | 616.07/56 |
| Altri autori (Persone) | RauchCarol A |
| Collana | Diagnostic standards of care |
| Soggetto topico |
Clinical chemistry
Diagnosis, Laboratory |
| ISBN |
1-4619-4825-8
1-61705-189-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Specimen receiving and processing -- Core chemistry -- Therapeutic drug monitoring/toxicology -- Point of care testing -- Endocrine/tumor markers/special chemistry -- Laboratory information systems/informatics -- Laboratory safety -- Outreach testing. |
| Record Nr. | UNINA-9910822470503321 |
|
Nichols James H. <1961->
|
||
| New York : , : Demos Medical Publishing, LLC, , [2014] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical laboratory medicine / / Kenneth D. McClatchey, editor ; Ruth W. Weinberg, acquisition editor ; Raymond E. Reter, developmental editor ; Mark Lerner, cover designer
| Clinical laboratory medicine / / Kenneth D. McClatchey, editor ; Ruth W. Weinberg, acquisition editor ; Raymond E. Reter, developmental editor ; Mark Lerner, cover designer |
| Edizione | [Second edition.] |
| Pubbl/distr/stampa | Philadelphia, Pennsylvania : , : Lippincott Williams & Wilkins, , 2002 |
| Descrizione fisica | 1 online resource (1709 p.) |
| Disciplina | 616.07/56 |
| Soggetto topico | Diagnosis, Laboratory |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-4698-7945-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
""Cover""; ""Copyright""; ""Editor""; ""DEDICATION""; ""PREFACE""; ""ACKNOWLEDGMENTS""; ""Contents""; ""Section 1 General Laboratory""; ""General Laboratory - Introduction""; ""1 Basic Laboratory Management""; ""2 Business Management of the Clinical Laboratory""; ""3 Laboratory Safety""; ""4 The Interpretation of Laboratory Tests""; ""5 Laboratory Information Systems""; ""6 Ethics in Laboratory Medicine""; ""Section 2 Molecular Pathology""; ""Molecular Pathology - Introduction""; ""7 Introduction to Molecular Diagnostics""; ""8 Molecular Biology of Inherited Diseases""
""9 Molecular Biology of Solid Tumors""""10 Molecular Biology of Infectious Diseases""; ""11 Clinical Applications of Molecular Biology Hematopoietic Disorders""; ""Section 3 Clinical Chemistry""; ""Clinical Chemistry - Introduction""; ""12 Immunochemical Methods""; ""13 The Plasma Proteins""; ""14 Diagnostic Enzymology and Other Biochemical Markers of Organ Damage""; ""15 Lipids and Lipoproteins""; ""16 Endocrine Function and Carbohydrates""; ""17 Electrolytes and Acid-Base Balance""; ""18 Respiration and Measurement of Oxygen and Hemoglobin""; ""19 Nitrogen Metabolites and Renal Function"" ""20 Calcium, Magnesium, and Phosphate""""21 Heme Synthesis and Catabolism""; ""22 Toxicology""; ""23 Trace Elements, Vitamins, and Nutrition""; ""24 Inborn Metabolic Errors""; ""25 Point-of-Care Testing""; ""26 Tumor Markers""; ""Section 4 Medical Microscopy and Urinalysis""; ""Medical Microscopy and Urinalysis - Introduction""; ""27 Synovial, Pleural, and Peritoneal Fluids""; ""28 Urine""; ""Section 5 Cytogenetics""; ""Cytogenetics - Introduction""; ""29 Basic Cytogenetics""; ""30 Clinical Cytogenetics""; ""31 Prenatal Cytogenetic Diagnosis"" ""32 Cytogenetic Studies in Neoplastic Hematologic Disorders""""33 The Chromosome-Breakage Syndromes: Clinical Features, Cytogenetics, and Molecular Genetics""; ""34 Solid Tumor Cytogenetics""; ""Section 6 The Major Histocompatibility Complex""; ""The Major Histocompatibility Complex - Introduction ""; ""35 HLA: Structure, Function, and Methodologies""; ""36 Molecular HLA Typing""; ""37 HLA: Applications""; ""38 Bone Marrow Transplantation""; ""Section 7 Hematology""; ""Hematology - Introduction""; ""39 Hematopoiesis and the Hematopoietic Growth Factors"" ""40 Peripheral Blood and Bone Marrow: Morphology, Counts and Differentials, and Reactive Disorders""""41 Red Blood Cell Disorders""; ""42 The Thalassemia and Hemoglobinopathy Syndromes""; ""43 Acute Leukemias and Myelodysplastic Syndromes""; ""44 Chronic Lymphoproliferative Disorders, Immunoproliferative Disorders, and Malignant Lymphoma""; ""45 Chronic Myeloproliferative Disorders""; ""Section 8 Coagulation""; ""Coagulation - Introduction""; ""46 Overview of Hemostasis""; ""47 Laboratory Evaluation of Platelet Disorders""; ""48 Coagulation Abnormalities""; ""49 Thrombophilia"" ""Section 9 Microbiology"" |
| Record Nr. | UNINA-9910453966003321 |
| Philadelphia, Pennsylvania : , : Lippincott Williams & Wilkins, , 2002 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
