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Epigenetic Mechanisms in Cellular Reprogramming / / edited by Alexander Meissner, Jörn Walter
| Epigenetic Mechanisms in Cellular Reprogramming / / edited by Alexander Meissner, Jörn Walter |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (244 p.) |
| Disciplina | 616.0277 |
| Collana | Epigenetics and Human Health |
| Soggetto topico |
Human genetics
Cytology Systems biology Nucleic acids Human Genetics Cell Biology Systems Biology Nucleic Acid Chemistry |
| ISBN | 3-642-31974-2 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Preface; Glossary; Contents; The Oocyte Determinants of Early Reprogramming; 1 Controversies Surrounding Oocyte Reprogramming; 2 A Brief History of SCNT; 3 The Uniqueness of the Oocyte: More than Totipotency; 4 Qualitative Aspects of Oocyte-Mediated Nuclear Reprogramming; 4.1 Characteristic Traits of the Oocyte Are Species Specific; 4.2 Transcriptional Activity in Germinal Vesicle-Stage Oocytes; 4.3 Different Maturation States and Accompanying Chromatin Configuration of Recipient Oocytes for SCNT; 5 Quantitative Aspects of Oocyte-Mediated Nuclear Reprogramming
5.1 Amount of Reprogramming Factors5.2 Kinetics of Reprogramming; 6 Gene Expression in Oocytes; 7 The Elusive Reprogramming Factors; 8 Using Transcriptomics and Proteomics to Search for the Molecular Fingerprint Indicative of an Oocyte´s Reprogramming Potenti...; 8.1 Candidate Gene Approach; 8.2 Transcriptome Analysis; 8.3 Proteome Analysis; Conclusion; References; Stella and Zygotic Reprogramming; 1 Stella; 1.1 Identification of Stella; 1.2 Expression Pattern of Stella; 1.3 Gene Disruption Analysis of Stella; 2 Epigenetic Reprogramming in Zygotes 2.1 Active Loss of 5mC in Zygotic Paternal Genome2.2 Protection of Imprinted Genes and Repetitive Sequences in Zygotes; 2.3 Involvement of 5hmC and Tet Proteins in Active Loss of 5mC; 2.4 Histone Modification in Zygotes; 3 Mechanism of Stella-Mediated Protection of 5mC in Zygotes; 3.1 Stella Protects Active Loss of 5mC in Zygotes; 3.2 Stella Protects Imprinted Genes and Repetitive Sequences; 3.3 Protective Function of Stella Depends on H3K9me2; 3.4 Mechanism of Stella-Mediated Protection of 5mC in Zygotes; 4 Perspectives; References; Histone Variants and Reprogramming in Early Development 1 Mammalian Development: Context and Early Epigenetic Reprogramming2 Mechanisms of Epigenetic Reprogramming and Chromatin Remodelling in the Early Embryo; 3 The Components of the Chromatin Change as Development Proceeds; 4 Histone Variants as Regulators of Epigenetic Information During Reprogramming; 5 H3.3 and De Novo Establishment of Heterochromatin; 6 H3 Variants: A Conserved Function in the Germline; 7 Variants of H2A: The Case of MacroH2A; 8 H2A.Z Shows a Dynamic Localisation During Early Reprogramming in Embryos 9 High Endogenous Levels of Phosphorylated H2A.X Are Characteristic of Early Embryos10 Barr Body-Deficient H2A: H2A.B; References; DNA Methylation Reprogramming in Preimplantation Development; 1 Epigenetic Profiles in Mature Gametes; 2 DNA Methylation Reprogramming in the Zygote; 3 The Mechanisms of DNA Demethylation; 4 DNA Methylation Reprogramming in Further Preimplantation Development; 5 Roles of Dnmts in Regulating DNA Methylation in Early Embryos; 5.1 Dnmt1; 5.2 Dnmt3a, Dnmt3L and Dnmt3b; 6 DNA Methylation Reprogramming in SCNT-Derived Embryos 7 Histone Modifications and DNA Methylation Crosstalk |
| Record Nr. | UNINA-9910298273003321 |
| Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Germline stem cells / edited by Steven X. Hou, Shree Ram Singh
| Germline stem cells / edited by Steven X. Hou, Shree Ram Singh |
| Pubbl/distr/stampa | Totowa : Humana Press, 2008 |
| Descrizione fisica | XII, 273 p. : ill. ; 24 cm |
| Disciplina | 616.0277 |
| Collana | Methods in molecular biology |
| Soggetto topico | Cellule staminali |
| ISBN | 978-1-60327-213-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-990003197420203316 |
| Totowa : Humana Press, 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
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Guide to cell therapy GxP : quality standards in the development of cell-based medicines in non-pharmaceutical environments / / Joaquim Vives, Gloria Carmona
| Guide to cell therapy GxP : quality standards in the development of cell-based medicines in non-pharmaceutical environments / / Joaquim Vives, Gloria Carmona |
| Autore | Vives Joaquim |
| Pubbl/distr/stampa | Amsterdam, Netherlands : , : Academic Press, , 2016 |
| Descrizione fisica | 1 online resource (279 p.) |
| Disciplina | 616.0277 |
| Soggetto topico |
Cellular therapy
Blood - Transfusion, Autologous - Treatment |
| ISBN | 0-12-803116-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Guide to Cell Therapy GxP; Copyright; Contents; List of Contributors; Foreword; Preface; 1 - Overview of the Development Program of a Cell-Based Medicine; 1. Introduction; 2. Key Pharmaceutical Factors to Consider in Early Development Stages; 3. TPP: Beginning with the End in Mind; 4. Stages of Drug Development; 5. Considering Stakeholders; 6. Product Lifecycle and Portfolio Management; 7. Performance Management and the Check Point Value; 8. Conclusions; References; Glossary; List of Acronyms and Abbreviations
1. Introduction2. Types of Cell-Based Advanced Therapy Medicinal Products and their Safety Considerations; 3. Regulations and Nonclinical Studies; 4. Nonclinical Assessment-The Risk-Based Approach; 5. The Requirement for Good Laboratory Practice; 6. General Study Design Considerations; 7. Specific Nonclinical Safety Considerations; 8. Conclusions; References; Glossary; List of Acronyms and Abbreviations; 4 - Good Manufacturing Practice Compliance in the Manufacture of Cell-Based Medicines; 1. Outline of the Chapter; 2. Quality Management; 3. Documentation; 4. Qualification and Validation 5. Premises and Equipment6. Personnel and Hygiene; 7. Manufacturing; 8. Quality Control; 9. Inspections, Audits, Complaints, Recalls, and Returns; 10. Conclusion; Acknowledgment; References; List of Abbreviations; 5 - Good Clinical Practice in Nonprofit Institutions; 1. Introduction; 2. The Elements of GCP Compliance; 3. The Clinical Trial Protocol; 4. The Investigator's Brochure; 5. The Informed Consent; 6. Essential Documents for Clinical Trial; 7. Clinical Trial Files; 8. Sponsor' Study Audit and Inspections; 9. Conclusion; References; Glossary; List of Acronyms and Abbreviations 6 - Compatibility of GxP with Existing Cell Therapy Quality Standards1. Quality Standards in Cell Therapy; 2. Adaptation of Existing Standards to GxP; 3. Impact of GxP Implementation; 4. Quality by Design; 5. Recommendations for Optimizing Integration of QA Systems; 6. Conclusions; References; Glossary; List of Abbreviations; Index |
| Record Nr. | UNINA-9910797368903321 |
Vives Joaquim
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| Amsterdam, Netherlands : , : Academic Press, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Guide to cell therapy GxP : quality standards in the development of cell-based medicines in non-pharmaceutical environments / / Joaquim Vives, Gloria Carmona
| Guide to cell therapy GxP : quality standards in the development of cell-based medicines in non-pharmaceutical environments / / Joaquim Vives, Gloria Carmona |
| Autore | Vives Joaquim |
| Pubbl/distr/stampa | Amsterdam, Netherlands : , : Academic Press, , 2016 |
| Descrizione fisica | 1 online resource (279 p.) |
| Disciplina | 616.0277 |
| Soggetto topico |
Cellular therapy
Blood - Transfusion, Autologous - Treatment |
| ISBN | 0-12-803116-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Guide to Cell Therapy GxP; Copyright; Contents; List of Contributors; Foreword; Preface; 1 - Overview of the Development Program of a Cell-Based Medicine; 1. Introduction; 2. Key Pharmaceutical Factors to Consider in Early Development Stages; 3. TPP: Beginning with the End in Mind; 4. Stages of Drug Development; 5. Considering Stakeholders; 6. Product Lifecycle and Portfolio Management; 7. Performance Management and the Check Point Value; 8. Conclusions; References; Glossary; List of Acronyms and Abbreviations
1. Introduction2. Types of Cell-Based Advanced Therapy Medicinal Products and their Safety Considerations; 3. Regulations and Nonclinical Studies; 4. Nonclinical Assessment-The Risk-Based Approach; 5. The Requirement for Good Laboratory Practice; 6. General Study Design Considerations; 7. Specific Nonclinical Safety Considerations; 8. Conclusions; References; Glossary; List of Acronyms and Abbreviations; 4 - Good Manufacturing Practice Compliance in the Manufacture of Cell-Based Medicines; 1. Outline of the Chapter; 2. Quality Management; 3. Documentation; 4. Qualification and Validation 5. Premises and Equipment6. Personnel and Hygiene; 7. Manufacturing; 8. Quality Control; 9. Inspections, Audits, Complaints, Recalls, and Returns; 10. Conclusion; Acknowledgment; References; List of Abbreviations; 5 - Good Clinical Practice in Nonprofit Institutions; 1. Introduction; 2. The Elements of GCP Compliance; 3. The Clinical Trial Protocol; 4. The Investigator's Brochure; 5. The Informed Consent; 6. Essential Documents for Clinical Trial; 7. Clinical Trial Files; 8. Sponsor' Study Audit and Inspections; 9. Conclusion; References; Glossary; List of Acronyms and Abbreviations 6 - Compatibility of GxP with Existing Cell Therapy Quality Standards1. Quality Standards in Cell Therapy; 2. Adaptation of Existing Standards to GxP; 3. Impact of GxP Implementation; 4. Quality by Design; 5. Recommendations for Optimizing Integration of QA Systems; 6. Conclusions; References; Glossary; List of Abbreviations; Index |
| Record Nr. | UNINA-9910806271003321 |
|
Vives Joaquim
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| Amsterdam, Netherlands : , : Academic Press, , 2016 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Therapy with cultured cells / / Howard Green
| Therapy with cultured cells / / Howard Green |
| Autore | Green Howard <1925-2015.> |
| Pubbl/distr/stampa | Singapore, : Pan Stanford, ©2010 |
| Descrizione fisica | 1 online resource (92 p.) |
| Disciplina | 616.0277 |
| Soggetto topico |
Cellular therapy
Human cell culture |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-429-06656-2
981-4267-71-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Cover; Contents; Introduction; Chapter 1. The Early History of Cell Culture; Chapter 2. The Beginnings of Keratinocyte Cultivation; Chapter 3. The Treatment of Burns; Chapter 4. Defining the Stem Cell Character of Keratinocytes; Chapter 5. Treatment with Allogeneic Cultured Keratinocytes; Chapter 6. Treatment of Ocular Disease; Chapter 7. Gene Therapy; Chapter 8. Therapy with Cultured Chondrocytes; Chapter 9. The Promise of Therapy with Embryonic Stem Cells; A Final Philosophical Reflection; References; Index |
| Record Nr. | UNINA-9910459315003321 |
|
Green Howard <1925-2015.>
|
||
| Singapore, : Pan Stanford, ©2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Therapy with cultured cells / / Howard Green
| Therapy with cultured cells / / Howard Green |
| Autore | Green Howard <1925-2015.> |
| Pubbl/distr/stampa | Singapore, : Pan Stanford, ©2010 |
| Descrizione fisica | 1 online resource (92 p.) |
| Disciplina | 616.0277 |
| Soggetto topico |
Cellular therapy
Human cell culture |
| ISBN |
0-429-53376-4
0-429-06656-2 981-4267-71-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Cover; Contents; Introduction; Chapter 1. The Early History of Cell Culture; Chapter 2. The Beginnings of Keratinocyte Cultivation; Chapter 3. The Treatment of Burns; Chapter 4. Defining the Stem Cell Character of Keratinocytes; Chapter 5. Treatment with Allogeneic Cultured Keratinocytes; Chapter 6. Treatment of Ocular Disease; Chapter 7. Gene Therapy; Chapter 8. Therapy with Cultured Chondrocytes; Chapter 9. The Promise of Therapy with Embryonic Stem Cells; A Final Philosophical Reflection; References; Index |
| Record Nr. | UNINA-9910792406803321 |
|
Green Howard <1925-2015.>
|
||
| Singapore, : Pan Stanford, ©2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Therapy with cultured cells / / Howard Green
| Therapy with cultured cells / / Howard Green |
| Autore | Green Howard <1925-2015.> |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Singapore, : Pan Stanford, ©2010 |
| Descrizione fisica | 1 online resource (92 p.) |
| Disciplina | 616.0277 |
| Soggetto topico |
Cellular therapy
Human cell culture |
| ISBN |
0-429-53376-4
0-429-06656-2 981-4267-71-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Cover; Contents; Introduction; Chapter 1. The Early History of Cell Culture; Chapter 2. The Beginnings of Keratinocyte Cultivation; Chapter 3. The Treatment of Burns; Chapter 4. Defining the Stem Cell Character of Keratinocytes; Chapter 5. Treatment with Allogeneic Cultured Keratinocytes; Chapter 6. Treatment of Ocular Disease; Chapter 7. Gene Therapy; Chapter 8. Therapy with Cultured Chondrocytes; Chapter 9. The Promise of Therapy with Embryonic Stem Cells; A Final Philosophical Reflection; References; Index |
| Record Nr. | UNINA-9910956043503321 |
|
Green Howard <1925-2015.>
|
||
| Singapore, : Pan Stanford, ©2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||