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Animal Models for the Study of Human Disease
| Animal Models for the Study of Human Disease |
| Autore | Conn P. Michael |
| Edizione | [2nd ed.] |
| Pubbl/distr/stampa | San Diego : , : Elsevier Science & Technology, , 2017 |
| Descrizione fisica | 1 online resource (1200 pages) |
| Disciplina |
616.027
616.0273 |
| Soggetto topico | Disease Models, Animal |
| ISBN | 0-12-809699-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover -- Dedication -- Title Page -- Copyright Page -- Dedication -- Contents -- List of Contributors -- Preface -- Part A - Ethics, resources, and approaches -- Chapter 1 - Ethics in Biomedical Animal Research: The Key Role of the Investigatora -- 1 - Nature and Scope of the Chapter -- 2 - The Subject Matter of Biomedical Animal Research Ethics -- 3 - Why Investigators Should Care About Biomedical Animal Research Ethics -- 3.1 - Investigators are Already Committed to High Ethical Standards -- 3.2 - Ethical Treatment of Animals is Required by Law -- 3.2.1 - General Commitment to Ethical Behavior -- 3.2.2 - Legal Requirements Reflecting General or Specific Ethical Principles -- 3.3 - Ethical Treatment of Animals Promotes Sound Scientific Results -- 3.4 - Ethical Treatment of Animals is Required by Funding Bodies -- 3.5 - Ethical Treatment of Animals is Required by Peer-Reviewed Journals -- 3.5.1 - The ARRIVE Guidelines -- 3.6 - Ethical Treatment of Animals is Essential for Public Support -- 3.7 - Ethical Treatment of Animals is the Right Thing to Do -- 4 - Aspects of Animal Use and Care Relevant to Biomedical Animal Research Ethics -- 5 - Use of Privately Owned Animals in Biomedical Research -- 6 - The Nature of Basic Animal Research -- 6.1 - "Basic" Research as the Search for Knowledge for its Own Sake -- 6.2 - "Basic" Research as the Search for Fundamental, Underlying Mechanisms, and Causes -- 6.3 - What Investigators Mean by "Basic" Animal Research -- 6.4 - Recommendations -- 7 - Why Investigators Play the Key Role in Ensuring the Ethical Conduct of Animal Research Projects -- 7.1 - The Nature of Principles of Biomedical Animal Research Ethics -- 7.2 - The Need for Scientific Expertise in Applying General Ethical Principles -- 7.3 - The Investigator as Captain of the Experimental Ship -- 7.3.1 - Primacy of Project Goals.
7.3.2 - Design and Implementation of Experimental Procedures -- 7.3.3 - The Importance of Sound Science in Ensuring Ethical Animal Experimentation -- 7.4 - The Role of Review Committees and Government Officials in Assessing the Ethical Appropriateness of Animal Experiments -- 7.4.1 - Ethical Review in the United States -- 8 - Sources of Guidance for Investigators in Conducting Ethical Research -- 8.1 - Scientific Resources -- 8.2 - Ethical and Ethically Relevant Resources -- 8.2.1 - Legally Mandated Ethical Principles -- 8.2.2 - Nongovernmental Documents Adherence to Which is Required by Law -- 8.2.3 - Publications of Workshops, Study Committees, and Nongovernmental Entities -- 8.2.4 - Ethical Guidelines of Professional Associations -- 9 - Developing Useful Ethical Guidelines -- 10 - Fundamental Principles of biomedical animal Research Ethics -- F1 - The Biomedical Research Principle -- F2 - The Animal Research Principle -- F3 - The Nuremberg Principle -- F4 - The Pain and Distress Minimization Principle -- F4.1 - Ethical Foundations of the Pain and Distress Minimization Principle -- F4.2 - Qualifications to the Pain and Distress Minimization Principle -- Uncertainty Regarding Minimization -- Imprecision in Estimates of Animal Pain or Distress -- F4.3 - The Incompleteness of the Pain and Distress Minimization Principle -- F5 - The Pain and Distress Justification Principle -- F6 - The Harm Justification Principle -- F6.1 - Determining the Value of a Research Project -- Medical Value of the Project -- Scientific Value of the Project -- F6.2 - Determining Whether the Value of a Project Justifies any Pain, Distress, or Other Harms Caused to the Animals -- Assessing the Project's Medical Value -- Assessing the Nature and Extent of Harms to the Animals. the project's scientific value as the justificatory link between medical value and harms to the animals -- predictability of results and scientific value -- likely limited impact of successful experimental results -- value of unsuccessful projects -- unpredictability of the impact of research results -- F6.3 - Problematic Expressions of the Harm Justification Principle: "Harm-Benefit Analysis" -- why the harm justification principle when properly interpreted should not require likely benefits -- problematic responses to the problem for the harm-benefit analysis of basic animal research -- F6.4 - Further Needed Discussion of the Harm Justification Principle -- F7 - The Harm Minimization Principle -- F8 - The General Justification Principle -- F8.1 - Applying the General Justification Principle to Projects That do and Those That do not Cause Animals Harm -- F8.2 - Why Many Projects That do not Harm Animals Will be Easily Justified -- F9 - The 3Rs Principle -- F9.1 - Redefinition of "Replacement" -- F9.2 - Redefinition of "Refinement" -- F9.3 - The Need for Clarity and Argument -- F10 - The Species-Appropriate Housing Principle -- F10.1 - Definitions of and Ethical Arguments for Research Animal "Well-Being" -- Well-Being as Absence of Pain or Distress -- Well-Being as Including Positive Feelings and Experiences -- Questions About Providing Positive Experiences to Research Animals -- F10.2 - Environmental Enrichment -- Differing Definitions of "Enrichment" -- Differing Views of the Aims of Enrichment -- Potential Effects on Research Results -- F11 - The Appropriate Care Principle -- F12 - The Appreciation Principle -- F13 - The Translation Principle -- 11 - Practical Ethical Guidelines for Investigators -- P1 - Approach all phases and aspects of an animal research project with the aim of making the project ethically as well as ... P2 - Appreciate that as the source of the project's scientific goals, you play the key role in determining whether the proj... -- P3 - Keep in mind that the central question in the ethical assessment of a project is whether its value justifies its use a... -- P4 - To be able to make the strongest case for the medical value of the project, always keep up-to-date information and doc... -- P5 - Design the project with the maximum possible scientific value, by framing sound scientific questions that relate to th... -- P6 - If the project has the potential to cause harms to animals, specifically pain or distress, but also any other signific... -- P7 - In designing and conducting the project, take all reasonable steps to minimize any pain or distress that the animals m... -- P8 - Regard your attending veterinarian as a constant source of information and guidance during all stages of the project -- P9 - Collect, read, and regularly consult publications that enunciate or apply ethical principles relevant to your research -- P10 - Although you should follow legal requirements applicable to the project, when such requirements impose only minimum e... -- 12 - Some Current Difficult Issues in Animal Research Ethics -- 12.1 - The Nature and Weight of Harms to be Justified by the Value of Animal Research Projects -- Unpleasant Experiences Other Than Pain and Distress -- Frustration of an Animal's Nature or Telos -- Killing Research Animals -- 12.2 - Ethical Relevance of Species and Species Characteristics -- The IOM Chimpanzee Report -- The Relative Moral Cost View -- Criteria for Ranking Species -- Number of Ranked Categories -- Research Implications of Species Rankings -- 13 - General Suggestions for Investigators -- S1 - Communicate to the public the nature and potential benefits of your research, and the ethical values and standards you... S2 - Become familiar with some of the animal research ethics literature -- S3 - Participate in discussions of ethical issues relating to biomedical animal research -- References -- Chapter 2 - Psychological Environmental Enrichment of Animals in Research -- 1 - Introduction -- 2 - Enrichment and Welfare -- 2.1 - Why Enrich? -- 2.2 - Common Abnormal Behaviors Seen in Captivity -- 2.3 - Types of Enrichment -- 2.3.1 - Social Enrichment -- 2.3.2 - Physical Enrichment -- 2.3.3 - Food Enrichment -- 2.3.4 - Sensory Enrichment -- 2.3.5 - Occupational Enrichment -- 3 - Enrichment and Animal Models -- 3.1 - Neuroplasticity and Neurogenesis -- 3.2 - Neurological Disorders -- 3.3 - Affective Disorders -- 3.4 - Obesity -- 3.5 - Cancer -- 4 - Enrichment and Experimental Variability -- 5 - Implementing an Enrichment Plan -- 5.1 - Understand the Natural History of the Species you are Trying to Enrich -- 5.2 - Devise Enrichment Plans With Specific Behavioral Outcomes in Mind -- 5.3 - Do no Harm -- 5.4 - Consider the Costs of the Enrichment -- 5.5 - "Listen" to the Animals to Determine Whether They Find the Enrichment Enriching -- 5.6 - Predictability is Important -- 5.7 - Document -- 6 - Example of an Enrichment Plan: Black-Tailed Prairie Dogs (Cynomys ludovicianus) -- 7 - Conclusions -- Acknowledgments -- References -- Further Reading -- Chapter 3 - Large Farm Animal Models of Human Neurobehavioral and Psychiatric Disorders: Methodological and Practical Considera... -- 1 - Animal Models -- 2 - Why Animal Experimental Studies? -- 3 - Animal Models in Biomedical Research -- 4 - Concerns About the Translatability of Findings From Animal Experimental Studies -- 5 - Translational Research -- 6 - Choice of Appropriate Animal Model -- 7 - Where in the Process of Modeling Human Diseases and Developing Putative Therapeutics Have Large Animal Models Been Used?. 8 - Which Model Animal Species Are Classified as Large in Scientific Research?. |
| Record Nr. | UNINA-9910583483703321 |
Conn P. Michael
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| San Diego : , : Elsevier Science & Technology, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Animal models for the study of human disease [[electronic resource] /] / edited by P. Michael Conn
| Animal models for the study of human disease [[electronic resource] /] / edited by P. Michael Conn |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | London, : Elsevier, 2013 |
| Descrizione fisica | 1 online resource (1109 p.) |
| Disciplina | 616.0273 |
| Altri autori (Persone) | ConnP. Michael |
| Soggetto topico |
Diseases - Animal models
Laboratory animals Pathology, Experimental |
| Soggetto genere / forma | Electronic books. |
| ISBN | 0-12-415912-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; ANIMAL MODELS FOR THE STUDY OF HUMAN DISEASE; Copyright; Contents; Preface; List of Contributors; Part I -ETHICS, RESOURCES AND APPROACHES; Chapter 1 - Ethics in Biomedical Animal Research: The Key Role of the Investigator; NATURE AND SCOPE OF THE CHAPTER; THE SUBJECT MATTER OF ANIMAL RESEARCH ETHICS; ASPECTS OF ANIMAL USE AND CARE RELEVANT TO ANIMAL RESEARCH ETHICS; WHY INVESTIGATORS ARE UNIQUELY QUALIFIED TO ENGAGE IN ETHICAL ASSESSMENT OF ANIMAL RESEARCH; WHY INVESTIGATORS SHOULD COMMIT THEMSELVES TO ETHICAL CONDUCT OF ANIMAL RESEARCH
WHY INVESTIGATORS PLAY THE KEY ROLE IN ASSURING THE ETHICAL CONDUCT OF ANIMAL RESEARCH PROJECTS SOURCES OF SUPPORT AND GUIDANCE IN CONDUCTING ETHICAL RESEARCH; DEVELOPING USEFUL ETHICAL GUIDELINES; FUNDAMENTAL PRINCIPLES OF ANIMAL RESEARCH ETHICS; PRACTICAL ETHICAL GUIDELINES FOR INVESTIGATORS; SOME CURRENT DIFFICULT ISSUES IN ANIMAL RESEARCH ETHICS; GENERAL SUGGESTIONS FOR INVESTIGATORS; References; Chapter 2 - Access to Resources: A Model Organism Database for Humans; THE PROBLEM; THE LAMHDI SOLUTION; THE IDEAL SOLUTION; Acknowledgments; References Chapter 3 - The Advent of the Golden Era of Animal Alternatives INTRODUCTION; ANALYTICAL TOOLS FOR THE DETECTION OF FOOD-BORNE DISEASE; AN INVITRO SYSTEM TO ASSESS ADVERSE EFFECTS DURING DEVELOPMENT; DISEASES-IN-A-DISH; NONINVASIVE IMAGING AND RECORDING; CONCLUSIONS; References; Chapter 4 - Environmental Enrichment for Animals Used in Research; INTRODUCTION; APPLIED SCIENCE: ENRICHMENT AS A WELFARE TOOL; BASIC SCIENCE: ENRICHMENT AND ANIMAL MODELS; ENRICHMENT AND EXPERIMENTAL VARIABILITY; ENVIRONMENTAL ENRICHMENT REGULATIONS; IMPLEMENTING AN ENRICHMENT PLAN; CONCLUSIONS; Acknowledgments References Part II -VISION; Chapter 5 - Animal Models of Age-Related Macular Degeneration; INTRODUCTION; COMPARATIVE RETINAL ANATOMY AND THE PATHOLOGY OF AMD; THE GENETICS OF AMD; INFLAMMATION IN AMD; HTRA1 AND LOC387715/ARMS2 IN AMD; OXIDATIVE DAMAGE AND AMD; LIPID METABOLISM AND AMD; SPONTANEOUSLY OCCURRING PRIMATE MODELS OF AMD; MODELING CHOROIDAL NEOVASCULARIZATION IN ADVANCED AMD; CONCLUSION; References; Chapter 6 - N-Methyl-N-Nitrosourea Animal Models for Retinitis Pigmentosa; INTRODUCTION; TIME-COURSE PROGRESSION OF MNU-INDUCED RETINAL DEGENERATION RETINAL DEGENERATION CAUSED BY MNU IN VARIOUS ANIMAL SPECIESAGE-RELATED PHOTORECEPTOR CELL DAMAGE AND SENSITIVITY TO MNU; PHOTORECEPTOR CELL DEATH, CELL DEBRIS REMOVAL, AND RPE CELL MIGRATION; MOLECULAR MECHANISMS IN PHOTORECEPTOR CELL DEATH CAUSED BY MNU; THERAPEUTIC TRIALS AGAINST MNU-INDUCED PHOTORECEPTOR APOPTOSIS; CONCLUDING REMARKS; Acknowledgments; References; Part III -CARDIAC AND CARDIOVASCULAR; Chapter 7 - Animal Models of Myocardial Disease; INTRODUCTION; THE SPECTRUM OF CARDIOVASCULAR DISEASE; CHOICE OF ANIMAL SYSTEM; EXPERIMENTAL DESIGN; ISCHEMIC HEART DISEASE SYSTOLIC HEART FAILURE |
| Record Nr. | UNINA-9910459131603321 |
| London, : Elsevier, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Animal models for the study of human disease / / edited by P. Michael Conn
| Animal models for the study of human disease / / edited by P. Michael Conn |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | London, : Elsevier, 2013 |
| Descrizione fisica | 1 online resource (xviii, 1089 pages) : illustrations (some color) |
| Disciplina | 616.0273 |
| Collana | Gale eBooks |
| Soggetto topico |
Diseases - Animal models
Laboratory animals Pathology, Experimental |
| ISBN | 0-12-415912-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; ANIMAL MODELS FOR THE STUDY OF HUMAN DISEASE; Copyright; Contents; Preface; List of Contributors; Part I -ETHICS, RESOURCES AND APPROACHES; Chapter 1 - Ethics in Biomedical Animal Research: The Key Role of the Investigator; NATURE AND SCOPE OF THE CHAPTER; THE SUBJECT MATTER OF ANIMAL RESEARCH ETHICS; ASPECTS OF ANIMAL USE AND CARE RELEVANT TO ANIMAL RESEARCH ETHICS; WHY INVESTIGATORS ARE UNIQUELY QUALIFIED TO ENGAGE IN ETHICAL ASSESSMENT OF ANIMAL RESEARCH; WHY INVESTIGATORS SHOULD COMMIT THEMSELVES TO ETHICAL CONDUCT OF ANIMAL RESEARCH
WHY INVESTIGATORS PLAY THE KEY ROLE IN ASSURING THE ETHICAL CONDUCT OF ANIMAL RESEARCH PROJECTS SOURCES OF SUPPORT AND GUIDANCE IN CONDUCTING ETHICAL RESEARCH; DEVELOPING USEFUL ETHICAL GUIDELINES; FUNDAMENTAL PRINCIPLES OF ANIMAL RESEARCH ETHICS; PRACTICAL ETHICAL GUIDELINES FOR INVESTIGATORS; SOME CURRENT DIFFICULT ISSUES IN ANIMAL RESEARCH ETHICS; GENERAL SUGGESTIONS FOR INVESTIGATORS; References; Chapter 2 - Access to Resources: A Model Organism Database for Humans; THE PROBLEM; THE LAMHDI SOLUTION; THE IDEAL SOLUTION; Acknowledgments; References Chapter 3 - The Advent of the Golden Era of Animal Alternatives INTRODUCTION; ANALYTICAL TOOLS FOR THE DETECTION OF FOOD-BORNE DISEASE; AN INVITRO SYSTEM TO ASSESS ADVERSE EFFECTS DURING DEVELOPMENT; DISEASES-IN-A-DISH; NONINVASIVE IMAGING AND RECORDING; CONCLUSIONS; References; Chapter 4 - Environmental Enrichment for Animals Used in Research; INTRODUCTION; APPLIED SCIENCE: ENRICHMENT AS A WELFARE TOOL; BASIC SCIENCE: ENRICHMENT AND ANIMAL MODELS; ENRICHMENT AND EXPERIMENTAL VARIABILITY; ENVIRONMENTAL ENRICHMENT REGULATIONS; IMPLEMENTING AN ENRICHMENT PLAN; CONCLUSIONS; Acknowledgments References Part II -VISION; Chapter 5 - Animal Models of Age-Related Macular Degeneration; INTRODUCTION; COMPARATIVE RETINAL ANATOMY AND THE PATHOLOGY OF AMD; THE GENETICS OF AMD; INFLAMMATION IN AMD; HTRA1 AND LOC387715/ARMS2 IN AMD; OXIDATIVE DAMAGE AND AMD; LIPID METABOLISM AND AMD; SPONTANEOUSLY OCCURRING PRIMATE MODELS OF AMD; MODELING CHOROIDAL NEOVASCULARIZATION IN ADVANCED AMD; CONCLUSION; References; Chapter 6 - N-Methyl-N-Nitrosourea Animal Models for Retinitis Pigmentosa; INTRODUCTION; TIME-COURSE PROGRESSION OF MNU-INDUCED RETINAL DEGENERATION RETINAL DEGENERATION CAUSED BY MNU IN VARIOUS ANIMAL SPECIESAGE-RELATED PHOTORECEPTOR CELL DAMAGE AND SENSITIVITY TO MNU; PHOTORECEPTOR CELL DEATH, CELL DEBRIS REMOVAL, AND RPE CELL MIGRATION; MOLECULAR MECHANISMS IN PHOTORECEPTOR CELL DEATH CAUSED BY MNU; THERAPEUTIC TRIALS AGAINST MNU-INDUCED PHOTORECEPTOR APOPTOSIS; CONCLUDING REMARKS; Acknowledgments; References; Part III -CARDIAC AND CARDIOVASCULAR; Chapter 7 - Animal Models of Myocardial Disease; INTRODUCTION; THE SPECTRUM OF CARDIOVASCULAR DISEASE; CHOICE OF ANIMAL SYSTEM; EXPERIMENTAL DESIGN; ISCHEMIC HEART DISEASE SYSTOLIC HEART FAILURE |
| Record Nr. | UNINA-9910792482703321 |
| London, : Elsevier, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Animal models for the study of human disease / / edited by P. Michael Conn
| Animal models for the study of human disease / / edited by P. Michael Conn |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | London, : Elsevier, 2013 |
| Descrizione fisica | 1 online resource (xviii, 1089 pages) : illustrations (some color) |
| Disciplina | 616.0273 |
| Collana | Gale eBooks |
| Soggetto topico |
Diseases - Animal models
Laboratory animals Pathology, Experimental |
| ISBN | 0-12-415912-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; ANIMAL MODELS FOR THE STUDY OF HUMAN DISEASE; Copyright; Contents; Preface; List of Contributors; Part I -ETHICS, RESOURCES AND APPROACHES; Chapter 1 - Ethics in Biomedical Animal Research: The Key Role of the Investigator; NATURE AND SCOPE OF THE CHAPTER; THE SUBJECT MATTER OF ANIMAL RESEARCH ETHICS; ASPECTS OF ANIMAL USE AND CARE RELEVANT TO ANIMAL RESEARCH ETHICS; WHY INVESTIGATORS ARE UNIQUELY QUALIFIED TO ENGAGE IN ETHICAL ASSESSMENT OF ANIMAL RESEARCH; WHY INVESTIGATORS SHOULD COMMIT THEMSELVES TO ETHICAL CONDUCT OF ANIMAL RESEARCH
WHY INVESTIGATORS PLAY THE KEY ROLE IN ASSURING THE ETHICAL CONDUCT OF ANIMAL RESEARCH PROJECTS SOURCES OF SUPPORT AND GUIDANCE IN CONDUCTING ETHICAL RESEARCH; DEVELOPING USEFUL ETHICAL GUIDELINES; FUNDAMENTAL PRINCIPLES OF ANIMAL RESEARCH ETHICS; PRACTICAL ETHICAL GUIDELINES FOR INVESTIGATORS; SOME CURRENT DIFFICULT ISSUES IN ANIMAL RESEARCH ETHICS; GENERAL SUGGESTIONS FOR INVESTIGATORS; References; Chapter 2 - Access to Resources: A Model Organism Database for Humans; THE PROBLEM; THE LAMHDI SOLUTION; THE IDEAL SOLUTION; Acknowledgments; References Chapter 3 - The Advent of the Golden Era of Animal Alternatives INTRODUCTION; ANALYTICAL TOOLS FOR THE DETECTION OF FOOD-BORNE DISEASE; AN INVITRO SYSTEM TO ASSESS ADVERSE EFFECTS DURING DEVELOPMENT; DISEASES-IN-A-DISH; NONINVASIVE IMAGING AND RECORDING; CONCLUSIONS; References; Chapter 4 - Environmental Enrichment for Animals Used in Research; INTRODUCTION; APPLIED SCIENCE: ENRICHMENT AS A WELFARE TOOL; BASIC SCIENCE: ENRICHMENT AND ANIMAL MODELS; ENRICHMENT AND EXPERIMENTAL VARIABILITY; ENVIRONMENTAL ENRICHMENT REGULATIONS; IMPLEMENTING AN ENRICHMENT PLAN; CONCLUSIONS; Acknowledgments References Part II -VISION; Chapter 5 - Animal Models of Age-Related Macular Degeneration; INTRODUCTION; COMPARATIVE RETINAL ANATOMY AND THE PATHOLOGY OF AMD; THE GENETICS OF AMD; INFLAMMATION IN AMD; HTRA1 AND LOC387715/ARMS2 IN AMD; OXIDATIVE DAMAGE AND AMD; LIPID METABOLISM AND AMD; SPONTANEOUSLY OCCURRING PRIMATE MODELS OF AMD; MODELING CHOROIDAL NEOVASCULARIZATION IN ADVANCED AMD; CONCLUSION; References; Chapter 6 - N-Methyl-N-Nitrosourea Animal Models for Retinitis Pigmentosa; INTRODUCTION; TIME-COURSE PROGRESSION OF MNU-INDUCED RETINAL DEGENERATION RETINAL DEGENERATION CAUSED BY MNU IN VARIOUS ANIMAL SPECIESAGE-RELATED PHOTORECEPTOR CELL DAMAGE AND SENSITIVITY TO MNU; PHOTORECEPTOR CELL DEATH, CELL DEBRIS REMOVAL, AND RPE CELL MIGRATION; MOLECULAR MECHANISMS IN PHOTORECEPTOR CELL DEATH CAUSED BY MNU; THERAPEUTIC TRIALS AGAINST MNU-INDUCED PHOTORECEPTOR APOPTOSIS; CONCLUDING REMARKS; Acknowledgments; References; Part III -CARDIAC AND CARDIOVASCULAR; Chapter 7 - Animal Models of Myocardial Disease; INTRODUCTION; THE SPECTRUM OF CARDIOVASCULAR DISEASE; CHOICE OF ANIMAL SYSTEM; EXPERIMENTAL DESIGN; ISCHEMIC HEART DISEASE SYSTOLIC HEART FAILURE |
| Record Nr. | UNINA-9910808758703321 |
| London, : Elsevier, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Animal models in medicine and biology / / edited by Eva Tvrdá and Sarat Chandra Yenisetti
| Animal models in medicine and biology / / edited by Eva Tvrdá and Sarat Chandra Yenisetti |
| Pubbl/distr/stampa | London, England : , : IntechOpen, , [2020] |
| Descrizione fisica | 1 online resource (246 pages) : illustrations |
| Disciplina | 616.0273 |
| Soggetto topico |
Animal experimentation
Animal models in research |
| ISBN | 1-83880-012-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910409737103321 |
| London, England : , : IntechOpen, , [2020] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Comparative physiology, natural animal models, and clinical medicine [[electronic resource] ] : insights into clinical medicine from animal adaptations / / Michael A. Singer
| Comparative physiology, natural animal models, and clinical medicine [[electronic resource] ] : insights into clinical medicine from animal adaptations / / Michael A. Singer |
| Autore | Singer Michael A (Michael Allan), <1940-> |
| Pubbl/distr/stampa | London, : Imperial College Press, c2007 |
| Descrizione fisica | 1 online resource (292 p.) |
| Disciplina |
616.0076
616.0273 |
| Soggetto topico |
Diseases - Animal models
Physiology, Comparative Laboratory animals |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-86755-1
9786611867553 1-86094-949-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Acknowledgements; Introduction; Chapter 1 Diabetes Mellitus; Introduction; Blood Glucose Values in Birds; Do Birds Suffer Adverse Consequences from a High Blood Glucose Concentration; Anatomic and Physiologic Design Features; Eye; Retinal nutrient supply; Retinal vascularization in mammals; Avian and mammalian retinal physiology and development; Diabetic retinopathy; Kidney; Kidney anatomy and function in birds and mammals; Diabetic nephropathy; (a) Renal glucose transporters; (b) Juxtaglomerular apparatus; Glycated hemoglobin; Concluding Remarks and Future Research; References
Chapter 2 Chronic Renal FailureIntroduction; Metabolic Rate and Renal Function; Nitrogen and Urea Metabolism and Protein Turnover; Nitrogen and urea metabolism; Urea transport proteins; Protein turnover; Alterations in urea and protein metabolism in chronic renal failure; Additional Aspects of Renal Failure; Natural Animal Model; Bear and Small Mammal Hibernators; Concluding Remarks and Future Directions; References; Chapter 3 Atherosclerotic Vascular Disease; Introduction; Atherosclerosis in Mammals; Biology of the Arterial System: Implications for the Genesis of Atherosclerosis in Mammals Genesis of Atherosclerotic LesionsNatural Animal Model: The Fish; Fish Coronary Circulation; Fish Coronary Artery Thickenings; Genesis of Fish Lesions; Biomechanical Factors in Fish; Dietary In.uences and Role of Cholesterol in Fish; Biology of the Vascular Smooth Muscle in Fish; Concluding Remarks: What Can We Learn From the Fish as a Natural Model?; References; Chapter 4 Disuse Osteoporosis and Disuse Muscle Atrophy; Disuse Osteoporosis; Bone biology; Parathyroid hormone (PTH); Vitamin D; Leptin; Mechanical stress; Disuse osteoporosis Natural animal model: American black bear (Ursus americanus)Bone homeostasis in the bear: research questions; Disuse Muscle Atrophy; Maintenance of muscle mass; Protein degradation: mechanisms; Animal models; Studies in humans and small mammal hibernators; Humans; Small mammal hibernators; Natural animal model: the American black bear; The bear: a perspective; References; Chapter 5 Ammonia Toxicity; Ammonia Tolerance and Metabolism; Ammonia tolerance; Ammonia metabolism; Brain Ammonia Metabolism; Glutamatergic Neurons; General considerations (Purves et al., 2004) Glutamate, a Neurotransmitter and the "Glutamate-Glutamine" CycleMechanism of Ammonia Neurotoxicity; Neuropathological effects; Effects on Brain Energy Metabolism; Effects on Glutamatergic Synapses; Ammonia and the Fish Central Nervous System; Role of glutamine; Glutamate; Brain energy metabolism; NMDA receptors; Summary; References; Chapter 6 Hypoxia/Ischemia; Cerebral Blood Flow: Its Regulation; Brain Energy Metabolism; Oxygen and Oxygen/Glucose Deprivation and the Brain; General features of neuronal response; Anoxia tolerant mammalian neurons; Neonatal brain; Dorsal vagal neurons Neonatal neurons |
| Record Nr. | UNINA-9910458113103321 |
|
Singer Michael A (Michael Allan), <1940->
|
||
| London, : Imperial College Press, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Comparative physiology, natural animal models, and clinical medicine [[electronic resource] ] : insights into clinical medicine from animal adaptations / / Michael A. Singer
| Comparative physiology, natural animal models, and clinical medicine [[electronic resource] ] : insights into clinical medicine from animal adaptations / / Michael A. Singer |
| Autore | Singer Michael A (Michael Allan), <1940-> |
| Pubbl/distr/stampa | London, : Imperial College Press, c2007 |
| Descrizione fisica | 1 online resource (292 p.) |
| Disciplina |
616.0076
616.0273 |
| Soggetto topico |
Diseases - Animal models
Physiology, Comparative Laboratory animals |
| ISBN |
1-281-86755-1
9786611867553 1-86094-949-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Acknowledgements; Introduction; Chapter 1 Diabetes Mellitus; Introduction; Blood Glucose Values in Birds; Do Birds Suffer Adverse Consequences from a High Blood Glucose Concentration; Anatomic and Physiologic Design Features; Eye; Retinal nutrient supply; Retinal vascularization in mammals; Avian and mammalian retinal physiology and development; Diabetic retinopathy; Kidney; Kidney anatomy and function in birds and mammals; Diabetic nephropathy; (a) Renal glucose transporters; (b) Juxtaglomerular apparatus; Glycated hemoglobin; Concluding Remarks and Future Research; References
Chapter 2 Chronic Renal FailureIntroduction; Metabolic Rate and Renal Function; Nitrogen and Urea Metabolism and Protein Turnover; Nitrogen and urea metabolism; Urea transport proteins; Protein turnover; Alterations in urea and protein metabolism in chronic renal failure; Additional Aspects of Renal Failure; Natural Animal Model; Bear and Small Mammal Hibernators; Concluding Remarks and Future Directions; References; Chapter 3 Atherosclerotic Vascular Disease; Introduction; Atherosclerosis in Mammals; Biology of the Arterial System: Implications for the Genesis of Atherosclerosis in Mammals Genesis of Atherosclerotic LesionsNatural Animal Model: The Fish; Fish Coronary Circulation; Fish Coronary Artery Thickenings; Genesis of Fish Lesions; Biomechanical Factors in Fish; Dietary In.uences and Role of Cholesterol in Fish; Biology of the Vascular Smooth Muscle in Fish; Concluding Remarks: What Can We Learn From the Fish as a Natural Model?; References; Chapter 4 Disuse Osteoporosis and Disuse Muscle Atrophy; Disuse Osteoporosis; Bone biology; Parathyroid hormone (PTH); Vitamin D; Leptin; Mechanical stress; Disuse osteoporosis Natural animal model: American black bear (Ursus americanus)Bone homeostasis in the bear: research questions; Disuse Muscle Atrophy; Maintenance of muscle mass; Protein degradation: mechanisms; Animal models; Studies in humans and small mammal hibernators; Humans; Small mammal hibernators; Natural animal model: the American black bear; The bear: a perspective; References; Chapter 5 Ammonia Toxicity; Ammonia Tolerance and Metabolism; Ammonia tolerance; Ammonia metabolism; Brain Ammonia Metabolism; Glutamatergic Neurons; General considerations (Purves et al., 2004) Glutamate, a Neurotransmitter and the "Glutamate-Glutamine" CycleMechanism of Ammonia Neurotoxicity; Neuropathological effects; Effects on Brain Energy Metabolism; Effects on Glutamatergic Synapses; Ammonia and the Fish Central Nervous System; Role of glutamine; Glutamate; Brain energy metabolism; NMDA receptors; Summary; References; Chapter 6 Hypoxia/Ischemia; Cerebral Blood Flow: Its Regulation; Brain Energy Metabolism; Oxygen and Oxygen/Glucose Deprivation and the Brain; General features of neuronal response; Anoxia tolerant mammalian neurons; Neonatal brain; Dorsal vagal neurons Neonatal neurons |
| Record Nr. | UNINA-9910784887003321 |
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Singer Michael A (Michael Allan), <1940->
|
||
| London, : Imperial College Press, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Comparative physiology, natural animal models, and clinical medicine : insights into clinical medicine from animal adaptations / / Michael A. Singer
| Comparative physiology, natural animal models, and clinical medicine : insights into clinical medicine from animal adaptations / / Michael A. Singer |
| Autore | Singer Michael A (Michael Allan), <1940-> |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | London, : Imperial College Press, c2007 |
| Descrizione fisica | 1 online resource (292 p.) |
| Disciplina |
616.0076
616.0273 |
| Soggetto topico |
Diseases - Animal models
Physiology, Comparative Laboratory animals |
| ISBN |
1-281-86755-1
9786611867553 1-86094-949-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Acknowledgements; Introduction; Chapter 1 Diabetes Mellitus; Introduction; Blood Glucose Values in Birds; Do Birds Suffer Adverse Consequences from a High Blood Glucose Concentration; Anatomic and Physiologic Design Features; Eye; Retinal nutrient supply; Retinal vascularization in mammals; Avian and mammalian retinal physiology and development; Diabetic retinopathy; Kidney; Kidney anatomy and function in birds and mammals; Diabetic nephropathy; (a) Renal glucose transporters; (b) Juxtaglomerular apparatus; Glycated hemoglobin; Concluding Remarks and Future Research; References
Chapter 2 Chronic Renal FailureIntroduction; Metabolic Rate and Renal Function; Nitrogen and Urea Metabolism and Protein Turnover; Nitrogen and urea metabolism; Urea transport proteins; Protein turnover; Alterations in urea and protein metabolism in chronic renal failure; Additional Aspects of Renal Failure; Natural Animal Model; Bear and Small Mammal Hibernators; Concluding Remarks and Future Directions; References; Chapter 3 Atherosclerotic Vascular Disease; Introduction; Atherosclerosis in Mammals; Biology of the Arterial System: Implications for the Genesis of Atherosclerosis in Mammals Genesis of Atherosclerotic LesionsNatural Animal Model: The Fish; Fish Coronary Circulation; Fish Coronary Artery Thickenings; Genesis of Fish Lesions; Biomechanical Factors in Fish; Dietary In.uences and Role of Cholesterol in Fish; Biology of the Vascular Smooth Muscle in Fish; Concluding Remarks: What Can We Learn From the Fish as a Natural Model?; References; Chapter 4 Disuse Osteoporosis and Disuse Muscle Atrophy; Disuse Osteoporosis; Bone biology; Parathyroid hormone (PTH); Vitamin D; Leptin; Mechanical stress; Disuse osteoporosis Natural animal model: American black bear (Ursus americanus)Bone homeostasis in the bear: research questions; Disuse Muscle Atrophy; Maintenance of muscle mass; Protein degradation: mechanisms; Animal models; Studies in humans and small mammal hibernators; Humans; Small mammal hibernators; Natural animal model: the American black bear; The bear: a perspective; References; Chapter 5 Ammonia Toxicity; Ammonia Tolerance and Metabolism; Ammonia tolerance; Ammonia metabolism; Brain Ammonia Metabolism; Glutamatergic Neurons; General considerations (Purves et al., 2004) Glutamate, a Neurotransmitter and the "Glutamate-Glutamine" CycleMechanism of Ammonia Neurotoxicity; Neuropathological effects; Effects on Brain Energy Metabolism; Effects on Glutamatergic Synapses; Ammonia and the Fish Central Nervous System; Role of glutamine; Glutamate; Brain energy metabolism; NMDA receptors; Summary; References; Chapter 6 Hypoxia/Ischemia; Cerebral Blood Flow: Its Regulation; Brain Energy Metabolism; Oxygen and Oxygen/Glucose Deprivation and the Brain; General features of neuronal response; Anoxia tolerant mammalian neurons; Neonatal brain; Dorsal vagal neurons Neonatal neurons |
| Record Nr. | UNINA-9910819948803321 |
|
Singer Michael A (Michael Allan), <1940->
|
||
| London, : Imperial College Press, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The minipig in biomedical research / / edited by Peter A. McAnulty. [et al.]
| The minipig in biomedical research / / edited by Peter A. McAnulty. [et al.] |
| Pubbl/distr/stampa | Boca Raton : , : CRC Press, , 2012 |
| Descrizione fisica | 1 online resource (695 p.) |
| Disciplina | 616.0273 |
| Altri autori (Persone) | McAnultyPeter A |
| Soggetto topico |
Swine as laboratory animals
Medicine - Research Biology - Research |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-429-14939-5
1-280-12162-9 9786613525482 1-4398-1119-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | section 1. Origin and management of the minipig -- section 2. Welfare and experimental usage of the minipig -- section 3. Pharmacology and ADME studies in the minipig -- section 4. Safety assessment in the minipig : principle body systems -- section 5. Genetics and immunology -- section 6. Disease models -- section 7. Regulatory perspective and use of the minipig in developing marketed products -- section 8. New horizons and perspectives. |
| Record Nr. | UNINA-9910457892503321 |
| Boca Raton : , : CRC Press, , 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The minipig in biomedical research / / edited by Peter A. McAnulty. [et al.]
| The minipig in biomedical research / / edited by Peter A. McAnulty. [et al.] |
| Pubbl/distr/stampa | Boca Raton : , : CRC Press, , 2012 |
| Descrizione fisica | 1 online resource (695 p.) |
| Disciplina | 616.0273 |
| Altri autori (Persone) | McAnultyPeter A |
| Soggetto topico |
Swine as laboratory animals
Medicine - Research Biology - Research |
| ISBN |
0-429-14939-5
1-280-12162-9 9786613525482 1-4398-1119-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | section 1. Origin and management of the minipig -- section 2. Welfare and experimental usage of the minipig -- section 3. Pharmacology and ADME studies in the minipig -- section 4. Safety assessment in the minipig : principle body systems -- section 5. Genetics and immunology -- section 6. Disease models -- section 7. Regulatory perspective and use of the minipig in developing marketed products -- section 8. New horizons and perspectives. |
| Record Nr. | UNINA-9910781529103321 |
| Boca Raton : , : CRC Press, , 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
