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Quantitative modeling in toxicology [[electronic resource] /] / editors, Kannan Krishnan, Melvin E. Andersen
| Quantitative modeling in toxicology [[electronic resource] /] / editors, Kannan Krishnan, Melvin E. Andersen |
| Pubbl/distr/stampa | Chichester, West Sussex ; ; Hoboken, : John Wiley & Sons, 2010 |
| Descrizione fisica | 1 online resource (505 p.) |
| Disciplina |
615.90015118
615.907 |
| Altri autori (Persone) |
KrishnanKannan <1961->
AndersenMelvin E |
| Soggetto topico |
Toxicology - Mathematical models
Biological models |
| ISBN |
1-282-68958-4
9786612689581 0-470-68626-X 0-470-68670-7 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Quantitative Modeling in Toxicology; Contents; Preface; About the Editors; About the Book; List of Contributors; SECTION 1 INTRODUCTION; 1 Quantitative Modeling in Toxicology: An Introduction; SECTION 2 PHYSIOLOGICALLY-BASED TOXICOKINETIC AND PHARMACOKINETIC (PBPK) MODELING; 2 PBPK Modeling: A Primer; 3 Pharmacokinetic Modeling of Manganese - An Essential Element; 4 Physiologically Based Modeling of Pharmacokinetic Interactions in Chemical Mixtures; 5 Physiological Parameters and Databases for PBPK Modeling; SECTION 3 MODELING TOXICANT-TARGET INTERACTIONS; 6 Modeling Cholinesterase Inhibition
7 Modeling of Protein Induction and Dose-Dependent Hepatic Sequestration8 Bistable Signaling Motifs and Cell Fate Decisions; 9 Ultrasensitive Response Motifs in Biochemical Networks; 10 Gene and Protein Expression - Modeling Nested Motifs in Cellular and Tissue Response Networks; 11 Modeling Liver and Kidney Cytotoxicity; SECTION 4 MODELING TISSUE AND ORGANISM RESPONSES; 12 Computational Model for Iodide Economy and the HPT Axis in the Adult Rat; 13 Two-Stage Clonal Growth Modeling of Cancer; 14 Statistical and Physiological Modeling of the Toxicity of Chemicals in Mixtures 15 (Q)SAR Models of Adverse Responses: Acute Systemic ToxicitySECTION 5 MODEL APPLICATION AND EVALUATION; 16 Modeling Exposures to Chemicals From Multiple Sources and Routes; 17 Probabilistic Reverse Dosimetry Modeling for Interpreting Biomonitoring Data; 18 Quantitative Modeling in Noncancer Risk Assessment; 19 Application of Physiologically Based Pharmacokinetic Modeling in Health Risk Assessment; 20 Uncertainty, Variability, and Sensitivity Analyses in Simulation Models; 21 Evaluation of Quantitative Models in Toxicology: Progress and Challenges; Index |
| Record Nr. | UNINA-9910139509603321 |
| Chichester, West Sussex ; ; Hoboken, : John Wiley & Sons, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Quantitative modeling in toxicology [[electronic resource] /] / editors, Kannan Krishnan, Melvin E. Andersen
| Quantitative modeling in toxicology [[electronic resource] /] / editors, Kannan Krishnan, Melvin E. Andersen |
| Pubbl/distr/stampa | Chichester, West Sussex ; ; Hoboken, : John Wiley & Sons, 2010 |
| Descrizione fisica | 1 online resource (505 p.) |
| Disciplina |
615.90015118
615.907 |
| Altri autori (Persone) |
KrishnanKannan <1961->
AndersenMelvin E |
| Soggetto topico |
Toxicology - Mathematical models
Biological models |
| ISBN |
1-282-68958-4
9786612689581 0-470-68626-X 0-470-68670-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Quantitative Modeling in Toxicology; Contents; Preface; About the Editors; About the Book; List of Contributors; SECTION 1 INTRODUCTION; 1 Quantitative Modeling in Toxicology: An Introduction; SECTION 2 PHYSIOLOGICALLY-BASED TOXICOKINETIC AND PHARMACOKINETIC (PBPK) MODELING; 2 PBPK Modeling: A Primer; 3 Pharmacokinetic Modeling of Manganese - An Essential Element; 4 Physiologically Based Modeling of Pharmacokinetic Interactions in Chemical Mixtures; 5 Physiological Parameters and Databases for PBPK Modeling; SECTION 3 MODELING TOXICANT-TARGET INTERACTIONS; 6 Modeling Cholinesterase Inhibition
7 Modeling of Protein Induction and Dose-Dependent Hepatic Sequestration8 Bistable Signaling Motifs and Cell Fate Decisions; 9 Ultrasensitive Response Motifs in Biochemical Networks; 10 Gene and Protein Expression - Modeling Nested Motifs in Cellular and Tissue Response Networks; 11 Modeling Liver and Kidney Cytotoxicity; SECTION 4 MODELING TISSUE AND ORGANISM RESPONSES; 12 Computational Model for Iodide Economy and the HPT Axis in the Adult Rat; 13 Two-Stage Clonal Growth Modeling of Cancer; 14 Statistical and Physiological Modeling of the Toxicity of Chemicals in Mixtures 15 (Q)SAR Models of Adverse Responses: Acute Systemic ToxicitySECTION 5 MODEL APPLICATION AND EVALUATION; 16 Modeling Exposures to Chemicals From Multiple Sources and Routes; 17 Probabilistic Reverse Dosimetry Modeling for Interpreting Biomonitoring Data; 18 Quantitative Modeling in Noncancer Risk Assessment; 19 Application of Physiologically Based Pharmacokinetic Modeling in Health Risk Assessment; 20 Uncertainty, Variability, and Sensitivity Analyses in Simulation Models; 21 Evaluation of Quantitative Models in Toxicology: Progress and Challenges; Index |
| Record Nr. | UNINA-9910830686103321 |
| Chichester, West Sussex ; ; Hoboken, : John Wiley & Sons, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||