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Comparative pathophysiology and toxicology of cyclooxygenases [[electronic resource] /] / Zaher A. Radi
| Comparative pathophysiology and toxicology of cyclooxygenases [[electronic resource] /] / Zaher A. Radi |
| Autore | Radi Zaher A |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2012 |
| Descrizione fisica | 1 online resource (338 p.) |
| Disciplina | 615.9/5137 |
| Soggetto topico |
Cyclooxygenases - Pathophysiology
Cyclooxygenases - Toxicology |
| ISBN |
1-283-57607-4
9786613888525 1-118-35191-6 1-118-35190-8 1-118-35188-6 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
COMPARATIVE PATHOPHYSIOLOGY AND TOXICOLOGY OF CYCLOOXYGENASES; CONTENTS; PREFACE; INTRODUCTION: DISCOVERY OF CYCLOOXYGENASES AND HISTORICAL PERSPECTIVE; Aspirin; Prostaglandins; Cyclooxygenases; COX-2 Selective NSAIDs; References; CHAPTER 1 GASTROINTESTINAL TRACT; Introduction; Comparative COX-1 and COX-2 Expression in the GI Tract; Effects of ns-NSAIDs on the GI Tract; Effects of Arylpropionic Acid ns-NSAIDs on the GI Tract; Effects of Enolic Acid (Oxicam) ns-NSAIDs on the GI Tract; Effects of Acetic Acid Derivative ns-NSAIDs on the GI Tract
Effects of Aminonicotinic Acid Derivative ns-NSAIDs on the GI TractEffects of Pyrazolone Derivative ns-NSAIDs on the GI Tract; Effects of Salicylic Acid Derivative ns-NSAIDs on the GI Tract; Effects of Anthranilic Acid Derivative ns-NSAIDs on the GI Tract; Effects of COX-1 Inhibitors on the GI Tract; Effects of COX-2 s-NSAIDs on the GI Tract; Pathophysiology and Mechanisms of NSAID-Associated GI Toxicity; Role of Cyclooxygenase Potency; Species Differences in NSAID-Associated Susceptibility to GI Injury; GI Anatomical Differences; Enterohepatic Recirculation and NSAID Toxicity Role of Xenobiotic GlucuronidationAging and Stress and NSAID GI Effects; Disruption of GI Physiological Mucosal Defense Mechanisms; GI Disequilibrium; Effects on Physiological GI Mucosal Cell Renewal Mechanisms After Mucosal Injury; Effects on Leukocyte Adhesion Molecules and Trafficking; Effects of GI Physiological Local pH, Gut Absorption, and Fasting; NSAID Topical Effect-Mediated Injury; Changes in GI Motility, Microcirculation, and Enterobacteria; Decreased Phosphatidylcholine Levels; Impaired Drug Metabolism; Role of Toll-like Receptor (TLR)-4/MyD88 and Enteric Bacteria Role of Uncoupling of Mitochondrial Oxidative PhosphorylationRole of Peroxisome Proliferator-Activated Receptor g; Role of Mitogen-Activated Protein Kinases; NSAID GI Injury-Associated Risk Factors; Conclusions; References; CHAPTER 2 BONE-TENDON-LIGAMENT SYSTEM; Introduction; Comparative Physiological and Anatomical Aspects of the Skeleton; Role of Prostaglandins in Skeleton Metabolism; The Process of Bone Healing and Potential Role of Prostaglandins; Inflammatory Response; Bone Resorption; Bone Formation COX-1 and COX-2 Expression in Bone, Tendon, and Ligament During Repair and in Pathological ConditionsEffects of ns-NSAIDs on Bone Healing; Effects of COX-2 s-NSAIDs on Bone Healing; Effects of ns-NSAIDs on Ligament and Tendon Healing; Effects of COX-2 s-NSAIDs on Ligament and Tendon Healing; Conclusions; References; CHAPTER 3 RENAL SYSTEM; Introduction; Comparative Physiological, Developmental, and Anatomical Aspects of the Renal System; Role of Prostaglandins in the Renal System; COX-1 and COX-2 Expression in the Kidney; Effects of ns-NSAIDs on the Kidney Effects of COX-2 s-NSAIDs on the Kidney |
| Record Nr. | UNINA-9910141413203321 |
Radi Zaher A
|
||
| Hoboken, N.J., : Wiley, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Comparative pathophysiology and toxicology of cyclooxygenases [[electronic resource] /] / Zaher A. Radi
| Comparative pathophysiology and toxicology of cyclooxygenases [[electronic resource] /] / Zaher A. Radi |
| Autore | Radi Zaher A |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2012 |
| Descrizione fisica | 1 online resource (338 p.) |
| Disciplina | 615.9/5137 |
| Soggetto topico |
Cyclooxygenases - Pathophysiology
Cyclooxygenases - Toxicology |
| ISBN |
1-283-57607-4
9786613888525 1-118-35191-6 1-118-35190-8 1-118-35188-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
COMPARATIVE PATHOPHYSIOLOGY AND TOXICOLOGY OF CYCLOOXYGENASES; CONTENTS; PREFACE; INTRODUCTION: DISCOVERY OF CYCLOOXYGENASES AND HISTORICAL PERSPECTIVE; Aspirin; Prostaglandins; Cyclooxygenases; COX-2 Selective NSAIDs; References; CHAPTER 1 GASTROINTESTINAL TRACT; Introduction; Comparative COX-1 and COX-2 Expression in the GI Tract; Effects of ns-NSAIDs on the GI Tract; Effects of Arylpropionic Acid ns-NSAIDs on the GI Tract; Effects of Enolic Acid (Oxicam) ns-NSAIDs on the GI Tract; Effects of Acetic Acid Derivative ns-NSAIDs on the GI Tract
Effects of Aminonicotinic Acid Derivative ns-NSAIDs on the GI TractEffects of Pyrazolone Derivative ns-NSAIDs on the GI Tract; Effects of Salicylic Acid Derivative ns-NSAIDs on the GI Tract; Effects of Anthranilic Acid Derivative ns-NSAIDs on the GI Tract; Effects of COX-1 Inhibitors on the GI Tract; Effects of COX-2 s-NSAIDs on the GI Tract; Pathophysiology and Mechanisms of NSAID-Associated GI Toxicity; Role of Cyclooxygenase Potency; Species Differences in NSAID-Associated Susceptibility to GI Injury; GI Anatomical Differences; Enterohepatic Recirculation and NSAID Toxicity Role of Xenobiotic GlucuronidationAging and Stress and NSAID GI Effects; Disruption of GI Physiological Mucosal Defense Mechanisms; GI Disequilibrium; Effects on Physiological GI Mucosal Cell Renewal Mechanisms After Mucosal Injury; Effects on Leukocyte Adhesion Molecules and Trafficking; Effects of GI Physiological Local pH, Gut Absorption, and Fasting; NSAID Topical Effect-Mediated Injury; Changes in GI Motility, Microcirculation, and Enterobacteria; Decreased Phosphatidylcholine Levels; Impaired Drug Metabolism; Role of Toll-like Receptor (TLR)-4/MyD88 and Enteric Bacteria Role of Uncoupling of Mitochondrial Oxidative PhosphorylationRole of Peroxisome Proliferator-Activated Receptor g; Role of Mitogen-Activated Protein Kinases; NSAID GI Injury-Associated Risk Factors; Conclusions; References; CHAPTER 2 BONE-TENDON-LIGAMENT SYSTEM; Introduction; Comparative Physiological and Anatomical Aspects of the Skeleton; Role of Prostaglandins in Skeleton Metabolism; The Process of Bone Healing and Potential Role of Prostaglandins; Inflammatory Response; Bone Resorption; Bone Formation COX-1 and COX-2 Expression in Bone, Tendon, and Ligament During Repair and in Pathological ConditionsEffects of ns-NSAIDs on Bone Healing; Effects of COX-2 s-NSAIDs on Bone Healing; Effects of ns-NSAIDs on Ligament and Tendon Healing; Effects of COX-2 s-NSAIDs on Ligament and Tendon Healing; Conclusions; References; CHAPTER 3 RENAL SYSTEM; Introduction; Comparative Physiological, Developmental, and Anatomical Aspects of the Renal System; Role of Prostaglandins in the Renal System; COX-1 and COX-2 Expression in the Kidney; Effects of ns-NSAIDs on the Kidney Effects of COX-2 s-NSAIDs on the Kidney |
| Record Nr. | UNINA-9910817130503321 |
|
Radi Zaher A
|
||
| Hoboken, N.J., : Wiley, c2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The utility of proximity-based herbicide exposure assessment in epidemiologic studies of Vietnam veterans [[electronic resource] /] / Committee on Making Best Use of the Agent Orange Exposure Reconstruction Model, Board on Military and Veterans Health, Institute of Medicine of the National Academies
| The utility of proximity-based herbicide exposure assessment in epidemiologic studies of Vietnam veterans [[electronic resource] /] / Committee on Making Best Use of the Agent Orange Exposure Reconstruction Model, Board on Military and Veterans Health, Institute of Medicine of the National Academies |
| Pubbl/distr/stampa | Washington, D.C., : National Academies Press, c2008 |
| Descrizione fisica | 1 online resource (160 p.) |
| Disciplina | 615.9/5137 |
| Soggetto topico |
Agent Orange - Health aspects
Agent Orange - Toxicology Vietnam War, 1961-1975 - Veterans - Health risk assessment - United States Veterans - Health aspects - United States Herbicides - Health aspects |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-30021-7
9786611300210 0-309-11450-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
""Front Matter""; ""Reviewers""; ""Preface""; ""Acknowledgments""; ""Contents""; ""Acronyms and Abbreviations""; ""Summary""; ""1 Introduction and Background""; ""2 The Herbicide Exposure Assessment Model""; ""3 Assessment of the Model and Its Capacity to Produce Useful Exposure Metrics""; ""4 Data for Epidemiologic Studies of Vietnam Veterans""; ""5 Recommendations Regarding Epidemiologic Studies Using the Exposure Assessment Model""; ""Appendixes""; ""Appendix A: Agendas for Information-Gathering Meetings""; ""Appendix B: Exposure Measures in Studies of U.S. Vietnam Veterans""
""Appendix C: Biographical Sketches of Committee Members"" |
| Record Nr. | UNINA-9910454590603321 |
| Washington, D.C., : National Academies Press, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The utility of proximity-based herbicide exposure assessment in epidemiologic studies of Vietnam veterans [[electronic resource] /] / Committee on Making Best Use of the Agent Orange Exposure Reconstruction Model, Board on Military and Veterans Health, Institute of Medicine of the National Academies
| The utility of proximity-based herbicide exposure assessment in epidemiologic studies of Vietnam veterans [[electronic resource] /] / Committee on Making Best Use of the Agent Orange Exposure Reconstruction Model, Board on Military and Veterans Health, Institute of Medicine of the National Academies |
| Pubbl/distr/stampa | Washington, D.C., : National Academies Press, c2008 |
| Descrizione fisica | 1 online resource (160 p.) |
| Disciplina | 615.9/5137 |
| Soggetto topico |
Agent Orange - Health aspects
Agent Orange - Toxicology Vietnam War, 1961-1975 - Veterans - Health risk assessment - United States Veterans - Health aspects - United States Herbicides - Health aspects |
| ISBN |
0-309-17810-X
1-281-30021-7 9786611300210 0-309-11450-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
""Front Matter""; ""Reviewers""; ""Preface""; ""Acknowledgments""; ""Contents""; ""Acronyms and Abbreviations""; ""Summary""; ""1 Introduction and Background""; ""2 The Herbicide Exposure Assessment Model""; ""3 Assessment of the Model and Its Capacity to Produce Useful Exposure Metrics""; ""4 Data for Epidemiologic Studies of Vietnam Veterans""; ""5 Recommendations Regarding Epidemiologic Studies Using the Exposure Assessment Model""; ""Appendixes""; ""Appendix A: Agendas for Information-Gathering Meetings""; ""Appendix B: Exposure Measures in Studies of U.S. Vietnam Veterans""
""Appendix C: Biographical Sketches of Committee Members"" |
| Record Nr. | UNINA-9910782897403321 |
| Washington, D.C., : National Academies Press, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The utility of proximity-based herbicide exposure assessment in epidemiologic studies of Vietnam veterans [[electronic resource] /] / Committee on Making Best Use of the Agent Orange Exposure Reconstruction Model, Board on Military and Veterans Health, Institute of Medicine of the National Academies
| The utility of proximity-based herbicide exposure assessment in epidemiologic studies of Vietnam veterans [[electronic resource] /] / Committee on Making Best Use of the Agent Orange Exposure Reconstruction Model, Board on Military and Veterans Health, Institute of Medicine of the National Academies |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Washington, D.C., : National Academies Press, c2008 |
| Descrizione fisica | 1 online resource (160 p.) |
| Disciplina | 615.9/5137 |
| Soggetto topico |
Agent Orange - Health aspects
Agent Orange - Toxicology Vietnam War, 1961-1975 - Veterans - Health risk assessment - United States Veterans - Health aspects - United States Herbicides - Health aspects |
| ISBN |
0-309-17810-X
1-281-30021-7 9786611300210 0-309-11450-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
""Front Matter""; ""Reviewers""; ""Preface""; ""Acknowledgments""; ""Contents""; ""Acronyms and Abbreviations""; ""Summary""; ""1 Introduction and Background""; ""2 The Herbicide Exposure Assessment Model""; ""3 Assessment of the Model and Its Capacity to Produce Useful Exposure Metrics""; ""4 Data for Epidemiologic Studies of Vietnam Veterans""; ""5 Recommendations Regarding Epidemiologic Studies Using the Exposure Assessment Model""; ""Appendixes""; ""Appendix A: Agendas for Information-Gathering Meetings""; ""Appendix B: Exposure Measures in Studies of U.S. Vietnam Veterans""
""Appendix C: Biographical Sketches of Committee Members"" |
| Record Nr. | UNINA-9910809517603321 |
| Washington, D.C., : National Academies Press, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Veterans and Agent Orange [[electronic resource] ] : update 2006 / / Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides, Board on Population Health and Public Health Practice, Institute of Medicine of the National Academies
| Veterans and Agent Orange [[electronic resource] ] : update 2006 / / Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides, Board on Population Health and Public Health Practice, Institute of Medicine of the National Academies |
| Edizione | [6th biennial update.] |
| Pubbl/distr/stampa | Washington, D.C., : National Academies Press, c2007 |
| Descrizione fisica | 1 online resource (893 p.) |
| Disciplina | 615.9/5137 |
| Soggetto topico |
Agent Orange - Health aspects
Agent Orange - Toxicology Vietnam War, 1961-1975 - Veterans - Health risk assessment - United States |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-281-11021-3
9786611110215 0-309-10709-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front matter; Reviewers; Preface; Contents; Abbreviations and Acronyms; Summary; 1 Introduction; 2 Evaluating the Evidence; 3 Toxicology; 4 Epidemiologic Studies-New Citations for Update 2006 and Background on Repeatedly Studied Populations; 5 Exposure Assessment; 6 Cancer; 7 Reproductive and Developmental Effects; 8 Neurologic Disorders; 9 Other Health Effects; 10 Research Recommendations; APPENDIX A Agendas of Public Meetings Held by the Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Sixth Biennial Update)
APPENDIX B Clarification of Cancer Groupings Used in Reporting Results, with Correspondence to NIOSH Cause-of-Death Codes and ICD Codes for CancersAPPENDIX C Epidemiologic Tables for Chapter 4; APPENDIX D Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Sixth Biennial Update) and Staff Biographies |
| Record Nr. | UNINA-9910454742403321 |
| Washington, D.C., : National Academies Press, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Veterans and Agent Orange [[electronic resource] ] : update 2006 / / Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides, Board on Population Health and Public Health Practice, Institute of Medicine of the National Academies
| Veterans and Agent Orange [[electronic resource] ] : update 2006 / / Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides, Board on Population Health and Public Health Practice, Institute of Medicine of the National Academies |
| Edizione | [6th biennial update.] |
| Pubbl/distr/stampa | Washington, D.C., : National Academies Press, c2007 |
| Descrizione fisica | 1 online resource (893 p.) |
| Disciplina | 615.9/5137 |
| Soggetto topico |
Agent Orange - Health aspects
Agent Orange - Toxicology Vietnam War, 1961-1975 - Veterans - Health risk assessment - United States |
| ISBN |
1-281-11021-3
9786611110215 0-309-10709-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front matter; Reviewers; Preface; Contents; Abbreviations and Acronyms; Summary; 1 Introduction; 2 Evaluating the Evidence; 3 Toxicology; 4 Epidemiologic Studies-New Citations for Update 2006 and Background on Repeatedly Studied Populations; 5 Exposure Assessment; 6 Cancer; 7 Reproductive and Developmental Effects; 8 Neurologic Disorders; 9 Other Health Effects; 10 Research Recommendations; APPENDIX A Agendas of Public Meetings Held by the Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Sixth Biennial Update)
APPENDIX B Clarification of Cancer Groupings Used in Reporting Results, with Correspondence to NIOSH Cause-of-Death Codes and ICD Codes for CancersAPPENDIX C Epidemiologic Tables for Chapter 4; APPENDIX D Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Sixth Biennial Update) and Staff Biographies |
| Record Nr. | UNINA-9910782731503321 |
| Washington, D.C., : National Academies Press, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Veterans and Agent Orange [[electronic resource] ] : update 2006 / / Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides, Board on Population Health and Public Health Practice, Institute of Medicine of the National Academies
| Veterans and Agent Orange [[electronic resource] ] : update 2006 / / Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides, Board on Population Health and Public Health Practice, Institute of Medicine of the National Academies |
| Edizione | [6th biennial update.] |
| Pubbl/distr/stampa | Washington, D.C., : National Academies Press, c2007 |
| Descrizione fisica | 1 online resource (893 p.) |
| Disciplina | 615.9/5137 |
| Soggetto topico |
Agent Orange - Health aspects
Agent Orange - Toxicology Vietnam War, 1961-1975 - Veterans - Health risk assessment - United States |
| ISBN |
1-281-11021-3
9786611110215 0-309-10709-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front matter; Reviewers; Preface; Contents; Abbreviations and Acronyms; Summary; 1 Introduction; 2 Evaluating the Evidence; 3 Toxicology; 4 Epidemiologic Studies-New Citations for Update 2006 and Background on Repeatedly Studied Populations; 5 Exposure Assessment; 6 Cancer; 7 Reproductive and Developmental Effects; 8 Neurologic Disorders; 9 Other Health Effects; 10 Research Recommendations; APPENDIX A Agendas of Public Meetings Held by the Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Sixth Biennial Update)
APPENDIX B Clarification of Cancer Groupings Used in Reporting Results, with Correspondence to NIOSH Cause-of-Death Codes and ICD Codes for CancersAPPENDIX C Epidemiologic Tables for Chapter 4; APPENDIX D Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Sixth Biennial Update) and Staff Biographies |
| Record Nr. | UNINA-9910819745303321 |
| Washington, D.C., : National Academies Press, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Veterans and Agent Orange [[electronic resource] ] : update 2004 / / Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides, Board on Health Promotion and Disease Prevention, Institute of Medicine of the National Academies
| Veterans and Agent Orange [[electronic resource] ] : update 2004 / / Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides, Board on Health Promotion and Disease Prevention, Institute of Medicine of the National Academies |
| Edizione | [5th biennial update.] |
| Pubbl/distr/stampa | Washington, D.C., : National Academies Press, c2005 |
| Descrizione fisica | 1 online resource (680 p.) |
| Disciplina | 615.9/5137 |
| Soggetto topico |
Agent Orange - Health aspects
Agent Orange - Toxicology Vietnam War, 1961-1975 - Veterans - Health risk assessment - United States |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-282-08327-9
9786612083273 0-309-54893-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910450348703321 |
| Washington, D.C., : National Academies Press, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Veterans and Agent Orange [[electronic resource] ] : update 2004 / / Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides, Board on Health Promotion and Disease Prevention, Institute of Medicine of the National Academies
| Veterans and Agent Orange [[electronic resource] ] : update 2004 / / Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides, Board on Health Promotion and Disease Prevention, Institute of Medicine of the National Academies |
| Edizione | [5th biennial update.] |
| Pubbl/distr/stampa | Washington, D.C., : National Academies Press, c2005 |
| Descrizione fisica | 1 online resource (680 p.) |
| Disciplina | 615.9/5137 |
| Soggetto topico |
Agent Orange - Health aspects
Agent Orange - Toxicology Vietnam War, 1961-1975 - Veterans - Health risk assessment - United States |
| ISBN |
0-309-16522-9
1-282-08327-9 9786612083273 0-309-54893-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910783335503321 |
| Washington, D.C., : National Academies Press, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
