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Alternatives to animal testing / / editors, R.E. Hester and R.M. Harrison
Alternatives to animal testing / / editors, R.E. Hester and R.M. Harrison
Edizione [1st ed.]
Pubbl/distr/stampa Cambridge, U.K., : Royal Society of Chemistry, c2006
Descrizione fisica 1 online resource (137 p.)
Disciplina 615.9/07
Altri autori (Persone) HesterR. E (Ronald E.)
HarrisonRoy M. <1948->
Collana ISSN
Issues in environmental science and technology
Soggetto topico Alternative toxicity testing
Animal experimentation
ISBN 1-84755-245-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Alternatives to Animal Testing_publicity; i_iv; v_vi; vii_viii; ix_x; xi_xii; 001_027; 028_052; 053_073; 074_094; 095_118; 119_124
Record Nr. UNINA-9910139801403321
Cambridge, U.K., : Royal Society of Chemistry, c2006
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Analytical toxicology for clinical, forensic, and pharmaceutical chemists / / editors, H. Brandenberger, R.A.A. Maes
Analytical toxicology for clinical, forensic, and pharmaceutical chemists / / editors, H. Brandenberger, R.A.A. Maes
Edizione [Reprint 2010]
Pubbl/distr/stampa Berlin ; ; New York, : W. de Gruyter, 1997
Descrizione fisica 1 online resource (764 p.)
Disciplina 615.9/07
Altri autori (Persone) BrandenbergerH (Hans)
MaesR. A. A <1937-> (Robert A. A.)
Collana Clinical biochemistry
Soggetto topico Analytical toxicology
Poisons - Analysis
ISBN 9781680152180
1680152181
9783110881615
3110881616
Classificazione XI 2500
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Frontmatter -- Part 1 Chapters of General Nature -- 1.1 Emergency Toxicology / Schmidt, M. / Roth, M. -- 1.2 Therapeutic Drug Monitoring / Fraser, A. D. -- 1.3 Special Aspects of Forensic Toxicology / Brandenberger, H. -- 1.4 Analytical Aspects of Doping in Sports / Boer, D. de / Seppenwoolde-Waasdorp, T. J. A. / Maes, R. A. A. -- 1.5 Pharmacokinetics as Applied to Drug and Doping Research / Vree, Τ. B. -- 1.6 The Future of Immunochemical Drug Analysis / Takatori, T. / Nagao, M. -- 1.7 The Future of Instrumental Analysis in Toxicology / Brandenberger, H. -- Part 2 Chapters Concerned with Special Poison Classes -- 2.1 Natural Gases and Vapors / Brandenberger, H. -- 2.2 Carbon Monoxide / Kojima, T. -- 2.3 Determination of Alcohol Levels in the Body / Brandenberger, H. / Brandenberger, R. / Halder, K. -- 2.4 Volatile Hydrocarbons / Nagata, Τ. / Kimura, K. -- 2.5 Volatile Halogenated Compounds / Flanagan, R. J. -- 2.6 Pesticides / Geldmacher-v. Mallinckrodt, M. / Machbert, G. -- 2.7 Glycols / Roth, M. -- 2.8 Inorganic Anions / Roth, M. -- 2.9 Non-Metals of Group 16 / Roth, M. / Pelletier, M. -- 2.10 Metals of Toxicological Significance / Brandenberger, H. / Roth, M. -- Part 3 Toxicological Drug Analysis -- 3.1 Barbiturates / Brandenberger, H. -- 3.2 Benzodiazepines / Schütz, H. -- 3.3 Hypnotics and Sedatives Not Belonging to the Classes of Barbiturates and Benzodiazepines / Brandenberger, H. -- 3.4 Anticonvulsants Not Belonging to the Classes of Barbiturates and Benzodiazepines / Külpmann, W. R. -- 3.5 Neuroleptics / Whelpton, R. -- 3.6 Antidepressants / Braithwaite, R. A. -- 3.7 Beta-Blocking Drugs / Leloux, M. S. -- 3.8 Analgesics, Antipyretics and Non-Steroidal Anti-Inflammatory Agents / Widdop, B. -- 3.9 Antihistamines / Brandenberger, H. -- 3.10 Volatiles Used and Abused as Anesthetics / Brandenberger, H. -- 3.11 Digitalis (= Cardiac) Glycosides / Hallbach, J. / Vogel, H. -- 3.12 Cyclosporins / Holt, D. W. -- 3.13 Anticoagulants / Geldmacher-v. Mallinckrodt, M. -- 3.14 Alkaloids / Kuroiwa, Y. / Yoshida, T. -- 3.15 Stimulants / Boer, D. de / Seppenwoolde-Waasdorp, T. J. A. / Maes, R. A. A. -- 3.16 Designer Drugs / Henderson, G. L. -- Part 4 Blood Level Data -- 4.1 Blood Level Data / Uges, D. R. A. -- Index -- Backmatter
Altri titoli varianti Analytical toxicology
Record Nr. UNINA-9911006496403321
Berlin ; ; New York, : W. de Gruyter, 1997
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Biologic markers in immunotoxicology [[electronic resource] /] / Subcommittee on Immunotoxicology, Committee on Biologic Markers ... [et al.]
Biologic markers in immunotoxicology [[electronic resource] /] / Subcommittee on Immunotoxicology, Committee on Biologic Markers ... [et al.]
Pubbl/distr/stampa Washington, D.C., : National Academy Press, 1992
Descrizione fisica 1 online resource (224 p.)
Disciplina 615.9/07
Soggetto topico Immunotoxicology
Biochemical markers
Soggetto genere / forma Electronic books.
ISBN 1-280-21206-3
9786610212064
0-309-59504-5
0-585-02611-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910454883703321
Washington, D.C., : National Academy Press, 1992
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Biologic markers in immunotoxicology [[electronic resource] /] / Subcommittee on Immunotoxicology, Committee on Biologic Markers ... [et al.]
Biologic markers in immunotoxicology [[electronic resource] /] / Subcommittee on Immunotoxicology, Committee on Biologic Markers ... [et al.]
Pubbl/distr/stampa Washington, D.C., : National Academy Press, 1992
Descrizione fisica 1 online resource (224 p.)
Disciplina 615.9/07
Soggetto topico Immunotoxicology
Biochemical markers
ISBN 1-280-21206-3
9786610212064
0-309-59504-5
0-585-02611-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910778876703321
Washington, D.C., : National Academy Press, 1992
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Biologic markers in immunotoxicology / / Subcommittee on Immunotoxicology, Committee on Biologic Markers ... [et al.]
Biologic markers in immunotoxicology / / Subcommittee on Immunotoxicology, Committee on Biologic Markers ... [et al.]
Edizione [1st ed.]
Pubbl/distr/stampa Washington, D.C., : National Academy Press, 1992
Descrizione fisica 1 online resource (224 p.)
Disciplina 615.9/07
Soggetto topico Immunotoxicology
Biochemical markers
ISBN 9786610212064
9781280212062
1280212063
9780309595049
0309595045
9780585026114
0585026114
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Biologic Markers in Immunotoxicology -- Copyright -- Preface -- Contents -- List of Abbreviations -- Summary -- HYPERSENSITIVITY -- AUTOIMMUNITY -- IMMUNE SUPPRESSION -- BIOASSAYS OF IMMUNOTOXICITY -- CLINICAL APPLICATION OF EXISTING IMMUNOTOXICOLOGIC BIOLOGIC MARKERS -- ROLE OF BIOLOGIC MARKERS OF IMMUNOTOXICITY IN EPIDEMIOLOGY -- INDOOR AIR POLLUTION AND MULTIPLE CHEMICAL SENSITIVITY -- 1 Introduction -- BIOLOGIC MARKERS -- Markers of Exposure -- Markers of Effect -- Markers of Susceptibility -- VALIDITY OF BIOLOGIC MARKERS -- UNCERTAINTY AND RISK -- ETHICAL AND PRACTICAL ISSUES -- STRUCTURE OF THE REPORT -- 2 The Structure and Function Of the Immune System And Mechanisms of Immunotoxicity -- DEVELOPMENT AND FUNCTION OF THE IMMUNE SYSTEM -- MECHANISMS OF CHEMICALLY INDUCED IMMUNE DISEASE -- IgE-Mediated Hypersensitivity -- Complement-Mediated and Immune-Complex-Mediated Injury -- T-Cell Reactions -- EFFECTS OF XENOBIOTICS ON THE IMMUNE SYSTEM -- 3 Biologic Markers For Immune-Mediated Disease -- DEFINITION OF THE PROBLEM -- EXPOSURE THROUGH INHALATION (PULMONARY HYPERSENSITIVITY) -- Occupational Asthma and Rhinitis -- Hypersensitivity Pneumonitis -- EXPOSURE THROUGH INGESTION -- DERMAL EXPOSURE -- Contact Dermatitis -- Photocontact Dermatitis -- Contact Urticaria -- NONSPECIFIC IMMUNE ENHANCEMENT -- BIOLOGIC MARKERS OF HYPERSENSITIVITY -- History and Clinical Signs -- Skin Tests -- Serum IgE Concentration -- In Vitro Assays for Specific Antibody -- In Vitro Assays for Cellular Immunity -- Provocation Challenges -- Bronchoalveolar Lavage -- ANIMAL MODELS FOR DETECTING CHEMICALLY MEDIATED HYPERSENSITIVITY -- Techniques Used in Animal Studies to Determine the Potential of Chemicals to Cause Hypersensitivity -- IgE-and IgG-Mediated Immediate Reactions -- Cytotoxic Reactions -- Antigen-Antibody Complexes -- Contact Hypersensitivity -- SUMMARY.
RECOMMENDATIONS FOR FUTURE RESEARCH -- IgE Sensitivity -- Immunologically Mediated Adverse Reactions -- Local Versus Systemic Immunity -- Sensitizers -- Individual Differences in Sensitivity -- Development of Self-Antigens -- Effects of Exposure Conditions -- Epidemiology -- IGE AND CELLULAR IMMUNITY -- Cellular and Antibody Immunity -- Individual Variability -- Local Versus Systemic Immunity -- Organic Versus Chemical Hypersensitivity -- Effects of Exposure -- Particle Composition -- Chemical Haptens -- 4 Autoimmune Diseases -- DEFINITION OF THE PROBLEM -- INCIDENCE OF AUTOIMMUNE DISEASES -- SUSCEPTIBILITY VERSUS EXPOSURE -- XENOBIOTIC-INDUCED AUTOIMMUNITY -- MECHANISMS -- ANIMAL MODELS -- BIOLOGIC MARKERS -- MAJOR HISTOCOMPATIBILITY COMPLEX -- IMMUNOGLOBULIN ALLOTYPES -- OTHER GENETIC MARKERS -- RATE OF ACETYLATION -- Antinuclear Antibodies -- Specific Tissue Autoantibodies -- Histopathologic Examination -- Immune Complexes -- Complement -- SUMMARY AND RECOMMENDATIONS -- 5 The Capacity of Toxic Agents to Compromise the Immune System (Biologic Markers of Immunosuppression) -- CONSEQUENCES OF IMMUNOSUPPRESSION -- ENVIRONMENTAL CONTAMINANTS -- Human Studies -- Experimental Studies -- Aromatic Hydrocarbons -- Benzene -- Metals -- Complex Mixtures -- Miscellaneous -- INHALATION AND IMMUNOSUPPRESSION -- SKIN AND IMMUNOSUPPRESSION -- MYELOTOXICITY AND IMMUNOSUPPRESSION -- DIFFICULTIES IN ESTABLISHING HUMAN RISK -- FACTORS THAT AFFECT SUSCEPTIBILITY -- Age and External Factors -- Metabolic Differences -- Species Differences -- IMPORTANCE OF MECHANISTIC STUDIES -- SUMMARY -- RECOMMENDATIONS -- 6 Animal Models for Use in Detecting Immunotoxic Potential And Determining Mechanisms of Action -- ANIMAL IMMUNOTOXICITY BIOASSAYS -- Pathologic Evaluation -- Humoral Immunity -- Cellular Immunity -- Nonspecific Immunity -- Bone Marrow -- Host Resistance.
Mechanistic Studies -- ASSAYS OF PULMONARY IMMUNOCOMPETENCE -- ASSAYS REQUIRING ADDITIONAL DEVELOPMENT -- USE OF IMMUNOTOXICITY BIOASSAYS -- Considerations in the Design of Immunotoxicity Testing -- Immunotoxicity as a Basis for Risk Assessment -- SUMMARY -- RECOMMENDATIONS -- 7 Human Immune-System Biologic Markers of Immunotoxicity -- TESTS FOR ASSESSING IMMUNITY -- TESTS OF THE HUMORAL IMMUNE SYSTEM -- Immunoglobulin Concentration -- Antibody Formation -- B Cells -- CELLULAR IMMUNE SYSTEM -- Skin Testing -- In Vitro Stimulation of Lymphocytes -- OTHER TESTS -- OPPORTUNITIES FOR DEVELOPMENT OF BIOLOGIC MARKERS THAT ASSESS THE EFFECT OF IMMUNOTOXICANTS -- Primary Humoral Immune Responses -- Activation Antigens on Lymphocyte Surfaces and in Serum -- Synthesis and Secretion of Lymphokines After Lymphocyte Activation -- Proliferative Responses to Super-Antigens -- Self-HLA-Restricted Cell-Mediated Cytotoxicity -- PROPOSED TESTING REGIMEN -- SUMMARY -- RECOMMENDATIONS -- 8 Application of Biologic Markers Of Immunotoxicity in Epidemiology -- EPIDEMIOLOGY -- CONTRIBUTION OF BIOLOGIC MARKERS TO EPIDEMIOLOGY -- VARIABILITY IN REFERENCE POPULATIONS -- SENSITIVITY, SPECIFICITY, AND PREDICTIVE VALUE -- AUTHENTICATION OF THE EVENT STATUS -- STUDY DESIGN -- REFERENCE POPULATIONS -- CASE STUDIES -- Background -- Study Design -- Results -- Strengths -- Limitations -- Background -- Study Design -- Results -- Strengths -- Limitations -- Background -- Study Design -- Results -- Strengths -- Limitations -- Background -- Study Design -- Results -- Strengths -- Limitations -- RECOMMENDATIONS -- 9 Use of Biologic Markers In Controversial Areas Of Environmental Health -- EVIDENCE OF EXPOSURE TO ORGANIC CHEMICALS -- HEALTH EFFECTS OF INDOOR AIR CONTAMINANTS -- CASE DEFINITIONS OF MULTIPLE-CHEMICAL-SENSITIVITY SYNDROME -- IMMUNE-SYSTEM DYSFUNCTION IN MCS PATIENTS.
BIOLOGIC MARKERS OF SENSITIVITY TO CHEMICALS -- Provocative Challenge -- Skin Tests -- ANTIBODIES TO FORMALDEHYDE-HUMAN SERUM ALBUMIN ADDUCTS -- Avoidance Regimens -- T-cell Helper-to-Suppressor Ratios -- CONCLUSIONS -- RECOMMENDATIONS -- 10 Summary and Recommendations -- CHEMICAL-INDUCED IMMUNOSUPPRESSION IN HUMANS -- Conclusions -- Recommendations -- ROLE OF ENVIRONMENTAL CHEMICAL EXPOSURE IN HYPERSENSITIVITY AND AUTOIMMUNE DISEASES -- Conclusions -- Recommendations -- ANIMAL AND IN VITRO MODELS -- Conclusions -- Recommendations -- MARKERS OF SKIN AND MUCOSAL RESPONSES -- Conclusions -- Recommendations -- EDUCATION AND TRAINING -- Conclusions -- Recommendations -- ENVIRONMENTAL EXPOSURES AND SENSITIVITY SYNDROMES -- Conclusions -- Recommendations -- REFERENCES -- Glossary -- BIOGRAPHIES -- INDEX.
Record Nr. UNINA-9910953846303321
Washington, D.C., : National Academy Press, 1992
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Complex mixtures [[electronic resource] ] : methods for in vivo toxicity testing / / Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council
Complex mixtures [[electronic resource] ] : methods for in vivo toxicity testing / / Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council
Pubbl/distr/stampa Washington, D.C., : National Academy Press, 1988
Descrizione fisica 1 online resource (239 p.)
Disciplina 615.9/07
Soggetto topico Toxicity testing - Evaluation
Toxicology, Experimental
Soggetto genere / forma Electronic books.
ISBN 1-280-22163-1
9786610221639
0-309-55513-2
0-585-14460-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910455427803321
Washington, D.C., : National Academy Press, 1988
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Complex mixtures : methods for in vivo toxicity testing / / Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council
Complex mixtures : methods for in vivo toxicity testing / / Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council
Pubbl/distr/stampa Washington, D.C. : , : National Academy Press, , 1988
Descrizione fisica 1 online resource (xi, 227 pages) : illustrations
Disciplina 615.9/07
Soggetto topico Toxicity testing - Evaluation
Toxicology, Experimental
ISBN 1-280-22163-1
9786610221639
0-309-55513-2
0-585-14460-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto 1 Front Matter; 2 Executive Summary; 3 1. Introduction; 4 2. Concepts for Analyzing Human Exposure to Complex Chemical Mixtures; 5 3. Testing Strategies and Methods; 6 4. Sampling and Chemical Characterization; 7 5. Interpretation and Modeling of Toxicity-Test Results; 8 Appendix A: Origins of Complex Mixtures; 9 Appendix B: Case Studies Establishing Active Agents and/or Interactions in Complex Mixtures; 10 Appendix C: Case Studies on Strategies for Testing the Toxicity of Complex Mixtures; 11 Appendix D: Predicting the Joint Risk of a Misture in Terms of the Component Risks; 12 Appendix E: Cancer Models; 13 Appendix F: Developmental Toxicology; 14 Appendix G: Empirical Modeling of the Toxicity of Mixtures; 15 Index
Record Nr. UNINA-9910778711903321
Washington, D.C. : , : National Academy Press, , 1988
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Complex mixtures : methods for in vivo toxicity testing / / Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council
Complex mixtures : methods for in vivo toxicity testing / / Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council
Edizione [1st ed.]
Pubbl/distr/stampa Washington, D.C., : National Academy Press, 1988
Descrizione fisica 1 online resource (xi, 227 pages) : illustrations
Disciplina 615.9/07
Soggetto topico Toxicity testing - Evaluation
Toxicology, Experimental
ISBN 9786610221639
9781280221637
1280221631
9780309555135
0309555132
9780585144603
0585144605
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto 1 Front Matter; 2 Executive Summary; 3 1. Introduction; 4 2. Concepts for Analyzing Human Exposure to Complex Chemical Mixtures; 5 3. Testing Strategies and Methods; 6 4. Sampling and Chemical Characterization; 7 5. Interpretation and Modeling of Toxicity-Test Results; 8 Appendix A: Origins of Complex Mixtures; 9 Appendix B: Case Studies Establishing Active Agents and/or Interactions in Complex Mixtures; 10 Appendix C: Case Studies on Strategies for Testing the Toxicity of Complex Mixtures; 11 Appendix D: Predicting the Joint Risk of a Misture in Terms of the Component Risks; 12 Appendix E: Cancer Models; 13 Appendix F: Developmental Toxicology; 14 Appendix G: Empirical Modeling of the Toxicity of Mixtures; 15 Index
Record Nr. UNINA-9910966150503321
Washington, D.C., : National Academy Press, 1988
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A History of the Development of Alternatives to Animals in Research and Testing
A History of the Development of Alternatives to Animals in Research and Testing
Autore Parascandola John
Edizione [1st ed.]
Pubbl/distr/stampa West Lafayette, IN : , : Purdue University Press, , 2024
Descrizione fisica 1 online resource (195 pages)
Disciplina 615.9/07
Collana New Directions in the Human-Animal Bond Series
Soggetto topico Alternative toxicity testing - History
Laboratory animals
Soggetto genere / forma Electronic books.
ISBN 9781612499642
1612499643
9781612499659
1612499651
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Alternatives before the three Rs -- Russell, Burch, and the three Rs -- An underwhelming response : the 1960s -- Increased attention to alternatives : the 1970s -- Alternatives come of age : the 1980s.
Record Nr. UNINA-9910872501403321
Parascandola John  
West Lafayette, IN : , : Purdue University Press, , 2024
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Molecular and cellular toxicology : an introduction / / Dr. Lesley A. Stanley
Molecular and cellular toxicology : an introduction / / Dr. Lesley A. Stanley
Autore Stanley Lesley
Pubbl/distr/stampa Chichester, England : , : Wiley Blackwell, , 2014
Descrizione fisica 1 online resource (435 p.)
Disciplina 615.9/07
Soggetto topico Toxicity Tests
Molecular biology
Xenobiotics - toxicity
Soggetto genere / forma Electronic books.
ISBN 1-119-95207-7
1-118-52607-4
1-118-52601-5
1-118-52606-6
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Background to molecular and cellular toxicology -- Individual susceptibility to toxic chemicals -- Omics techniques -- In vitro methods for predicting in vivo toxicity -- In vitro methods for absorption, distribution, metabolism and excretion -- In silico methods and structure-activity relationships -- Transgenic animal models for ADME and systemic toxicity -- Genotoxicity and its measurement -- Oncogenes and the identification of human carcinogens -- Emerging techniques.
Record Nr. UNINA-9910453772803321
Stanley Lesley  
Chichester, England : , : Wiley Blackwell, , 2014
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