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Alternatives to animal testing / / editors, R.E. Hester and R.M. Harrison
| Alternatives to animal testing / / editors, R.E. Hester and R.M. Harrison |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Cambridge, U.K., : Royal Society of Chemistry, c2006 |
| Descrizione fisica | 1 online resource (137 p.) |
| Disciplina | 615.9/07 |
| Altri autori (Persone) |
HesterR. E (Ronald E.)
HarrisonRoy M. <1948-> |
| Collana |
ISSN
Issues in environmental science and technology |
| Soggetto topico |
Alternative toxicity testing
Animal experimentation |
| ISBN | 1-84755-245-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Alternatives to Animal Testing_publicity; i_iv; v_vi; vii_viii; ix_x; xi_xii; 001_027; 028_052; 053_073; 074_094; 095_118; 119_124 |
| Record Nr. | UNINA-9910139801403321 |
| Cambridge, U.K., : Royal Society of Chemistry, c2006 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Biologic markers in immunotoxicology [[electronic resource] /] / Subcommittee on Immunotoxicology, Committee on Biologic Markers ... [et al.]
| Biologic markers in immunotoxicology [[electronic resource] /] / Subcommittee on Immunotoxicology, Committee on Biologic Markers ... [et al.] |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1992 |
| Descrizione fisica | 1 online resource (224 p.) |
| Disciplina | 615.9/07 |
| Soggetto topico |
Immunotoxicology
Biochemical markers |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-21206-3
9786610212064 0-309-59504-5 0-585-02611-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910454883703321 |
| Washington, D.C., : National Academy Press, 1992 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biologic markers in immunotoxicology [[electronic resource] /] / Subcommittee on Immunotoxicology, Committee on Biologic Markers ... [et al.]
| Biologic markers in immunotoxicology [[electronic resource] /] / Subcommittee on Immunotoxicology, Committee on Biologic Markers ... [et al.] |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1992 |
| Descrizione fisica | 1 online resource (224 p.) |
| Disciplina | 615.9/07 |
| Soggetto topico |
Immunotoxicology
Biochemical markers |
| ISBN |
1-280-21206-3
9786610212064 0-309-59504-5 0-585-02611-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910778876703321 |
| Washington, D.C., : National Academy Press, 1992 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biologic markers in immunotoxicology / / Subcommittee on Immunotoxicology, Committee on Biologic Markers ... [et al.]
| Biologic markers in immunotoxicology / / Subcommittee on Immunotoxicology, Committee on Biologic Markers ... [et al.] |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1992 |
| Descrizione fisica | 1 online resource (224 p.) |
| Disciplina | 615.9/07 |
| Soggetto topico |
Immunotoxicology
Biochemical markers |
| ISBN |
1-280-21206-3
9786610212064 0-309-59504-5 0-585-02611-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Biologic Markers in Immunotoxicology -- Copyright -- Preface -- Contents -- List of Abbreviations -- Summary -- HYPERSENSITIVITY -- AUTOIMMUNITY -- IMMUNE SUPPRESSION -- BIOASSAYS OF IMMUNOTOXICITY -- CLINICAL APPLICATION OF EXISTING IMMUNOTOXICOLOGIC BIOLOGIC MARKERS -- ROLE OF BIOLOGIC MARKERS OF IMMUNOTOXICITY IN EPIDEMIOLOGY -- INDOOR AIR POLLUTION AND MULTIPLE CHEMICAL SENSITIVITY -- 1 Introduction -- BIOLOGIC MARKERS -- Markers of Exposure -- Markers of Effect -- Markers of Susceptibility -- VALIDITY OF BIOLOGIC MARKERS -- UNCERTAINTY AND RISK -- ETHICAL AND PRACTICAL ISSUES -- STRUCTURE OF THE REPORT -- 2 The Structure and Function Of the Immune System And Mechanisms of Immunotoxicity -- DEVELOPMENT AND FUNCTION OF THE IMMUNE SYSTEM -- MECHANISMS OF CHEMICALLY INDUCED IMMUNE DISEASE -- IgE-Mediated Hypersensitivity -- Complement-Mediated and Immune-Complex-Mediated Injury -- T-Cell Reactions -- EFFECTS OF XENOBIOTICS ON THE IMMUNE SYSTEM -- 3 Biologic Markers For Immune-Mediated Disease -- DEFINITION OF THE PROBLEM -- EXPOSURE THROUGH INHALATION (PULMONARY HYPERSENSITIVITY) -- Occupational Asthma and Rhinitis -- Hypersensitivity Pneumonitis -- EXPOSURE THROUGH INGESTION -- DERMAL EXPOSURE -- Contact Dermatitis -- Photocontact Dermatitis -- Contact Urticaria -- NONSPECIFIC IMMUNE ENHANCEMENT -- BIOLOGIC MARKERS OF HYPERSENSITIVITY -- History and Clinical Signs -- Skin Tests -- Serum IgE Concentration -- In Vitro Assays for Specific Antibody -- In Vitro Assays for Cellular Immunity -- Provocation Challenges -- Bronchoalveolar Lavage -- ANIMAL MODELS FOR DETECTING CHEMICALLY MEDIATED HYPERSENSITIVITY -- Techniques Used in Animal Studies to Determine the Potential of Chemicals to Cause Hypersensitivity -- IgE-and IgG-Mediated Immediate Reactions -- Cytotoxic Reactions -- Antigen-Antibody Complexes -- Contact Hypersensitivity -- SUMMARY.
RECOMMENDATIONS FOR FUTURE RESEARCH -- IgE Sensitivity -- Immunologically Mediated Adverse Reactions -- Local Versus Systemic Immunity -- Sensitizers -- Individual Differences in Sensitivity -- Development of Self-Antigens -- Effects of Exposure Conditions -- Epidemiology -- IGE AND CELLULAR IMMUNITY -- Cellular and Antibody Immunity -- Individual Variability -- Local Versus Systemic Immunity -- Organic Versus Chemical Hypersensitivity -- Effects of Exposure -- Particle Composition -- Chemical Haptens -- 4 Autoimmune Diseases -- DEFINITION OF THE PROBLEM -- INCIDENCE OF AUTOIMMUNE DISEASES -- SUSCEPTIBILITY VERSUS EXPOSURE -- XENOBIOTIC-INDUCED AUTOIMMUNITY -- MECHANISMS -- ANIMAL MODELS -- BIOLOGIC MARKERS -- MAJOR HISTOCOMPATIBILITY COMPLEX -- IMMUNOGLOBULIN ALLOTYPES -- OTHER GENETIC MARKERS -- RATE OF ACETYLATION -- Antinuclear Antibodies -- Specific Tissue Autoantibodies -- Histopathologic Examination -- Immune Complexes -- Complement -- SUMMARY AND RECOMMENDATIONS -- 5 The Capacity of Toxic Agents to Compromise the Immune System (Biologic Markers of Immunosuppression) -- CONSEQUENCES OF IMMUNOSUPPRESSION -- ENVIRONMENTAL CONTAMINANTS -- Human Studies -- Experimental Studies -- Aromatic Hydrocarbons -- Benzene -- Metals -- Complex Mixtures -- Miscellaneous -- INHALATION AND IMMUNOSUPPRESSION -- SKIN AND IMMUNOSUPPRESSION -- MYELOTOXICITY AND IMMUNOSUPPRESSION -- DIFFICULTIES IN ESTABLISHING HUMAN RISK -- FACTORS THAT AFFECT SUSCEPTIBILITY -- Age and External Factors -- Metabolic Differences -- Species Differences -- IMPORTANCE OF MECHANISTIC STUDIES -- SUMMARY -- RECOMMENDATIONS -- 6 Animal Models for Use in Detecting Immunotoxic Potential And Determining Mechanisms of Action -- ANIMAL IMMUNOTOXICITY BIOASSAYS -- Pathologic Evaluation -- Humoral Immunity -- Cellular Immunity -- Nonspecific Immunity -- Bone Marrow -- Host Resistance. Mechanistic Studies -- ASSAYS OF PULMONARY IMMUNOCOMPETENCE -- ASSAYS REQUIRING ADDITIONAL DEVELOPMENT -- USE OF IMMUNOTOXICITY BIOASSAYS -- Considerations in the Design of Immunotoxicity Testing -- Immunotoxicity as a Basis for Risk Assessment -- SUMMARY -- RECOMMENDATIONS -- 7 Human Immune-System Biologic Markers of Immunotoxicity -- TESTS FOR ASSESSING IMMUNITY -- TESTS OF THE HUMORAL IMMUNE SYSTEM -- Immunoglobulin Concentration -- Antibody Formation -- B Cells -- CELLULAR IMMUNE SYSTEM -- Skin Testing -- In Vitro Stimulation of Lymphocytes -- OTHER TESTS -- OPPORTUNITIES FOR DEVELOPMENT OF BIOLOGIC MARKERS THAT ASSESS THE EFFECT OF IMMUNOTOXICANTS -- Primary Humoral Immune Responses -- Activation Antigens on Lymphocyte Surfaces and in Serum -- Synthesis and Secretion of Lymphokines After Lymphocyte Activation -- Proliferative Responses to Super-Antigens -- Self-HLA-Restricted Cell-Mediated Cytotoxicity -- PROPOSED TESTING REGIMEN -- SUMMARY -- RECOMMENDATIONS -- 8 Application of Biologic Markers Of Immunotoxicity in Epidemiology -- EPIDEMIOLOGY -- CONTRIBUTION OF BIOLOGIC MARKERS TO EPIDEMIOLOGY -- VARIABILITY IN REFERENCE POPULATIONS -- SENSITIVITY, SPECIFICITY, AND PREDICTIVE VALUE -- AUTHENTICATION OF THE EVENT STATUS -- STUDY DESIGN -- REFERENCE POPULATIONS -- CASE STUDIES -- Background -- Study Design -- Results -- Strengths -- Limitations -- Background -- Study Design -- Results -- Strengths -- Limitations -- Background -- Study Design -- Results -- Strengths -- Limitations -- Background -- Study Design -- Results -- Strengths -- Limitations -- RECOMMENDATIONS -- 9 Use of Biologic Markers In Controversial Areas Of Environmental Health -- EVIDENCE OF EXPOSURE TO ORGANIC CHEMICALS -- HEALTH EFFECTS OF INDOOR AIR CONTAMINANTS -- CASE DEFINITIONS OF MULTIPLE-CHEMICAL-SENSITIVITY SYNDROME -- IMMUNE-SYSTEM DYSFUNCTION IN MCS PATIENTS. BIOLOGIC MARKERS OF SENSITIVITY TO CHEMICALS -- Provocative Challenge -- Skin Tests -- ANTIBODIES TO FORMALDEHYDE-HUMAN SERUM ALBUMIN ADDUCTS -- Avoidance Regimens -- T-cell Helper-to-Suppressor Ratios -- CONCLUSIONS -- RECOMMENDATIONS -- 10 Summary and Recommendations -- CHEMICAL-INDUCED IMMUNOSUPPRESSION IN HUMANS -- Conclusions -- Recommendations -- ROLE OF ENVIRONMENTAL CHEMICAL EXPOSURE IN HYPERSENSITIVITY AND AUTOIMMUNE DISEASES -- Conclusions -- Recommendations -- ANIMAL AND IN VITRO MODELS -- Conclusions -- Recommendations -- MARKERS OF SKIN AND MUCOSAL RESPONSES -- Conclusions -- Recommendations -- EDUCATION AND TRAINING -- Conclusions -- Recommendations -- ENVIRONMENTAL EXPOSURES AND SENSITIVITY SYNDROMES -- Conclusions -- Recommendations -- REFERENCES -- Glossary -- BIOGRAPHIES -- INDEX. |
| Record Nr. | UNINA-9910817058503321 |
| Washington, D.C., : National Academy Press, 1992 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Complex mixtures [[electronic resource] ] : methods for in vivo toxicity testing / / Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council
| Complex mixtures [[electronic resource] ] : methods for in vivo toxicity testing / / Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council |
| Pubbl/distr/stampa | Washington, D.C., : National Academy Press, 1988 |
| Descrizione fisica | 1 online resource (239 p.) |
| Disciplina | 615.9/07 |
| Soggetto topico |
Toxicity testing - Evaluation
Toxicology, Experimental |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-22163-1
9786610221639 0-309-55513-2 0-585-14460-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910455427803321 |
| Washington, D.C., : National Academy Press, 1988 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Complex mixtures : methods for in vivo toxicity testing / / Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council
| Complex mixtures : methods for in vivo toxicity testing / / Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council |
| Pubbl/distr/stampa | Washington, D.C. : , : National Academy Press, , 1988 |
| Descrizione fisica | 1 online resource (xi, 227 pages) : illustrations |
| Disciplina | 615.9/07 |
| Soggetto topico |
Toxicity testing - Evaluation
Toxicology, Experimental |
| ISBN |
1-280-22163-1
9786610221639 0-309-55513-2 0-585-14460-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1 Front Matter; 2 Executive Summary; 3 1. Introduction; 4 2. Concepts for Analyzing Human Exposure to Complex Chemical Mixtures; 5 3. Testing Strategies and Methods; 6 4. Sampling and Chemical Characterization; 7 5. Interpretation and Modeling of Toxicity-Test Results; 8 Appendix A: Origins of Complex Mixtures; 9 Appendix B: Case Studies Establishing Active Agents and/or Interactions in Complex Mixtures; 10 Appendix C: Case Studies on Strategies for Testing the Toxicity of Complex Mixtures; 11 Appendix D: Predicting the Joint Risk of a Misture in Terms of the Component Risks; 12 Appendix E: Cancer Models; 13 Appendix F: Developmental Toxicology; 14 Appendix G: Empirical Modeling of the Toxicity of Mixtures; 15 Index |
| Record Nr. | UNINA-9910778711903321 |
| Washington, D.C. : , : National Academy Press, , 1988 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Complex mixtures : methods for in vivo toxicity testing / / Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council
| Complex mixtures : methods for in vivo toxicity testing / / Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council |
| Pubbl/distr/stampa | Washington, D.C. : , : National Academy Press, , 1988 |
| Descrizione fisica | 1 online resource (xi, 227 pages) : illustrations |
| Disciplina | 615.9/07 |
| Soggetto topico |
Toxicity testing - Evaluation
Toxicology, Experimental |
| ISBN |
1-280-22163-1
9786610221639 0-309-55513-2 0-585-14460-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1 Front Matter; 2 Executive Summary; 3 1. Introduction; 4 2. Concepts for Analyzing Human Exposure to Complex Chemical Mixtures; 5 3. Testing Strategies and Methods; 6 4. Sampling and Chemical Characterization; 7 5. Interpretation and Modeling of Toxicity-Test Results; 8 Appendix A: Origins of Complex Mixtures; 9 Appendix B: Case Studies Establishing Active Agents and/or Interactions in Complex Mixtures; 10 Appendix C: Case Studies on Strategies for Testing the Toxicity of Complex Mixtures; 11 Appendix D: Predicting the Joint Risk of a Misture in Terms of the Component Risks; 12 Appendix E: Cancer Models; 13 Appendix F: Developmental Toxicology; 14 Appendix G: Empirical Modeling of the Toxicity of Mixtures; 15 Index |
| Record Nr. | UNINA-9910828411103321 |
| Washington, D.C. : , : National Academy Press, , 1988 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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A History of the Development of Alternatives to Animals in Research and Testing
| A History of the Development of Alternatives to Animals in Research and Testing |
| Autore | Parascandola John |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | West Lafayette, IN : , : Purdue University Press, , 2024 |
| Descrizione fisica | 1 online resource (195 pages) |
| Disciplina | 615.9/07 |
| Collana | New Directions in the Human-Animal Bond Series |
| Soggetto topico |
Alternative toxicity testing - History
Laboratory animals |
| ISBN |
1-61249-964-3
1-61249-965-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Alternatives before the three Rs -- Russell, Burch, and the three Rs -- An underwhelming response : the 1960s -- Increased attention to alternatives : the 1970s -- Alternatives come of age : the 1980s. |
| Record Nr. | UNINA-9910872501403321 |
Parascandola John
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| West Lafayette, IN : , : Purdue University Press, , 2024 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular and cellular toxicology : an introduction / / Dr. Lesley A. Stanley
| Molecular and cellular toxicology : an introduction / / Dr. Lesley A. Stanley |
| Autore | Stanley Lesley |
| Pubbl/distr/stampa | Chichester, England : , : Wiley Blackwell, , 2014 |
| Descrizione fisica | 1 online resource (435 p.) |
| Disciplina | 615.9/07 |
| Soggetto topico |
Toxicity Tests
Molecular biology Xenobiotics - toxicity |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-119-95207-7
1-118-52607-4 1-118-52601-5 1-118-52606-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Background to molecular and cellular toxicology -- Individual susceptibility to toxic chemicals -- Omics techniques -- In vitro methods for predicting in vivo toxicity -- In vitro methods for absorption, distribution, metabolism and excretion -- In silico methods and structure-activity relationships -- Transgenic animal models for ADME and systemic toxicity -- Genotoxicity and its measurement -- Oncogenes and the identification of human carcinogens -- Emerging techniques. |
| Record Nr. | UNINA-9910453772803321 |
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Stanley Lesley
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| Chichester, England : , : Wiley Blackwell, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular and cellular toxicology : an introduction / / Dr. Lesley A. Stanley
| Molecular and cellular toxicology : an introduction / / Dr. Lesley A. Stanley |
| Autore | Stanley Lesley |
| Pubbl/distr/stampa | Chichester, England : , : Wiley Blackwell, , 2014 |
| Descrizione fisica | 1 online resource (435 p.) |
| Disciplina | 615.9/07 |
| Collana | New York Academy of Sciences |
| Soggetto topico |
Toxicity testing
Molecular biology Xenobiotics - toxicity |
| ISBN |
1-119-95207-7
1-118-52607-4 1-118-52601-5 1-118-52606-6 |
| Classificazione |
491.59
QV 602 615.9/07 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Background to molecular and cellular toxicology -- Individual susceptibility to toxic chemicals -- Omics techniques -- In vitro methods for predicting in vivo toxicity -- In vitro methods for absorption, distribution, metabolism and excretion -- In silico methods and structure-activity relationships -- Transgenic animal models for ADME and systemic toxicity -- Genotoxicity and its measurement -- Oncogenes and the identification of human carcinogens -- Emerging techniques. |
| Record Nr. | UNINA-9910790941303321 |
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Stanley Lesley
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| Chichester, England : , : Wiley Blackwell, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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