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Advances in toxicology and risk assessment of nanomaterials and emerging contaminants / / Liang-Hong Guo, Monika Mortimer, editors
| Advances in toxicology and risk assessment of nanomaterials and emerging contaminants / / Liang-Hong Guo, Monika Mortimer, editors |
| Pubbl/distr/stampa | Singapore : , : Springer, , [2022] |
| Descrizione fisica | 1 online resource (375 pages) |
| Disciplina | 615.7040724 |
| Soggetto topico |
Nanostructured materials - Toxicology
Nanostructured materials - Transport properties |
| ISBN |
981-16-9115-0
981-16-9116-9 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910743346903321 |
| Singapore : , : Springer, , [2022] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Nanomaterial Biointeractions at the Cellular, Organismal and System Levels / / edited by Nilesh Sharma, Shivendra Sahi
| Nanomaterial Biointeractions at the Cellular, Organismal and System Levels / / edited by Nilesh Sharma, Shivendra Sahi |
| Edizione | [1st ed. 2021.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2021 |
| Descrizione fisica | 1 online resource (xvii, 459 pages) : illustrations |
| Disciplina | 615.7040724 |
| Collana | Nanotechnology in the Life Sciences |
| Soggetto topico |
Plants - Development
Nanotechnology Botanical chemistry Plant biotechnology Biochemistry Plants - Evolution Plant Development Plant Biochemistry Plant Biotechnology Chemical Biology Plant Evolution Materials nanoestructurats Toxicologia |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-65792-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface -- 1. Pros and cons of metal oxide nanomaterial use in Australian broadacre agriculture -- 2. Accumulation of metal-oxide nanomaterials by unicellular algae and their transfer within marine and aquatic food-webs -- 3. The chemistry behind nanotoxicological processes in living systems -- 4. Nanoparticles and Sustainable Agriculture: Concepts and controversies -- 5. Elucidating the role of nano-bio interactions in nanotoxicology -- 6. Potential of nonotechnology for increasing micronutrients fertilizer use efficiency in crop production -- 7. Fate and effect of engineered nanomaterials in agricultural systems -- 8. Effects of engineered nanomaterials on the alleviation of abiotic stress in plants -- 9. Titanium Dioxide Nanoparticles Interactions: I. In vitro Studies in Animal Cells -- 10. Titanium Dioxide Nanoparticles Interactions: II. An Analysis Based on Animal Organ System -- 11. Engineered nanomaterials toxicity at different growth phases of agricultural species -- 12. Nanotoxicology Research Based on Drosophila Models -- 13. Caenorhabditis elegans – A unique animal model to study soil–nanoparticles–organism interactions -- 14. Cytotoxic efficacy of green engineered biomolecules-loaded silver nanoparticles on HeLa Cell line using leaf extracts of Leucas aspera -- 15. Zebrafish models of nanotoxicity – A comprehensive account -- 16. Responses of terrestrial plants to metallic nanomaterial exposure – a Mechanistic analysis -- Index. . |
| Record Nr. | UNINA-9910483615903321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Physiologically based pharmacokinetic modeling [[electronic resource] ] : science and applications / / edited by Micaela B. Reddy ... [et al.]
| Physiologically based pharmacokinetic modeling [[electronic resource] ] : science and applications / / edited by Micaela B. Reddy ... [et al.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2005 |
| Descrizione fisica | 1 online resource (442 p.) |
| Disciplina |
615.7040724
615/.7 |
| Altri autori (Persone) | ReddyMicaela B |
| Soggetto topico |
Pharmacokinetics
Xenobiotics Toxicology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-27583-9
9786610275830 0-470-24616-2 0-471-47876-8 0-471-47877-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING; CONTENTS; PREFACE; ACKNOWLEDGMENTS; CONTRIBUTORS; CHAPTER 1 INTRODUCTION: A HISTORICAL PERSPECTIVE OF THE DEVELOPMENT AND APPLICATIONS OF PBPK MODELS; 1.1 Introduction; 1.2 A Historical Perspective; 1.2.1 Responses to Inhaled Compounds; 1.2.2 Pharmaceutical Applications; 1.2.3 Occupational and Environmental Applications; 1.2.4 Digital Computation and PBPK Modeling; 1.3 Expansion of PBPK Model Applications; 1.3.1 PBPK Models for Tissue Dosimetry from Secondary Data; 1.3.2 Biological Mechanisms Underlying Pharmacokinetic Behaviors
1.3.3 Chemicals as Probes of Biological Processes1.3.4 Risk Assessment Applications; 1.3.5 PBPK Models as Repository of Mechanistic Data on Distribution and Response; 1.4 Summary; Notation; References; PART I PBPK MODELING FOR VOLATILE ORGANIC COMPOUNDS; CHAPTER 2 HALOGENATED ALKANES; 2.1 Introduction; 2.2 PBPK Model Development for Volatile Organics; 2.2.1 Model Formulation; 2.2.2 Model Equations; 2.2.3 Model Parameterization; 2.2.4 Model Calculations; 2.3 Experimental Methods Demonstrated for Groups of Chemicals; 2.4 PBPK Models for Halogenated Alkanes; 2.4.1 Anesthetic Gases 2.4.2 Chlorofluorocarbons (CFCs), Refrigerants, and Halons2.4.3 Halogenated Alkanes; 2.5 Summary; Notation; References; CHAPTER 3 HALOGENATED ALKENES; 3.1 Introduction; 3.2 The Chloroethylenes: Background; 3.3 Review of PBPK Models; 3.3.1 Vinyl Chloride (VC); 3.3.2 Vinyl Fluoride (VF); 3.3.3 cis-1,2-Dichloroethylene (cDCE) and trans-1,2-Dichloroethylene (tDCE); 3.3.4 Vinylidene Chloride (VDC); 3.3.5 Trichloroethylene (TCE); 3.3.6 Tetrachloroethylene (PERC); 3.3.7 Allyl Chloride (AC); 3.3.8 b-Chloroprene (CD); 3.3.9 Hexachlorobutadiene, HCB; 3.4 Summary; Notation; References CHAPTER 4 ALKENE AND AROMATIC COMPOUNDS4.1 Introduction; 4.2 PK and Pharmacodynamic Properties Important in PBPK Model Development for Aromatic and Alkene Compounds; 4.2.1 Metabolism and Mode of Action; 4.2.2 Model Structures; 4.2.3 PK Differences; 4.2.4 Extrahepatic Metabolism and Transport of Metabolites; 4.2.5 GSH Conjugation; 4.2.6 Endogenous Production; 4.2.7 Reactivity with DNA and Protein; 4.2.8 Inhibition of Second Oxidative Steps; 4.2.9 Variability and PK Differences; 4.2.10 Subcompartments in PBPK Models; 4.2.11 "Privileged Access" of Epoxide Hydratase to Epoxide Substrates 4.3 Review of Aromatic and Alkene PBPK Models4.3.1 Benzene-A Known Human Carcinogen with an Uncertain Mode of Action; 4.3.2 Styrene-Early PBPK Models; 4.3.3 1,3-Butadiene; 4.3.4 Isoprene; 4.3.5 Ethylene, Propylene, and Their Oxides; 4.3.6 Naphthalene and Other PAHs; 4.3.7 Halobenzenes; 4.3.8 Miscellaneous Related Compounds; 4.4 Summary; Notation; References; CHAPTER 5 REACTIVE VAPORS IN THE NASAL CAVITY; 5.1 Introduction; 5.1.1 Nasal Effects and Risk Assessment; 5.1.2 General Models for Nasal Uptake; 5.2 No Air-Phase Models; 5.2.1 The "Perfused Nose" Model; 5.2.2 Vinyl Acetate 5.3 Creating the Air-Phase Compartments |
| Record Nr. | UNINA-9910143555503321 |
| Hoboken, N.J., : Wiley-Interscience, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Physiologically based pharmacokinetic modeling [[electronic resource] ] : science and applications / / edited by Micaela B. Reddy ... [et al.]
| Physiologically based pharmacokinetic modeling [[electronic resource] ] : science and applications / / edited by Micaela B. Reddy ... [et al.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2005 |
| Descrizione fisica | 1 online resource (442 p.) |
| Disciplina |
615.7040724
615/.7 |
| Altri autori (Persone) | ReddyMicaela B |
| Soggetto topico |
Pharmacokinetics
Xenobiotics Toxicology |
| ISBN |
1-280-27583-9
9786610275830 0-470-24616-2 0-471-47876-8 0-471-47877-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING; CONTENTS; PREFACE; ACKNOWLEDGMENTS; CONTRIBUTORS; CHAPTER 1 INTRODUCTION: A HISTORICAL PERSPECTIVE OF THE DEVELOPMENT AND APPLICATIONS OF PBPK MODELS; 1.1 Introduction; 1.2 A Historical Perspective; 1.2.1 Responses to Inhaled Compounds; 1.2.2 Pharmaceutical Applications; 1.2.3 Occupational and Environmental Applications; 1.2.4 Digital Computation and PBPK Modeling; 1.3 Expansion of PBPK Model Applications; 1.3.1 PBPK Models for Tissue Dosimetry from Secondary Data; 1.3.2 Biological Mechanisms Underlying Pharmacokinetic Behaviors
1.3.3 Chemicals as Probes of Biological Processes1.3.4 Risk Assessment Applications; 1.3.5 PBPK Models as Repository of Mechanistic Data on Distribution and Response; 1.4 Summary; Notation; References; PART I PBPK MODELING FOR VOLATILE ORGANIC COMPOUNDS; CHAPTER 2 HALOGENATED ALKANES; 2.1 Introduction; 2.2 PBPK Model Development for Volatile Organics; 2.2.1 Model Formulation; 2.2.2 Model Equations; 2.2.3 Model Parameterization; 2.2.4 Model Calculations; 2.3 Experimental Methods Demonstrated for Groups of Chemicals; 2.4 PBPK Models for Halogenated Alkanes; 2.4.1 Anesthetic Gases 2.4.2 Chlorofluorocarbons (CFCs), Refrigerants, and Halons2.4.3 Halogenated Alkanes; 2.5 Summary; Notation; References; CHAPTER 3 HALOGENATED ALKENES; 3.1 Introduction; 3.2 The Chloroethylenes: Background; 3.3 Review of PBPK Models; 3.3.1 Vinyl Chloride (VC); 3.3.2 Vinyl Fluoride (VF); 3.3.3 cis-1,2-Dichloroethylene (cDCE) and trans-1,2-Dichloroethylene (tDCE); 3.3.4 Vinylidene Chloride (VDC); 3.3.5 Trichloroethylene (TCE); 3.3.6 Tetrachloroethylene (PERC); 3.3.7 Allyl Chloride (AC); 3.3.8 b-Chloroprene (CD); 3.3.9 Hexachlorobutadiene, HCB; 3.4 Summary; Notation; References CHAPTER 4 ALKENE AND AROMATIC COMPOUNDS4.1 Introduction; 4.2 PK and Pharmacodynamic Properties Important in PBPK Model Development for Aromatic and Alkene Compounds; 4.2.1 Metabolism and Mode of Action; 4.2.2 Model Structures; 4.2.3 PK Differences; 4.2.4 Extrahepatic Metabolism and Transport of Metabolites; 4.2.5 GSH Conjugation; 4.2.6 Endogenous Production; 4.2.7 Reactivity with DNA and Protein; 4.2.8 Inhibition of Second Oxidative Steps; 4.2.9 Variability and PK Differences; 4.2.10 Subcompartments in PBPK Models; 4.2.11 "Privileged Access" of Epoxide Hydratase to Epoxide Substrates 4.3 Review of Aromatic and Alkene PBPK Models4.3.1 Benzene-A Known Human Carcinogen with an Uncertain Mode of Action; 4.3.2 Styrene-Early PBPK Models; 4.3.3 1,3-Butadiene; 4.3.4 Isoprene; 4.3.5 Ethylene, Propylene, and Their Oxides; 4.3.6 Naphthalene and Other PAHs; 4.3.7 Halobenzenes; 4.3.8 Miscellaneous Related Compounds; 4.4 Summary; Notation; References; CHAPTER 5 REACTIVE VAPORS IN THE NASAL CAVITY; 5.1 Introduction; 5.1.1 Nasal Effects and Risk Assessment; 5.1.2 General Models for Nasal Uptake; 5.2 No Air-Phase Models; 5.2.1 The "Perfused Nose" Model; 5.2.2 Vinyl Acetate 5.3 Creating the Air-Phase Compartments |
| Record Nr. | UNINA-9910830979003321 |
| Hoboken, N.J., : Wiley-Interscience, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Preclinical development handbook Toxicology [[electronic resource] /] / [edited by] Shayne Cox Gad
| Preclinical development handbook Toxicology [[electronic resource] /] / [edited by] Shayne Cox Gad |
| Pubbl/distr/stampa | Hoboken, NJ, : Wiley-Interscience, c2008 |
| Descrizione fisica | 1 online resource (1075 p.) |
| Disciplina |
615.7
615.7040724 615.9 |
| Altri autori (Persone) | GadShayne C. <1948-> |
| Collana | Pharmaceutical Development Series |
| Soggetto topico |
Drugs - Toxicology
Drugs - Toxicity testing |
| ISBN |
1-281-23742-6
9786611237424 0-470-24905-6 0-470-24904-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
PRECLINICAL DEVELOPMENT HANDBOOK Toxicology; CONTRIBUTORS; CONTENTS; Preface; 1 Preclinical Drug Development Planning; 2 Use of Project Teams in Preclinical Development; 3 Relationship between Animal Models and Clinical Research: Using Mucositis as a Practical Example; 4 Bacterial Mutation Assay; 5 In Vitro Mammalian Cell Mutation Assays; 6 In Vitro Mammalian Cytogenetic Tests; 7 In Vivo Genotoxicity Assays; 8 Repeat Dose Toxicity Studies; 9 Irritation and Local Tissue Tolerance Studies in Pharmacetical Safety Assessment; 10 Safety Assessment Studies: Immunotoxicity
11 Immunotoxicity Testing: ICH Guideline S8 and Related Aspects12 Reproductive and Developmental Toxicology; 13 Carcinogenicity Studies; 14 Toxicokinetics: An Integral Component of Preclinical Toxicity Studies; 15 In Vitro Toxicokinetics and Dynamics: Modeling and Interpretation of Toxicity Data; 16 Toxicologic Pathology; 17 Secondary Pharmacodynamic Studies and In Vitro Pharmacological Profiling; 18 Current Practices in Safety Pharmacology; 19 Safety Assessment of Biotechnology-Derived Therapeutics; 20 Preclinical Development of Protein Pharmaceuticals: An Overview 21 The Pharmacogenomics of Personalized Medicine22 Genomics; 23 Proteomics; 24 Toxicogenomics in Preclinical Development; 25 Toxicoproteomics: Preclinical Studies; 26 Regulatory Considerations; 27 Regulatory Issues in Preclinical Safety Studies (U.S. FDA); 28 Selection and Utilization of CROs for Safety Assessment; 29 Auditing and Inspecting Preclinical Research and Compliance with Good Laboratory Practice (GLP); 30 Drug Impurities and Degradants and Their Safety Qualification; 31 Bridging Studies in Preclinical Pharmaceutical Safety Assessment; Index |
| Record Nr. | UNINA-9910784842603321 |
| Hoboken, NJ, : Wiley-Interscience, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Rechtliche Zulässigkeit von Placebokontrollgruppen in Arzneimittelstudien : Unter besonderer Berücksichtigung der Blankoeinwilligung und der Zulässigkeit weiterer Kontrollvarianten / / Franziska B. Friske
| Rechtliche Zulässigkeit von Placebokontrollgruppen in Arzneimittelstudien : Unter besonderer Berücksichtigung der Blankoeinwilligung und der Zulässigkeit weiterer Kontrollvarianten / / Franziska B. Friske |
| Autore | Friske Franziska B. |
| Pubbl/distr/stampa | Göttingen : , : Universitätsverlag Göttingen, , 2017 |
| Descrizione fisica | 1 online resource (315 pages) |
| Disciplina | 615.7040724 |
| Soggetto topico | Drug testing |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ger |
| Record Nr. | UNINA-9910725023903321 |
Friske Franziska B.
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| Göttingen : , : Universitätsverlag Göttingen, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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