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Antibody-Drug Conjugates and Immunotoxins : From Pre-Clinical Development to Therapeutic Applications / / edited by Gail Lewis Phillips
| Antibody-Drug Conjugates and Immunotoxins : From Pre-Clinical Development to Therapeutic Applications / / edited by Gail Lewis Phillips |
| Edizione | [1st ed. 2013.] |
| Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Humana, , 2013 |
| Descrizione fisica | 1 online resource (369 p.) |
| Disciplina |
615.37
615.373 |
| Altri autori (Persone) | PhillipsGail Lewis |
| Collana | Cancer Drug Discovery and Development |
| Soggetto topico |
Cancer
Medicine - Research Biology - Research Immunospecificity Cancer Biology Biomedical Research Adaptive Immunity |
| ISBN |
1-283-93413-2
1-4614-5456-5 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Antibody Directed Delivery for Treatment of Cancer: Antibody Drug Conjugates and Immunotoxins -- Antibody-Drug Conjugate Development -- Components of ADC Development: Assay Methodologies and Challenges -- Clinical Pharmacology Strategies in the Development of Antibody-Drug Conjugates -- Predictive Biomarkers for Antibody-Drug Conjugates -- Factors Involved in the Design of Cytotoxic Payloads for Antibody-Drug Conjugates -- Linker Technology and Impact of Linker Design on ADC Properties -- Antibody-drug conjugates for the treatment of B-cell malignancies -- Targeting CD19 with SAR3419, an anti-CD19-Maytansinoid Conjugate for the Treatment of B Cell Malignancies -- Brentuximab Vedotin (SGN-35) for CD30 Positive Malignancies -- Trastuzumab Emtansine (T-DM1) for the Treatment of HER2-Positive Cancer -- CDX-011 (Glembatumumab Vedotin, CR011-vcMMAE) -- Case Study: An Antibody-Drug Conjugate Targeting MUC16 for Ovarian Cancer -- EphA2 Immunoconjugate -- Anti-PSMA Antibody-Drug Conjugates -- Targeting CD56 (NCAM)-expressing Neoplasms with Lorvotuzumab Mertansine -- Studies on the Metabolism of Antibody-Drug Conjugates -- Design, Development and Characterization of Recombinant Immunotoxins Targeting HER2/neu -- The Preclinical and Clinical Evaluation of VB6-845: An Immunotoxin with a De-Immunized Payload for the Systemic Treatment of Solid Tumors -- Index. |
| Record Nr. | UNINA-9910437996003321 |
| New York, NY : , : Springer New York : , : Imprint : Humana, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Emerging contaminants of concern / / Alandra Kahl
| Emerging contaminants of concern / / Alandra Kahl |
| Autore | Kahl Alandra |
| Pubbl/distr/stampa | New York : , : Momentum Press, Engineering, , [2019] |
| Descrizione fisica | 1 online resource (180 pages) |
| Disciplina | 615.373 |
| Collana | Environmental Engineering Collection |
| Soggetto topico |
Toxins
Environmental toxicology |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-947083-45-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910467360603321 |
Kahl Alandra
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| New York : , : Momentum Press, Engineering, , [2019] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Emerging contaminants of concern / / Alandra Kahl
| Emerging contaminants of concern / / Alandra Kahl |
| Autore | Kahl Alandra |
| Pubbl/distr/stampa | New York : , : Momentum Press, Engineering, , [2019] |
| Descrizione fisica | 1 online resource (180 pages) |
| Disciplina | 615.373 |
| Collana | Environmental Engineering Collection |
| Soggetto topico |
Toxins
Environmental toxicology |
| ISBN | 1-947083-45-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910793261803321 |
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Kahl Alandra
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| New York : , : Momentum Press, Engineering, , [2019] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Emerging contaminants of concern / / Alandra Kahl
| Emerging contaminants of concern / / Alandra Kahl |
| Autore | Kahl Alandra |
| Pubbl/distr/stampa | New York : , : Momentum Press, Engineering, , [2019] |
| Descrizione fisica | 1 online resource (180 pages) |
| Disciplina | 615.373 |
| Collana | Environmental Engineering Collection |
| Soggetto topico |
Toxins
Environmental toxicology |
| ISBN | 1-947083-45-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910825238703321 |
|
Kahl Alandra
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| New York : , : Momentum Press, Engineering, , [2019] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Microbial toxins / editors Samuel J. Ajl ... [et al.]
| Microbial toxins / editors Samuel J. Ajl ... [et al.] |
| Pubbl/distr/stampa | New York ; London, : Academic press, 1970-1972 |
| Descrizione fisica | Volumi : ill. ; 24 cm |
| Disciplina | 615.373 |
| Soggetto non controllato | Tossine microbiche |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910772397703321 |
| New York ; London, : Academic press, 1970-1972 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins / / edited by Ulf Grawunder, Stefan Barth
| Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins / / edited by Ulf Grawunder, Stefan Barth |
| Edizione | [1st ed. 2017.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 |
| Descrizione fisica | 1 online resource (XI, 181 p. 57 illus., 39 illus. in color.) |
| Disciplina | 615.373 |
| Collana | Milestones in Drug Therapy |
| Soggetto topico |
Pharmacology
Immunoglobulins Chemotherapy Cancer - Research Oncology Pharmacology/Toxicology Antibodies Pharmacotherapy Cancer Research |
| ISBN | 3-319-46877-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chemical Assembly of Antibody-Drug Conjugates -- Pre-clinical evaluation of ADCs delivering highly potent pyrrolobenzodiazepine (PBD) dimers -- Stable and homogeneous drug conjugation by sequential bis-alkylation at disulfide bonds using bis-sulfone reagents -- Calicheamicin antibody-drug conjugates for liquid- and solid tumor indications -- Enzyme-based strategies to generate site-specifically conjugated Antibody Drug Conjugates -- Substance P – Saporin for the Treatment of Intractable Pain -- Recombinant immunotoxins for Chronic Inflammatory Disease -- BL22: A milestone in targeting CD22. |
| Record Nr. | UNINA-9910253931703321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Perspectives in toxicology / edited by Alan W. Bernheimer
| Perspectives in toxicology / edited by Alan W. Bernheimer |
| Pubbl/distr/stampa | New York : Wiley, 1977 |
| Descrizione fisica | XIII, 204 p. : ill. ; 26 cm |
| Disciplina | 615.373 |
| Collana | Developments in medical microbiology and infectious diseases |
| Soggetto non controllato | Batteri |
| ISBN | 0471018554 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-990009189440403321 |
| New York : Wiley, 1977 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Plant toxin analysis / edited by H. F. Linskens and J. F. Jackson ; contributors J. T. Arnason
| Plant toxin analysis / edited by H. F. Linskens and J. F. Jackson ; contributors J. T. Arnason |
| Pubbl/distr/stampa | Berlin [etc.] : Springer, c1992 |
| Descrizione fisica | XXV, 389 p. ; 24 cm. |
| Disciplina | 615.373 |
| Collana | Modern methods of plant analysis |
| Soggetto topico | Tossine vegetali |
| ISBN | 0-387-52328-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNIBAS-000014956 |
| Berlin [etc.] : Springer, c1992 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. della Basilicata | ||
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Resistance to Immunotoxins in Cancer Therapy / / edited by Rama Shanker Verma, Benjamin Bonavida
| Resistance to Immunotoxins in Cancer Therapy / / edited by Rama Shanker Verma, Benjamin Bonavida |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (259 p.) |
| Disciplina | 615.373 |
| Collana | Resistance to Targeted Anti-Cancer Therapeutics |
| Soggetto topico |
Cancer - Research
Drug resistance Pharmacology Cancer Research Drug Resistance Pharmacology/Toxicology |
| ISBN | 3-319-17275-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Preface ; About the Editor ; Contents; Contributors; Chapter-1; Targeted Cancer Therapy: History and Development of Immunotoxins; 1.1 Introduction; 1.2 Chemotherapy; 1.3 Cancer Immunotherapy; 1.3.1 Antibodies in Cancer Therapy; 1.3.2 Tumor Antigens; 1.3.3 Antibodies for the Clinic; 1.3.4 Antibodies as Carriers; 1.4 Immunotoxins in Cancer Therapy; 1.4.1 Targeting Moiety; 1.4.2 Toxins in Cancer Immunotherapy; 1.5 Construction of an Immunotoxin; 1.6 Internalization and Cytotoxic Activity of Immunotoxins; 1.7 Immunotoxins in Clinical Study; 1.8 Conclusions; References; Chapter-2
Immunotoxins, Resistance and Cancer Stem Cells: Future Perspective2.1 Introduction; 2.2 Factors Responsible for Cancer Resistance; 2.2.1 Gene Mutations in Signalling Pathways; 2.2.2 Drug Transporters; 2.2.3 Tumor Microenvironment and Accessibility; 2.3 Resistance to Immunotoxins; 2.3.1 Dysfunctional Apoptotic Pathways; 2.3.2 ABC Transporters; 2.3.3 Lysosomal Degradation; 2.3.4 Other Factors; 2.4 Cancer Stem Cells and Resistance; 2.4.1 Drug Efflux; 2.4.2 Detoxification and Cellular Repair; 2.4.3 DNA Repair and Modification; 2.4.4 Survival Pathways; 2.4.5 Autophagy and EMT; 2.4.6 Quiescence 2.4.7 Microenvironment2.5 Strategies Used to Overcome Resistance; 2.5.1 Inhibitors of Anti-apoptotic Proteins; 2.5.2 Blocking Membrane Drug Transporters; 2.5.3 Delivery and Intracellular Trafficking; 2.5.4 Inhibition of DNA Repair and Telomerase Activity; 2.5.5 Combination Therapy; 2.5.6 Nanotechnology; 2.5.7 Other Novel Strategies; 2.6.1 Targeting Signaling Pathways in CSC's; 2.6 Targeting Cancer Stem Cells; 2.6.2 Targeting Apoptosis and Cellular Repair Mechanisms in CSC's; 2.6.3 Targeting Autophagy and Microenvironment in CSC's; 2.6.4 Targeting Membrane Transporters and CSC Surface Markers 2.7 ConclusionReferences; Chapter-3; Factors that Determine Sensitivity and Resistances of Tumor Cells Towards Antibody-Targeted Protein Toxins; 3.1 Introduction; 3.2 Intoxication Pathways Define Determinants for Sensitivity and/or Resistances of Tumor Cells Towards Immunotoxins; 3.3 Step 1-Access to Target Cells: Immunogenicity can be a Relevant Factor for Immunotoxin Therapy; 3.4 Step 2-Target Cell Binding: Loss or Reduction of Target Antigens Reduce Sensitivity of Tumor Cells Towards Targeted Toxins 3.5 Step 3-Entry of Toxins into Cells: Loss of Processing Enzymes and Modulation of Vesicular Compartments Reduce Toxin Activity in Cultured Cells3.6 Step 4-ADP-Ribosylation of eEF2: Reduced or Altered Expression of Diphthamide Synthesis Genes is Associated with Immunotoxin Resistances; 3.7 Step 5-Signaling and Apoptosis: Protective Factors and Pathways can Reduce Toxin Sensitivity; 3.8 Conclusions and Outlook; References; Chapter-4; Cell Signaling and Resistance to Immunotoxins; 4.1 Introduction; 4.2 Conceptual Considerations on Cellular Immunotoxin Resistance 4.2.1 Alteration of Immunotoxin Resistance via Modulation of Caspase Activation Pathways |
| Record Nr. | UNINA-9910298266803321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Toxins in Drug Discovery and Pharmacology / / edited by Steve Peigneur
| Toxins in Drug Discovery and Pharmacology / / edited by Steve Peigneur |
| Pubbl/distr/stampa | Basel, Switzerland : , : MDPI - Multidisciplinary Digital Publishing Institute, , 2018 |
| Descrizione fisica | 1 online resource (316 pages) |
| Disciplina | 615.373 |
| Soggetto topico |
Pharmacology
Toxins |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910597903603321 |
| Basel, Switzerland : , : MDPI - Multidisciplinary Digital Publishing Institute, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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