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Coenzyme Q in Aging / / edited by Guillermo López Lluch
| Coenzyme Q in Aging / / edited by Guillermo López Lluch |
| Edizione | [1st ed. 2020.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 |
| Descrizione fisica | 1 online resource (XII, 369 p. 50 illus., 17 illus. in color.) |
| Disciplina | 615.35 |
| Soggetto topico |
Medicine
Cell biology Internal medicine Biochemistry Physiology Biomedicine, general Cell Biology Internal Medicine Biochemistry, general Envelliment Coenzims Citologia |
| Soggetto genere / forma | Llibres electrònics |
| ISBN | 3-030-45642-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface -- Part 1 Basics on coenzyme Q -- Introduction. The current coenzyme Q science and knowledge -- Molecular structure, biosynthesis, and distribution of coenzyme Q -- Coenzyme Q function in mitochondria -- Extramitochondrial coenzyme Q10 in aging -- Regulation of the synthesis of Coenzyme Q10 -- Part 2 Coenzyme Q in aging studies -- Coenzyme Q and aging in C. elegans -- Coenzyme Q and aging in the fruit fly Drosophila melanogaster -- The aging process and coenzyme Q: clk-1 mouse models -- Reduced coenzyme Q10 decelerates senescence and age-related hearing loss in senescence-accelerated mice by activating mitochondrial functions -- Part 3 Age-related diseases and coenzyme Q -- Coenzyme Q, mtDNA and mitochondrial dysfunction during aging -- Coenzyme Q10 and metabolic syndrome -- Coenzyme Q and age-related neurodegenerative disorders: Parkinson and Alzheimer diseases -- Immunosenescence and CoQ10 -- Coenzyme Q10 in fertility and reproduction -- Part 4 Prolongevity effectors and Coenzyme Q -- Calorie restriction, longevity and coenzyme Q -- Age dependent changes of coenzyme Q levels and its induction in experimental systems -- Effects of coenzyme Q10 supplementation on elderly people -- Index. |
| Record Nr. | UNINA-9910416102603321 |
| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cytochrome P450 function and pharmacological roles in inflammation and cancer / edited by James P. Hardwick, S. J. Enna, Lynn Lecount
| Cytochrome P450 function and pharmacological roles in inflammation and cancer / edited by James P. Hardwick, S. J. Enna, Lynn Lecount |
| Pubbl/distr/stampa | Amsterdam [etc.], : Boston, copyr. 2015 |
| Descrizione fisica | XXXI, 473 p. : ill. ; 24 cm |
| Disciplina | 615.35 |
| Collana | Advances in pharmacology |
| Soggetto topico |
Farmacologia
Enzimi |
| ISBN | 978-0-12-803119-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-990006078310203316 |
| Amsterdam [etc.], : Boston, copyr. 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Drug metabolizing enzymes : cytochrome P450 and other enzymes in drug discovery and development / edited by Jae S. Lee, R. Scott Obach and Michael B. Fischer
| Drug metabolizing enzymes : cytochrome P450 and other enzymes in drug discovery and development / edited by Jae S. Lee, R. Scott Obach and Michael B. Fischer |
| Pubbl/distr/stampa | New York : Marcel Dekker |
| Descrizione fisica | XX, 588 p. ; 25 cm |
| Disciplina | 615.35 |
| Soggetto topico |
Medicinali - Metabolismo
Enzimi |
| ISBN | 0-8247-4293-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-990001297080203316 |
| New York : Marcel Dekker | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Enzybiotics [[electronic resource] ] : antibiotic enzymes as drugs and therapeutics / / edited by Tomas G. Villa, Patricia Veiga Crespo
| Enzybiotics [[electronic resource] ] : antibiotic enzymes as drugs and therapeutics / / edited by Tomas G. Villa, Patricia Veiga Crespo |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley & Sons, c2010 |
| Descrizione fisica | 1 online resource (296 p.) |
| Disciplina |
615.329
615.35 |
| Altri autori (Persone) |
González VillaTomás
Veiga-CrespoPatricia |
| Soggetto topico |
Enzymes - Therapeutic use
Antibacterial agents |
| ISBN |
1-282-68479-5
9786612684791 0-470-57054-7 0-470-57053-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ENZYBIOTICS; CONTENTS; PREFACE; CONTRIBUTORS; 1 ENZYBIOTICS AND THEIR POTENTIAL APPLICATIONS IN MEDICINE; 2 ADVANTAGES AND DISADVANTAGES IN THE USE OF ANTIBIOTICS OR PHAGES AS THERAPEUTIC AGENTS; 3 ENZYBIOTICS AS SELECTIVE KILLERS OF TARGET BACTERIA; 4 PHYLOGENY OF ENZYBIOTICS; 5 BACTERIOPHAGE LYSINS: THE ULTIMATE ENZYBIOTIC; 6 BACTERIOPHAGE HOLINS AND THEIR MEMBRANE-DISRUPTING ACTIVITY; 7 ANTI-STAPHYLOCOCCAL LYTIC ENZYMES; 8 MEMBRANE-TARGETED ENZYBIOTICS; 9 DESIGN OF PHAGE COCKTAILS FOR THERAPY FROM A HOST RANGE POINT OF VIEW; 10 IDENTIFYING PHAGE LYTIC ENZYMES: PAST, PRESENT, AND FUTURE
11 USE OF GENETICALLY MODIFIED PHAGES TO DELIVER SUICIDAL GENES TO TARGET BACTERIACONCLUDING REMARKS: THE FUTURE OF ENZYBIOTICS; INDEX |
| Record Nr. | UNINA-9910139493503321 |
| Hoboken, NJ, : John Wiley & Sons, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Enzybiotics [[electronic resource] ] : antibiotic enzymes as drugs and therapeutics / / edited by Tomas G. Villa, Patricia Veiga Crespo
| Enzybiotics [[electronic resource] ] : antibiotic enzymes as drugs and therapeutics / / edited by Tomas G. Villa, Patricia Veiga Crespo |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley & Sons, c2010 |
| Descrizione fisica | 1 online resource (296 p.) |
| Disciplina |
615.329
615.35 |
| Altri autori (Persone) |
González VillaTomás
Veiga-CrespoPatricia |
| Soggetto topico |
Enzymes - Therapeutic use
Antibacterial agents |
| ISBN |
1-282-68479-5
9786612684791 0-470-57054-7 0-470-57053-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ENZYBIOTICS; CONTENTS; PREFACE; CONTRIBUTORS; 1 ENZYBIOTICS AND THEIR POTENTIAL APPLICATIONS IN MEDICINE; 2 ADVANTAGES AND DISADVANTAGES IN THE USE OF ANTIBIOTICS OR PHAGES AS THERAPEUTIC AGENTS; 3 ENZYBIOTICS AS SELECTIVE KILLERS OF TARGET BACTERIA; 4 PHYLOGENY OF ENZYBIOTICS; 5 BACTERIOPHAGE LYSINS: THE ULTIMATE ENZYBIOTIC; 6 BACTERIOPHAGE HOLINS AND THEIR MEMBRANE-DISRUPTING ACTIVITY; 7 ANTI-STAPHYLOCOCCAL LYTIC ENZYMES; 8 MEMBRANE-TARGETED ENZYBIOTICS; 9 DESIGN OF PHAGE COCKTAILS FOR THERAPY FROM A HOST RANGE POINT OF VIEW; 10 IDENTIFYING PHAGE LYTIC ENZYMES: PAST, PRESENT, AND FUTURE
11 USE OF GENETICALLY MODIFIED PHAGES TO DELIVER SUICIDAL GENES TO TARGET BACTERIACONCLUDING REMARKS: THE FUTURE OF ENZYBIOTICS; INDEX |
| Record Nr. | UNINA-9910678065903321 |
| Hoboken, NJ, : John Wiley & Sons, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Enzyme inhibition in drug discovery and development [[electronic resource] ] : the good and the bad / / edited by Chuang Lu, Albert P. Li
| Enzyme inhibition in drug discovery and development [[electronic resource] ] : the good and the bad / / edited by Chuang Lu, Albert P. Li |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley, c2010 |
| Descrizione fisica | 1 online resource (878 p.) |
| Disciplina |
615.35
615/.19 |
| Altri autori (Persone) |
LuChuang
LiA. P |
| Soggetto topico |
Enzyme inhibitors
Drug development Drugs - Metabolism |
| ISBN |
1-282-49134-2
9786612491344 0-470-53895-3 0-470-53894-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ENZYME INHIBITION IN DRUG DISCOVERY AND DEVELOPMENT; CONTENTS; PREFACE; CONTRIBUTORS; PART I. DRUG DISCOVERY APPROACHES AND TECHNOLOGIES; 1. The Drug Discovery Process; 2. Medicinal Chemistry of the Optimization of Enzyme Inhibitors; 3. Bioanalytical Technologies in Drug Discovery; 4. Safety Biomarkers in Drug Development: Emerging Trends and Implications; 5. The Role of Drug Metabolism in Drug Discovery; 6. Applied Pharmacokinetics in Drug Discovery and Development; PART II. INHIBITION OF THE DRUG METABOLIZING ENZYMES-THE UNDESIRABLE INHIBITION
7. Enzyme Inhibition and Inactivation: Cytochrome P450 Enzymes8. Cytochrome P450 Induction; 9. Inhibition of Drug-Metabolizing Enzymes in the Gastrointestinal Tract and Its Influence on the Drug-Drug Interaction Prediction; 10. Enzyme Inhibition in Various In Vitro Systems; 11. Cytochrome P450 Degradation and Its Clinical Relevance; 12. Complexities of Working with UDP-Glucuronosyltransferases (UGTs): Focus on Enzyme Inhibition; 13. Evaluation of Inhibitors of Drug Metabolism in Human Hepatocytes; 14. Grapefruit Juice and Its Constituents as New Esterase Inhibitors 15. Transporter-Xenobiotic Interactions: An Important Aspect of Drug Development Studies16. Polymorphisms of Drug Transporters and Their Clinical Implications; 17. Clinical Drug Interactions Due to Metabolic Inhibition: Prediction, Assessment, and Interpretation; 18. Predicting Interindividual Variability of Metabolic Drug-Drug Interactions: Identifying the Causes and Accounting for Them Using a Systems Approach; PART III. INHIBITION OF THE DRUG TARGET ENZYMES-THE DESIRABLE INHIBITION; 19. NF-κB: Mechanism, Tumor Biology, and Inhibitors; 20. G-Protein-Coupled Receptors as Drug Targets 21. Pharmacological Modulation of Ion Channels for the Treatment of Chronic Pain22. Targeting the mTOR Pathway for Tumor Therapeutics; 23. HIV-1 Protease Inhibitors as Antiretroviral Agents; INDEX |
| Record Nr. | UNINA-9910139522703321 |
| Hoboken, NJ, : John Wiley, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Enzyme inhibition in drug discovery and development [[electronic resource] ] : the good and the bad / / edited by Chuang Lu, Albert P. Li
| Enzyme inhibition in drug discovery and development [[electronic resource] ] : the good and the bad / / edited by Chuang Lu, Albert P. Li |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley, c2010 |
| Descrizione fisica | 1 online resource (878 p.) |
| Disciplina |
615.35
615/.19 |
| Altri autori (Persone) |
LuChuang
LiA. P |
| Soggetto topico |
Enzyme inhibitors
Drug development Drugs - Metabolism |
| ISBN |
1-282-49134-2
9786612491344 0-470-53895-3 0-470-53894-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ENZYME INHIBITION IN DRUG DISCOVERY AND DEVELOPMENT; CONTENTS; PREFACE; CONTRIBUTORS; PART I. DRUG DISCOVERY APPROACHES AND TECHNOLOGIES; 1. The Drug Discovery Process; 2. Medicinal Chemistry of the Optimization of Enzyme Inhibitors; 3. Bioanalytical Technologies in Drug Discovery; 4. Safety Biomarkers in Drug Development: Emerging Trends and Implications; 5. The Role of Drug Metabolism in Drug Discovery; 6. Applied Pharmacokinetics in Drug Discovery and Development; PART II. INHIBITION OF THE DRUG METABOLIZING ENZYMES-THE UNDESIRABLE INHIBITION
7. Enzyme Inhibition and Inactivation: Cytochrome P450 Enzymes8. Cytochrome P450 Induction; 9. Inhibition of Drug-Metabolizing Enzymes in the Gastrointestinal Tract and Its Influence on the Drug-Drug Interaction Prediction; 10. Enzyme Inhibition in Various In Vitro Systems; 11. Cytochrome P450 Degradation and Its Clinical Relevance; 12. Complexities of Working with UDP-Glucuronosyltransferases (UGTs): Focus on Enzyme Inhibition; 13. Evaluation of Inhibitors of Drug Metabolism in Human Hepatocytes; 14. Grapefruit Juice and Its Constituents as New Esterase Inhibitors 15. Transporter-Xenobiotic Interactions: An Important Aspect of Drug Development Studies16. Polymorphisms of Drug Transporters and Their Clinical Implications; 17. Clinical Drug Interactions Due to Metabolic Inhibition: Prediction, Assessment, and Interpretation; 18. Predicting Interindividual Variability of Metabolic Drug-Drug Interactions: Identifying the Causes and Accounting for Them Using a Systems Approach; PART III. INHIBITION OF THE DRUG TARGET ENZYMES-THE DESIRABLE INHIBITION; 19. NF-κB: Mechanism, Tumor Biology, and Inhibitors; 20. G-Protein-Coupled Receptors as Drug Targets 21. Pharmacological Modulation of Ion Channels for the Treatment of Chronic Pain22. Targeting the mTOR Pathway for Tumor Therapeutics; 23. HIV-1 Protease Inhibitors as Antiretroviral Agents; INDEX |
| Record Nr. | UNINA-9910830438803321 |
| Hoboken, NJ, : John Wiley, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Enzyme inhibition in drug discovery and development [[electronic resource] ] : the good and the bad / / edited by Chuang Lu, Albert P. Li
| Enzyme inhibition in drug discovery and development [[electronic resource] ] : the good and the bad / / edited by Chuang Lu, Albert P. Li |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley, c2010 |
| Descrizione fisica | 1 online resource (878 p.) |
| Disciplina |
615.35
615/.19 |
| Altri autori (Persone) |
LuChuang
LiA. P |
| Soggetto topico |
Enzyme inhibitors
Drug development Drugs - Metabolism |
| ISBN |
1-282-49134-2
9786612491344 0-470-53895-3 0-470-53894-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ENZYME INHIBITION IN DRUG DISCOVERY AND DEVELOPMENT; CONTENTS; PREFACE; CONTRIBUTORS; PART I. DRUG DISCOVERY APPROACHES AND TECHNOLOGIES; 1. The Drug Discovery Process; 2. Medicinal Chemistry of the Optimization of Enzyme Inhibitors; 3. Bioanalytical Technologies in Drug Discovery; 4. Safety Biomarkers in Drug Development: Emerging Trends and Implications; 5. The Role of Drug Metabolism in Drug Discovery; 6. Applied Pharmacokinetics in Drug Discovery and Development; PART II. INHIBITION OF THE DRUG METABOLIZING ENZYMES-THE UNDESIRABLE INHIBITION
7. Enzyme Inhibition and Inactivation: Cytochrome P450 Enzymes8. Cytochrome P450 Induction; 9. Inhibition of Drug-Metabolizing Enzymes in the Gastrointestinal Tract and Its Influence on the Drug-Drug Interaction Prediction; 10. Enzyme Inhibition in Various In Vitro Systems; 11. Cytochrome P450 Degradation and Its Clinical Relevance; 12. Complexities of Working with UDP-Glucuronosyltransferases (UGTs): Focus on Enzyme Inhibition; 13. Evaluation of Inhibitors of Drug Metabolism in Human Hepatocytes; 14. Grapefruit Juice and Its Constituents as New Esterase Inhibitors 15. Transporter-Xenobiotic Interactions: An Important Aspect of Drug Development Studies16. Polymorphisms of Drug Transporters and Their Clinical Implications; 17. Clinical Drug Interactions Due to Metabolic Inhibition: Prediction, Assessment, and Interpretation; 18. Predicting Interindividual Variability of Metabolic Drug-Drug Interactions: Identifying the Causes and Accounting for Them Using a Systems Approach; PART III. INHIBITION OF THE DRUG TARGET ENZYMES-THE DESIRABLE INHIBITION; 19. NF-κB: Mechanism, Tumor Biology, and Inhibitors; 20. G-Protein-Coupled Receptors as Drug Targets 21. Pharmacological Modulation of Ion Channels for the Treatment of Chronic Pain22. Targeting the mTOR Pathway for Tumor Therapeutics; 23. HIV-1 Protease Inhibitors as Antiretroviral Agents; INDEX |
| Record Nr. | UNINA-9910840861703321 |
| Hoboken, NJ, : John Wiley, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Pharmaceutical enzymes / edited by Albert Lauwers, Simon Scharpé
| Pharmaceutical enzymes / edited by Albert Lauwers, Simon Scharpé |
| Pubbl/distr/stampa | New York [etc.] : Marcel Dekker, copyr. 1997 |
| Descrizione fisica | VIII, 401 p. : ill. ; 23 cm |
| Disciplina | 615.35 |
| Collana | Drugs and the pharmaceutical sciences |
| Soggetto topico | Enzimi - Uso terapeutico |
| ISBN | 0-8247-9375-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-990002867350203316 |
| New York [etc.] : Marcel Dekker, copyr. 1997 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Targeting Lysine Demethylases in Cancer and Other Human Diseases / / edited by Qin Yan
| Targeting Lysine Demethylases in Cancer and Other Human Diseases / / edited by Qin Yan |
| Autore | Yan Qin |
| Edizione | [1st ed. 2023.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023 |
| Descrizione fisica | 1 online resource (187 pages) |
| Disciplina | 615.35 |
| Collana | Advances in Experimental Medicine and Biology |
| Soggetto topico |
Medicine - Research
Biology - Research Biomedical Research |
| ISBN | 3-031-38176-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Chapter 1. Lysine demethylation in pathogenesis -- Chapter 2. Targeting the LSD1/KDM1 Family of Lysine Demethylases in Cancer and Other Human Diseases -- Chapter 3. KDM2 demethylases as drug targets -- Chapter 4. Role of histone demethylase KDM3 (JMJD1) in transcriptional regulation and cancer progression -- Chapter 5. KDM4 demethylases as drug targets -- Chapter 6. KDM5 lysine demethylases in pathogenesis, from basic science discovery to the clinic -- Chapter 7. Context-dependent functions of lysine demethylases in physiology and disease -- Chapter 8. KDM7 demethylases as drug targets. |
| Record Nr. | UNINA-9910746993803321 |
Yan Qin
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| Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||