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Endocrine disrupters [[electronic resource] ] : hazard testing and assessment methods / / edited by Peter Matthiessen
| Endocrine disrupters [[electronic resource] ] : hazard testing and assessment methods / / edited by Peter Matthiessen |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, 2013 |
| Descrizione fisica | 1 online resource (412 p.) |
| Disciplina | 615.3/6 |
| Altri autori (Persone) | MatthiessenPeter |
| Soggetto topico |
Endocrine disrupting chemicals - Toxicity testing
Endocrine disrupting chemicals - Environmental aspects Endocrine toxicology |
| ISBN |
1-118-35596-2
1-299-24236-7 1-118-35594-6 |
| Classificazione | SCI013060 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ENDOCRINE DISRUPTERS; CONTENTS; PREFACE; CONTRIBUTORS; CHAPTER 1 Ecotoxicity Test Methods for Endocrine-Disrupting Chemicals : AN INTRODUCTION; 1.1 BACKGROUND; 1.2 REGULATORY CONCERNS; 1.3 INVERTEBRATES; 1.4 VERTEBRATES; 1.5 TESTING SCHEMES FOR EDCs; REFERENCE; CHAPTER 2 Endocrine Disruption in Wildlife : BACKGROUND, EFFECTS, AND IMPLICATIONS; 2.1 BACKGROUND TO ENDOCRINE DISRUPTION; 2.1.1 Introduction; 2.1.2 Brief Account of the History of Endocrine Disruption; 2.1.3 What Are Endocrine-Disrupting Chemicals?; 2.1.4 Vertebrate Endocrine System; 2.1.5 Invertebrate Endocrine System
2.1.6 Mechanisms of Endocrine Disruption2.1.7 Endocrine Disrupters in the Environment; 2.2 EFFECTS OF EDCs ON WILDLIFE; 2.2.1 Mammals; 2.2.2 Birds; 2.2.3 Reptiles and Amphibians; 2.2.4 Fish; 2.2.5 Invertebrates; 2.3 WEIGHT OF EVIDENCE AND ECOLOGICAL SIGNIFICANCE OF ED EFFECTS; 2.4 IMPLICATIONS FOR EFFECT ASSESSMENT AND TOXICITY TESTING; 2.5 NEED FOR MORE FIELD STUDIES AND AN INTEGRATED APPROACH; 2.6 CONCLUDING POINTS; REFERENCES; CHAPTER 3 The Regulatory Need for Tests to Detect EDCs and Assess Their Hazards to Wildlife 3.1 EMERGING CONCERNS AND POLICY RESPONSES: FOCUSING ON EDCs AS A LARGE PSEUDO-UNIFORM GROUP OF SUBSTANCES3.1.1 Regulatory Action Among Public Concern, Policy, Stakeholder Interests, and Scientific Complexity: The Starting Point; 3.1.2 Policy Responses to the Initial General Concern: General Strategies; 3.2 GENERAL APPROACHES IN SUBSTANCE-RELATED REGULATORY FRAMEWORKS (EU); 3.2.1 Highlighted Role of ED Properties in General Parts of Regulatory Frameworks; 3.2.2 REACH: Authorization in Cases of "Very High Concern" 3.2.3 Plant Protection Products: Major Change from Directive 91/414 to New Regulation 1107/20093.2.4 Biocides; 3.2.5 Pharmaceuticals; 3.2.6 Other Regulatory Frameworks Not Primarily Related to Substances; 3.3 HOW TO MAKE EDC DEFINITIONS OPERATIONAL FOR SUBSTANCE-RELATED REGULATORY WORK; 3.4 FUTURE PERSPECTIVES; 3.5 CONCLUSIONS; REFERENCES; CHAPTER 4 Techniques for Measuring Endocrine Disruption in Insects; 4.1 INTRODUCTION; 4.1.1 Insects; 4.1.2 Insect Hormones; 4.1.3 Endocrine Disruption and Insects; 4.1.4 Development of Insecticides Targeting the Endocrine System; 4.2 METHODS 4.2.1 Mechanistic Assays4.2.2 Apical Assays; 4.3 DISCUSSION; 4.3.1 Mechanism and Effect; 4.3.2 Exposure Considerations; 4.4 CONCLUSION; 4.5 ACKNOWLEDGMENTS; REFERENCES; CHAPTER 5 Crustaceans; 5.1 INTRODUCTION; 5.2 BACKGROUND TO CRUSTACEAN ENDOCRINOLOGY; 5.2.1 General; 5.2.2 Overview of the Crustacean Endocrine System; 5.3 STATE OF THE ART: WHAT DO WE KNOW ABOUT ENDOCRINE DISRUPTION IN CRUSTACEANS?; 5.3.1 General; 5.3.2 Daphnia sp.; 5.3.3 Barnacles; 5.3.4 Copepods; 5.3.5 Amphipods; 5.3.6 Mysids; 5.3.7 Other Studies Using Larger Crustaceans 5.4 AVAILABLE SUBCHRONIC/CHRONIC STANDARD TEST PROTOCOLS |
| Record Nr. | UNINA-9910141610703321 |
| Hoboken, N.J., : Wiley, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Endocrine disrupters : hazard testing and assessment methods / / edited by Peter Matthiessen
| Endocrine disrupters : hazard testing and assessment methods / / edited by Peter Matthiessen |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, 2013 |
| Descrizione fisica | 1 online resource (412 p.) |
| Disciplina | 615.3/6 |
| Altri autori (Persone) | MatthiessenPeter |
| Soggetto topico |
Endocrine disrupting chemicals - Toxicity testing
Endocrine disrupting chemicals - Environmental aspects Endocrine toxicology |
| ISBN |
1-118-35596-2
1-299-24236-7 1-118-35594-6 |
| Classificazione | SCI013060 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ENDOCRINE DISRUPTERS; CONTENTS; PREFACE; CONTRIBUTORS; CHAPTER 1 Ecotoxicity Test Methods for Endocrine-Disrupting Chemicals : AN INTRODUCTION; 1.1 BACKGROUND; 1.2 REGULATORY CONCERNS; 1.3 INVERTEBRATES; 1.4 VERTEBRATES; 1.5 TESTING SCHEMES FOR EDCs; REFERENCE; CHAPTER 2 Endocrine Disruption in Wildlife : BACKGROUND, EFFECTS, AND IMPLICATIONS; 2.1 BACKGROUND TO ENDOCRINE DISRUPTION; 2.1.1 Introduction; 2.1.2 Brief Account of the History of Endocrine Disruption; 2.1.3 What Are Endocrine-Disrupting Chemicals?; 2.1.4 Vertebrate Endocrine System; 2.1.5 Invertebrate Endocrine System
2.1.6 Mechanisms of Endocrine Disruption2.1.7 Endocrine Disrupters in the Environment; 2.2 EFFECTS OF EDCs ON WILDLIFE; 2.2.1 Mammals; 2.2.2 Birds; 2.2.3 Reptiles and Amphibians; 2.2.4 Fish; 2.2.5 Invertebrates; 2.3 WEIGHT OF EVIDENCE AND ECOLOGICAL SIGNIFICANCE OF ED EFFECTS; 2.4 IMPLICATIONS FOR EFFECT ASSESSMENT AND TOXICITY TESTING; 2.5 NEED FOR MORE FIELD STUDIES AND AN INTEGRATED APPROACH; 2.6 CONCLUDING POINTS; REFERENCES; CHAPTER 3 The Regulatory Need for Tests to Detect EDCs and Assess Their Hazards to Wildlife 3.1 EMERGING CONCERNS AND POLICY RESPONSES: FOCUSING ON EDCs AS A LARGE PSEUDO-UNIFORM GROUP OF SUBSTANCES3.1.1 Regulatory Action Among Public Concern, Policy, Stakeholder Interests, and Scientific Complexity: The Starting Point; 3.1.2 Policy Responses to the Initial General Concern: General Strategies; 3.2 GENERAL APPROACHES IN SUBSTANCE-RELATED REGULATORY FRAMEWORKS (EU); 3.2.1 Highlighted Role of ED Properties in General Parts of Regulatory Frameworks; 3.2.2 REACH: Authorization in Cases of "Very High Concern" 3.2.3 Plant Protection Products: Major Change from Directive 91/414 to New Regulation 1107/20093.2.4 Biocides; 3.2.5 Pharmaceuticals; 3.2.6 Other Regulatory Frameworks Not Primarily Related to Substances; 3.3 HOW TO MAKE EDC DEFINITIONS OPERATIONAL FOR SUBSTANCE-RELATED REGULATORY WORK; 3.4 FUTURE PERSPECTIVES; 3.5 CONCLUSIONS; REFERENCES; CHAPTER 4 Techniques for Measuring Endocrine Disruption in Insects; 4.1 INTRODUCTION; 4.1.1 Insects; 4.1.2 Insect Hormones; 4.1.3 Endocrine Disruption and Insects; 4.1.4 Development of Insecticides Targeting the Endocrine System; 4.2 METHODS 4.2.1 Mechanistic Assays4.2.2 Apical Assays; 4.3 DISCUSSION; 4.3.1 Mechanism and Effect; 4.3.2 Exposure Considerations; 4.4 CONCLUSION; 4.5 ACKNOWLEDGMENTS; REFERENCES; CHAPTER 5 Crustaceans; 5.1 INTRODUCTION; 5.2 BACKGROUND TO CRUSTACEAN ENDOCRINOLOGY; 5.2.1 General; 5.2.2 Overview of the Crustacean Endocrine System; 5.3 STATE OF THE ART: WHAT DO WE KNOW ABOUT ENDOCRINE DISRUPTION IN CRUSTACEANS?; 5.3.1 General; 5.3.2 Daphnia sp.; 5.3.3 Barnacles; 5.3.4 Copepods; 5.3.5 Amphipods; 5.3.6 Mysids; 5.3.7 Other Studies Using Larger Crustaceans 5.4 AVAILABLE SUBCHRONIC/CHRONIC STANDARD TEST PROTOCOLS |
| Record Nr. | UNINA-9910809347503321 |
| Hoboken, N.J., : Wiley, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The ghrelin system / / volume editors, A. Benso [and others]
| The ghrelin system / / volume editors, A. Benso [and others] |
| Pubbl/distr/stampa | Basel : , : Karger, , [2013] |
| Descrizione fisica | 1 online resource (181 p.) |
| Disciplina | 615.3/6 |
| Altri autori (Persone) | BensoAndrea |
| Collana | Endocrine development |
| Soggetto topico |
Ghrelin - Physiology
Ghrelin - Therpeutics |
| ISBN | 3-8055-9909-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
""Cover""; ""Front Matter""; ""Contents""; ""Preface""; ""Ghrelin Discovery: A Decade After""; ""Abstract""; ""Beginning""; ""Stomach""; ""A Novel Peptide""; ""After the Discovery of Ghrelin""; ""Epilogue""; ""References""; ""The Ghrelin Receptors (GHS-R1a and GHS-R1b)""; ""Abstract""; ""History""; ""GHS-R1a, Glucose Homeostasis and Obesity""; ""GHS-R1a in the Brain""; ""GHS-R1a Heterodimerization with Dopamine Receptors in the Brain""; ""GHS-R1a and Neuroprotection""; ""Impact of GHS-R1a Activation in the Cardiovascular System""
""Potential Benefits of GHS-R1a Activation during Malnutrition and Cachexia""""GHS-R1a in Other Aging-Related Conditions""; ""Other Ghrelin Receptors""; ""Conclusion""; ""References""; ""Discovery of Ghrelin O -Acyltransferase""; ""Abstract""; ""From the U-Factor to GOAT""; ""Discovery of GOAT""; ""Pattern of GOAT mRNA and Protein Expression in Tissues""; ""Implications of GOAT in Metabolism and Metabolic Disorders""; ""Conclusions""; ""Acknowledgments""; ""References""; ""Genetics of the Ghrelin System""; ""Abstract""; ""Genetic Studies in Humans""; ""Eating Behaviour""; ""Metabolism"" ""Conclusions""""References""; ""Ghrelin and the Gut""; ""Abstract""; ""Relationship of Ghrelin with Motilin""; ""Distribution of Ghrelin Along the Gastrointestinal Tract""; ""Receptor Distribution and Cross-Reactivity with Motilin""; ""Effects of Ghrelin on Gut Function""; ""Gastroprotection""; ""Intestinal Inflammation""; ""Gastrointestinal Motility""; ""Pathophysiology""; ""Ghrelin Agonists for Motility Disorders""; ""References""; ""Ghrelin as a GH-Releasing Factor""; ""Abstract""; ""GH Secretion and Role of Ghrelin""; ""Does Circulating Ghrelin Act on GH Secretion Control?"" ""Interactions between Ghrelin and Obestatin to Regulate GH Secretion""""Ghrelin and GH in Elderly""; ""Pharmacology of the Ghrelin/GHS-R1a System""; ""Concluding Remarks""; ""References""; ""Other than Growth HormoneNeuroendocrine Actions of Ghrelin""; ""Abstract""; ""Hypothalamo-Pituitary-Adrenal Axis""; ""Lactotroph Function""; ""Hypothalamo-Pituitary-Thyroid Axis""; ""Hypothalamo-Pituitary-Gonadal Axis""; ""Neuroendocrine Actions of the Alternative Ghrelin Gene Products: Unacylated Ghrelin and Obestatin ""; ""Conclusions""; ""References"" ""Ghrelin, the Gonadal Axis and the Onset of Puberty""""Abstract""; ""Metabolic Control of the Reproductive Axis along the Lifespan""; ""Ghrelin and the Metabolic Control of Reproduction: General Considerations""; ""Ghrelin and the Control of Puberty: Experimental Evidence""; ""Ghrelin and the Control of the Gonadotropic Axis in Adulthood""; ""Modes and Sites of Action of Ghrelin for the Central Control of Puberty andGonadotropic Axis""; ""Ghrelin and Direct Control of the Gonads: Evidence from Expression Studies"" ""Ghrelin and Direct Control of the Gonads: Evidence from Functional Studies"" |
| Record Nr. | UNINA-9910163021403321 |
| Basel : , : Karger, , [2013] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The gland illusion : early attempts at rejuvenation through male hormone therapy / / John B. Nanninga, M.D
| The gland illusion : early attempts at rejuvenation through male hormone therapy / / John B. Nanninga, M.D |
| Autore | Nanninga John B. |
| Pubbl/distr/stampa | Jefferson, North Carolina : , : McFarland & Company, Inc., Publishers, , 2017 |
| Descrizione fisica | 1 online resource (219 pages) : illustrations, photographs |
| Disciplina | 615.3/6 |
| Soggetto topico |
Organotherapy - History
Rejuvenation - History Hormone therapy |
| ISBN | 1-4766-2659-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910162915103321 |
Nanninga John B.
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| Jefferson, North Carolina : , : McFarland & Company, Inc., Publishers, , 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Mammalian Cell Cultures for Biologics Manufacturing / / edited by Weichang Zhou, Anne Kantardjieff
| Mammalian Cell Cultures for Biologics Manufacturing / / edited by Weichang Zhou, Anne Kantardjieff |
| Edizione | [1st ed. 2014.] |
| Pubbl/distr/stampa | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014 |
| Descrizione fisica | 1 online resource (VIII, 259 p. 71 illus., 54 illus. in color.) |
| Disciplina | 615.3/6 |
| Collana | Advances in Biochemical Engineering/Biotechnology |
| Soggetto topico |
Biotechnology
Cell culture Pharmaceutical technology Cell Culture Pharmaceutical Sciences/Technology |
| ISBN | 3-642-54050-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Mammalian Cell Cultures for Biologics Manufacturing -- Mammalian Cell Line Developments in Speed and Efficiency -- Cell Culture Process Operations for Recombinant Protein Production -- Equipment for Large-Scale Mammalian Cell Culture -- Development and Characterization of a Cell Culture Manufacturing Process Using Quality by Design (QbD) Principles -- Product Quality Considerations for Mammalian Cell Culture Process Development and Manufacturing -- Safety Assurance for Biologics Manufactured in Mammalian Cell Cultures: A Multitiered Strategy -- Mammalian Cell Culture Capacity for Biopharmaceutical Manufacturing -- Transcriptomics as a Tool for Assessing the Scalability of Mammalian Cell Perfusion Systems -- Lifecycle Management for Recombinant Protein Production Using Mammalian Cell Culture Technology. |
| Record Nr. | UNINA-9910298653303321 |
| Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2014 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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