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Antimicrobial peptides [[electronic resource] /] / David A. Phoenix, Sarah R. Dennison, and Frederick Harris
| Antimicrobial peptides [[electronic resource] /] / David A. Phoenix, Sarah R. Dennison, and Frederick Harris |
| Autore | Phoenix David A |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2013 |
| Descrizione fisica | 1 online resource (254 p.) |
| Disciplina |
572.65
615/.1 |
| Altri autori (Persone) |
DennisonSarah R
HarrisFrederick |
| Soggetto topico | Peptide antibiotics |
| Soggetto non controllato |
Medicine--Basic Sciences
Pharmacy |
| ISBN |
3-527-65285-X
3-527-65287-6 1-299-15730-0 3-527-65288-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Related Titles; Title page; Copyright page; Contents; Preface; References; List of Abbreviations; 1: Antimicrobial Peptides: Their History, Evolution, and Functional Promiscuity; Summary; 1.1 Introduction: The History of Antimicrobial Peptides; 1.2 AMPs: Evolutionarily Ancient Molecules; 1.3 AMPs: Multifunctional Molecules; 1.3.1 Defensins as Effectors of Immunity; 1.3.2 Defensins and Wound Healing; 1.3.3 Defensins and Canine Coat Color; 1.4 Discussion; References; 2: Cationic Antimicrobial Peptides; Summary; 2.1 Introduction; 2.2 CAMPs and Their Antimicrobial Action
2.3 CAMPs That Adopt an α-Helical Structure2.4 CAMPs That Adopt a β-Sheet Structure; 2.5 CAMPs That Adopt Extended Structures Rich in Specific Residues; 2.6 Discussion; References; 3: Anionic Antimicrobial Peptides; Summary; 3.1 Introduction; 3.2 AAMPs in the Respiratory Tract; 3.3 AAMPs in the Brain; 3.4 AAMPs in the Epidermis; 3.5 AAMPs in the Epididymis; 3.6 AAMPs in Blood Components; 3.7 AAMPs in the Gastrointestinal Tract and Food Proteins; 3.8 AAMPs and Their Structure-Function Relationships; 3.9 Discussion; References 4: Graphical Techniques to Visualize the Amphiphilic Structures of Antimicrobial PeptidesSummary; 4.1 Introduction; 4.2 Amphiphilic Structures Adopted by AMPs; 4.3 Qualitative Methods for Identifying Amphiphilic Structure; 4.4 Quantitative Techniques for Analyzing Amphiphilic Structure; 4.4.1 Techniques Based on Hydropathy Plot Analysis; 4.4.2 Techniques Based on Fourier Transforms; 4.4.3 Amphipathic Index; 4.4.4 Hydrophobic Moment Analysis; 4.4.5 Classification of Amphiphilic α-Helices Using the Approach of Segrest; 4.4.6 Amphiphilicity Profiling Analysis of Tilted α-Helices 4.4.7 Extended Hydrophobic Moment Plot Analysis of Tilted α-Helices4.4.8 Amphiphilicity Quantified Using the Approach of Keller; 4.4.9 Amphiphilicity Quantified Using the Approach of Brasseur; 4.5 Discussion; References; 5: Models for the Membrane Interactions of Antimicrobial Peptides; Summary; 5.1 Introduction; 5.2 CM-Associated Factors That Affect the Antimicrobial Action of α-CAMPs; 5.3 Mechanisms Used by CAMPs for Microbial Membrane Interaction; 5.4 Established Models for the Membrane Interactions of α-AMPs; 5.4.1 Barrel-Stave and Toroidal Pore Models 5.4.2 Carpet Mechanism and the Shai-Huang-Matsazuki Model5.5 Recent Novel Models for the Membrane Interactions of α-AMPs; 5.6 Tilted Peptide Mechanism; 5.7 Amyloidogenic Mechanisms; 5.8 Discussion; References; 6: Selectivity and Toxicity of Oncolytic Antimicrobial Peptides; Summary; 6.1 Introduction; 6.2 Peptide-Based Factors That Contribute to the Anticancer Action of Anticancer Peptides; 6.2.1 Sequence Length; 6.2.2 Net Positive Charge; 6.2.3 Hydrophobicity; 6.2.4 Amphiphilicity; 6.3 Membrane-Based Factors That Contribute to the Anticancer Action of ACPs; 6.3.1 Membrane Receptors 6.3.2 Cholesterol |
| Record Nr. | UNINA-9910141488903321 |
Phoenix David A
|
||
| Weinheim, : Wiley-VCH, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Antimicrobial peptides [[electronic resource] /] / David A. Phoenix, Sarah R. Dennison, and Frederick Harris
| Antimicrobial peptides [[electronic resource] /] / David A. Phoenix, Sarah R. Dennison, and Frederick Harris |
| Autore | Phoenix David A |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2013 |
| Descrizione fisica | 1 online resource (254 p.) |
| Disciplina |
572.65
615/.1 |
| Altri autori (Persone) |
DennisonSarah R
HarrisFrederick |
| Soggetto topico | Peptide antibiotics |
| Soggetto non controllato |
Medicine--Basic Sciences
Pharmacy |
| ISBN |
3-527-65285-X
3-527-65287-6 1-299-15730-0 3-527-65288-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Related Titles; Title page; Copyright page; Contents; Preface; References; List of Abbreviations; 1: Antimicrobial Peptides: Their History, Evolution, and Functional Promiscuity; Summary; 1.1 Introduction: The History of Antimicrobial Peptides; 1.2 AMPs: Evolutionarily Ancient Molecules; 1.3 AMPs: Multifunctional Molecules; 1.3.1 Defensins as Effectors of Immunity; 1.3.2 Defensins and Wound Healing; 1.3.3 Defensins and Canine Coat Color; 1.4 Discussion; References; 2: Cationic Antimicrobial Peptides; Summary; 2.1 Introduction; 2.2 CAMPs and Their Antimicrobial Action
2.3 CAMPs That Adopt an α-Helical Structure2.4 CAMPs That Adopt a β-Sheet Structure; 2.5 CAMPs That Adopt Extended Structures Rich in Specific Residues; 2.6 Discussion; References; 3: Anionic Antimicrobial Peptides; Summary; 3.1 Introduction; 3.2 AAMPs in the Respiratory Tract; 3.3 AAMPs in the Brain; 3.4 AAMPs in the Epidermis; 3.5 AAMPs in the Epididymis; 3.6 AAMPs in Blood Components; 3.7 AAMPs in the Gastrointestinal Tract and Food Proteins; 3.8 AAMPs and Their Structure-Function Relationships; 3.9 Discussion; References 4: Graphical Techniques to Visualize the Amphiphilic Structures of Antimicrobial PeptidesSummary; 4.1 Introduction; 4.2 Amphiphilic Structures Adopted by AMPs; 4.3 Qualitative Methods for Identifying Amphiphilic Structure; 4.4 Quantitative Techniques for Analyzing Amphiphilic Structure; 4.4.1 Techniques Based on Hydropathy Plot Analysis; 4.4.2 Techniques Based on Fourier Transforms; 4.4.3 Amphipathic Index; 4.4.4 Hydrophobic Moment Analysis; 4.4.5 Classification of Amphiphilic α-Helices Using the Approach of Segrest; 4.4.6 Amphiphilicity Profiling Analysis of Tilted α-Helices 4.4.7 Extended Hydrophobic Moment Plot Analysis of Tilted α-Helices4.4.8 Amphiphilicity Quantified Using the Approach of Keller; 4.4.9 Amphiphilicity Quantified Using the Approach of Brasseur; 4.5 Discussion; References; 5: Models for the Membrane Interactions of Antimicrobial Peptides; Summary; 5.1 Introduction; 5.2 CM-Associated Factors That Affect the Antimicrobial Action of α-CAMPs; 5.3 Mechanisms Used by CAMPs for Microbial Membrane Interaction; 5.4 Established Models for the Membrane Interactions of α-AMPs; 5.4.1 Barrel-Stave and Toroidal Pore Models 5.4.2 Carpet Mechanism and the Shai-Huang-Matsazuki Model5.5 Recent Novel Models for the Membrane Interactions of α-AMPs; 5.6 Tilted Peptide Mechanism; 5.7 Amyloidogenic Mechanisms; 5.8 Discussion; References; 6: Selectivity and Toxicity of Oncolytic Antimicrobial Peptides; Summary; 6.1 Introduction; 6.2 Peptide-Based Factors That Contribute to the Anticancer Action of Anticancer Peptides; 6.2.1 Sequence Length; 6.2.2 Net Positive Charge; 6.2.3 Hydrophobicity; 6.2.4 Amphiphilicity; 6.3 Membrane-Based Factors That Contribute to the Anticancer Action of ACPs; 6.3.1 Membrane Receptors 6.3.2 Cholesterol |
| Record Nr. | UNINA-9910829850203321 |
|
Phoenix David A
|
||
| Weinheim, : Wiley-VCH, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Antimicrobial peptides / / David A. Phoenix, Sarah R. Dennison, and Frederick Harris
| Antimicrobial peptides / / David A. Phoenix, Sarah R. Dennison, and Frederick Harris |
| Autore | Phoenix David A |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2013 |
| Descrizione fisica | 1 online resource (254 p.) |
| Disciplina |
572.65
615/.1 |
| Altri autori (Persone) |
DennisonSarah R
HarrisFrederick |
| Soggetto topico | Peptide antibiotics |
| ISBN |
3-527-65285-X
3-527-65287-6 1-299-15730-0 3-527-65288-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Related Titles; Title page; Copyright page; Contents; Preface; References; List of Abbreviations; 1: Antimicrobial Peptides: Their History, Evolution, and Functional Promiscuity; Summary; 1.1 Introduction: The History of Antimicrobial Peptides; 1.2 AMPs: Evolutionarily Ancient Molecules; 1.3 AMPs: Multifunctional Molecules; 1.3.1 Defensins as Effectors of Immunity; 1.3.2 Defensins and Wound Healing; 1.3.3 Defensins and Canine Coat Color; 1.4 Discussion; References; 2: Cationic Antimicrobial Peptides; Summary; 2.1 Introduction; 2.2 CAMPs and Their Antimicrobial Action
2.3 CAMPs That Adopt an α-Helical Structure2.4 CAMPs That Adopt a β-Sheet Structure; 2.5 CAMPs That Adopt Extended Structures Rich in Specific Residues; 2.6 Discussion; References; 3: Anionic Antimicrobial Peptides; Summary; 3.1 Introduction; 3.2 AAMPs in the Respiratory Tract; 3.3 AAMPs in the Brain; 3.4 AAMPs in the Epidermis; 3.5 AAMPs in the Epididymis; 3.6 AAMPs in Blood Components; 3.7 AAMPs in the Gastrointestinal Tract and Food Proteins; 3.8 AAMPs and Their Structure-Function Relationships; 3.9 Discussion; References 4: Graphical Techniques to Visualize the Amphiphilic Structures of Antimicrobial PeptidesSummary; 4.1 Introduction; 4.2 Amphiphilic Structures Adopted by AMPs; 4.3 Qualitative Methods for Identifying Amphiphilic Structure; 4.4 Quantitative Techniques for Analyzing Amphiphilic Structure; 4.4.1 Techniques Based on Hydropathy Plot Analysis; 4.4.2 Techniques Based on Fourier Transforms; 4.4.3 Amphipathic Index; 4.4.4 Hydrophobic Moment Analysis; 4.4.5 Classification of Amphiphilic α-Helices Using the Approach of Segrest; 4.4.6 Amphiphilicity Profiling Analysis of Tilted α-Helices 4.4.7 Extended Hydrophobic Moment Plot Analysis of Tilted α-Helices4.4.8 Amphiphilicity Quantified Using the Approach of Keller; 4.4.9 Amphiphilicity Quantified Using the Approach of Brasseur; 4.5 Discussion; References; 5: Models for the Membrane Interactions of Antimicrobial Peptides; Summary; 5.1 Introduction; 5.2 CM-Associated Factors That Affect the Antimicrobial Action of α-CAMPs; 5.3 Mechanisms Used by CAMPs for Microbial Membrane Interaction; 5.4 Established Models for the Membrane Interactions of α-AMPs; 5.4.1 Barrel-Stave and Toroidal Pore Models 5.4.2 Carpet Mechanism and the Shai-Huang-Matsazuki Model5.5 Recent Novel Models for the Membrane Interactions of α-AMPs; 5.6 Tilted Peptide Mechanism; 5.7 Amyloidogenic Mechanisms; 5.8 Discussion; References; 6: Selectivity and Toxicity of Oncolytic Antimicrobial Peptides; Summary; 6.1 Introduction; 6.2 Peptide-Based Factors That Contribute to the Anticancer Action of Anticancer Peptides; 6.2.1 Sequence Length; 6.2.2 Net Positive Charge; 6.2.3 Hydrophobicity; 6.2.4 Amphiphilicity; 6.3 Membrane-Based Factors That Contribute to the Anticancer Action of ACPs; 6.3.1 Membrane Receptors 6.3.2 Cholesterol |
| Record Nr. | UNINA-9910876672703321 |
|
Phoenix David A
|
||
| Weinheim, : Wiley-VCH, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Antimicrobial peptides : discovery, design, and novel therapeutic strategies / / edited by Guangshun Wang
| Antimicrobial peptides : discovery, design, and novel therapeutic strategies / / edited by Guangshun Wang |
| Edizione | [18th ed.] |
| Pubbl/distr/stampa | Wallingford, Oxfordshire, UK, : CABI, c2010 |
| Descrizione fisica | 1 online resource (xvii, 230 pages) : illustrations |
| Disciplina | 615/.1 |
| Altri autori (Persone) | WangGuangshun |
| Collana | Advances in molecular and cellular microbiology |
| Soggetto topico |
Peptide antibiotics
Pharmaceutical chemistry |
| ISBN |
1-282-89349-1
9786612893490 1-84593-694-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Contents; Contributors; Preface; Introduction; PART I: NATURAL ANTIMICROBIAL PEPTIDES: NOMENCLATURE, CLASSIFICATION AND INTERESTING TEMPLATES FOR PEPTIDE ENGINEERING; PART II: EXPANDING THE PEPTIDE SPACE: PREDICTION METHODS, DESIGN STRATEGIES AND PEPTIDOMIMETICS; PART III: BIOPHYSICS, STRUCTURAL BIOLOGY AND MECHANISM OF ACTION OF ANTIMICROBIAL PEPTIDES; PART IV: NOVEL THERAPEUTIC STRATEGIES TO BOLSTER HOST DEFENCE; Index |
| Record Nr. | UNINA-9910446318603321 |
| Wallingford, Oxfordshire, UK, : CABI, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Approved drug products with therapeutic equivalence evaluations
| Approved drug products with therapeutic equivalence evaluations |
| Pubbl/distr/stampa | [Rockville, Md.], : U.S. Dept. of Health and Human Services, Public Health Service, Food and Drug Administration, Center for Drugs and Biologics |
| Descrizione fisica | 1 online resource (volumes) |
| Disciplina |
615
615/.1 |
| Soggetto topico |
Drugs - Therapeutic equivalency
Drugs - Bioavailability Drugs Pharmaceutical services insurance Medical care - United States Medical care Pharmaceutical Preparations Therapeutic Equivalency |
| Soggetto genere / forma |
Catalogs.
Periodicals. Catalog Periodical |
| ISSN | 2158-7744 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Orange book |
| Record Nr. | UNINA-9910132234103321 |
| [Rockville, Md.], : U.S. Dept. of Health and Human Services, Public Health Service, Food and Drug Administration, Center for Drugs and Biologics | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
ASHP's clinical pearls [[electronic resource] /] / [edited by] Bruce Canaday
| ASHP's clinical pearls [[electronic resource] /] / [edited by] Bruce Canaday |
| Pubbl/distr/stampa | Bethesda, Md., : American Society of Health-System Pharmacists, c2009 |
| Descrizione fisica | ix, 129p. : ill |
| Disciplina | 615/.1 |
| Altri autori (Persone) | CanadayBruce Robert |
| Soggetto topico | Clinical pharmacology |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-58528-409-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Potter's pain : Harry, hogwarts, and headaches : migraine prophylaxis in an adolescent and young adult population / Daniel S. Longyhore -- My life on the D-list : clinical importance of the clindamycin inducible resistance test for Staphylococcus aureus / Joseph Kishel -- Getting the knack of IV NAC : a novel dosing strategy of N-acetylcysteine in a patient presenting with severe acetaminophen toxicity / Erick J. Borkowski -- Pharmacy proofs : CLCR ? GFR / Jaime L. Borkowski -- Succinylcholine in the critically ill patient : when is it not ok+? / Clyde Birringer -- Insulin sliding scales : to use or not to use, that is the question / Jon Horton -- Glycemic control in the ICU : how low should we go? / Debra J. Skaar -- ASAP : aspirin-use screen for acute myocardial infarction patients / Hoytin T. Lee Ghin -- Soy, you want to be a girlie man? Effect of soy supplementation on testosterone in healthy males / Susan Goodin -- Plan B dosing for plan B? : alternative dosing strategies for emergency contraception with levonorgestrel / Laura B. Hansen -- Warfarin and cotrimoxazole : averting disaster / Todd R. Marcy -- Celiac disease : dangers of gluten in medications / Robert A. Magione -- Circumcision : ouch!! / Rita K. Jew -- Friend or foe? Ibuprofen for patent ductus arterious / Allison Jun -- Hyporesponse to erythropoietic stimulating agents : uh-oh, what do we do now? / Sarah Tomasello. |
| Record Nr. | UNINA-9910464557403321 |
| Bethesda, Md., : American Society of Health-System Pharmacists, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
ASHP's clinical pearls [[electronic resource] /] / [edited by] Bruce Canaday
| ASHP's clinical pearls [[electronic resource] /] / [edited by] Bruce Canaday |
| Pubbl/distr/stampa | Bethesda, Md., : American Society of Health-System Pharmacists, c2009 |
| Descrizione fisica | ix, 129p. : ill |
| Disciplina | 615/.1 |
| Altri autori (Persone) | CanadayBruce Robert |
| Soggetto topico | Clinical pharmacology |
| ISBN | 1-58528-409-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Potter's pain : Harry, hogwarts, and headaches : migraine prophylaxis in an adolescent and young adult population / Daniel S. Longyhore -- My life on the D-list : clinical importance of the clindamycin inducible resistance test for Staphylococcus aureus / Joseph Kishel -- Getting the knack of IV NAC : a novel dosing strategy of N-acetylcysteine in a patient presenting with severe acetaminophen toxicity / Erick J. Borkowski -- Pharmacy proofs : CLCR ? GFR / Jaime L. Borkowski -- Succinylcholine in the critically ill patient : when is it not ok+? / Clyde Birringer -- Insulin sliding scales : to use or not to use, that is the question / Jon Horton -- Glycemic control in the ICU : how low should we go? / Debra J. Skaar -- ASAP : aspirin-use screen for acute myocardial infarction patients / Hoytin T. Lee Ghin -- Soy, you want to be a girlie man? Effect of soy supplementation on testosterone in healthy males / Susan Goodin -- Plan B dosing for plan B? : alternative dosing strategies for emergency contraception with levonorgestrel / Laura B. Hansen -- Warfarin and cotrimoxazole : averting disaster / Todd R. Marcy -- Celiac disease : dangers of gluten in medications / Robert A. Magione -- Circumcision : ouch!! / Rita K. Jew -- Friend or foe? Ibuprofen for patent ductus arterious / Allison Jun -- Hyporesponse to erythropoietic stimulating agents : uh-oh, what do we do now? / Sarah Tomasello. |
| Record Nr. | UNINA-9910789498903321 |
| Bethesda, Md., : American Society of Health-System Pharmacists, c2009 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Assuring data quality and validity in clinical trials for regulatory decision making [[electronic resource] ] : workshop report : Roundtable on Research and Development of Drugs, Biologics, and Medical Devices / / Jonathan R. Davis ... [et al.] editors
| Assuring data quality and validity in clinical trials for regulatory decision making [[electronic resource] ] : workshop report : Roundtable on Research and Development of Drugs, Biologics, and Medical Devices / / Jonathan R. Davis ... [et al.] editors |
| Pubbl/distr/stampa | Washington, DC, : National Academy Press, c1999 |
| Descrizione fisica | 1 online resource (88 p.) |
| Disciplina | 615/.1 |
| Altri autori (Persone) | DavisJonathan R |
| Collana | The compass series |
| Soggetto topico | Clinical trials - Quality control |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-309-52024-X
0-585-14261-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Front Matter; Preface; Acknowledgments; Contents; Executive Summary; Introduction; Presubmission and Submission; FDA Regulatory Review; Summary of Issues; Directions for the Future; Final Comments; APPENDIX A Workshop Agenda; APPENDIX B Speakers and Panelists; APPENDIX C Workshop Registrants; APPENDIX D Glossary and Acronyms |
| Record Nr. | UNINA-9910456122403321 |
| Washington, DC, : National Academy Press, c1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Assuring data quality and validity in clinical trials for regulatory decision making [[electronic resource] ] : workshop report : Roundtable on Research and Development of Drugs, Biologics, and Medical Devices / / Jonathan R. Davis ... [et al.] editors
| Assuring data quality and validity in clinical trials for regulatory decision making [[electronic resource] ] : workshop report : Roundtable on Research and Development of Drugs, Biologics, and Medical Devices / / Jonathan R. Davis ... [et al.] editors |
| Pubbl/distr/stampa | Washington, DC, : National Academy Press, c1999 |
| Descrizione fisica | 1 online resource (88 p.) |
| Disciplina | 615/.1 |
| Altri autori (Persone) | DavisJonathan R |
| Collana | The compass series |
| Soggetto topico | Clinical trials - Quality control |
| ISBN |
0-309-17280-2
0-309-52024-X 0-585-14261-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Front Matter; Preface; Acknowledgments; Contents; Executive Summary; Introduction; Presubmission and Submission; FDA Regulatory Review; Summary of Issues; Directions for the Future; Final Comments; APPENDIX A Workshop Agenda; APPENDIX B Speakers and Panelists; APPENDIX C Workshop Registrants; APPENDIX D Glossary and Acronyms |
| Record Nr. | UNINA-9910778746103321 |
| Washington, DC, : National Academy Press, c1999 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Characterization of impurities and degradants using mass spectrometry / / edited by Birendra N. Pramanik, Mike S. Lee, Guodong Chen
| Characterization of impurities and degradants using mass spectrometry / / edited by Birendra N. Pramanik, Mike S. Lee, Guodong Chen |
| Pubbl/distr/stampa | Hoboken : , : Wiley, , 2011 |
| Descrizione fisica | 1 online resource (xxii, 462 pages) : illustrations |
| Disciplina |
615.1
615/.1 |
| Altri autori (Persone) |
PramanikBirendra N. <1944->
LeeMike S. <1960-> ChenGuodong |
| Collana | Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods |
| Soggetto topico |
Drugs - Analysis
Drugs - Spectra Mass spectrometry Contamination (Technology) Public Health Chemistry Techniques, Analytical Investigative Techniques Environment and Public Health Health Care Pharmaceutical Preparations Mass Spectrometry Drug Contamination Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN |
1-283-23943-4
9786613239433 0-470-92136-6 0-470-92137-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
CHARACTERIZATION OF IMPURITIES AND DEGRADANTS USING MASS SPECTROMETRY; CONTENTS; PREFACE; CONTRIBUTORS; ACRONYMS; PART I: METHODOLOGY; 1. Introduction to Mass Spectrometry; 1.1. History; 1.1.1. Atomic Physics; 1.1.2. Early Applications; 1.1.3. Organic Structural Analysis; 1.1.4. The Biological Mass Spectrometry Revolution; 1.2. Ionization Methods; 1.3. Mass Spectrometer Types; 1.3.1. Magnetic Sector Mass Spectrometers; 1.3.2. Quadrupole Mass Filter and Quadrupole Ion Trap Mass Spectrometers; 1.3.3. Time-of-Flight Mass Spectrometers
1.3.4. Fourier Transform Ion Cyclotron Resonance Mass Spectrometers; 1.3.5. Orbitrap Mass Spectrometers; 1.4. Tandem Mass Spectrometry; 1.4.1. Ion Isolation; 1.4.2. Ion-Molecule Collisions and Collision-Induced Dissociation; 1.4.3. Electron Capture Dissociation and Electron Transfer Dissociation; 1.5. Separation Techniques Coupled to Mass Spectrometry; 1.5.1. Gas Chromatography-Mass Spectrometry; 1.5.2. Liquid Chromatography-Mass Spectrometry; 1.5.3. Capillary Electrophoresis-Mass Spectrometry; 1.5.4. Ion Mobility Spectrometry-Mass Spectrometry; 1.6. Prospects for Mass Spectrometry; References 2. LC Method Development and Strategies; 2.1. Introduction; 2.2. Column, pH, and Solvent Screening; 2.2.1. Resolution: Goal of Separation; 2.2.2. Screening: Systematic Approach to Seeking Selectivity; 2.2.3. Screening Instrumentation and Controlling Software; 2.3. Gradient and Temperature Optimization; 2.4. Orthogonal Screening; 2.4.1. Method Orthogonality; 2.4.2. Selection of Orthogonal Methods; 2.4.3. Impurity Orthogonal Screening; 2.5. High-Efficiency Separation; 2.6. Conclusions; References 3. Rapid Analysis of Drug-Related Substances using Desorption Electrospray Ionization and Direct Analysis in Real Time Ionization Mass Spectrometry; 3.1. Introduction; 3.2. Ionization Apparatus, Mechanisms, and General Performance; 3.2.1. Desorption Electrospray Ionization (DESI); 3.2.2. Direct Analysis in Real Time (DART); 3.3. Drug Analysis in Biological Matrices using DESI and DART; 3.3.1. DESI Application; 3.3.2. DART Application; 3.4. High-Throughput Analysis; 3.5. Chemical Imaging and Profiling; 3.6. Future Perspectives; References; 4. Orbitrap High-Resolution Applications 4.1. Historical Anecdote; 4.2. General Description of Orbitrap Operating Principles; 4.3. The Orbitrap is a "Fourier Transform" Device; 4.4. Performing Experiments in Trapping Devices; 4.4.1. "Raw" HPLC Data Look Like Infusion Data; 4.4.2. How Much Mass Resolution Should Be Used During HPLC; 4.5. Determining Elemental Compositions of "Unknowns" Using an Orbitrap; 4.6. Orbitrap Figures of Merit in Mass Measurement; 4.6.1. Accuracy; 4.6.2. Precision; 4.6.3. Discussion; 4.7. HPLC Orbitrap MS: Accurate Mass Demonstration and Differentiation of Small Molecule Formulas Very Proximate in Mass/Charge Ratio Space |
| Record Nr. | UNINA-9910132377503321 |
| Hoboken : , : Wiley, , 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
