Advances in Tumor Immunology and Immunotherapy / / edited by Joseph D. Rosenblatt, Eckhard R. Podack, Glen N. Barber, Augusto Ochoa |
Edizione | [1st ed. 2014.] |
Pubbl/distr/stampa | New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 |
Descrizione fisica | 1 online resource (369 p.) |
Disciplina |
614.5999
616.994079 |
Collana | Current Cancer Research |
Soggetto topico |
Cancer - Research
Pharmacology Cancer Research Pharmacology/Toxicology |
ISBN | 1-4614-8809-5 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Contents; Introduction; Part IImmune Activation, Suppression and Manipulation of the Immune Antitumor Response; Myeloid-Derived Suppressor Cells in Cancer; 1 Introduction; 2 Preclinical Data; 2.1 Phenotype; 2.2 Expansion and Activation of MDSCs in Tumor Models; 2.3 Mechanisms of Immunosuppression of MDSCs in Cancer; 2.3.1 Metabolism of l -Arginine; 2.3.2 ROS and Peroxynitrite; 3 Clinical Data; 4 Pharmacologic Modulation of MDSCs; 5 Conclusions; References; The Role of B Cells in Shaping the Antitumor Immune Response; 1 Introduction; 2 B Cells and Antitumor Immunity
3 Mechanisms of B Cell Modulation of Immune Response3.1 Be1 and Be2 Differentiation and Skewing of T Cell Response; 3.2 B Cells and Antigen Presentation; 3.3 B Cells and Expansion of Tregs; 3.4 B10 Cells and Immune Suppression; 3.5 Other Breg Subsets and Role of TGF-β; 3.6 B Cells and Chronic Inflammation; 4 Effects of B Cell Depletion on Antitumor Immunity; 5 B Cell Infiltration in Human Tumors; 6 Conclusions; References; Heat-Shock Protein-Based Cancer Immunotherapy; 1 Heat-Shock Proteins, Sterile Inflammation, and Immunosurveillance; 2 Autologous Purified HSP Vaccines 3 Allogeneic Cell-Based HSP Vaccines4 Recombinant and Nucleic Acid-Based HSP Vaccines; 5 Conclusions Based on Clinical Evidence; References; Activation of NK Cell Responses and Immunotherapy of Cancer; 1 Background and History of NK Cells; 2 NK Cell Activation; 3 NK Cells and Cancer; 4 Activated NK Cells as a Cancer Immunotherapy; 5 NK Cells and Other Immunotherapeutic Approaches; 6 Conclusion; References; Induction of Tumor Immunity by Targeted Inhibition of Nonsense-Mediated mRNA Decay; 1 Introduction; 2 Nonsense-Mediated mRNA Decay: A Primer; 2.1 Physiological Roles of NMD 2.2 Role of NMD in Cancer3 Tumor-Targeted NMD Inhibition to Express New Antigens in Disseminated Tumor Lesions; 3.1 The Concept and Rationale; 3.2 Preclinical Proof-of-Concept Studies in Murine Tumor Models; 4 Conclusions and Future Directions; 4.1 Cytotoxic Therapy or Immunotherapy?; 4.2 What If?; References; Employing T Cell Homeostasis as an Antitumor Strategy; 1 Introduction; 2 Homeostasis of T Lymphocytes; 3 Lymphopenia-Induced T Cell Proliferation; 4 Lymphopenia-Induced Pathologies; 5 Lymphopenia-Induced Antitumor Immune Responses; 6 Clinical Evidence/The Human Model 7 Adoptive Immunotherapy of Cancer8 Vaccine Augmentation; 9 Lymphopenia-Induced Changes in T reg Percentages; 10 The Dose Makes the Poison; 11 Conclusion; References; Adoptive Cell Therapy of Systemic Metastases Using erbB-2-Specific T Cells Redirected with a Chimeric Antibody-Based Receptor; 1 Introduction; 2 Results and Discussion; 2.1 Phenotypic and Functional Profile of the erbB-2-Specific CAR in Transgenic Mice; 2.2 Naïve TgN29 Mice Reject Renca-erbB-2 Tumors; 2.3 Adoptive Transfer of Naïve Lymphocytes from TgN29 Mice Extends the Survival of Mice with Systemic Lung Metastases 2.4 Redirected Allogeneic T Cells (Allo-T-Bodies) as Potential Universal Donors |
Record Nr. | UNINA-9910300096003321 |
New York, NY : , : Springer New York : , : Imprint : Springer, , 2014 | ||
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Analysis of cancer risks in populations near nuclear facilities [[electronic resource] ] : phase I / / Committee on the Analysis of Cancer Risks in Populations near Nuclear Facilities--Phase I, Nuclear and Radiation Studies Board, Division of Earth and Life Studies, National Research Council of the National Academies |
Pubbl/distr/stampa | Washington, D.C., : National Academies Press, c2012 |
Descrizione fisica | 1 online resource (424 p.) |
Disciplina | 614.5999 |
Soggetto topico |
Cancer - Risk factors
Epidemiology Nuclear facilities - Health aspects - United States |
Soggetto genere / forma | Electronic books. |
ISBN |
1-280-88010-4
9786613721419 0-309-25572-4 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
""Front Matter""; ""Acknowledgments""; ""Contents""; ""Summary""; ""1 Introduction""; ""2 Effluent Releases from Nuclear Power Plants and Fuel-Cycle Facilities""; ""3 Radiation Dose Assessment""; ""4 Epidemiological Studies""; ""5 Risk Communication and Public Engagement""; ""Appendixes""; ""Appendix A: Radiation as a Carcinogen""; ""Appendix B: Biographical Sketches of Committee and Staff""; ""Appendix C: Presentations and Visits""; ""Appendix D: Origin of Radioactivity in Nuclear Plants""; ""Appendix E: Origin of Radioactivity in Fuel-Cycle Facilities""
""Appendix F: Regulation of Effluent Releases""""Appendix G: Radiological Effluent Technical Specifications (RETS)""; ""Appendix H: Radiological Environmental Monitoring Program (REMP)""; ""Appendix I: Radiation Dose Assessment""; ""Appendix J: Modeling Incidence and Mortality Data in an Ecologic Study""; ""Appendix K: Letter Template to State Cancer Registries""; ""Appendix L: Letter Template to State Vital Statistics Offices""; ""Appendix M: Letter Template to Departments of Public Health""; ""Appendix N: Glossary""; ""Appendix O: Acronyms"" |
Record Nr. | UNINA-9910452788703321 |
Washington, D.C., : National Academies Press, c2012 | ||
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Analysis of cancer risks in populations near nuclear facilities [[electronic resource] ] : phase I / / Committee on the Analysis of Cancer Risks in Populations near Nuclear Facilities--Phase I, Nuclear and Radiation Studies Board, Division of Earth and Life Studies, National Research Council of the National Academies |
Pubbl/distr/stampa | Washington, D.C., : National Academies Press, c2012 |
Descrizione fisica | 1 online resource (424 p.) |
Disciplina | 614.5999 |
Soggetto topico |
Cancer - Risk factors
Epidemiology Nuclear facilities - Health aspects - United States |
ISBN |
1-280-88010-4
9786613721419 0-309-25572-4 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
""Front Matter""; ""Acknowledgments""; ""Contents""; ""Summary""; ""1 Introduction""; ""2 Effluent Releases from Nuclear Power Plants and Fuel-Cycle Facilities""; ""3 Radiation Dose Assessment""; ""4 Epidemiological Studies""; ""5 Risk Communication and Public Engagement""; ""Appendixes""; ""Appendix A: Radiation as a Carcinogen""; ""Appendix B: Biographical Sketches of Committee and Staff""; ""Appendix C: Presentations and Visits""; ""Appendix D: Origin of Radioactivity in Nuclear Plants""; ""Appendix E: Origin of Radioactivity in Fuel-Cycle Facilities""
""Appendix F: Regulation of Effluent Releases""""Appendix G: Radiological Effluent Technical Specifications (RETS)""; ""Appendix H: Radiological Environmental Monitoring Program (REMP)""; ""Appendix I: Radiation Dose Assessment""; ""Appendix J: Modeling Incidence and Mortality Data in an Ecologic Study""; ""Appendix K: Letter Template to State Cancer Registries""; ""Appendix L: Letter Template to State Vital Statistics Offices""; ""Appendix M: Letter Template to Departments of Public Health""; ""Appendix N: Glossary""; ""Appendix O: Acronyms"" |
Record Nr. | UNINA-9910779133903321 |
Washington, D.C., : National Academies Press, c2012 | ||
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Lo trovi qui: Univ. Federico II | ||
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Asbestos and mesothelioma / / edited by Joseph R. Testa |
Edizione | [1st ed. 2017.] |
Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 |
Descrizione fisica | 1 online resource (VIII, 407 p. 65 illus., 43 illus. in color.) |
Disciplina | 614.5999 |
Collana | Current Cancer Research |
Soggetto topico |
Cancer - Research
Cancer Research |
ISBN | 3-319-53560-9 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | 1. Malignant Mesothelioma – An Asbestos Legacy -- 2. Asbestos and Fibrous Erionite -- 3. Epidemiology of Mesothelioma -- 4. Malignant Pleural Mesothelioma: History, Controversy and Future of a Man-Made Epidemic -- 5. Communities at High Risk in the Third Wave of Mesothelioma -- 6. Mesothelioma Pathology -- 7. Asbestos-Induced Inflammation in Malignant Mesothelioma and Other Lung Diseases -- 8. Germline and Somatic Mutations in Human Mesothelioma and Lessons from Asbestos-Exposed Genetically Engineered Mouse Models -- 9. Gene Signature of Malignant Pleural Mesothelioma -- 10. Cell Signaling and Epigenetic Mechanisms in Mesothelioma -- 11. 3D Models of Mesothelioma in the Study of Mechanisms of Cell Survival -- 12. Biomarkers of Response to Asbestos Exposure -- 13. Surgery Approaches in Mesothelioma -- 14. Radiotherapy and Photodynamic Therapy for Malignant Pleural Mesothelioma -- 15. Standard Chemotherapy Options and Clinical Trials of Novel Agents for Mesothelioma -- 16. Immunotherapeutic Approaches to Mesothelioma -- 17. Challenges Facing Mesothelioma Patients and Their Families: Medical/Legal Intersections -- 18. The Patient’s Experience of Malignant Mesothelioma. |
Record Nr. | UNINA-9910254477503321 |
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2017 | ||
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Atlas of cancer mortality : in England and Wales, 1968-1978 / M. J. Gardner ... [et al.] |
Pubbl/distr/stampa | Chichester : Wiley, 1983 |
Descrizione fisica | XI, 116 p. : ill. ; 29 cm |
Disciplina | 614.5999 |
Collana | Wiley medical publication |
Soggetto non controllato | Cancro - Mortalità - Inghilterra |
ISBN | 0471900427 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-990009186950403321 |
Chichester : Wiley, 1983 | ||
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Biochemistry of Oxidative Stress : Physiopathology and Clinical Aspects / / edited by Ricardo Jorge Gelpi, Alberto Boveris, Juan José Poderoso |
Edizione | [1st ed. 2016.] |
Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 |
Descrizione fisica | 1 online resource (XI, 454 p. 74 illus., 47 illus. in color.) |
Disciplina | 614.5999 |
Collana | Advances in Biochemistry in Health and Disease |
Soggetto topico |
Cancer research
Cell physiology Oxidative stress Cancer Research Cell Physiology Oxidative Stress |
ISBN | 3-319-45865-5 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Introduction -- Section 1 GENERAL ASPECTS: 1 The concept of oxidative stress after 30 years -- 2 Evolution of atmospheric oxygen and oxygen metabolism -- 3 Mitochondria as origin of cellular oxidative stress -- 4 Biochemistry and physiology of mtNOS -- 5 Biochemistry of nitrogen reactive species -- 6 Biochemistry of nitro fatty acids -- 7 Mammalian adaptation to life at high altitude -- 8 Metabolic syndrome and oxidative stress in rat pancreas -- 9 Progesterone prevents mitochondrial dysfunction and oxidative stress in the spinal cord of wobbler mice -- 10 Mitochondrial transfer by intercellular nanotubes -- Section 2 CARDIOVASCULAR: 11 Role of Oxidative Stress in Subcellular Defects in Ischemic Heart Disease -- 12 Regulation of protein nitrosylation by Trx1 -- 13 Inhibition of adenylyl cyclase type 5 increases longevity and healthful aging through oxidative stress protection -- 14 Antioxidant supplementation in elderly cardiovascular patients -- 15 Rupture of redox homeostasis in a model of pulmonary artery -- 16 Mitochondrial reactive oxygen species triggered by the cardiac renin-angiotensin-aldosterone system -- 17 Mitochondrial complex I inactivation and increased autooxidation after ischemia-reperfusion in the stunned heart -- 18 Oxidized LDL and atherogenesis -- 19 Reactive oxygen species and cyclooxygenase products in the regulation of blood flow in small vessels -- 20 Thioredoxin-1 attenuates postischemic ventricular and mitochondrial dysfunctions -- 21 Nitro-arachidonic acid reduces the damaged area in rat myocardial infarction -- 22 Inhaled particulate matter and myocardial dysfunction -- Section 3 NEURODEGENERATION AND NEURONAL FUNCTION: 23 Effect of lipoic acid in the triple transgenic mouse model of Alzhaimer’s disease -- 24 Neurovascular coupling mediated by NO in the hippocampus -- 25 Protection from neurodegeneration: signaling and mitocondrial regulation -- 26 Oxidative stress and neurodegeneration -- 27 Oxidative stress, metabolic syndrome and Alzheimer´s disease -- 28 Systemic oxidative stress in patients with neurodegenerative diseases -- Section 4 CANCER: 29 Oxygen metabolism and oxidative stress in cancer cells -- 30 Mitochondrial biogenesis is required for survival and propagation of cancer cells -- 31 Tumor immunology & immunotherapy in patients -- 32 Oncogene-induced Nrf2 repression as adaptive response of cancer cells to acquire a pro-oxidant state favoring cell survival and in vivo tumor growth -- 33 Mitochondrial dynamics regulate oxidative metabolism in Leydig tumor cells -- Index. |
Record Nr. | UNINA-9910157474903321 |
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016 | ||
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Lo trovi qui: Univ. Federico II | ||
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Biological Effects of Static Magnetic Fields / / by Xin Zhang, Kevin Yarema, An Xu |
Autore | Zhang Xin |
Edizione | [1st ed. 2017.] |
Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2017 |
Descrizione fisica | 1 online resource (XI, 220 p. 64 illus., 45 illus. in color.) |
Disciplina | 614.5999 |
Soggetto topico |
Cancer research
Cell biology Cancer Research Cell Biology |
ISBN | 981-10-3579-2 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Part 1: Introductory and Background Information -- Chapter 1: Parameters of Magnetic fields -- Chapter 2: Static magnetic fields -- Part 2: Scientific basis for SMF effects on biological systems -- Chapter 3. Impact of SMF on biological molecules -- Chapter 4. Impact of SMF on cells -- Chapter 5. Impact of SMF on animals and other organisms -- Part 3: Opportunities for SMF-based therapies -- Chapter 6. Potential applications of SMF in cancer treatment -- Chapter 7. Potential applications of SMF in other disease treatment. |
Record Nr. | UNINA-9910253909503321 |
Zhang Xin
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Singapore : , : Springer Singapore : , : Imprint : Springer, , 2017 | ||
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Lo trovi qui: Univ. Federico II | ||
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Biomarker Discovery in the Developing World: Dissecting the Pipeline for Meeting the Challenges [[electronic resource] /] / edited by Sanjeeva Srivastava |
Edizione | [1st ed. 2016.] |
Pubbl/distr/stampa | New Delhi : , : Springer India : , : Imprint : Springer, , 2016 |
Descrizione fisica | 1 online resource (XI, 118 p. 28 illus. in color.) |
Disciplina | 614.5999 |
Soggetto topico |
Cancer research
Proteomics Infectious diseases Drug resistance Cancer Research Infectious Diseases Drug Resistance |
ISBN | 81-322-2837-5 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Chapter 1: Exigencies of biomarker research in developing world: A focus on the dearth of biobanking resources -- Chapter 2: Geographic pervasiveness of cancer: Prospects of novel biomarker and therapeutic research in developing countries using OMICs approaches -- Chapter 3: Omics data processing and analysis -- Chapter 4: Basics of mass spectrometry and its applications in biomarker discovery -- Chapter 5: Angel Philanthropy and Crowdfunding to Accelerate Cancer Research in Developing World -- Chapter 6: Delivering on the Promise of Bioeconomy in Developing World: Link it with Social Innovation and Education -- Chapter 7: Role of proteomics in characterization of biosimilar products -- Chapter 8: Regulatory norms and intellectual property rights for biomarker research. |
Record Nr. | UNINA-9910253896103321 |
New Delhi : , : Springer India : , : Imprint : Springer, , 2016 | ||
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Lo trovi qui: Univ. Federico II | ||
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Biomarkers in Bone Disease [[electronic resource] /] / edited by Victor R. Preedy |
Pubbl/distr/stampa | Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2020 |
Descrizione fisica | 1 online resource (800 p. 50 illus.) |
Disciplina | 614.5999 |
Collana | Biomarkers in Disease: Methods, Discoveries and Applications |
Soggetto topico |
Cancer - Research
Oncology Pharmacology Cancer Research Pharmacology/Toxicology |
ISBN | 94-007-7745-0 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto | Serum uric acid and biomarkers of lumbar spine bone mineral density -- Use of alkaline phosphatase (ALP) activity and disease severity to determine secular changes in bone disease as applied to Paget's disease of the bone -- Bone Turnover and Spinal Cord Injury -- Bone-related proteins as markers in vascular remodelling -- Serum Sclerostin as Biomarker in Osteogenesis Imperfecta -- Parathyroid Hormone (PTH) assays and applications to bone disease: Overview on methodology -- Registered microcomputed tomography data as a four dimensional imaging biomarker of bone formation and resorption -- Use of bone biomarkers after weight loss: Example of bariatric surgery -- Adiponectin as biomarker of osteoporosis -- Effect of statins on bone turnover markers -- Chitinases as biomarkers in bone studies -- Hormone relaxin as biomarker for bone health and disease -- Panoramic radiomorphometric indices of mandible: Biomarker for osteoporosis -- Hip Fracture Risk is Strongly Related to Circulating Levels of the Advanced Glycation End-product Carboxy-Methyl Lysine (CML) -- Effects of glucose on bone markers: Overview of current knowledge with focus on diabetes, glucose, and bone markers -- Traditional medicine and use of bone biomarkers -- Osteosarcoma Biomarkers discovery using "omics" approaches -- Creatine kinase as biomarker in osteogenesis imperfecta -- Ameloblastin as biomarker of bone -- Biomarker genes in autosomal dominant osteopetrosis type II (ADO II) -- Bone markers in Rett syndrome -- Bone Specific Alkaline Phosphatase and Exercise -- Bone turnover markers and glucocorticoid treatments -- Overview of biochemical markers of bone metabolism -- Biomarkers of natural radionuclides in bone and teeth -- Bone markers throughout sexual development: epidemiological significance and population-based findings -- Parathyroid hormone (PTH) and the relationship between PTH and bone health: structure, physiology, actions, and ethnicity -- Quantitative ultrasound as a biomarker tool in newborn infants for bone -- Bone biomarkers in gestational hypertension -- Bone biomarkers in intrauterine growth restriction -- Raman spectroscopy as a biomarker-investigative tool in bone metabolism -- Pentosidine as a biomarker for poor bone quality and elevated fracture risk -- Spine bone texture and the trabecular bone score (TBS) -- Bone biomarkers in HIV -- Bone Biomarkers Related to Osteoarthritis -- Dietary Soy Phytoestrogens and Biomarkers of Osteoporosis -- Utilisation and reference values of osteocalcin and procollagen type 1 n-propeptide -- Analysis of integrin alpha2beta1 (a2b1) expression as a biomarker of skeletal metastasis -- Circulating Sclerostin in Bone Sclerosing Disorders -- Pentraxin 3 as a bone biomarker -- Sirtuins as markers of bone disease: a focus on osteoarthritis and osteoporosis -- Tartarate resistant acid phosphatase as a biomarker of bone remodeling. . |
Record Nr. | UNINA-9910349265803321 |
Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2020 | ||
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Biomarkers in Cancer [[electronic resource] /] / edited by Victor R. Preedy, Vinood B. Patel |
Pubbl/distr/stampa | Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2020 |
Descrizione fisica | 1 online resource (800 p. 50 illus.) |
Disciplina | 614.5999 |
Collana | Biomarkers in Disease: Methods, Discoveries and Applications |
Soggetto topico |
Cancer research
Oncology Pharmacology Cancer Research Oncology Pharmacology/Toxicology |
ISBN | 94-007-7744-2 |
Formato | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Record Nr. | UNINA-9910349266803321 |
Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2020 | ||
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Lo trovi qui: Univ. Federico II | ||
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