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Congenital Hyperinsulinism : A Practical Guide to Diagnosis and Management / / edited by Diva D. De León-Crutchlow, Charles A. Stanley
| Congenital Hyperinsulinism : A Practical Guide to Diagnosis and Management / / edited by Diva D. De León-Crutchlow, Charles A. Stanley |
| Edizione | [1st ed. 2019.] |
| Pubbl/distr/stampa | Cham : , : Springer International Publishing : , : Imprint : Humana, , 2019 |
| Descrizione fisica | 1 online resource (XV, 165 pages :22 illustrations, 12 illus. in color.) |
| Disciplina |
616.4
612.34 |
| Collana | Contemporary Endocrinology |
| Soggetto topico |
Endocrinology
Pediatrics Endocrinology |
| ISBN | 3-030-02961-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Approach to the Diagnosis of Neonates and Infants with Persistent Hypoglycemia -- Diazoxide-Responsive Forms of Congenital Hyperinsulinism -- Diazoxide-Unresponsive Forms of Congenital Hyperinsulinism -- Syndromic Causes of Congenital Hyperinsulinism -- Molecular Diagnosis of Congenital Hyperinsulinism -- Medical Management of Hyperinsulinism -- 18F-DOPA PET -- Histopathology of the Pancreas in Congenital Hyperinsulinism -- Surgery for Congenital Hyperinsulinism -- Perioperative Management of Hyperinsulinism -- Management of the Child with Persistent Hypoglycemia After Surgery -- Management of Diabetes and Pancreatic Insufficiency after Pancreatectomy -- Feeding Problems in Congenital Hyperinsulinism -- Neurodevelopmental Outcomes. |
| Record Nr. | UNINA-9910337513803321 |
| Cham : , : Springer International Publishing : , : Imprint : Humana, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Insulin resistance [[electronic resource] ] : insulin action and its disturbances in disease / / editors, Sudhesh Kumar, Stephen O'Rahilly
| Insulin resistance [[electronic resource] ] : insulin action and its disturbances in disease / / editors, Sudhesh Kumar, Stephen O'Rahilly |
| Pubbl/distr/stampa | Chichester, West Sussex, England ; ; Hoboken, N.J., : J. Wiley, c2005 |
| Descrizione fisica | 1 online resource (617 p.) |
| Disciplina |
612.34
616.4/6207 616.46207 |
| Altri autori (Persone) |
KumarSudhesh
O'RahillyS (Stephen) |
| Soggetto topico | Insulin resistance |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-27609-6
9786610276097 0-470-01126-2 0-470-01132-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Insulin Resistance; Contents; Preface; List of Contributors; 1 The Insulin Receptor and Downstream Signalling; 1.1 Introduction; 1.2 Insulin receptor structure and function; 1.3 Insulin receptor substrates; 1.4 Downstream signalling pathways; 1.5 The basis of insulin's signalling specificity; 1.6 Conclusion; References; 2 Insulin-mediated Regulation of Glucose Metabolism; 2.1 Introduction; 2.2 Insulin as a master regulator of whole body glucose disposal; 2.3 Insulin-mediated regulation of glucose metabolic pathways
2.4 Glucose uptake into skeletal muscle - the rate-limiting step in glucose metabolismAcknowledgements; References; 3 Insulin Action on Lipid Metabolism; 3.1 Introduction: does insulin affect lipid metabolism?; 3.2 Molecular mechanisms by which insulin regulates lipid metabolism; 3.3 Insulin and lipolysis; 3.4 Insulin, lipoprotein lipase and cellular fatty acid uptake; 3.5 Co-ordinated regulation of fatty acid synthesis and ketogenesis; 3.6 Insulin and cholesterol synthesis; 3.7 Insulin effects on lipoprotein metabolism; Acknowledgement; References 4 The Effect of Insulin on Protein Metabolism4.1 Introduction; 4.2 Molecular mechanisms of insulin's effect on protein turnover; 4.3 Measurement of protein metabolism (synthesis and breakdown or turnover) in human subjects; 4.4 Whole body and regional protein turnover; Acknowledgements; References; 5 Genetically Modified Mouse Models of Insulin Resistance; 5.1 Introduction; 5.2 Genetic modification as a tool to dissect the mechanisms leading to insulin resistance; 5.3 Candidate genes involved in the mechanisms of insulin resistance; 5.4 Insulin signalling network 5.5 Factors leading to insulin resistance5.6 Defining the function of the insulin cascade molecules through global knockouts; 5.7 Double heterozygous mice as models of polygenic forms of diabetes; 5.8 Defining tissue and/or organ relevance for the maintenance of insulin sensitivity; 5.9 Genetically modified mice to study modulators of insulin sensitivity; 5.10 Lipodystrophy versus obesity, the insulin resistance paradox; 5.11 Excess of nutrients as a cause of insulin resistance; 5.12 PPARs, key mediators of nutritional-regulated gene expression and insulin sensitivity; References 6 Insulin Resistance in Glucose Disposal and Production in Man with Specific Reference to Metabolic Syndrome and Type 2 Diabetes6.1 Introduction; 6.2 Measurement of insulin resistance; 6.3 Insulin-resistant states; 6.4 Conclusion and perspectives; References; 7 Central Regulation of Peripheral Glucose Metabolism; 7.1 Introduction; 7.2 Counter-regulation of hypoglycaemia - role of the CNS; 7.3 Brain regions involved in counter-regulation; 7.4 Glucosensing neurons; 7.5 Central control of peripheral organs involved in glucoregulation 7.6 Additional afferent signals to the CNS regulating peripheral glucose metabolism |
| Record Nr. | UNINA-9910144640103321 |
| Chichester, West Sussex, England ; ; Hoboken, N.J., : J. Wiley, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Insulin resistance [[electronic resource] ] : insulin action and its disturbances in disease / / editors, Sudhesh Kumar, Stephen O'Rahilly
| Insulin resistance [[electronic resource] ] : insulin action and its disturbances in disease / / editors, Sudhesh Kumar, Stephen O'Rahilly |
| Pubbl/distr/stampa | Chichester, West Sussex, England ; ; Hoboken, N.J., : J. Wiley, c2005 |
| Descrizione fisica | 1 online resource (617 p.) |
| Disciplina |
612.34
616.4/6207 616.46207 |
| Altri autori (Persone) |
KumarSudhesh
O'RahillyS (Stephen) |
| Soggetto topico | Insulin resistance |
| ISBN |
1-280-27609-6
9786610276097 0-470-01126-2 0-470-01132-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Insulin Resistance; Contents; Preface; List of Contributors; 1 The Insulin Receptor and Downstream Signalling; 1.1 Introduction; 1.2 Insulin receptor structure and function; 1.3 Insulin receptor substrates; 1.4 Downstream signalling pathways; 1.5 The basis of insulin's signalling specificity; 1.6 Conclusion; References; 2 Insulin-mediated Regulation of Glucose Metabolism; 2.1 Introduction; 2.2 Insulin as a master regulator of whole body glucose disposal; 2.3 Insulin-mediated regulation of glucose metabolic pathways
2.4 Glucose uptake into skeletal muscle - the rate-limiting step in glucose metabolismAcknowledgements; References; 3 Insulin Action on Lipid Metabolism; 3.1 Introduction: does insulin affect lipid metabolism?; 3.2 Molecular mechanisms by which insulin regulates lipid metabolism; 3.3 Insulin and lipolysis; 3.4 Insulin, lipoprotein lipase and cellular fatty acid uptake; 3.5 Co-ordinated regulation of fatty acid synthesis and ketogenesis; 3.6 Insulin and cholesterol synthesis; 3.7 Insulin effects on lipoprotein metabolism; Acknowledgement; References 4 The Effect of Insulin on Protein Metabolism4.1 Introduction; 4.2 Molecular mechanisms of insulin's effect on protein turnover; 4.3 Measurement of protein metabolism (synthesis and breakdown or turnover) in human subjects; 4.4 Whole body and regional protein turnover; Acknowledgements; References; 5 Genetically Modified Mouse Models of Insulin Resistance; 5.1 Introduction; 5.2 Genetic modification as a tool to dissect the mechanisms leading to insulin resistance; 5.3 Candidate genes involved in the mechanisms of insulin resistance; 5.4 Insulin signalling network 5.5 Factors leading to insulin resistance5.6 Defining the function of the insulin cascade molecules through global knockouts; 5.7 Double heterozygous mice as models of polygenic forms of diabetes; 5.8 Defining tissue and/or organ relevance for the maintenance of insulin sensitivity; 5.9 Genetically modified mice to study modulators of insulin sensitivity; 5.10 Lipodystrophy versus obesity, the insulin resistance paradox; 5.11 Excess of nutrients as a cause of insulin resistance; 5.12 PPARs, key mediators of nutritional-regulated gene expression and insulin sensitivity; References 6 Insulin Resistance in Glucose Disposal and Production in Man with Specific Reference to Metabolic Syndrome and Type 2 Diabetes6.1 Introduction; 6.2 Measurement of insulin resistance; 6.3 Insulin-resistant states; 6.4 Conclusion and perspectives; References; 7 Central Regulation of Peripheral Glucose Metabolism; 7.1 Introduction; 7.2 Counter-regulation of hypoglycaemia - role of the CNS; 7.3 Brain regions involved in counter-regulation; 7.4 Glucosensing neurons; 7.5 Central control of peripheral organs involved in glucoregulation 7.6 Additional afferent signals to the CNS regulating peripheral glucose metabolism |
| Record Nr. | UNINA-9910677482003321 |
| Chichester, West Sussex, England ; ; Hoboken, N.J., : J. Wiley, c2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Islets of Langerhans [[electronic resource] /] / edited by Md. Shahidul Islam
| Islets of Langerhans [[electronic resource] /] / edited by Md. Shahidul Islam |
| Edizione | [2nd ed. 2015.] |
| Pubbl/distr/stampa | Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (XXXI, 1415 p. 170 illus., 113 illus. in color. eReference.) : online resource |
| Disciplina | 612.34 |
| Soggetto topico |
Medicine
Cell biology Diabetes Bioorganic chemistry Human physiology Biomedicine, general Cell Biology Science, Humanities and Social Sciences, multidisciplinary Bioorganic Chemistry Human Physiology |
| ISBN | 94-007-6686-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Microscopic Anatomy of the Human Islet of Langerhans -- The Comparative Anatomy of Islets -- Approaches for Imaging Islets: Recent Advances and Future Prospects -- Islet Cell Development -- High Fat Programming of β-Cell Failure -- Electrophysiology of Islet Cells -- ATP-Sensitive Potassium Channels in Health and Disease -- Role of Mitochondria in β-cell Function and Dysfunction -- Basement Membrane in Pancreatic Islet Function -- Calcium Signaling in the Islets -- Electrical Bursting, Calcium Oscillations, and Synchronization of Pancreatic Islets -- Exocytosis in Islet β-Cells -- Proteomics and Islet Research -- Wnt Signaling in Pancreatic Islets -- Mechanisms of Pancreatic β-Cell Apoptosis in Diabetes and Its Therapies -- β-Cell Function in Obese-Hyperglycemic Mice [ob/ob Mice] -- Islet Structure and Function in the GK Rat -- The β-Cell in Human Type 2 Diabetes -- Clinical Approaches to Preserve β-Cell Function in Diabetes -- Immunology of β-Cell Destruction -- Prevention of β-Cell Destruction in Autoimmune Diabetes: Current Approaches and Future Prospects -- Islet Isolation for Clinical Transplantation -- Human Islet Autotransplantation: The Trail Thus Far and the Highway Ahead -- Modulation of Early Inflammatory Reactions to Promote -- Successes and Disappointments with Clinical Islet Transplantation -- Exercise-induced pancreatic islets adaptations in health and disease -- Role Reg family proteins on islet cell growth and survival -- Circadian control of islet function -- Zinc Transporters in the pancreas -- Making Islets from Human Embryonic Stem Cells -- Chloride channels and Transporters in ß-cell physiology -- Pancreatic beta cells in metabolic syndrome -- Insulin and IGF-1 receptor signalling in insulin secreting cells -- Beta cell store-operated ion channels -- Isolation of Rodent Islets of Langerhans -- Anionic Transporters and Channels in Pancreatic Islet Cells -- Glucose-Induced Apoptosis in Pancreatics Islets -- In Vivo Biomarkers for Detection of Beta Cell Death -- Inflammatory Pathways Linked to Beta Cell Demise in Diabetes -- Islet Encapsulation -- Islet Isolation for Autotransplantation -- Islet Xenotransplantation: recent advances and future prospects -- Molecular basis of cAMP signaling in pancreatic beta cells -- NADPH Oxidase in Beta Cell Dysfunction -- Pancreatic Neuroendocrine Tumors -- Physiological and Pathophysiological Control of Glucagon Secretion by Pancreatic Alpha-Cells -- Reproductive Hormones and Islet Adaptation to Metabolic Stress -- Stem Cells in Pancreatic Islets -- Transcriptional co-Activators in Beta-Cell Function and Disease Pathology. |
| Record Nr. | UNINA-9910298283103321 |
| Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Ultimate Guide to Insulin / / edited by Gaffar Zaman
| Ultimate Guide to Insulin / / edited by Gaffar Zaman |
| Pubbl/distr/stampa | London, United Kingdom : , : IntechOpen, , 2019 |
| Descrizione fisica | 1 online resource (130 pages) : illustrations some color |
| Disciplina | 612.34 |
| Soggetto topico | Insulin |
| ISBN |
1-83962-001-3
1-78984-922-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910317764903321 |
| London, United Kingdom : , : IntechOpen, , 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||