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Cell membrane [[electronic resource] ] : the red blood cell as a model / / Yoshihito Yawata
| Cell membrane [[electronic resource] ] : the red blood cell as a model / / Yoshihito Yawata |
| Autore | Yawata Yoshihito <1936-> |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2003 |
| Descrizione fisica | 1 online resource (457 p.) |
| Disciplina |
612.111
616.0792 |
| Soggetto topico |
Erythrocyte membranes
Membrane proteins |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-52041-8
9786610520411 3-527-60532-0 3-527-60153-8 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cell Membrane; Contents; Preface; Foreword; Acknowledgments; 1 Introduction: History of Red Cell Membrane Research; 1.1 Invention of Optical Microscopes and Their Application to Hematology; 1.2 Discovery of Hereditary Spherocytosis by Light Microscopy; 1.3 The Dawn of Red Cell Membrane Research; 1.4 Commencement of Membrane Protein Biochemistry: Introduction of Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis; 1.5 Elucidation of the Pathogenesis of Red Cell Membrane Disorders; 1.6 Genotypes of Red Cell Membrane Disorders
1.7 Reevaluation of Molecular Electron Microscopy for Phenotypes2 Composition of Normal Red Cell Membranes; 2.1 Introduction; 2.2 Membrane Lipids; 2.2.1 The Contents and Nature of Membrane Lipids; 2.2.2 Asymmetry of the Membrane Lipid Bilayer; 2.2.3 Membrane Fluidity; 2.2.4 Renewal of Membrane Lipids; 2.2.5 Interactions Between Membrane Lipids and Proteins; 2.2.6 Membrane Lipids as a Determinant of Red Cell Shape; 2.3 Membrane Proteins; 2.3.1 Separation and Identification of Membrane Proteins; 2.3.2 Membrane Proteins and Membrane Structure; 2.3.3 Membrane Proteins in the Red Cell Surface 2.3.4 Membrane Proteins and Membrane Functions2.3.4.1 Red Cell Morphology and Shape Change; 2.3.4.2 Red Cell Deformability; 2.3.4.3 Membrane Transport and Permeability; 3 Stereotactic Structure of Red Cell Membranes; 3.1 Historical Background to Membrane Models; 3.2 Ultrastructure of Red Cell Membranes; 3.2.1 Introduction; 3.2.2 Evaluation of the Cytoskeletal Network; 3.2.2.1 Electron Microscopy With the Negative Staining Method; 3.2.2.2 Electron Microscopy With the Quick-Freeze Deep-Etching (QFDE) Method; 3.2.2.3 Electron Microscopy With the Surface Replica (SR) Method 3.2.3 Integral Proteins Examined by Electron Microscopy With the Freeze Fracture Method3.2.4 Visualization of Glycophorins by Field Emission Scanning Electron Microscopy; 4 Skeletal Proteins; 4.1 α- and β-Spectrins; 4.1.1 Introduction; 4.1.2 Structure of Red Cell Spectrins; 4.1.3 Functions of Red Cell Spectrins; 4.1.4 Erythroid and Nonerythroid Spectrins; 4.2 Protein 4.1; 4.2.1 Structure of Protein 4.1; 4.2.2 Binding to Other Membrane Proteins; 4.2.3 Extensive Alternative Splicings; 4.2.4 Nonerythroid Protein 4.1 Isoforms; 4.3 Actin; 4.4 Other Minor Skeletal Proteins; 4.4.1 The p55 Protein 4.4.2 Adducin4.4.3 Dematin (Protein 4.9); 4.4.4 Tropomyosin; 4.4.5 Tropomodulin; 4.4.6 Other Membrane Proteins; 5 Integral Proteins; 5.1 Band 3; 5.1.1 Structure of Band 3; 5.1.2 Functions of Band 3; 5.1.2.1 Membrane Protein Binding by the Cytoplasmic Domain of Band 3; 5.1.2.2 Binding to Glycolytic Enzymes by the Cytoplasmic Domain of Band 3; 5.1.2.3 Binding to Hemoglobin by the Cytoplasmic Domain of Band 3; 5.1.2.4 Anion Exchange Channel by the Transmembrane Domain of Band 3; 5.1.2.5 Lateral and Rotational Mobility of Band 3; 5.1.2.6 Blood Type Antigens and Band 3 5.1.3 Band 3 in Nonerythyroid Cells |
| Record Nr. | UNINA-9910146242603321 |
Yawata Yoshihito <1936->
|
||
| Weinheim, : Wiley-VCH, c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cell membrane [[electronic resource] ] : the red blood cell as a model / / Yoshihito Yawata
| Cell membrane [[electronic resource] ] : the red blood cell as a model / / Yoshihito Yawata |
| Autore | Yawata Yoshihito <1936-> |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, c2003 |
| Descrizione fisica | 1 online resource (457 p.) |
| Disciplina |
612.111
616.0792 |
| Soggetto topico |
Erythrocyte membranes
Membrane proteins |
| ISBN |
1-280-52041-8
9786610520411 3-527-60532-0 3-527-60153-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cell Membrane; Contents; Preface; Foreword; Acknowledgments; 1 Introduction: History of Red Cell Membrane Research; 1.1 Invention of Optical Microscopes and Their Application to Hematology; 1.2 Discovery of Hereditary Spherocytosis by Light Microscopy; 1.3 The Dawn of Red Cell Membrane Research; 1.4 Commencement of Membrane Protein Biochemistry: Introduction of Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis; 1.5 Elucidation of the Pathogenesis of Red Cell Membrane Disorders; 1.6 Genotypes of Red Cell Membrane Disorders
1.7 Reevaluation of Molecular Electron Microscopy for Phenotypes2 Composition of Normal Red Cell Membranes; 2.1 Introduction; 2.2 Membrane Lipids; 2.2.1 The Contents and Nature of Membrane Lipids; 2.2.2 Asymmetry of the Membrane Lipid Bilayer; 2.2.3 Membrane Fluidity; 2.2.4 Renewal of Membrane Lipids; 2.2.5 Interactions Between Membrane Lipids and Proteins; 2.2.6 Membrane Lipids as a Determinant of Red Cell Shape; 2.3 Membrane Proteins; 2.3.1 Separation and Identification of Membrane Proteins; 2.3.2 Membrane Proteins and Membrane Structure; 2.3.3 Membrane Proteins in the Red Cell Surface 2.3.4 Membrane Proteins and Membrane Functions2.3.4.1 Red Cell Morphology and Shape Change; 2.3.4.2 Red Cell Deformability; 2.3.4.3 Membrane Transport and Permeability; 3 Stereotactic Structure of Red Cell Membranes; 3.1 Historical Background to Membrane Models; 3.2 Ultrastructure of Red Cell Membranes; 3.2.1 Introduction; 3.2.2 Evaluation of the Cytoskeletal Network; 3.2.2.1 Electron Microscopy With the Negative Staining Method; 3.2.2.2 Electron Microscopy With the Quick-Freeze Deep-Etching (QFDE) Method; 3.2.2.3 Electron Microscopy With the Surface Replica (SR) Method 3.2.3 Integral Proteins Examined by Electron Microscopy With the Freeze Fracture Method3.2.4 Visualization of Glycophorins by Field Emission Scanning Electron Microscopy; 4 Skeletal Proteins; 4.1 α- and β-Spectrins; 4.1.1 Introduction; 4.1.2 Structure of Red Cell Spectrins; 4.1.3 Functions of Red Cell Spectrins; 4.1.4 Erythroid and Nonerythroid Spectrins; 4.2 Protein 4.1; 4.2.1 Structure of Protein 4.1; 4.2.2 Binding to Other Membrane Proteins; 4.2.3 Extensive Alternative Splicings; 4.2.4 Nonerythroid Protein 4.1 Isoforms; 4.3 Actin; 4.4 Other Minor Skeletal Proteins; 4.4.1 The p55 Protein 4.4.2 Adducin4.4.3 Dematin (Protein 4.9); 4.4.4 Tropomyosin; 4.4.5 Tropomodulin; 4.4.6 Other Membrane Proteins; 5 Integral Proteins; 5.1 Band 3; 5.1.1 Structure of Band 3; 5.1.2 Functions of Band 3; 5.1.2.1 Membrane Protein Binding by the Cytoplasmic Domain of Band 3; 5.1.2.2 Binding to Glycolytic Enzymes by the Cytoplasmic Domain of Band 3; 5.1.2.3 Binding to Hemoglobin by the Cytoplasmic Domain of Band 3; 5.1.2.4 Anion Exchange Channel by the Transmembrane Domain of Band 3; 5.1.2.5 Lateral and Rotational Mobility of Band 3; 5.1.2.6 Blood Type Antigens and Band 3 5.1.3 Band 3 in Nonerythyroid Cells |
| Record Nr. | UNINA-9910830882603321 |
|
Yawata Yoshihito <1936->
|
||
| Weinheim, : Wiley-VCH, c2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The erythrocyte : a unique cell / / edited by Vani Rajashekaraiah
| The erythrocyte : a unique cell / / edited by Vani Rajashekaraiah |
| Pubbl/distr/stampa | London : , : IntechOpen, , 2023 |
| Descrizione fisica | 1 Online-Ressource (156 pages) |
| Disciplina | 612.111 |
| Soggetto topico |
Erythrocytes
Erythropoiesis |
| ISBN | 1-80356-732-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. Reactive Oxygen Species and Antioxidant Interactions in Erythrocytes -- 2. Erythrocytes as Messengers for Information and Energy Exchange between Cells -- 3. Hormones Action on Erythrocytes and Signaling Pathways -- 4. Reticulocytes-Mother of Erythrocytes -- 5. Genetics of Thalassemia -- 6. Portal Vein Thrombosis in Patients with β-Thalassemia -- 7. Congenital Defects with Impaired Red Blood Cell Deformability - The Role of Next-Generation Ektacytometry. |
| Record Nr. | UNINA-9910727286603321 |
| London : , : IntechOpen, , 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Erythrocyte : A Peripheral Biomarker For Infection and Inflammation / / edited by Kaneez Fatima Shad
| Erythrocyte : A Peripheral Biomarker For Infection and Inflammation / / edited by Kaneez Fatima Shad |
| Pubbl/distr/stampa | London : , : IntechOpen, , 2021 |
| Descrizione fisica | 1 online resource (xi, 118 pages) : illustrations |
| Disciplina | 612.111 |
| Soggetto topico |
Biochemical markers
Erythrocytes |
| ISBN | 1-83969-121-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Erythrocyte |
| Record Nr. | UNINA-9910586688803321 |
| London : , : IntechOpen, , 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Erythropoietic stimulating agents / / editor, Elisio Costa; co-editors, Flavio Reis and Alice Santos-Silva
| Erythropoietic stimulating agents / / editor, Elisio Costa; co-editors, Flavio Reis and Alice Santos-Silva |
| Pubbl/distr/stampa | Oak Park, Illinois : , : Bentham Science Publishers, , 2013 |
| Descrizione fisica | 1 online resource (306 p.) |
| Disciplina | 612.111 |
| Altri autori (Persone) |
CostaElisio
ReisFlávio Santos-SilvaAlice |
| Collana | Frontiers in drug discovery |
| Soggetto topico |
Erythrocytes
Erythropoiesis - Regulation |
| Soggetto genere / forma | Electronic books. |
| ISBN | 1-60805-747-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Cover; TItle; EUL; Contents; Foreword; Preface; List of Contributors; Chapter 01; Chapter 02; Chapter 03; Chapter 04; Chapter 05; Chapter 06; Chatper 07; Chapter 08; Chatper 09; Chapter 10; Chapter 11; Chapter 12; Chapter 13; Chapter 14; Index; Bak Cover |
| Record Nr. | UNINA-9910463771903321 |
| Oak Park, Illinois : , : Bentham Science Publishers, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Erythropoietic stimulating agents / / editor, Elisio Costa; co-editors, Flavio Reis and Alice Santos-Silva
| Erythropoietic stimulating agents / / editor, Elisio Costa; co-editors, Flavio Reis and Alice Santos-Silva |
| Pubbl/distr/stampa | Oak Park, Illinois : , : Bentham Science Publishers, , 2013 |
| Descrizione fisica | 1 online resource (306 p.) |
| Disciplina | 612.111 |
| Altri autori (Persone) |
CostaElisio
ReisFlávio Santos-SilvaAlice |
| Collana | Frontiers in drug discovery |
| Soggetto topico |
Erythrocytes
Erythropoiesis - Regulation |
| ISBN | 1-60805-747-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Cover; TItle; EUL; Contents; Foreword; Preface; List of Contributors; Chapter 01; Chapter 02; Chapter 03; Chapter 04; Chapter 05; Chapter 06; Chatper 07; Chapter 08; Chatper 09; Chapter 10; Chapter 11; Chapter 12; Chapter 13; Chapter 14; Index; Bak Cover |
| Record Nr. | UNINA-9910787323703321 |
| Oak Park, Illinois : , : Bentham Science Publishers, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Erythropoietic stimulating agents / / editor, Elisio Costa; co-editors, Flavio Reis and Alice Santos-Silva
| Erythropoietic stimulating agents / / editor, Elisio Costa; co-editors, Flavio Reis and Alice Santos-Silva |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Oak Park, Illinois : , : Bentham Science Publishers, , 2013 |
| Descrizione fisica | 1 online resource (306 p.) |
| Disciplina | 612.111 |
| Altri autori (Persone) |
CostaElisio
ReisFlávio Santos-SilvaAlice |
| Collana | Frontiers in drug discovery |
| Soggetto topico |
Erythrocytes
Erythropoiesis - Regulation |
| ISBN | 1-60805-747-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Cover; TItle; EUL; Contents; Foreword; Preface; List of Contributors; Chapter 01; Chapter 02; Chapter 03; Chapter 04; Chapter 05; Chapter 06; Chatper 07; Chapter 08; Chatper 09; Chapter 10; Chapter 11; Chapter 12; Chapter 13; Chapter 14; Index; Bak Cover |
| Record Nr. | UNINA-9910829088503321 |
| Oak Park, Illinois : , : Bentham Science Publishers, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Erythropoietin [[electronic resource] ] : blood, brain and beyond / / Arthur J. Sytkowski
| Erythropoietin [[electronic resource] ] : blood, brain and beyond / / Arthur J. Sytkowski |
| Autore | Sytkowski Arthur J |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, 2004 |
| Descrizione fisica | 1 online resource (240 p.) |
| Disciplina |
612.111
615.39 |
| Soggetto topico |
Erythropoietin
Erythropoietin - Physiological effect Erythropoietin - Therapeutic use |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-52052-3
9786610520527 3-527-60543-6 3-527-60238-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Erythropoietin; Preface; Contents; 1 Introduction and History; 1.1 Early Observations; 1.2 Carnot and Deflandre: A Humoral Factor that Stimulates Erythropoiesis; 1.3 Reissmann, Erslev, Jacobson and Stohlman: The Kidney as the Likely Source; 1.4 More Evidence for the Kidney . . . Erythrogenin?; 1.5 Early Assays for Erythropoietin; 1.6 Standardization: What is a "Unit" of Erythropoietin?; 1.7 References; 2 Developmental Biology of Erythropoiesis and Erythropoietin Production; 2.1 Introduction; 2.2 Yolk Sac Hematopoiesis; 2.2.1 The Role of Erythropoietin in Yolk Sac Erythropoiesis
2.2.2 Genes Essential to Primitive Erythropoiesis2.3 Fetal Liver and Bone Marrow (Definitive) Erythropoiesis; 2.4 Genes Essential for Definitive Erythropoiesis; 2.5 Erythropoietin Production; 2.6 References; 3 Regulation of the Erythropoietin Gene: A Paradigm for Hypoxia-dependent Genes; 3.1 The Structure of the Erythropoietin Gene; 3.2 Tissue-specific Expression; 3.3 Mechanism of Hypoxic Regulation - Identification of Transcription Factors and Other Regulatory Proteins; 3.3.1 Is the Oxygen Sensor a Heme Protein? 3.3.2 The 3 ́ Flanking Region of the Erythropoietin Gene Contains Important Regulatory Sequences3.3.3 Identification of the Hypoxia-inducible Factor - Hypoxia Regulates More Than the Erythropoietin Gene; 3.3.4 Other Interacting Proteins and the Regulation of HIF-1; 3.3.5 The von Hippel-Lindau Protein, Proline Hydroxylation and the Oxygen Sensor; 3.3.6 Modulation of HIF-1 Activity by Other Signals; 3.3.7 A Final Word on the Heme Protein Hypothesis; 3.4 References; 4 Physiology and Metabolism of Erythropoietin; 4.1 The Kidney as the Site of Production 4.2 The Liver as a Site of Erythropoietin Production4.3 Erythropoietin Produced in the Bone Marrow; 4.4 Metabolism and Clearance of Erythropoietin; 4.5 Erythropoietin and the Maternal/Fetal Circulation; 4.6 References; 5 Biochemistry and Protein Structure; 5.1 Naturally Occurring Epo; 5.1.1 Difficulties in Purifying the Hormone; 5.1.2 The Purification of Human Urinary Epo; 5.1.3 Biochemical Properties of Human Urinary Epo; 5.1.4 Some Biochemical Properties of Human Serum Epo; 5.2 Recombinant Human Epo; 5.2.1 Cloning the Human Epo Gene; 5.2.2 Glycosylation of Epo 5.2.3 Physicochemical Properties of Epo5.3 Structure-activity Relationships; 5.3.1 Antibody Studies; 5.3.2 Mutagenesis Studies; 5.4 The Tertiary Structure of Epo; 5.5 References; 6 Receptor Biology and Signal Transduction; 6.1 Receptor Biology; 6.1.1 Identification of the Erythropoietin Receptor; 6.1.2 The Erythropoietin Receptor Gene; 6.1.3 The Structure of the Erythropoietin Receptor: A Member of the Cytokine Receptor Superfamily; 6.1.4 The Extracellular Portion of the Erythropoietin Receptor; 6.1.5 The Cytoplasmic Portion of the Erythropoietin Receptor; 6.2 Signal Transduction Pathways 6.2.1 Phosphorylation of the Erythropoietin Receptor |
| Record Nr. | UNINA-9910146241603321 |
|
Sytkowski Arthur J
|
||
| Weinheim, : Wiley-VCH, 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Erythropoietin [[electronic resource] ] : blood, brain and beyond / / Arthur J. Sytkowski
| Erythropoietin [[electronic resource] ] : blood, brain and beyond / / Arthur J. Sytkowski |
| Autore | Sytkowski Arthur J |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, 2004 |
| Descrizione fisica | 1 online resource (240 p.) |
| Disciplina |
612.111
615.39 |
| Soggetto topico |
Erythropoietin
Erythropoietin - Physiological effect Erythropoietin - Therapeutic use |
| ISBN |
1-280-52052-3
9786610520527 3-527-60543-6 3-527-60238-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Erythropoietin; Preface; Contents; 1 Introduction and History; 1.1 Early Observations; 1.2 Carnot and Deflandre: A Humoral Factor that Stimulates Erythropoiesis; 1.3 Reissmann, Erslev, Jacobson and Stohlman: The Kidney as the Likely Source; 1.4 More Evidence for the Kidney . . . Erythrogenin?; 1.5 Early Assays for Erythropoietin; 1.6 Standardization: What is a "Unit" of Erythropoietin?; 1.7 References; 2 Developmental Biology of Erythropoiesis and Erythropoietin Production; 2.1 Introduction; 2.2 Yolk Sac Hematopoiesis; 2.2.1 The Role of Erythropoietin in Yolk Sac Erythropoiesis
2.2.2 Genes Essential to Primitive Erythropoiesis2.3 Fetal Liver and Bone Marrow (Definitive) Erythropoiesis; 2.4 Genes Essential for Definitive Erythropoiesis; 2.5 Erythropoietin Production; 2.6 References; 3 Regulation of the Erythropoietin Gene: A Paradigm for Hypoxia-dependent Genes; 3.1 The Structure of the Erythropoietin Gene; 3.2 Tissue-specific Expression; 3.3 Mechanism of Hypoxic Regulation - Identification of Transcription Factors and Other Regulatory Proteins; 3.3.1 Is the Oxygen Sensor a Heme Protein? 3.3.2 The 3 ́ Flanking Region of the Erythropoietin Gene Contains Important Regulatory Sequences3.3.3 Identification of the Hypoxia-inducible Factor - Hypoxia Regulates More Than the Erythropoietin Gene; 3.3.4 Other Interacting Proteins and the Regulation of HIF-1; 3.3.5 The von Hippel-Lindau Protein, Proline Hydroxylation and the Oxygen Sensor; 3.3.6 Modulation of HIF-1 Activity by Other Signals; 3.3.7 A Final Word on the Heme Protein Hypothesis; 3.4 References; 4 Physiology and Metabolism of Erythropoietin; 4.1 The Kidney as the Site of Production 4.2 The Liver as a Site of Erythropoietin Production4.3 Erythropoietin Produced in the Bone Marrow; 4.4 Metabolism and Clearance of Erythropoietin; 4.5 Erythropoietin and the Maternal/Fetal Circulation; 4.6 References; 5 Biochemistry and Protein Structure; 5.1 Naturally Occurring Epo; 5.1.1 Difficulties in Purifying the Hormone; 5.1.2 The Purification of Human Urinary Epo; 5.1.3 Biochemical Properties of Human Urinary Epo; 5.1.4 Some Biochemical Properties of Human Serum Epo; 5.2 Recombinant Human Epo; 5.2.1 Cloning the Human Epo Gene; 5.2.2 Glycosylation of Epo 5.2.3 Physicochemical Properties of Epo5.3 Structure-activity Relationships; 5.3.1 Antibody Studies; 5.3.2 Mutagenesis Studies; 5.4 The Tertiary Structure of Epo; 5.5 References; 6 Receptor Biology and Signal Transduction; 6.1 Receptor Biology; 6.1.1 Identification of the Erythropoietin Receptor; 6.1.2 The Erythropoietin Receptor Gene; 6.1.3 The Structure of the Erythropoietin Receptor: A Member of the Cytokine Receptor Superfamily; 6.1.4 The Extracellular Portion of the Erythropoietin Receptor; 6.1.5 The Cytoplasmic Portion of the Erythropoietin Receptor; 6.2 Signal Transduction Pathways 6.2.1 Phosphorylation of the Erythropoietin Receptor |
| Record Nr. | UNINA-9910830768503321 |
|
Sytkowski Arthur J
|
||
| Weinheim, : Wiley-VCH, 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Erythropoietin : blood, brain and beyond / / Arthur J. Sytkowski
| Erythropoietin : blood, brain and beyond / / Arthur J. Sytkowski |
| Autore | Sytkowski Arthur J |
| Pubbl/distr/stampa | Weinheim, : Wiley-VCH, 2004 |
| Descrizione fisica | 1 online resource (240 p.) |
| Disciplina |
612.111
615.39 |
| Soggetto topico |
Erythropoietin
Erythropoietin - Physiological effect Erythropoietin - Therapeutic use |
| ISBN |
1-280-52052-3
9786610520527 3-527-60543-6 3-527-60238-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Erythropoietin; Preface; Contents; 1 Introduction and History; 1.1 Early Observations; 1.2 Carnot and Deflandre: A Humoral Factor that Stimulates Erythropoiesis; 1.3 Reissmann, Erslev, Jacobson and Stohlman: The Kidney as the Likely Source; 1.4 More Evidence for the Kidney . . . Erythrogenin?; 1.5 Early Assays for Erythropoietin; 1.6 Standardization: What is a "Unit" of Erythropoietin?; 1.7 References; 2 Developmental Biology of Erythropoiesis and Erythropoietin Production; 2.1 Introduction; 2.2 Yolk Sac Hematopoiesis; 2.2.1 The Role of Erythropoietin in Yolk Sac Erythropoiesis
2.2.2 Genes Essential to Primitive Erythropoiesis2.3 Fetal Liver and Bone Marrow (Definitive) Erythropoiesis; 2.4 Genes Essential for Definitive Erythropoiesis; 2.5 Erythropoietin Production; 2.6 References; 3 Regulation of the Erythropoietin Gene: A Paradigm for Hypoxia-dependent Genes; 3.1 The Structure of the Erythropoietin Gene; 3.2 Tissue-specific Expression; 3.3 Mechanism of Hypoxic Regulation - Identification of Transcription Factors and Other Regulatory Proteins; 3.3.1 Is the Oxygen Sensor a Heme Protein? 3.3.2 The 3 ́ Flanking Region of the Erythropoietin Gene Contains Important Regulatory Sequences3.3.3 Identification of the Hypoxia-inducible Factor - Hypoxia Regulates More Than the Erythropoietin Gene; 3.3.4 Other Interacting Proteins and the Regulation of HIF-1; 3.3.5 The von Hippel-Lindau Protein, Proline Hydroxylation and the Oxygen Sensor; 3.3.6 Modulation of HIF-1 Activity by Other Signals; 3.3.7 A Final Word on the Heme Protein Hypothesis; 3.4 References; 4 Physiology and Metabolism of Erythropoietin; 4.1 The Kidney as the Site of Production 4.2 The Liver as a Site of Erythropoietin Production4.3 Erythropoietin Produced in the Bone Marrow; 4.4 Metabolism and Clearance of Erythropoietin; 4.5 Erythropoietin and the Maternal/Fetal Circulation; 4.6 References; 5 Biochemistry and Protein Structure; 5.1 Naturally Occurring Epo; 5.1.1 Difficulties in Purifying the Hormone; 5.1.2 The Purification of Human Urinary Epo; 5.1.3 Biochemical Properties of Human Urinary Epo; 5.1.4 Some Biochemical Properties of Human Serum Epo; 5.2 Recombinant Human Epo; 5.2.1 Cloning the Human Epo Gene; 5.2.2 Glycosylation of Epo 5.2.3 Physicochemical Properties of Epo5.3 Structure-activity Relationships; 5.3.1 Antibody Studies; 5.3.2 Mutagenesis Studies; 5.4 The Tertiary Structure of Epo; 5.5 References; 6 Receptor Biology and Signal Transduction; 6.1 Receptor Biology; 6.1.1 Identification of the Erythropoietin Receptor; 6.1.2 The Erythropoietin Receptor Gene; 6.1.3 The Structure of the Erythropoietin Receptor: A Member of the Cytokine Receptor Superfamily; 6.1.4 The Extracellular Portion of the Erythropoietin Receptor; 6.1.5 The Cytoplasmic Portion of the Erythropoietin Receptor; 6.2 Signal Transduction Pathways 6.2.1 Phosphorylation of the Erythropoietin Receptor |
| Record Nr. | UNINA-9910877407603321 |
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Sytkowski Arthur J
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| Weinheim, : Wiley-VCH, 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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