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The hERG cardial potassium channel [[electronic resource] ] : structure, function, and long QT syndrome / / [editors, Derek J. Chadwick, James Goode]
| The hERG cardial potassium channel [[electronic resource] ] : structure, function, and long QT syndrome / / [editors, Derek J. Chadwick, James Goode] |
| Pubbl/distr/stampa | New York, : J. Wiley, 2005 |
| Descrizione fisica | 1 online resource (309 p.) |
| Disciplina |
612.1/7
612.173 616.1207 |
| Altri autori (Persone) |
ChadwickDerek
GoodeJamie |
| Collana | Novartis Foundation symposium |
| Soggetto topico |
Potassium channels
Long QT syndrome Heart - Physiology Heart - Pathophysiology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-27526-X
9786610275267 0-470-02142-X 0-470-02141-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
THE hERG CARDIAC POTASSIUM CHANNEL: STRUCTURE, FUNCTION AND LONG QT SYNDROME; Contents; Participants; Chair's introduction; Gating and assembly of heteromeric hERG1a/1b channels underlying I(Kr) in the heart; Discussion; Structure-function studies of the outer mouth and voltage sensor domain of hERG; Discussion; General discussion I; Voltage sensor movement in the hERGK(+) channel; Discussion; hERG channel trafficking; Discussion; Dynamic control of hERG/I(Kr) by PKA-mediated interactions with 14-3-3; Discussion; General discussion II
Does hERG coassemble with a b subunit? Evidence for roles of MinK and MiRP1Discussion; hERG block, QT liability and sudden cardiac death; Discussion; Structural determinants for high-affinity block of hERG potassium channels; Discussion; Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs; Discussion; In silico modelling-pharmacophores and hERG channel models; Discussion; The long QTsyndrome: a clinical counterpart of HERG mutations; Discussion; Cellular mechanisms of Torsade de Pointes; Discussion Expression and role of hERG channels in cancer cellsDiscussion; TRIad: foundation for proarrhythmia (triangulation, reverse use dependence and instability); Discussion; Drug-induced QT interval prolongation: regulatory guidance and perspectives on hERG channel studies; Discussion; Closing remarks; Index of contributors; Subject index |
| Record Nr. | UNINA-9910143740603321 |
| New York, : J. Wiley, 2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The hERG cardial potassium channel : structure, function, and long QT syndrome / / [editors, Derek J. Chadwick, James Goode]
| The hERG cardial potassium channel : structure, function, and long QT syndrome / / [editors, Derek J. Chadwick, James Goode] |
| Pubbl/distr/stampa | New York, : J. Wiley, 2005 |
| Descrizione fisica | 1 online resource (309 p.) |
| Disciplina | 612.1/7 |
| Altri autori (Persone) |
ChadwickDerek
GoodeJamie |
| Collana | Novartis Foundation symposium |
| Soggetto topico |
Potassium channels
Long QT syndrome Heart - Physiology Heart - Pathophysiology |
| ISBN |
1-280-27526-X
9786610275267 0-470-02142-X 0-470-02141-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
THE hERG CARDIAC POTASSIUM CHANNEL: STRUCTURE, FUNCTION AND LONG QT SYNDROME; Contents; Participants; Chair's introduction; Gating and assembly of heteromeric hERG1a/1b channels underlying I(Kr) in the heart; Discussion; Structure-function studies of the outer mouth and voltage sensor domain of hERG; Discussion; General discussion I; Voltage sensor movement in the hERGK(+) channel; Discussion; hERG channel trafficking; Discussion; Dynamic control of hERG/I(Kr) by PKA-mediated interactions with 14-3-3; Discussion; General discussion II
Does hERG coassemble with a b subunit? Evidence for roles of MinK and MiRP1Discussion; hERG block, QT liability and sudden cardiac death; Discussion; Structural determinants for high-affinity block of hERG potassium channels; Discussion; Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs; Discussion; In silico modelling-pharmacophores and hERG channel models; Discussion; The long QTsyndrome: a clinical counterpart of HERG mutations; Discussion; Cellular mechanisms of Torsade de Pointes; Discussion Expression and role of hERG channels in cancer cellsDiscussion; TRIad: foundation for proarrhythmia (triangulation, reverse use dependence and instability); Discussion; Drug-induced QT interval prolongation: regulatory guidance and perspectives on hERG channel studies; Discussion; Closing remarks; Index of contributors; Subject index |
| Record Nr. | UNINA-9910876807403321 |
| New York, : J. Wiley, 2005 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Physiology of the heart / / Arnold M. Katz
| Physiology of the heart / / Arnold M. Katz |
| Autore | Katz Arnold M |
| Edizione | [Fifth edition.] |
| Pubbl/distr/stampa | Philadelphia : , : Wolters Kluwer Health/Lippincott Williams & Wilkins Health, , [2011] |
| Descrizione fisica | 1 online resource (592 p.) |
| Disciplina | 612.1/7 |
| Soggetto topico |
Heart - Physiology
Heart - Pathophysiology |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-4511-4912-3
1-4511-2497-X 1-4698-7688-4 1-60831-171-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. Structure of the Heart and Cardiac Muscle 2. Energetics and Energy Production 3. Energy Utilization (Work and Heat) 4. The Contractile Proteins 5. The Cytoskeleton 6. Active State, Length-Tension Relationship, Cardiac Mechanics 7. Excitation-Contraction Coupling: Extracellular and Intracellular Calcium Cycles 8. Signal Transduction: Functional Signaling 9. Signal Transduction: Proliferative Signaling 10. Regulation of Cardiac Muscle Performance 11. The Heart as a Muscular Pump 12. The Working Heart 13. Cardiac Ion Channels 14. The Cardiac Action Potential 15. The Electrocardiogram 16. Arrhythmias 17. The Ischemic Heart 18. Heart Failure. |
| Record Nr. | UNINA-9910464740603321 |
Katz Arnold M
|
||
| Philadelphia : , : Wolters Kluwer Health/Lippincott Williams & Wilkins Health, , [2011] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Physiology of the heart / / Arnold M. Katz
| Physiology of the heart / / Arnold M. Katz |
| Autore | Katz Arnold M |
| Edizione | [Fifth edition.] |
| Pubbl/distr/stampa | Philadelphia : , : Wolters Kluwer Health/Lippincott Williams & Wilkins Health, , [2011] |
| Descrizione fisica | 1 online resource (592 p.) |
| Disciplina | 612.1/7 |
| Soggetto topico |
Heart - Physiology
Heart - Pathophysiology |
| ISBN |
1-4511-4912-3
1-4511-2497-X 1-4698-7688-4 1-60831-171-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. Structure of the Heart and Cardiac Muscle 2. Energetics and Energy Production 3. Energy Utilization (Work and Heat) 4. The Contractile Proteins 5. The Cytoskeleton 6. Active State, Length-Tension Relationship, Cardiac Mechanics 7. Excitation-Contraction Coupling: Extracellular and Intracellular Calcium Cycles 8. Signal Transduction: Functional Signaling 9. Signal Transduction: Proliferative Signaling 10. Regulation of Cardiac Muscle Performance 11. The Heart as a Muscular Pump 12. The Working Heart 13. Cardiac Ion Channels 14. The Cardiac Action Potential 15. The Electrocardiogram 16. Arrhythmias 17. The Ischemic Heart 18. Heart Failure. |
| Record Nr. | UNINA-9910789320203321 |
|
Katz Arnold M
|
||
| Philadelphia : , : Wolters Kluwer Health/Lippincott Williams & Wilkins Health, , [2011] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Physiology of the heart / / Arnold M. Katz
| Physiology of the heart / / Arnold M. Katz |
| Autore | Katz Arnold M |
| Edizione | [Fifth edition.] |
| Pubbl/distr/stampa | Philadelphia : , : Wolters Kluwer Health/Lippincott Williams & Wilkins Health, , [2011] |
| Descrizione fisica | 1 online resource (592 p.) |
| Disciplina | 612.1/7 |
| Soggetto topico |
Heart - Physiology
Heart - Pathophysiology |
| ISBN |
1-4511-4912-3
1-4511-2497-X 1-4698-7688-4 1-60831-171-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1. Structure of the Heart and Cardiac Muscle 2. Energetics and Energy Production 3. Energy Utilization (Work and Heat) 4. The Contractile Proteins 5. The Cytoskeleton 6. Active State, Length-Tension Relationship, Cardiac Mechanics 7. Excitation-Contraction Coupling: Extracellular and Intracellular Calcium Cycles 8. Signal Transduction: Functional Signaling 9. Signal Transduction: Proliferative Signaling 10. Regulation of Cardiac Muscle Performance 11. The Heart as a Muscular Pump 12. The Working Heart 13. Cardiac Ion Channels 14. The Cardiac Action Potential 15. The Electrocardiogram 16. Arrhythmias 17. The Ischemic Heart 18. Heart Failure. |
| Record Nr. | UNINA-9910821003203321 |
|
Katz Arnold M
|
||
| Philadelphia : , : Wolters Kluwer Health/Lippincott Williams & Wilkins Health, , [2011] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Renin angiotensin system and the heart / / edited by Walmor C. De Mello
| Renin angiotensin system and the heart / / edited by Walmor C. De Mello |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley & Sons, c2004 |
| Descrizione fisica | 1 online resource (258 p.) |
| Disciplina | 612.1/7 |
| Altri autori (Persone) | De MelloWalmor C |
| Soggetto topico |
Renin-angiotensin system
Heart - Physiology Heart - Pathophysiology |
| ISBN |
1-280-24185-3
9786610241859 0-470-30030-2 0-470-03210-3 0-470-86294-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Intracellular signaling and the cardiac renin angiotensin system / George W. Booz and Kenneth M. Baker -- Cardiac physiology and the renin-angiotensin system: lessons from transgenic animal models / Alisdair Ryding and John J. Mullins -- Prorenin uptake in the heart / A.H. Jan Danser -- Role of local renin-angiotensin systems in cardiac damage / Michael Bader -- Cardiac renin: de novo synthesis and uptake / J"rg Peters -- The cardiac renin receptors / Genevieve Nguyen, Celine Burckle, and Benjamin Tremey -- Angiotensin II AT2 receptors and cardiac function / Jun suzuki ... [et al.] -- The heart, a target for the renin angiotension system: evidence of an intracrine system / Walmor C. De Mello -- ACE2: its role in the counter-regulatory response to heart failure / Lawrence S. Zisman -- Wound healing and the tissue renin-angiotensin-aldosterone system / Yao Sun, and Karl T. Weber -- Trophic effects of aldosterone / Claude Delcayre ... [el al.] -- Intracellular angiotensin and the actions of intracrine hormones / Richard N. Re -- Angiotensin ii and myocardial fibrosis, clinical implications / Begona Lopez, Arantxa Gonzalez and Javier Diez -- Hypertensive heart disease: significance of renin angiotensin system / Jasmina Varagic and Edward D Frohlich. |
| Record Nr. | UNINA-9910877629703321 |
| Hoboken, NJ, : John Wiley & Sons, c2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||