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Platelet proteomics : principles, analysis, and applications / / edited by Angel Garcia, Yotis Senis
| Platelet proteomics : principles, analysis, and applications / / edited by Angel Garcia, Yotis Senis |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Hoboken, NJ, : John Wiley & Sons, c2011 |
| Descrizione fisica | 1 online resource (425 p.) |
| Disciplina | 612.1/17 |
| Altri autori (Persone) |
GarciaAngel <1968->
SenisYotis A. <1970-> |
| Collana | Wiley-Interscience series on mass spectrometry |
| Soggetto topico |
Blood platelets
Proteomics |
| ISBN |
9786613082015
9781118002070 1118002075 9781283082013 1283082012 9780470940297 0470940298 9780470940280 047094028X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
PLATELET PROTEOMICS; CONTENTS; Contributors; Foreword; Preface; Acronyms; PART I GENERAL OVERVIEW: PLATELETS, SAMPLE PREPARATION, AND MASS SPECTROMETRY-BASED PROTEOMICS; 1 Platelets and Their Role in Thrombotic and Cardiovascular Disease: The Impact of Proteomic Analysis; 2 Mass-Spectrometry-Based Proteomics: General Overview and Posttranslational Modification Analysis in the Context of Platelet Research; 3 Sample Preparation Variables in Platelet Proteomics for Biomarker Research; PART II ANALYSIS OF THE PLATELET PROTEOME: GLOBAL APPROACHES AND SUBPROTEOMES
4 Two-Dimensional Gel Electrophoresis: Basic Principles and Application to Platelet Signaling Studies5 The Platelet Membrane Proteome; 6 Proteomics of Platelet Granules, Organelles, and Releasate; 7 The Platelet Microparticle Proteome; 8 N-Terminal Combined Fractional Diagonal Chromatographic (COFRADIC) Analysis of the Human Platelet Proteome; PART III INTEGRATED "OMICS" AND APPLICATION TO DISEASE; 9 Serial Analysis of Gene Expression (SAGE) For Studying the Platelet and Megakaryocyte Transcriptome 10 The Application of Microarray Analysis and Its Integration with Proteomics for Study of Platelet-Associated Disorders11 Platelet Functional Genomics; 12 Systems Biology to Study Platelet-Related Bleeding Disorders; 13 Platelet Proteomics in Transfusion Medicine; 14 Cardiovascular Proteomics; Index |
| Record Nr. | UNINA-9910139450803321 |
| Hoboken, NJ, : John Wiley & Sons, c2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Platelets [[electronic resource] /] / editor, Alan D. Michelson
| Platelets [[electronic resource] /] / editor, Alan D. Michelson |
| Edizione | [3rd ed.] |
| Pubbl/distr/stampa | Amsterdam, : Elsevier, 2013 |
| Descrizione fisica | 1 online resource (1398 p.) |
| Disciplina |
612.1
612.1/17 612.117 |
| Altri autori (Persone) | MichelsonAlan D |
| Soggetto topico |
Blood platelets
Blood platelet disorders |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-283-70649-0
0-12-387838-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Platelets; Copyright Page; Contents; List of Contributors; Preface; Foreword: A Brief History of Ideas About Platelets in Health and Disease; I. The Role of Platelets in Human Hemostasis, Platelet Transfusion, and the Bleeding Time; II. Immune Thrombocytopenia; III. Alloantigens, Single Nucleotide Polymorphisms, and Alloimmune Thrombocytopenias; IV. Platelet Physiology, Assays of Platelet "Adhesiveness", ADP, Platelet Aggregation, Myocardial Infarction, and P2Y12 Anta...
V. Aspirin, Arachidonic Acid, Prostaglandins, Gpiib-iiia, Nitric Oxide, Endothelial Gpiib-iiia, and AngiogenesisVI. Clot Retraction, Glanzmann Thrombasthenia, GPIIb-IIIa Receptor, and GPIIb-IIIa Antagonists; VII. Bernard-Soulier Syndrome, the Gpib-IX-V Complex, von Willebrand Factor, Shear, ADAMTS-13, and Thrombotic Thrombocytopen...; VIII. Thrombin-induced Platelet Activation; IX. Platelets and Metastases; X. Reflections on the Past and Thoughts About the Future; Reference List; I. Platelet Biology; 1 The Evolution of Mammalian Platelets; I Introduction; II Invertebrates III Nonmammalian VertebratesIV Comparative Hemostasis; V A Comparison of Human Platelets and Limulus Amebocytes; VI The Evolution of Hemostasis and Blood Coagulation; VII Megakaryocytes and Mammals; A Marine Mammals; B Order Monotremata; C Order Marsupialia; D Platelet Levels; E A Comparison of Nonplacental and Placental Mammals; VIII Conclusions; Acknowledgments; References; 2 Megakaryocyte Development and Platelet Formation; I Introduction; II Megakaryocyte Development; A The Hematopoietic Program; B Committed Megakaryocyte Progenitor Cells; C Immediate Megakaryocyte Precursors D Endomitosis and Polyploid Formation E Megakaryocyte Cytoplasmic Maturation; 1 Demarcation Membrane System; 2 Dense Tubular System; 3 Granules; III Platelet Formation; A Mechanisms of Platelet Production; 1 Budding from the Megakaryocyte Surface; 2 Cytoplasmic Fragmentation via the Demarcation Membrane System; 3 Proplatelet Formation; a The Proplatelet Theory; b Proplatelet Morphogenesis; c The Cytoskeletal Mechanics of Proplatelet Formation; i Microtubules Power Proplatelet Elongation; ii Actin-Dependent Proplatelet Branching; iii Organelle Transport in Proplatelets iv Spectrin-Based Membrane Skeleton in Platelet Production v Release of Platelets; B The Sites of Platelet Formation In Vivo; 1 Platelet Formation in the Bone Marrow; 2 Platelet Formation in the Bloodstream; 3 Platelet Formation in the Lung; C Apoptosis and Platelet Production; D Production of Platelets for Infusion; IV Regulation of Megakaryocyte Development and Platelet Formation; V Murine Model Systems and Human Diseases as Tools to Study Platelet Biogenesis; A Transcription Factors; 1 GATA-1; 2 Nuclear Factor-Erythroid 2; B Cytoskeletal Proteins; 1 β1 Tubulin 2 Glycoprotein Ib-IX-V Complex |
| Record Nr. | UNINA-9910462043403321 |
| Amsterdam, : Elsevier, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Platelets [[electronic resource] /] / editor, Alan D. Michelson
| Platelets [[electronic resource] /] / editor, Alan D. Michelson |
| Edizione | [3rd ed.] |
| Pubbl/distr/stampa | Amsterdam, : Elsevier, 2013 |
| Descrizione fisica | 1 online resource (1398 p.) |
| Disciplina |
612.1
612.1/17 612.117 |
| Altri autori (Persone) | MichelsonAlan D |
| Soggetto topico |
Blood platelets
Blood platelet disorders |
| ISBN |
1-283-70649-0
0-12-387838-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Platelets; Copyright Page; Contents; List of Contributors; Preface; Foreword: A Brief History of Ideas About Platelets in Health and Disease; I. The Role of Platelets in Human Hemostasis, Platelet Transfusion, and the Bleeding Time; II. Immune Thrombocytopenia; III. Alloantigens, Single Nucleotide Polymorphisms, and Alloimmune Thrombocytopenias; IV. Platelet Physiology, Assays of Platelet "Adhesiveness", ADP, Platelet Aggregation, Myocardial Infarction, and P2Y12 Anta...
V. Aspirin, Arachidonic Acid, Prostaglandins, Gpiib-iiia, Nitric Oxide, Endothelial Gpiib-iiia, and AngiogenesisVI. Clot Retraction, Glanzmann Thrombasthenia, GPIIb-IIIa Receptor, and GPIIb-IIIa Antagonists; VII. Bernard-Soulier Syndrome, the Gpib-IX-V Complex, von Willebrand Factor, Shear, ADAMTS-13, and Thrombotic Thrombocytopen...; VIII. Thrombin-induced Platelet Activation; IX. Platelets and Metastases; X. Reflections on the Past and Thoughts About the Future; Reference List; I. Platelet Biology; 1 The Evolution of Mammalian Platelets; I Introduction; II Invertebrates III Nonmammalian VertebratesIV Comparative Hemostasis; V A Comparison of Human Platelets and Limulus Amebocytes; VI The Evolution of Hemostasis and Blood Coagulation; VII Megakaryocytes and Mammals; A Marine Mammals; B Order Monotremata; C Order Marsupialia; D Platelet Levels; E A Comparison of Nonplacental and Placental Mammals; VIII Conclusions; Acknowledgments; References; 2 Megakaryocyte Development and Platelet Formation; I Introduction; II Megakaryocyte Development; A The Hematopoietic Program; B Committed Megakaryocyte Progenitor Cells; C Immediate Megakaryocyte Precursors D Endomitosis and Polyploid Formation E Megakaryocyte Cytoplasmic Maturation; 1 Demarcation Membrane System; 2 Dense Tubular System; 3 Granules; III Platelet Formation; A Mechanisms of Platelet Production; 1 Budding from the Megakaryocyte Surface; 2 Cytoplasmic Fragmentation via the Demarcation Membrane System; 3 Proplatelet Formation; a The Proplatelet Theory; b Proplatelet Morphogenesis; c The Cytoskeletal Mechanics of Proplatelet Formation; i Microtubules Power Proplatelet Elongation; ii Actin-Dependent Proplatelet Branching; iii Organelle Transport in Proplatelets iv Spectrin-Based Membrane Skeleton in Platelet Production v Release of Platelets; B The Sites of Platelet Formation In Vivo; 1 Platelet Formation in the Bone Marrow; 2 Platelet Formation in the Bloodstream; 3 Platelet Formation in the Lung; C Apoptosis and Platelet Production; D Production of Platelets for Infusion; IV Regulation of Megakaryocyte Development and Platelet Formation; V Murine Model Systems and Human Diseases as Tools to Study Platelet Biogenesis; A Transcription Factors; 1 GATA-1; 2 Nuclear Factor-Erythroid 2; B Cytoskeletal Proteins; 1 β1 Tubulin 2 Glycoprotein Ib-IX-V Complex |
| Record Nr. | UNINA-9910785961803321 |
| Amsterdam, : Elsevier, 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||